List of works by John V Heymach

18F-fluorodeoxyglucose positron emission tomography correlates with tumor immunometabolic phenotypes in resected lung cancer

scientific article published on 16 April 2020

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016

scientific article published oln 16 November 2016

7-year follow-up after stereotactic ablative radiotherapy for patients with stage I non-small cell lung cancer: Results of a phase 2 clinical trial.

scientific article published on 27 March 2017

8-Chloroadenosine Sensitivity in Renal Cell Carcinoma Is Associated with AMPK Activation and mTOR Pathway Inhibition

scientific article published on 27 August 2015

A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis and Metastasis in Aneuploid Cancers

scientific article published on 04 December 2020

A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition

scientific article published on 29 September 2015

A Phase I/II Study of Neoadjuvant Cisplatin, Docetaxel and Nintedanib for Resectable Non-Small Cell Lung Cancer

scientific article published on 19 March 2020

A Phase II Trial of Alisertib (MLN8237) in Salvage Malignant Mesothelioma

scientific article published on 01 July 2020

A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components

scientific article published on 01 September 2020

A comprehensive evaluation of biomarkers predictive of response to PI3K inhibitors and of resistance mechanisms in head and neck squamous cell carcinoma

scientific article

A high content clonogenic survival drug screen identifies mek inhibitors as potent radiation sensitizers for KRAS mutant non-small-cell lung cancer

scientific article

A novel therapeutic combination for neuroblastoma: the vascular endothelial growth factor receptor/epidermal growth factor receptor/rearranged during transfection inhibitor vandetanib with 13-cis-retinoic acid

scientific article published on May 2010

A pan-cancer proteomic perspective on The Cancer Genome Atlas.

scientific article

A phase 2 pilot trial of low-dose, continuous infusion, or "metronomic" paclitaxel and oral celecoxib in patients with metastatic melanoma

scientific article

AXL Inhibition Suppresses the DNA Damage Response and Sensitizes Cells to PARP Inhibition in Multiple Cancers.

scientific article published on 26 September 2016

AXL inhibition induces DNA damage and replication stress in non-small cell lung cancer cells and promotes sensitivity to ATR inhibitors

scientific article published on 10 November 2020

AXL targeting restores PD-1 blockade sensitivity of <i>STK11/LKB1</i> mutant NSCLC through expansion of TCF1<sup>+</sup> CD8 T cells

scientific article published on 15 March 2022

Aberrant expression of proteins involved in signal transduction and DNA repair pathways in lung cancer and their association with clinical parameters

scientific article

About CD45-/CD31+/CD105+ circulating cells in patients with gynecologic malignancies--letter

scientific article published in March 2014

Abstract 1180: Impact of the spatial analysis of tumor-associated lymphocytes and tumor-associated macrophages on recurrence at early stage of non-small cell lung carcinoma

scholarly article

Abstract 2215: SLFN11 and EZH2 protein expression and localization in circulating tumor cells to predict response or resistance to DNA damaging therapies in small cell lung cancer

scholarly article

Abstract 2741: Comprehensive molecular profiling of primary tumors and paired distant metastases in non-small cell lung cancer

scholarly article

Abstract 4997: Responsiveness to immune checkpoint inhibitors in RET dependent cancers

scholarly article

Abstract 6513: Single cell and spatial profiling reveal molecular and immune evolution from precancers to invasive lung adenocarcinomas in genetic and carcinogen-induced mouse models

scientific article published in 2023

Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors

scientific article published on 21 November 2016

Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer

scientific article

Advanced Non-Small Cell Lung Cancer: Sequencing Agents in the EGFR-Mutated/ALK-Rearranged Populations

scientific article published on 01 January 2019

Agreement on Major Pathological Response in NSCLC Patients Receiving Neoadjuvant Chemotherapy

scientific article published on 04 March 2020

Altered regulation of HIF-1α in naïve- and drug-resistant EGFR mutant NSCLC: implications for a VEGF-dependent phenotype

scientific article published on 09 December 2020

An IRAK1-PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy

scientific article published on 21 January 2019

An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2.

scientific article published on 15 April 2015

An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance

scientific article published on 22 October 2012

An in vivo functional genomics screen of nuclear receptors and their co-regulators identifies FOXA1 as an essential gene in lung tumorigenesis

scientific article published on 13 May 2020

An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.

scientific article

Analysis of Factors Affecting Successful Clinical Trial Enrollment in the Context of Three Prospective, Randomized, Controlled Trials

scientific article

Angiogenesis inhibitors and hypoxia.

scientific article published in September 2003

Angiogenesis inhibitors for lung cancer: clinical developments and future directions.

scientific article published on September 2006

Antitumor activity of CD56-chimeric antigen receptor T cells in neuroblastoma and SCLC models.

scientific article published on 6 April 2018

Antitumor activity of a novel STAT3 inhibitor and redox modulator in non-small cell lung cancer cells

scientific article

Applying Artificial Intelligence to Address the Knowledge Gaps in Cancer Care

scientific article published on 16 November 2018

Association of Long-term Outcomes and Survival With Multidisciplinary Salvage Treatment for Local and Regional Recurrence After Stereotactic Ablative Radiotherapy for Early-Stage Lung Cancer

scientific article published on 03 August 2018

Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells

scientific article published on 9 December 2015

Author Correction: CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

scientific article published on 01 May 2019

Author Correction: Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer

scientific article published in Nature Communications

Author Correction: Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data

scientific article published on 01 July 2019

Axl Receptor Axis: A New Therapeutic Target in Lung Cancer.

