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List of works by Iannis Aifantis

3D Chromosomal Landscapes in Hematopoiesis and Immunity

scientific article published on 15 August 2019

A Deep Learning Framework for Predicting Response to Therapy in Cancer

scientific article published on 01 December 2019

A critical role for the cytoplasmic tail of pTα in T lymphocyte development

article

A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus

scholarly article

A new player SETs in myeloid malignancy ⬇️

scientific article published on August 1, 2013

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.

scientific article

A unique function for cyclin D3 in early B cell development

scientific article published on 2 April 2006

AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis

scientific article published on 15 January 2018

ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression

scientific article

Active and Inactive Enhancers Cooperate to Exert Localized and Long-Range Control of Gene Regulation.

scientific article published on 25 May 2016

Alternative roles for oxidized mCs and TETs

scientific article published on 7 December 2016

Analysis of TET2 mutations in paroxysmal nocturnal hemoglobinuria (PNH)

scientific article published on 21 August 2019

Apoptosis, Up the Ante

scientific article

Assessing quality and completeness of human transcriptional regulatory pathways on a genome-wide scale

scientific article published on 28 February 2011

Author Correction: The bone marrow microenvironment at single-cell resolution

scientific article published on 01 August 2019

Author Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia

scientific article published on 29 July 2020

BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells

scientific article published on 23 February 2017

Beating the Clock in T-cell Acute Lymphoblastic Leukemia

scientific article published on 22 December 2016

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia

scientific article published on June 2009

CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation

scientific article published on 03 September 2020

CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance

scientific article

CXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis

scientific article published on 02 September 2019

Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function

scientific article published on 16 November 2015

Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21

scientific article published on 26 April 2019

Cell-by-Cell Deconstruction of Stem Cell Niches

scientific article published on 01 July 2020

Coactivation of NF-κB and Notch signaling is sufficient to induce B-cell transformation and enables B-myeloid conversion

scientific article published on 01 January 2020

Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms

scientific article

Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome.

scientific article published on 11 February 2017

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

scientific article

Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes

scientific article

Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7

scientific article published on 12 May 2008

Cyclin C is a haploinsufficient tumour suppressor

scientific article

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia

scientific article

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo

scientific article

Deregulation of DUX4 and ERG in acute lymphoblastic leukemia

scientific article published on 24 October 2016

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells

scientific article published on 3 February 2013

Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice

scientific article

Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages

scientific article

Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential

scientific article published on 17 August 2003

Emerging concepts of epigenetic dysregulation in hematological malignancies

scientific article

Emerging roles for the FBXW7 ubiquitin ligase in leukemia and beyond

scientific article published on 28 September 2015

Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis

scientific article published on 05 September 2013

Energy addiction and lymphocyte differentiation: a new role for the liver kinase B1 kinase

scientific article published in January 2010

Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis

scientific article published on 01 January 2020

Erratum: TET1 is a tumor suppressor of hematopoietic malignancy

scientific article published on 01 August 2015

Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia

scientific article published on 14 May 2020

FBXW7 inactivation in a BrafV600E -driven mouse model leads to melanoma development

scientific article published on 5 June 2017

FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification

scientific article

Fingerprinting Acute Leukemia: DNA Methylation Profiling of B-Acute Lymphoblastic Leukemia ⬇️

scientific article published on November 1, 2012

From fly wings to targeted cancer therapies: a centennial for notch signaling

scientific article

Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

scientific article published on 21 December 2008

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

scientific article published on 6 February 2012

Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia

scientific article

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma

scientific article

Gut-resident CX3CR1hi macrophages induce tertiary lymphoid structures and IgA response in situ

scientific article published on 01 April 2020

Harald von Boehmer 1942-2018

scientific article published on 01 September 2018

Hedgehog and hematopoietic stem cell differentiation: don't believe the hype!

scientific article published on December 2009

Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus

scientific article published on 5 March 2006

Hedgehog signaling is dispensable for adult hematopoietic stem cell function

scientific article

Hes1 expression and CYLD repression are essential events downstream of Notch1 in T-cell leukemia.

scientific article published on April 2011

Hexamethylene bisacetamide as a treatment for T-cell leukemia (T-ALL).

scientific article published on 31 December 2007

HiC-bench: comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking

scientific article

Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers ⬇️

scientific article published on February 14, 2013

Hijacking T cell differentiation: new insights in TLX function in T-ALL.

scientific article published on April 2012

Immune-Based Therapies in Acute Leukemia

scientific article published on 29 August 2019

Impaired Expression of Rearranged Immunoglobulin Genes and Premature p53 Activation Block B Cell Development in BMI1 Null Mice

scientific article published on 01 January 2019

In Vivo Mapping of Notch Pathway Activity in Normal and Stress Hematopoiesis ⬇️

scientific article published on June 20, 2013

Leukemia-on-a-chip: Dissecting the chemoresistance mechanisms in B cell acute lymphoblastic leukemia bone marrow niche

scientific article published on 30 October 2020

Limited miR-17-92 overexpression drives hematologic malignancies

scientific article published on 10 December 2014

MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis

scientific article published on 24 August 2016

Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining

scientific article published on 30 July 2019

Mapping and targeting of the leukemic microenvironment

scientific article published on 01 February 2020

Mechanisms of Epigenetic Regulation of Leukemia Onset and Progression ⬇️

scientific article published on January 1, 2013

Molecular pathogenesis of T-cell leukaemia and lymphoma

scientific article published on May 2008

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.

scientific article published on 9 July 2016

Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia

scientific article published on April 2015

Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche

scientific article published on 17 May 2018

Notch pathway activation targets AML-initiating cell homeostasis and differentiation

scientific article published on 28 January 2013

Notch signaling: switching an oncogene to a tumor suppressor.

scientific article published on 07 March 2014

Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms.

scientific article published on 31 January 2006

Notches, NFkappaBs and the making of T cell leukemia

scientific article published on 17 February 2007

On Epigenetic Plasticity and Genome Topology

scientific article published on 07 February 2020

On the brink of becoming a T cell.

scientific article

Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think.

scientific article

Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia

scientific article published on 23 July 2018

Opposing functions of H2BK120 ubiquitylation and H3K79 methylation in the regulation of pluripotency by the Paf1 complex

scientific article

Positive selection by the pre-TCR yields mature CD8+ T cells

scientific article published in November 2002

Posttranslational regulation of the exon skipping machinery controls aberrant splicing in leukemia

scientific article published on 22 May 2020

Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development

scientific article

Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast.

scientific article published on 15 December 2013

Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast.

scientific article published on 6 May 2014

Publisher Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia

scientific article published on 07 January 2020

RNA Splicing and Cancer

scientific article published on 17 May 2020

RNA-binding proteins come out of the shadows

scientific article published on 01 August 2010

RNA-binding proteins, the guardians of the marginal zone

scientific article published in May 2017

Rapid Crypt Cell Remodeling Regenerates the Intestinal Stem Cell Niche after Notch Inhibition

scientific article published on 26 May 2020

Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor.

scientific article

Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression.

scientific article published on March 2013

Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex

scientific article

Regulation of hematopoietic stem cell fate by the ubiquitin proteasome system ⬇️

scientific article published on February 18, 2012

Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling.

scientific article

Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid

scholarly article

Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system

scientific article published on 25 October 2012

Regulation of stem cell function by protein ubiquitylation

scientific article published on 20 March 2014

Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a

scientific article published on 17 October 2016

Requirement for cyclin D3 in lymphocyte development and T cell leukemias

scientific journal article

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.

scientific article published on 16 August 2017

Role of dysregulated cytokine signaling and bacterial triggers in the pathogenesis of Cutaneous T Cell Lymphoma

scientific article

SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2 ⬇️

scientific article

SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition

scientific article published on May 2015

STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation.

scientific article

STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia

scientific article published on 01 September 2018

Spleen plays a major role in DLL4-driven acute T-cell lymphoblastic leukemia

scientific article published on 01 January 2021

Splicing the innate immune signalling in leukaemia

scientific article published on 01 May 2019

Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries

scientific article published on 7 February 2018

T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling.

scientific article published on 22 November 2011

TET family proteins and their role in stem cell differentiation and transformation.

scientific article published on September 2011

TET1 is a tumor suppressor of hematopoietic malignancy

scientific article

TET2 deficiency causes germinal center hyperplasia, impairs plasma cell differentiation and promotes B-cell lymphomagenesis

scientific article published on 01 October 2018

Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment

scientific article published on 02 May 2019

Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia

scientific article published on 21 February 2019

Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.

scientific article published on 17 December 2006

Tet2 facilitates the derepression of myeloid target genes during CEBPα-induced transdifferentiation of pre-B cells

scientific article published on 13 September 2012

Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells

scientific article

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

scientific journal article

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival

scientific journal article

The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasis

scientific article

The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells

scientific article

The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation

scientific article published on 12 August 2019

The Impact of DNA Methylation in Hematopoietic Malignancies

scientific article published on February 2016

The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.

scientific article

The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage ⬇️

scientific article published on January 1, 2013

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

scientific article

The Taming of the NF-κB: PP4R1 Navigates while PP4c Dephosphorylates ⬇️

scientific article published on October 19, 2012

The bone marrow microenvironment at single-cell resolution

scientific article published on 10 April 2019

The effect of chromatin states on cancer: big data lead the way

scientific article published on 01 June 2018

The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia

scientific article published on 25 November 2019

The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells

scientific article published on 07 April 2015

The pre-BCR to the rescue: therapeutic targeting of pre-B cell ALL.

scientific article

The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability

scientific article

The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells

scientific article published on 26 September 2016

Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL

scientific article published on 26 November 2019

Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia.

scientific article

Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia

scientific article published on 23 March 2020

Thymic selection revisited: how essential is it?

scientific article

Tracing lymphopoiesis with the aid of a pTα-controlled reporter gene

article

U.S. Biomedical Research Needs More Immigrant Scientists, Not Fewer!

scientific article published on 01 September 2020

Vitamin C in Stem Cell Reprogramming and Cancer

scientific article published on 30 April 2018

lncRNA-screen: an interactive platform for computationally screening long non-coding RNAs in large genomics datasets

scientific article

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