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List of works by Jos Jonkers

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

scientific article

A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation

scientific article published on 01 December 2018

A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors

scientific article

A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization

scientific article published in January 2004

Analysis of tumor heterogeneity and cancer gene networks using deep sequencing of MMTV-induced mouse mammary tumors.

scientific article

Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human

scientific journal article

Atlas of Lobular Breast Cancer Models: Challenges and Strategic Directions

scientific article published on 28 October 2021

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences

scientific article published on 01 February 2019

Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development

scientific article published on July 2006

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

scientific article published on 20 July 2017

BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny

scientific journal article

BRCA1-associated mammary tumorigenesis is dependent on estrogen rather than progesterone signaling

scientific article published on 04 July 2018

BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations

scientific article

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1

scientific article published on 25 July 2016

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping

scientific journal article

BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers

scientific article published on 01 February 2020

BRD7 is a candidate tumour suppressor gene required for p53 function

scientific article

Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system ⬇️

scientific article published on 06 March 2012

Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.

scientific article

Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer

scientific article published in Nature Communications

Computational identification of insertional mutagenesis targets for cancer gene discovery ⬇️

scientific article published on June 7, 2011

Conditional mouse models of sporadic cancer

scientific article

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

scientific article published on 07 January 2021

CopywriteR: DNA copy number detection from off-target sequence data

scientific article

Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers

scientific article

Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance ⬇️

scientific article published on July 11, 2011

Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours ⬇️

scientific article published on February 22, 2012

Developmental stage‐specific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland ⬇️

scientific article published on November 1, 2012

EZH2 Is Overexpressed in -like Breast Tumors and Predictive for Sensitivity to High-Dose Platinum-Based Chemotherapy

scientific article published on 29 April 2019

EZN-2208 (PEG-SN38) overcomes ABCG2-mediated topotecan resistance in BRCA1-deficient mouse mammary tumors

scientific article (publication date: 2012)

Error-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasia

scientific article

Exogenous ERα Expression in the Mammary Epithelium Decreases Over Time and Does Not Contribute to p53-Deficient Mammary Tumor Formation in Mice

scientific article published on 15 November 2019

Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways

scientific article

Feasibility of Phosphoproteomics on Leftover Samples After RNA Extraction With Guanidinium Thiocyanate

scientific article published on 02 April 2021

Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomas

scientific article

Frat is dispensable for canonical Wnt signaling in mammals

scientific journal article

Functional categorization of BRCA1 variants of uncertain clinical significance in homologous recombination repair complementation assays

scientific article published on 16 June 2020

GATA3 Truncating Mutations Promote Cistromic Re-Programming In Vitro, but Not Mammary Tumor Formation in Mice

scientific article published on 19 June 2019

Genetically engineered mouse models in oncology research and cancer medicine

scientific article

Genetically engineered mouse models of PI3K signaling in breast cancer

scientific article

Genomic instability in breast and ovarian cancers: translation into clinical predictive biomarkers ⬇️

scientific article published on September 16, 2011

Genomic patterns resembling BRCA1- and BRCA2-mutated breast cancers predict benefit of intensified carboplatin-based chemotherapy

scientific article

Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer

scientific article published on 16 July 2021

HELB Is a Feedback Inhibitor of DNA End Resection

scientific journal article

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

scientific article

Human and mouse oligonucleotide-based array CGH.

scientific article

Identification of cancer genes using a statistical framework for multiexperiment analysis of nondiscretized array CGH data

scientific article

Identification of networks of co-occurring, tumor-related DNA copy number changes using a genome-wide scoring approach

scientific article

Impact of intertumoral heterogeneity on predicting chemotherapy response of BRCA1-deficient mammary tumors

scientific article

In situ CRISPR-Cas9 base editing for the development of genetically engineered mouse models of breast cancer

scientific article published on 13 January 2020

Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma

scientific article published on 26 June 2017

Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes

scientific article

KC-SMARTR: An R package for detection of statistically significant aberrations in multi-experiment aCGH data.

scientific article

Lack of genomic heterogeneity at high-resolution aCGH between primary breast cancers and their paired lymph node metastases

scientific article

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

scientific article

Long-term expanding human airway organoids for disease modeling

scientific article published on 14 January 2019

Loss of p120-Catenin Induces Metastatic Progression of Breast Cancer by Inducing Anoikis Resistance and Augmenting Growth Factor Receptor Signaling ⬇️

scientific article published on June 3, 2013

Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression

scientific journal article

MEK inhibition as a strategy for targeting residual breast cancer cells with low DUSP4 expression ⬇️

scientific article published on November 5, 2012

MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling

scientific article published in 2022

Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice

scientific article

Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer

scientific article published on 5 July 2016

Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors

scientific article

Mouse Model Systems to Study Multistep Tumorigenesis ⬇️

scientific article published on 01 January 1994

Mutagenic insertion and chromosome engineering resource (MICER).

scientific article published on 4 July 2004

Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach

scientific article

Opportunities and hurdles in the treatment of BRCA1-related breast cancer ⬇️

scientific article published on August 19, 2013

PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer

scientific article published on 23 April 2019

PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma

scientific article published on 10 August 2016

Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer

scientific journal article

Patient-derived xenograft models: an emerging platform for translational cancer research

scientific article

Prophylactic window therapy with the clinical poly(ADP-ribose) polymerase inhibitor olaparib delays BRCA1-deficient mammary tumour formation in mice

scientific article published on 9 December 2016

Proteomics of genetically engineered mouse mammary tumors identifies fatty acid metabolism members as potential predictive markers for cisplatin resistance

scientific article published on 8 February 2013

Proteomics of mouse BRCA1-deficient mammary tumors identifies DNA repair proteins with potential diagnostic and prognostic value in human breast cancer

scientific article

Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

correction of a scholarly article

Radiosensitivity Is an Acquired Vulnerability of PARPi-Resistant BRCA1-Deficient Tumors

scientific article published on 10 December 2018

Rapid validation of cancer genes in chimeras derived from established genetically engineered mouse models ⬇️

scientific article published on 07 July 2011

Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin

scientific article published on 23 August 2019

Response of metastatic mouse invasive lobular carcinoma to mTOR inhibition is partly mediated by the adaptive immune system

scientific article published on 12 February 2020

Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer

scientific article published on 23 August 2016

Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.

scientific article

Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan

scientific article

Somatic structural rearrangements in genetically engineered mouse mammary tumors

scientific article

Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation

scientific article

Studying Therapy Response and Resistance in Mouse Models for BRCA1-Deficient Breast Cancer ⬇️

scientific article published on February 18, 2011

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer ⬇️

scientific article published on December 1, 2001

TRPS1 acts as a context-dependent regulator of mammary epithelial cell growth/differentiation and breast cancer development

scientific article published on 26 December 2019

The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance ⬇️

scientific article published on September 1, 2012

Tracking Evolution of BRCA1-Associated Breast Cancer ⬇️

scientific article published on June 1, 2012

Transcriptomics and Transposon Mutagenesis Identify Multiple Mechanisms of Resistance to the FGFR Inhibitor AZD4547

scientific article published on 16 August 2018

Truncated ASPP2 Drives Initiation and Progression of Invasive Lobular Carcinoma via Distinct Mechanisms

scientific article published on 14 February 2020

Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

scientific article published in August 2022

Tumor-initiating cells are not enriched in cisplatin-surviving BRCA1;p53-deficient mammary tumor cells in vivo

scientific article

Use of a single hybrid imaging agent for integration of target validation with in vivo and ex vivo imaging of mouse tumor lesions resembling human DCIS

scientific article

αE-catenin is a candidate tumor suppressor for the development of E-cadherin-expressing lobular-type breast cancer

scientific article published on 20 June 2018

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