scientific article published on 26 April 2016

BAP1 Is a Novel Target in HPV-Negative Head and Neck Cancer

scientific article published on 7 November 2017

Baseline vascular endothelial growth factor concentration as a potential predictive marker of benefit from vandetanib in non-small cell lung cancer.

scientific article published on 15 May 2009

Bayesian Adaptive Randomization Trial of Passive Scattering Proton Therapy and Intensity-Modulated Photon Radiotherapy for Locally Advanced Non-Small-Cell Lung Cancer

scientific article published on 2 January 2018

Bevacizumab beyond disease progression for advanced non-small cell lung cancer: Does persistence have its rewards?

scientific article published on February 2016

Beyond VEGF: inhibition of the fibroblast growth factor pathway and antiangiogenesis

scientific article

Biomarker-Integrated Neoadjuvant Dasatinib Trial in Resectable Malignant Pleural Mesothelioma

scientific article published on 4 December 2017

Blasted cell line names

scientific article

Blood-based biomarkers of SU11248 activity and clinical outcome in patients with metastatic imatinib-resistant gastrointestinal stromal tumor.

scientific article published on May 2007

C-Met inhibitor MK-8003 radiosensitizes c-Met-expressing non-small-cell lung cancer cells with radiation-induced c-Met-expression

scientific article

CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade

scientific article published on 16 July 2018

CD73 expression defines immune, molecular, and clinicopathological subgroups of lung adenocarcinoma

scientific article published on 08 January 2021

CDKN2A/p16 deletion in head and neck cancer cells is associated with Cdk2 activation, replication stress, and vulnerability to Chk1 inhibition

scientific article

CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib.

scientific article published on 10 May 2017

CMET-09. PAN-CANCER PROFILES OF BRAIN METASTASES: PRIORITIZATION OF THERAPEUTIC TARGETS

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

scientific article published on 24 May 2017

CXCR2 expression in tumor cells is a poor prognostic factor and promotes invasion and metastasis in lung adenocarcinoma

scientific article published on 30 November 2012

Can the Lung Cancer Pie Be Divided into Angiogenic Slices?

scientific article published on 31 July 2015

Characterization of Human Cancer Cell Lines by Reverse-phase Protein Arrays

scientific article

Characterization of the immune landscape of EGFR-mutant NSCLC identifies CD73/adenosine pathway as a potential therapeutic target

scientific article published on 31 December 2020

Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer.

scientific article published on 11 April 2018

Circulating Tumor DNA Dynamics Predict Benefit from Consolidation Immunotherapy in Locally Advanced Non-Small Cell Lung Cancer

scientific article published on 20 January 2020

Circulating biomarkers for vascular endothelial growth factor inhibitors in renal cell carcinoma

scientific article published on May 2009

Circulating inflammation signature predicts overall survival and relapse-free survival in metastatic colorectal cancer

scientific article published on 14 January 2019

Circulating metabolite profiles to predict overall survival in advanced non-small cell lung cancer patients receiving first-line chemotherapy

scientific article published on 2 November 2017

Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer

scientific article published in Nature Communications

Clinical Cancer Advances 2017: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology.

scientific article published in February 2017

Clinical Cancer Advances 2018: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology

scientific article published on 30 January 2018

Clinical and biomarker outcomes of the phase II vandetanib study from the BATTLE trial

scientific article published on May 2013

Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities

scientific article

Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy

scientific article published on 12 August 2019

Combination Treatment of the Oral CHK1 Inhibitor, SRA737, and Low-Dose Gemcitabine Enhances the Effect of Programmed Death Ligand 1 Blockade by Modulating the Immune Microenvironment in SCLC

scientific article published on 27 August 2019

Combined vascular endothelial growth factor receptor and epidermal growth factor receptor (EGFR) blockade inhibits tumor growth in xenograft models of EGFR inhibitor resistance

scientific article

Combining radiation and immunotherapy: a new systemic therapy for solid tumors?

scientific article

Comprehensive T cell repertoire characterization of non-small cell lung cancer

scientific article published on 30 January 2020

Comprehensive biomarker analysis and final efficacy results of sorafenib in the BATTLE trial

scientific article published on 28 October 2013

Computed tomography RECIST assessment of histopathologic response and prediction of survival in patients with resectable non-small-cell lung cancer after neoadjuvant chemotherapy

scientific article published on February 2013

Concurrent use of aspirin with osimertinib is associated with improved survival in advanced EGFR-mutant non-small cell lung cancer

scientific article published on 09 September 2020

Consolidative local therapy in oligometastatic patients - Authors' reply

scientific article published on 01 February 2017

Control of HIF-1alpha expression by eIF2 alpha phosphorylation-mediated translational repression

scientific article

Correction: Distinct co-acquired alterations and genomic evolution during TKI treatment in non-small-cell lung cancer patients with or without acquired T790M mutation

scientific article published on 01 February 2020

Correction: LCE: an open web portal to explore gene expression and clinical associations in lung cancer

scientific article published on 01 January 2020

Corrigendum to "Predicting outcomes in patients with advanced non-small cell lung cancer enrolled in early phase immunotherapy trials" [Lung Cancer 120 (June) (2018) 137-141]

scientific article published on 21 August 2019

Corrigendum: A pan-cancer proteomic perspective on The Cancer Genome Atlas

scientific article published on 28 January 2015

Cytokines associated with toxicity in the treatment of recurrent glioblastoma with aflibercept

scientific article published on 24 January 2013

DNA methylation intratumor heterogeneity in localized lung adenocarcinomas

scientific article published on March 2017

DNA repair biomarker profiling of head and neck cancer: Ku80 expression predicts locoregional failure and death following radiotherapy

scientific article

Dasatinib induces DNA damage and activates DNA repair pathways leading to senescence in non-small cell lung cancer cell lines with kinase-inactivating BRAF mutations

scientific article published on 23 November 2015

De novo lipogenesis represents a therapeutic target in mutant Kras non-small cell lung cancer

scientific article published on 15 June 2018

Definitive Management of Presumed Synchronous Early Stage Non-Small Cell Lung Cancers: Outcomes and Utility of Stereotactic Ablative Radiation Therapy

scientific article published on 07 February 2020

Detection of T790M, the Acquired Resistance EGFR Mutation, by Tumor Biopsy versus Noninvasive Blood-Based Analyses

scientific article published on 7 October 2015

Development and validation of an ultra-deep next-generation sequencing assay for testing of plasma cell-free DNA from patients with advanced cancer

scientific article

Different dietary patterns and reduction of lung cancer risk: A large case-control study in the U.S.

scientific article published on 27 May 2016

Differential Sensitivity Analysis for Resistant Malignancies (DISARM) identifies common candidate therapies across platinum-resistant cancers

scientific article published on 26 September 2018

Differential effects of vascular endothelial growth factor receptor-2 inhibitor ZD6474 on circulating endothelial progenitors and mature circulating endothelial cells: implications for use as a surrogate marker of antiangiogenic activity.

scientific article

Distinct co-acquired alterations and genomic evolution during TKI treatment in non-small-cell lung cancer patients with or without acquired T790M mutation

scientific article published on 21 November 2019

Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer.

scientific article

Dr. Folkman's legacy-a life of angiogenesis research

scientific article published in February 2008

Driver Mutations in Normal Airway Epithelium Elucidate Spatiotemporal Resolution of Lung Cancer

scientific article published on 01 September 2019

Dual EGFR/VEGF pathway inhibition: a promising strategy for patients with EGFR-mutant NSCLC

scientific article published on 20 October 2020

Dual targeting of the vascular endothelial growth factor and epidermal growth factor receptor pathways: rationale and clinical applications for non-small-cell lung cancer

scientific article published on February 2007

Dynamic variations in epithelial-to-mesenchymal transition (EMT), ATM, and SLFN11 govern response to PARP inhibitors and cisplatin in small cell lung cancer.

scientific article

Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome

scientific article

Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer.

scientific article

Effect of neoadjuvant chemotherapy on the immune microenvironment in non-small cell lung carcinomas as determined by multiplex immunofluorescence and image analysis approaches.

scientific article published on 6 June 2018

Emerging antiangiogenic agents in lung cancer

scientific article

Endostatin inhibits the vascular endothelial growth factor-induced mobilization of endothelial progenitor cells

scientific article published on 01 December 2003

Endothelial progenitor cells contribute to accelerated liver regeneration

scientific article published in July 2007

Epidermal growth factor receptor blockade in combination with conventional chemotherapy inhibits soft tissue sarcoma cell growth in vitro and in vivo

scientific article

Epidermal growth factor receptor inhibitors in development for the treatment of non-small cell lung cancer

scientific article published on July 2006

Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma

scientific article published on 5 February 2016

Epithelial-Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor-Mediated Apoptosis in Non-Small Cell Lung Cancer.

scientific article published on 23 November 2015

Erlotinib and the Risk of Oral Cancer: The Erlotinib Prevention of Oral Cancer (EPOC) Randomized Clinical Trial.

scientific article published on 5 November 2015

Erlotinib plus either pazopanib or placebo in patients with previously treated advanced non-small cell lung cancer: A randomized, placebo-controlled phase 2 trial with correlated serum proteomic signatures

scientific article published on 12 April 2018

Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas

scientific article published on 29 January 2021

Evolution of genomic and T cell repertoire heterogeneity of malignant pleural mesothelioma under dasatinib treatment

scientific article published on 14 August 2020

Farnesyl transferase inhibitors for patients with lung cancer

scientific article published in June 2004

Female Gender Predicts Augmented Immune Infiltration in Lung Adenocarcinoma

scientific article published on 14 June 2020

Focal Adhesion Kinase Regulates the DNA Damage Response and Its Inhibition Radiosensitizes Mutant KRAS Lung Cancer.

scientific article

Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus

scientific article published in 2012

Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer

scientific article

Genes suppressed by DNA methylation in non-small cell lung cancer reveal the epigenetics of epithelial-mesenchymal transition

scientific article

Genomic assessment distinguishes intrapulmonary metastases from synchronous primary lung cancers

scientific article published on 01 May 2020

Genomic heterogeneity of multiple synchronous lung cancer

scientific article published on 21 October 2016

Genotype-specific differences in circulating tumor DNA levels in advanced NSCLC

scientific article published on 31 December 2020

Germline Mutation of T790M and Dual/Multiple EGFR Mutations in Patients With Lung Adenocarcinoma

scientific article

Giant Circulating Cancer-Associated Macrophage-Like Cells Are Associated With Disease Recurrence and Survival in Non-Small-Cell Lung Cancer Treated With Chemoradiation and Atezolizumab

scientific article published on 20 June 2020

Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype

scientific article published on 10 September 2012

Global analysis of shared T cell specificities in human non-small cell lung cancer enables HLA inference and antigen discovery

scientific article published on 01 March 2021

Global evaluation of Eph receptors and ephrins in lung adenocarcinomas identifies EphA4 as an inhibitor of cell migration and invasion

scientific article

HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice

scientific article published on August 2009

HRAS mutations and resistance to the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in head and neck squamous cell carcinoma cells.

scientific article

High OX-40 expression in the tumor immune infiltrate is a favorable prognostic factor of overall survival in non-small cell lung cancer

scientific article published on 16 December 2019

Hypoxia pathway genetic variants predict survival of non-small-cell lung cancer patients receiving platinum-based chemotherapy

scientific article published on 10 February 2017

IASLC Multidisciplinary Recommendations for Pathologic Assessment of Lung Cancer Resection Specimens After Neoadjuvant Therapy

scientific article published on 28 January 2020

Identification and characterization of a suite of tumor targeting peptides for non-small cell lung cancer

scientific article

Identification of proteasomal catalytic subunit PSMA6 as a therapeutic target for lung cancer.

scientific article published on 6 February 2017

Image Analysis-based Assessment of PD-L1 and Tumor-Associated Immune Cells Density Supports Distinct Intratumoral Microenvironment Groups in Non-small Cell Lung Carcinoma Patients

scientific article published on June 2016

Immune and Circulating Tumor DNA Profiling After Radiation Treatment for Oligometastatic Non-Small Cell Lung Cancer: Translational Correlatives from a Mature Randomized Phase II Trial

scientific article published on 31 October 2019

Impact of Corticosteroid Administration on Outcomes Following Stereotactic Ablative Radiotherapy for Non-small-cell Lung Cancer

scientific article published on 15 March 2019

Improved Overall Survival With Comprehensive Local Consolidative Therapy in Synchronous Oligometastatic Non-Small-Cell Lung Cancer

scientific article published on 01 August 2019

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy

scientific article published on 05 April 2018

Increased VEGFR-2 gene copy is associated with chemoresistance and shorter survival in patients with non-small-cell lung carcinoma who receive adjuvant chemotherapy

scientific article

Induction Cisplatin Docetaxel Followed by Surgery and Erlotinib in Non-Small Cell Lung Cancer

scientific article published on 4 December 2017

Influence of low-dose radiation on abscopal responses in patients receiving high-dose radiation and immunotherapy

scientific article published on 04 September 2019

Inhibition of intra-abdominal adhesion formation with the angiogenesis inhibitor sunitinib

scientific article published on 21 November 2007

Inhibition of thioredoxin/thioredoxin reductase induces synthetic lethality in lung cancers with compromised glutathione homeostasis

scientific article published on 06 November 2018

Integrative Analysis Identifies a Novel AXL-PI3 Kinase-PD-L1 Signaling Axis Associated with Radiation Resistance in Head and Neck Cancer.

scientific article published on 5 May 2017

Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing

scientific article published in October 2014

Ipilimumab with Stereotactic Ablative Radiation Therapy: Phase I Results and Immunologic Correlates from Peripheral T Cells

scientific article

Joint prognostic effect of obesity and chronic systemic inflammation in patients with metastatic colorectal cancer.

scientific article published on 14 May 2015

KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling.

scientific article

KDR Amplification Is Associated with VEGF-Induced Activation of the mTOR and Invasion Pathways but does not Predict Clinical Benefit to the VEGFR TKI Vandetanib

scientific article published on 17 November 2015

KRT-232 and navitoclax enhance trametinib's anti-Cancer activity in non-small cell lung cancer patient-derived xenografts with KRAS mutations

scientific article published on 01 December 2020

LCE: an open web portal to explore gene expression and clinical associations in lung cancer

article

LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS-Mutant Lung Adenocarcinoma

scientific article published on 30 April 2019

LKB1 mutations in NSCLC are associated with KEAP1/NRF2-dependent radiotherapy resistance targetable by glutaminase inhibition

scientific article published on 15 December 2020

Landscape of EGFR-Dependent and -Independent Resistance Mechanisms to Osimertinib and Continuation Therapy Beyond Progression in EGFR-Mutant NSCLC

scientific article published on 18 September 2018

Local Consolidation Therapy (LCT) After First Line Tyrosine Kinase Inhibitor (TKI) for Patients With EGFR Mutant Metastatic Non-small-cell Lung Cancer (NSCLC)

scientific article published on 24 September 2018

Local Consolidative Therapy Vs. Maintenance Therapy or Observation for Patients With Oligometastatic Non-Small-Cell Lung Cancer: Long-Term Results of a Multi-Institutional, Phase II, Randomized Study

scientific article published on 08 May 2019

Local consolidative therapy versus maintenance therapy or observation for patients with oligometastatic non-small-cell lung cancer without progression after first-line systemic therapy: a multicentre, randomised, controlled, phase 2 study

scientific article published on 24 October 2016

Long-Term Outcomes of Salvage Stereotactic Ablative Radiotherapy for Isolated Lung Recurrence of Non-Small Cell Lung Cancer: A Phase II Clinical Trial

scientific article published in March 2017

Lung Cancer Models Reveal Severe Acute Respiratory Syndrome Coronavirus 2-Induced Epithelial-to-Mesenchymal Transition Contributes to Coronavirus Disease 2019 Pathophysiology

scientific article published on 16 July 2021

Lymphovascular Invasion Is Associated With Mutational Burden and PD-L1 in Resected Lung Cancer

scientific article published on 21 September 2019

MYB-fusions and other potential actionable targets in adenoid cystic carcinoma

scientific article published on 11 March 2016

Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small cell lung cancer.

scientific article published on 23 April 2018

Meeting Report: Fifth Annual AACR Frontiers in Cancer Prevention Research

scientific article published on 25 September 2007

Membrane carbonic anhydrase IX expression and relapse risk in resected stage I-II non-small-cell lung cancer

scientific article

Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells

scientific article published on 26 September 2019

Metabolic Responses to Metformin in Inoperable Early-stage Non-Small Cell Lung Cancer Treated With Stereotactic Radiotherapy: Results of a Randomized Phase II Clinical Trial

scientific article published on 01 April 2020

Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer

scientific article published on 28 May 2013

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

scientific article

Metronomic chemotherapy enhances the efficacy of antivascular therapy in ovarian cancer

scientific article published on January 2007

Modulation of c-Met signaling and cellular sensitivity to radiation: potential implications for therapy

scientific article published on 19 February 2013

Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases

scientific article published on 20 February 2019

Molecular landscape of BRAF-mutant NSCLC reveals an association between clonality and driver mutations and identifies targetable non-V600 driver mutations

scientific article published on 12 June 2020

Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data

scientific article published on 01 May 2019

Molecular targets for cancer chemoprevention

scientific article published on March 2009

Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma

scientific article published on 05 July 2019

Multifactorial Deep Learning Reveals Pan-Cancer Genomic Tumor Clusters with Distinct Immunogenomic Landscape and Response to Immunotherapy

scientific article published on 07 January 2020

Multiomics profiling of primary lung cancers and distant metastases reveals immunosuppression as a common characteristic of tumor cells with metastatic plasticity

scientific article published on 04 November 2020

Multiregion gene expression profiling reveals heterogeneity in molecular subtypes and immunotherapy response signatures in lung cancer

scientific article

Mutations and PD-1 Inhibitor Resistance in -Mutant Lung Adenocarcinoma

scientific article published on 17 May 2018

Myeloid biomarkers associated with glioblastoma response to anti-VEGF therapy with aflibercept

scientific article

Neoadjuvant Chemotherapy Increases Cytotoxic T cell, Tissue Resident Memory T cell and B Cell Infiltration in Resectable Non-Small Cell Lung Cancer

scientific article published on 20 October 2020

Neoadjuvant nivolumab or nivolumab plus ipilimumab in operable non-small cell lung cancer: the phase 2 randomized NEOSTAR trial

scientific article published on 18 February 2021

Neutrophil expansion defines an immunoinhibitory peripheral and intratumoral inflammatory milieu in resected non-small cell lung cancer: a descriptive analysis of a prospectively immunoprofiled cohort

scientific article published on 01 April 2020

New Verse for a Familiar Song: Small Molecule Inhibitors for MET exon 14 Skipping Non-Small Cell Lung Cancer

scientific article published on 27 August 2020

Next-Generation CDK2/9 Inhibitors and Anaphase Catastrophe in Lung Cancer

scientific article

Nodal immune flare mimics nodal disease progression following neoadjuvant immune checkpoint inhibitors in non-small cell lung cancer

scientific article published on 19 August 2021

Novel agents in the treatment of lung cancer: Fourth Cambridge Conference.

scientific article published in August 2007

Outcome analysis of Phase I trial patients with metastatic and/or mutant non-small cell lung cancer

Outcomes to first-line pembrolizumab in patients with PD-L1-high (≥50%) non-small cell lung cancer and a poor performance status

scientific article published on 01 August 2020

PD-1 Blockade Prevents the Development and Progression of Carcinogen-Induced Oral Premalignant Lesions

scientific article

PD-L1 Expression, Tumor Mutational Burden, and Cancer Gene Mutations Are Stronger Predictors of Benefit from Immune Checkpoint Blockade than HLA Class I Genotype in Non-Small Cell Lung Cancer

scientific article published on 16 February 2019

PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib

scientific article published on December 2007

Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity

scientific article published on 01 March 2020

Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity

scientific article published on 03 October 2019

Pathological nodal disease defines survival outcomes in patients with lung cancer with tumour major pathological response following neoadjuvant chemotherapy

scientific article published on 30 August 2020

Patient-derived tumor immune microenvironments in patient-derived xenografts of lung cancer

Patterns of protein expression in human head and neck cancer cell lines differ after proton vs photon radiotherapy

scientific article published on 11 November 2019

Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

scientific article published on 21 January 2021

Pembrolizumab with or without radiation therapy for metastatic non-small cell lung cancer: a randomized phase I/II trial

scientific article published on 01 October 2020

Pembrolizumab with or without radiotherapy for metastatic non-small-cell lung cancer: a pooled analysis of two randomised trials

scientific article published on 20 October 2020

Peripheral cytokines are not influenced by the type of surgical approach for non-small cell lung cancer by four weeks postoperatively

scientific article published on 27 June 2020

Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668.

scientific article

Phase 1-2 study of docetaxel plus aflibercept in patients with recurrent ovarian, primary peritoneal, or fallopian tube cancer

scientific article

Phase I Trial of Pembrolizumab and Radiation Therapy after Induction Chemotherapy for Extensive-Stage Small Cell Lung Cancer

scientific article published on 09 October 2019

Phase I study of vandetanib with radiation therapy with or without cisplatin in locally advanced head and neck squamous cell carcinoma

scientific article published on 29 October 2014

Phase I trial of cisplatin, pemetrexed, and imatinib mesylate in chemonaive patients with unresectable malignant pleural mesothelioma

scientific article published on 27 December 2013

Phase I, Dose-Escalation, Two-Part Trial of the PARP Inhibitor Talazoparib in Patients with Advanced Germline BRCA1/2 Mutations and Selected Sporadic Cancers

scientific article

Phase I/II Trial of Immunotherapy With Durvalumab and Tremelimumab With Continuous or Intermittent MEK Inhibitor Selumetinib in NSCLC: Early Trial Report

scientific article published on 04 March 2020

Phase I/II Trial of Pembrolizumab and Concurrent Chemoradiation Therapy for Limited-Stage Small Cell Lung Cancer

scientific article published on 08 September 2020

Phase II Trial of Cediranib in Combination With Cisplatin and Pemetrexed in Chemotherapy-Naïve Patients With Unresectable Malignant Pleural Mesothelioma (SWOG S0905)

scientific article published on 06 August 2019

Phase II Trial of Concurrent Atezolizumab With Chemoradiation for Unresectable NSCLC

scientific article published on 25 November 2019

Phase II Trial of Ipilimumab with Stereotactic Radiation Therapy for Metastatic Disease: Outcomes, Toxicities, and Low-Dose Radiation-Related Abscopal Responses

scientific article published on 28 October 2019

Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumors

scientific article

Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas

scientific article published in September 2004

Phase II trial of carboplatin, paclitaxel, cetuximab, and bevacizumab followed by cetuximab and bevacizumab in advanced nonsquamous non-small-cell lung cancer: SWOG S0536

scientific article

Phase II trial of erlotinib plus concurrent whole-brain radiation therapy for patients with brain metastases from non-small-cell lung cancer

scientific article published on 22 January 2013

Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistance

scientific article

Plasma cytokine and angiogenic factor profiling identifies markers associated with tumor shrinkage in early-stage non-small cell lung cancer patients treated with pazopanib ⬇️

scientific article published on 9 March 2010

Polo-like kinase 1 inhibition diminishes acquired resistance to epidermal growth factor receptor inhibition in non-small cell lung cancer with T790M mutations.

scientific article published on 30 June 2016

Positron emission tomography/computed tomography-guided intensity-modulated radiotherapy for limited-stage small-cell lung cancer

scientific article

Potent antitumor effects of ZD6474 on neuroblastoma via dual targeting of tumor cells and tumor endothelium.

scientific article

Predicting outcomes in patients with advanced non-small cell lung cancer enrolled in early phase immunotherapy trials.

scientific article published on 11 April 2018

Predictive biomarkers in precision medicine and drug development against lung cancer

scientific article

Profiles of brain metastases: Prioritization of therapeutic targets

scientific article published on 09 October 2018

Prognostic Factors as a Function of Disease-free Interval After Definitive (Chemo)radiation for Non-Small Cell Lung Cancer Using Conditional Survival Analysis

scientific article published on 3 November 2015

Prognostic Value of PD-L1 mRNA Sequencing Expression Profile in Non-Small Cell Lung Cancer.

scientific article published on 3 March 2018

Prognostic impact of radiation therapy to the primary tumor in patients with non-small cell lung cancer and oligometastasis at diagnosis

scientific article published on 13 April 2012

Prognostic or predictive plasma cytokines and angiogenic factors for patients treated with pazopanib for metastatic renal-cell cancer: a retrospective analysis of phase 2 and phase 3 trials

scientific article

Programmed Death Ligand 1 Heterogeneity and its Impact on Benefit from Immune Checkpoint Inhibitors in Non-Small-Cell Lung Cancer

scientific article published on 07 May 2020

Propensity score-matched analysis of comprehensive local therapy for oligometastatic non-small cell lung cancer that did not progress after front-line chemotherapy

scientific article published on 9 September 2014

Protein expression of TTF1 and cMYC define distinct molecular subgroups of small cell lung cancer with unique vulnerabilities to aurora kinase inhibition, DLL3 targeting, and other targeted therapies

scientific article published in September 2017

Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets

scientific article published on 10 November 2020

Proteomic Profiling Identifies PTK2/FAK as a Driver of Radioresistance in HPV-negative Head and Neck Cancer

scientific article published on April 2016

Proteomic markers of DNA repair and PI3K pathway activation predict response to the PARP inhibitor BMN 673 in small cell lung cancer

scientific article published on 27 September 2013

Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.

scientific article published on 6 September 2012

Proteomic profiling identifies pathways dysregulated in non-small cell lung cancer and an inverse association of AMPK and adhesion pathways with recurrence

scientific article

Proton Beam Radiotherapy and Concurrent Chemotherapy for Unresectable Stage III Non-Small Cell Lung Cancer: Final Results of a Phase 2 Study

scientific article published on 20 July 2017

Quantitative Proteomic Analysis of Optimal Cutting Temperature (OCT) Embedded Core-Needle Biopsy of Lung Cancer

scientific article published on 27 July 2017

Quantitative evaluation of drug-induced microvascular constriction in mice kidney using a novel tool for 3D geometrical analysis of ex vivo organ vasculature

scientific article published on 26 March 2014

RAD50 Expression Is Associated with Poor Clinical Outcomes after Radiotherapy for Resected Non-small Cell Lung Cancer

scientific article published on 13 October 2017

Radiation Followed by OX40 Stimulation Drives Local and Abscopal Antitumor Effects in an Anti-PD1-Resistant Lung Tumor Model.

scientific article published on 21 May 2018

Radiological tumor classification across imaging modality and histology

scientific article published on 09 August 2021

Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer

scientific article

Randomized, Double-Blind, Phase II Study of Temozolomide in Combination With Either Veliparib or Placebo in Patients With Relapsed-Sensitive or Refractory Small-Cell Lung Cancer.

scientific article published on 15 June 2018

Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer

scientific article published on September 2007

Realizing the potential of plasma genotyping in an age of genotype-directed therapies.

scientific article published on 8 August 2014

Reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer

scientific article

Response rates to single-agent chemotherapy after exposure to immune checkpoint inhibitors in advanced non-small cell lung cancer

scientific article published on 3 August 2017

Responsiveness to immune checkpoint inhibitors versus other systemic therapies in RET-aberrant malignancies

scientific article published on 01 October 2020

Revisiting clinical trials using EGFR inhibitor-based regimens in patients with advanced non-small cell lung cancer: a retrospective analysis of an MD Anderson Cancer Center phase I population

scientific article published on May 2013

Risk Factors for and Time to Recurrence of Symptomatic Malignant Pleural Effusion in Patients with Metastatic Non-Small Cell Lung Cancer with EGFR or ALK Mutations

scientific article published on 17 November 2020

Robust gene expression signature from formalin-fixed paraffin-embedded samples predicts prognosis of non-small-cell lung cancer patients

scientific article

SABR vs surgery for NSCLC in the media

scientific article published on 01 September 2015

SARS-CoV-2 infection induces EMT-like molecular changes, including ZEB1-mediated repression of the viral receptor ACE2, in lung cancer models

scientific article published on 29 May 2020

STING Pathway Expression Identifies NSCLC With an Immune-Responsive Phenotype

scientific article published on 15 February 2020

STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment.

scientific article published on February 2016

Second-line treatment of advanced non-small cell lung cancer

scientific article published in April 2008

Selective antitumor activity of ibrutinib in EGFR-mutant non-small cell lung cancer cells

scientific article

Serine Proteases Enhance Immunogenic Antigen Presentation on Lung Cancer Cells.

scientific article

Serum signature of hypoxia-regulated factors is associated with progression after induction therapy in head and neck squamous cell cancer

scientific article

Simplified molecular classification of lung adenocarcinomas based on EGFR, KRAS, and TP53 mutations

scientific article published on 31 January 2020

Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer

scientific article published on 17 February 2020

Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?

scientific article published on 29 January 2016

Specific blockade of VEGF and HER2 pathways results in greater growth inhibition of breast cancer xenografts that overexpress HER2.

scientific article published on 16 December 2008

Stage I lung cancer-to operate or to radiate? that is the question

scientific article published on September 2016

Stereotactic Ablative Radiation Therapy is Highly Safe and Effective for Elderly Patients With Early-stage Non-Small Cell Lung Cancer

scientific article published on 21 December 2016

Stereotactic ablative body radiation for oligometastatic and oligoprogressive disease

scientific article published on 01 February 2019

Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation

scientific article

Strategies for combining immunotherapy with radiation for anticancer therapy

scientific article (publication date: 2015)

Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers

scientific article published in November 2017

Structure-based classification predicts drug response in EGFR-mutant NSCLC

scientific article published on 15 September 2021

Summary statement novel agents in the treatment of lung cancer: Fifth Cambridge Conference assessing opportunities for combination therapy

scientific article published on 01 June 2008

Summary statement: novel agents in the treatment of lung cancer: advances in epidermal growth factor receptor-targeted agents.

scientific article

Synergistic anti-proliferative and pro-apoptotic activity of combined therapy with bortezomib, a proteasome inhibitor, with anti-epidermal growth factor receptor (EGFR) drugs in human cancer cells

scientific article

Systemic and CNS activity of the RET inhibitor vandetanib combined with the mTOR inhibitor everolimus in KIF5B-RET re-arranged non-small cell lung cancer with brain metastases

scientific article published on 22 April 2015

TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence.

scientific article published on 21 July 2017

TGFβ1 Polymorphisms Predict Distant Metastasis-Free Survival in Patients with Inoperable Non-Small-Cell Lung Cancer after Definitive Radiotherapy

scientific article

Taking it up a NOTCH: a novel subgroup of ACC is identified

scientific article published on 14 September 2017

Targeted Tissue and Cell-Free Tumor DNA Sequencing of Advanced Lung Squamous-Cell Carcinoma Reveals Clinically Significant Prevalence of Actionable Alterations

Targeted therapies for lung cancer: clinical experience and novel agents

scientific article

Targeting AXL and mTOR Pathway Overcomes Primary and Acquired Resistance to WEE1 Inhibition in Small-Cell Lung Cancer

scientific article published on 11 July 2017

Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer

scientific article published on 18 February 2019

Targeting EGFR activity in blood vessels is sufficient to inhibit tumor growth and is accompanied by an increase in VEGFR-2 dependence in tumor endothelial cells

scientific article

Targeting IL-1β as an immunopreventive and therapeutic modality for K-ras–mutant lung cancer

scientific article published in 2022

Targeting angiogenesis for patients with unresectable malignant pleural mesothelioma

scientific article published on 01 April 2019

Targeting of CD40 and PD-L1 pathways inhibit progression of oral premalignant lesions in a carcinogen-induced model of oral squamous cell carcinoma

scientific article published on 04 December 2020

Targeting the angiopoietin/Tie2 pathway: cutting tumor vessels with a double-edged sword?

scientific article published on 19 December 2011

Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors.

scientific article

The BATTLE trial: personalizing therapy for lung cancer

scientific article

The BATTLE-2 Study: A Biomarker-Integrated Targeted Therapy Study in Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer

scientific article published on August 2016

The HGF/c-MET Pathway Is a Driver and Biomarker of VEGFR-inhibitor Resistance and Vascular Remodeling in Non-Small Cell Lung Cancer

scientific article

The Influence of Body Mass Index on Overall Survival Following Surgical Resection of Non-Small Cell Lung Cancer

scientific article published on 25 May 2017

The Prognostic and Therapeutic Role of Genomic Subtyping by Sequencing Tumor or Cell-Free DNA in Pulmonary Large-Cell Neuroendocrine Carcinoma

scientific article published on 06 November 2019

The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA

scientific article

The association of alternate VEGF ligands with resistance to anti-VEGF therapy in metastatic colorectal cancer

scientific article

The convergent development of molecular-targeted drugs for cancer treatment and prevention

scientific article published on July 2007

The histologic phenotype of lung cancers is associated with transcriptomic features rather than genomic characteristics

scientific article published on 06 December 2021

The mutually regulatory loop of epithelial-mesenchymal transition and immunosuppression in cancer progression

scientific article published on 3 February 2015

The tyrosine kinase inhibitor cediranib for non-small cell lung cancer and other thoracic malignancies

scientific article

Therapeutic delivery of miR-200c enhances radiosensitivity in lung cancer

scientific article published on 5 May 2014

Therapeutic efficacy of endostatin exhibits a biphasic dose-response curve

scientific article published on 01 December 2005

Time since start of first-line therapy as a predictive clinical marker for nintedanib in patients with previously treated non-small cell lung cancer.

scientific article

Toxicity and Survival After Intensity-Modulated Proton Therapy Versus Passive Scattering Proton Therapy for NSCLC

scientific article published on 22 October 2020

Tumor characteristics associated with engraftment of patient-derived non-small cell lung cancer xenografts in immunocompromised mice

scientific article published on 09 July 2019

Tumor endothelial markers define novel subsets of cancer-specific circulating endothelial cells associated with antitumor efficacy

scientific article

ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer

scientific article published on 17 May 2021

Upregulated stromal EGFR and vascular remodeling in mouse xenograft models of angiogenesis inhibitor-resistant human lung adenocarcinoma

scientific article published on 23 March 2011

Urothelial cancer harbours EGFR and HER2 amplifications and exon 20 insertions

scientific article published on 27 January 2020

VEGF/VEGFR-2 upregulates EZH2 expression in lung adenocarcinoma cells and EZH2 depletion enhances the response to platinum-based and VEGFR-2-targeted therapy

scientific article

Validation of a standardized method for enumerating circulating endothelial cells and progenitors: flow cytometry and molecular and ultrastructural analyses.

scientific article published in January 2009

Validation of the 12-gene predictive signature for Adjuvant Chemotherapy Response in Lung Cancer

article

Vandetanib (ZD6474): an orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis

scientific article published on February 2007

Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial

scientific article published on July 2010

Vandetanib restores head and neck squamous cell carcinoma cells' sensitivity to cisplatin and radiation in vivo and in vitro.

scientific article

Vandetanib, A Dual Inhibitor of VEGFR and EGFR Tyrosine Kinase Activity

Variants with a low allele frequency detected in genomic DNA affect the accuracy of mutation detection in cell-free DNA by next-generation sequencing.

scientific article published on 27 November 2017

Vascular endothelial growth factor (VEGF) pathway

scientific article published on October 2006

Vascular endothelial growth factor accelerates compensatory lung growth after unilateral pneumonectomy

scientific article published on 22 November 2006

Vascular endothelial growth factor receptor tyrosine kinase inhibitors vandetanib (ZD6474) and AZD2171 in lung cancer

scientific article published on August 2007

What Do Patients With Non-Small-Cell Lung Cancer Experience? Content Domain for the MD Anderson Symptom Inventory for Lung Cancer

scientific article published on 15 June 2020

drexplorer: A tool to explore dose-response relationships and drug-drug interactions

scientific article published on 18 January 2015

eIF2β, a subunit of translation-initiation factor EIF2, is a potential therapeutic target for non-small cell lung cancer.

scientific article published on 6 April 2018

miR-125a-5p Functions as Tumor Suppressor microRNA And Is a Marker of Locoregional Recurrence And Poor prognosis in Head And Neck Cancer

scientific article published on 18 July 2019

miR-200 Inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1.

scientific article published on 29 November 2010

β-Adrenergic Signaling in Lung Cancer: A Potential Role for Beta-Blockers

scientific article published on 11 December 2019

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