List of works - Anil K Rustgi

A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4).

scientific article

A common p53 mutation (R175H) activates c-Met receptor tyrosine kinase to enhance tumor cell invasion

scientific article published on 18 June 2013

A historical perspective on clinical advances in pancreatic diseases

scientific article

A region-based gene association study combined with a leave-one-out sensitivity analysis identifies SMG1 as a pancreatic cancer susceptibility gene

scientific article published on 30 August 2019

A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification

scientific article

ARHGAP8 is a novel member of the RHOGAP family related to ARHGAP1/CDC42GAP/p50RHOGAP: mutation and expression analyses in colorectal and breast cancers

scientific article

Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase

scientific article

Advances in acute and chronic pancreatitis: from development to inflammation and repair

scientific article

Assessing Computational Steps for CLIP-Seq Data Analysis

scientific article

Author Correction: Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

scientific article published on 01 October 2018

BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non-Small Cell Lung Cancer

scientific article published on 07 August 2018

Barrett's Esophagus Translational Research Network (BETRNet): the pivotal role of multi-institutional collaboration in esophageal adenocarcinoma research

scientific article

Barrett's esophagus and its progression to adenocarcinoma

scientific article

Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer

scientific article

Bortezomib induces apoptosis in esophageal squamous cell carcinoma cells through activation of the p38 mitogen-activated protein kinase pathway

scientific article

CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer

scientific article

CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma

scientific article published on 06 January 2017

Cathepsin B is the driving force of esophageal cell invasion in a fibroblast-dependent manner

scientific article

Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagus

scientific article

Characterization of proteins in human pancreatic cancer serum using differential gel electrophoresis and tandem mass spectrometry

scientific article published in September 2005

Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.

scientific article

Comparative transcriptomes of adenocarcinomas and squamous cell carcinomas reveal molecular similarities that span classical anatomic boundaries

scientific article published on 07 August 2017

Coordinated functions of E-cadherin and transforming growth factor beta receptor II in vitro and in vivo

scientific article

Creating oral squamous cancer cells: a cellular model of oral-esophageal carcinogenesis

scientific article

Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers

scientific article

Dexamethasone treatment induces the reprogramming of pancreatic acinar cells to hepatocytes and ductal cells.

scientific article

EMT and dissemination precede pancreatic tumor formation

scientific article (publication date: 20 January 2012)

ETS-Transcription Factor ETV1 Regulates Stromal Expansion and Metastasis in Pancreatic Cancer.

scientific article published on 15 June 2016

Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo

scientific article

Erratum: Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2.

scientific article published on 9 June 2017

FBXO4 loss facilitates carcinogen induced papilloma development in mice

scientific article published on January 2015

Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion

scientific article

Generation and Characterization of Patient-Derived Head and Neck, Oral, and Esophageal Cancer Organoids

scientific article published on 01 June 2020

Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.

scientific article

IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment

scientific article published on 05 July 2018

Identification of a bone marrow-derived mesenchymal progenitor cell subset that can contribute to the gastric epithelium

scientific article

Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes

scientific article

Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma.

scientific article published on 24 November 2017

Isoform-specific upregulation of palladin in human and murine pancreas tumors

scientific article

Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture

scientific article

Isolation, culture and genetic manipulation of mouse pancreatic ductal cells

scientific article

K-ras Mutation Targeted to Gastric Tissue Progenitor Cells Results in Chronic Inflammation, an Altered Microenvironment, and Progression to Intraepithelial Neoplasia ⬇️

scientific article published on October 19, 2010

Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients.

scientific article

Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2.

scientific article published on 7 April 2017

Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration.

scientific article published on 8 May 2017

Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression

scientific article

Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon

scientific article

Modeling human gastrointestinal inflammatory diseases using microphysiological culture systems.

scientific article

Multiparametric profiling of non-small-cell lung cancers reveals distinct immunophenotypes

scientific article published on 08 September 2016

Mutant KRAS in the initiation of pancreatic cancer

scientific article

Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer.

scientific article published on 18 April 2018

Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase ⬇️

scientific article published on October 19, 2010

Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication

scientific article

O-010 Novel Regulation of Autophagy and Intestinal Homeostasis Via mRNA Binding Protein IMP1

scientific article published in March 2016

Pancreatic ductal cells in development, regeneration, and neoplasia ⬇️

scientific article published on December 1, 2011

Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex

scientific article

Preexisting oncogenic events impact trastuzumab sensitivity in ERBB2-amplified gastroesophageal adenocarcinoma

scientific article

Prrx1 isoform switching regulates pancreatic cancer invasion and metastatic colonization

scientific article

SOX15 governs transcription in human stratified epithelia and a subset of esophageal adenocarcinomas

scientific article

SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas

scientific article published on 03 March 2014

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas ⬇️

scientific article

Sa1664 - The Lin28B-Imp1 Axis Directs a Post-Transcriptional Regulon of Oncogenic Signaling in the Intestine

scholarly article published in May 2018

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

scientific article published on 21 March 2019

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.

scientific article published on 28 May 2018

The Fbx4 Tumor Suppressor Regulates Cyclin D1 Accumulation and Prevents Neoplastic Transformation ⬇️

scientific article published on September 12, 2011

The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine

scientific article published on 01 August 2018

The PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter

scientific journal article

The Pancreatic and Duodenal Homeobox Protein PDX-1 Regulates the Ductal Specific Keratin 19 through the Degradation of MEIS1 and DNA Binding ⬇️

scientific article published on August 19, 2010

The landscape of somatic copy-number alteration across human cancers

scientific article

The role of the miR-200 family in epithelial-mesenchymal transition

scientific article

The tumor microenvironment in esophageal cancer

scientific article

Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells

scientific article published on 14 September 2018

WNT7a induces E-cadherin in lung cancer cells

scientific article

Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer

scientific article published on 9 December 2015

Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells

scientific article

List of works by Anil K Rustgi

A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4).

A common p53 mutation (R175H) activates c-Met receptor tyrosine kinase to enhance tumor cell invasion

A historical perspective on clinical advances in pancreatic diseases

A region-based gene association study combined with a leave-one-out sensitivity analysis identifies SMG1 as a pancreatic cancer susceptibility gene

A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification

ARHGAP8 is a novel member of the RHOGAP family related to ARHGAP1/CDC42GAP/p50RHOGAP: mutation and expression analyses in colorectal and breast cancers

Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase

Advances in acute and chronic pancreatitis: from development to inflammation and repair

Assessing Computational Steps for CLIP-Seq Data Analysis

Author Correction: Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non-Small Cell Lung Cancer

Barrett's Esophagus Translational Research Network (BETRNet): the pivotal role of multi-institutional collaboration in esophageal adenocarcinoma research

Barrett's esophagus and its progression to adenocarcinoma

Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer

Bortezomib induces apoptosis in esophageal squamous cell carcinoma cells through activation of the p38 mitogen-activated protein kinase pathway

CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer

CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma

Cathepsin B is the driving force of esophageal cell invasion in a fibroblast-dependent manner

Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagus

Characterization of proteins in human pancreatic cancer serum using differential gel electrophoresis and tandem mass spectrometry

Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.

Comparative transcriptomes of adenocarcinomas and squamous cell carcinomas reveal molecular similarities that span classical anatomic boundaries

Coordinated functions of E-cadherin and transforming growth factor beta receptor II in vitro and in vivo

Creating oral squamous cancer cells: a cellular model of oral-esophageal carcinogenesis

Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers

Dexamethasone treatment induces the reprogramming of pancreatic acinar cells to hepatocytes and ductal cells.

EMT and dissemination precede pancreatic tumor formation

ETS-Transcription Factor ETV1 Regulates Stromal Expansion and Metastasis in Pancreatic Cancer.

Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo

Erratum: Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2.

FBXO4 loss facilitates carcinogen induced papilloma development in mice

Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion

Generation and Characterization of Patient-Derived Head and Neck, Oral, and Esophageal Cancer Organoids

Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.

IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment

Identification of a bone marrow-derived mesenchymal progenitor cell subset that can contribute to the gastric epithelium

Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes

Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma.

Isoform-specific upregulation of palladin in human and murine pancreas tumors

Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture

Isolation, culture and genetic manipulation of mouse pancreatic ductal cells

K-ras Mutation Targeted to Gastric Tissue Progenitor Cells Results in Chronic Inflammation, an Altered Microenvironment, and Progression to Intraepithelial Neoplasia ⬇️

Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients.

Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2.

Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration.

Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression

Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon

Modeling human gastrointestinal inflammatory diseases using microphysiological culture systems.

Multiparametric profiling of non-small-cell lung cancers reveals distinct immunophenotypes

Mutant KRAS in the initiation of pancreatic cancer

Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer.

Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase ⬇️

Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication

O-010 Novel Regulation of Autophagy and Intestinal Homeostasis Via mRNA Binding Protein IMP1

Pancreatic ductal cells in development, regeneration, and neoplasia ⬇️

Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex

Preexisting oncogenic events impact trastuzumab sensitivity in ERBB2-amplified gastroesophageal adenocarcinoma

Prrx1 isoform switching regulates pancreatic cancer invasion and metastatic colonization

SOX15 governs transcription in human stratified epithelia and a subset of esophageal adenocarcinomas

SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas ⬇️

Sa1664 - The Lin28B-Imp1 Axis Directs a Post-Transcriptional Regulon of Oncogenic Signaling in the Intestine

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.

The Fbx4 Tumor Suppressor Regulates Cyclin D1 Accumulation and Prevents Neoplastic Transformation ⬇️

The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine

The PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter

The Pancreatic and Duodenal Homeobox Protein PDX-1 Regulates the Ductal Specific Keratin 19 through the Degradation of MEIS1 and DNA Binding ⬇️

The landscape of somatic copy-number alteration across human cancers

The role of the miR-200 family in epithelial-mesenchymal transition

The tumor microenvironment in esophageal cancer

Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells

WNT7a induces E-cadherin in lung cancer cells

Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer

Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells