List of works - Dario Vignali

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

A Bayesian mixture model for clustering droplet-based single-cell transcriptomic data from population studies

scientific article published on 09 April 2019

Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion

scientific article published on 01 April 2019

B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma

scientific article published on 07 June 2021

B cell-Derived IL35 Drives STAT3-Dependent CD8+ T-cell Exclusion in Pancreatic Cancer

scientific article published on 05 February 2020

B7-H4 Modulates Regulatory CD4+ T Cell Induction and Function via Ligation of a Semaphorin 3a/Plexin A4/Neuropilin-1 Complex

scientific article published on 13 June 2018

Biochemical analysis of the regulatory T cell protein lymphocyte activation gene-3 (LAG-3; CD223).

scientific article

CD4 on the road to coreceptor status

scientific article

Cancer-associated MSC drive tumor immune exclusion and resistance to immunotherapy, which can be overcome by Hedgehog inhibition

scientific article published on 12 November 2021

Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4+ T cells

scientific article

Combination immunotherapy: Where do we go from here?

scientific article published on 18 August 2015

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

scientific article

Cutting edge: Human regulatory T cells require IL-35 to mediate suppression and infectious tolerance

scientific article

Cutting edge: accelerated autoimmune diabetes in the absence of LAG-3

scientific article

Cutting edge: molecular analysis of the negative regulatory function of lymphocyte activation gene-3

scientific journal article

Cutting edge: regulatory T cells do not mediate suppression via programmed cell death pathways

scientific article

Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease

scientific article

Development of thymically derived natural regulatory T cells

scientific article

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

scientific article

Differential subcellular localization of the regulatory T-cell protein LAG-3 and the coreceptor CD4.

scientific article

Distinct subunit pairing criteria within the heterodimeric IL-12 cytokine family

scientific article published on 7 April 2012

ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation

scientific article published on 19 April 2022

Functionally distinct LAG-3 and PD-1 subsets on activated and chronically stimulated CD8 T cells

scientific article

Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice

scientific article published on 7 February 2012

Human prostate tumor antigen-specific CD8+ regulatory T cells are inhibited by CTLA-4 or IL-35 blockade

scientific article

IL-12 family cytokines: immunological playmakers

scientific article

IL-35-mediated induction of a potent regulatory T cell population.

scientific article

Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR.

scientific article published on 24 June 2015

Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape

scientific article

Immune landscape in invasive ductal and lobular breast cancer reveals a divergent macrophage-driven microenvironment

scientific article published in 2023

In vitro Treg suppression assays

scientific article

In vivo Treg suppression assays

scientific article

Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups

scientific article published on 14 October 2019

Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung

scientific article published on 28 September 2020

Interleukin-35: Expanding Its Job Profile

scientific article

Intratumoral regulatory T cells: markers, subsets and their impact on anti-tumor immunity

scientific article published on 03 June 2019

LAG-3 regulates plasmacytoid dendritic cell homeostasis

scientific article

LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L.

scientific article

LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes.

scientific article published on March 2017

Lymphocyte Activation Gene-3 (LAG-3) negatively regulates environmentally-induced autoimmunity

scientific article

Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo

scientific article

Membrane association of the CD3ε signaling domain is required for optimal T cell development and function.

scientific article

Metalloproteases regulate T-cell proliferation and effector function via LAG-3

scientific article published on January 2007

Mutational analysis of TRAF6 reveals a conserved functional role of the RING dimerization interface and a potentially necessary but insufficient role of RING-dependent TRAF6 polyubiquitination towards NF-κB activation

scientific article

Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity

scientific article published on 13 July 2020

Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development

scientific journal article

Once a Treg, always a Treg?

scientific article

Organization of proximal signal initiation at the TCR:CD3 complex

scientific article

Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3).

scientific article

Prevention of autoimmune diabetes by ectopic pancreatic β-cell expression of interleukin-35.

scientific article

Publisher Correction: Immune landscape in invasive ductal and lobular breast cancer reveals a divergent macrophage-driven microenvironment

scientific article published in 2023

Rapid identification of MHC class I-restricted antigens relevant to autoimmune diabetes using retrogenic T cells

scientific article

Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding

scientific article published on 01 July 2020

Role of LAG-3 in regulatory T cells.

scientific article

Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis.

scientific article

Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses

scientific article

T cell-driven initiation and propagation of autoimmune diabetes

scientific article published on 4 November 2011

TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential.

scientific article

The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells

scientific article

The battle against immunopathology: infectious tolerance mediated by regulatory T cells

scientific article

The composition and signaling of the IL-35 receptor are unconventional

scientific journal article

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

scientific article

The plasticity of regulatory T cell function

scientific article published on 17 October 2011

Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice

scientific article

Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell development

scientific article

Type 1 diabetes: translating mechanistic observations into effective clinical outcomes

scientific article

List of works by Dario Vignali

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

A Bayesian mixture model for clustering droplet-based single-cell transcriptomic data from population studies

Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion

B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma

B cell-Derived IL35 Drives STAT3-Dependent CD8+ T-cell Exclusion in Pancreatic Cancer

B7-H4 Modulates Regulatory CD4+ T Cell Induction and Function via Ligation of a Semaphorin 3a/Plexin A4/Neuropilin-1 Complex

Biochemical analysis of the regulatory T cell protein lymphocyte activation gene-3 (LAG-3; CD223).

CD4 on the road to coreceptor status

Cancer-associated MSC drive tumor immune exclusion and resistance to immunotherapy, which can be overcome by Hedgehog inhibition

Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4+ T cells

Combination immunotherapy: Where do we go from here?

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

Cutting edge: Human regulatory T cells require IL-35 to mediate suppression and infectious tolerance

Cutting edge: accelerated autoimmune diabetes in the absence of LAG-3

Cutting edge: molecular analysis of the negative regulatory function of lymphocyte activation gene-3

Cutting edge: regulatory T cells do not mediate suppression via programmed cell death pathways

Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease

Development of thymically derived natural regulatory T cells

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

Differential subcellular localization of the regulatory T-cell protein LAG-3 and the coreceptor CD4.

Distinct subunit pairing criteria within the heterodimeric IL-12 cytokine family

ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation

Functionally distinct LAG-3 and PD-1 subsets on activated and chronically stimulated CD8 T cells

Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice

Human prostate tumor antigen-specific CD8+ regulatory T cells are inhibited by CTLA-4 or IL-35 blockade

IL-12 family cytokines: immunological playmakers

IL-35-mediated induction of a potent regulatory T cell population.

Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR.

Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape

Immune landscape in invasive ductal and lobular breast cancer reveals a divergent macrophage-driven microenvironment

In vitro Treg suppression assays

In vivo Treg suppression assays

Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups

Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung

Interleukin-35: Expanding Its Job Profile

Intratumoral regulatory T cells: markers, subsets and their impact on anti-tumor immunity

LAG-3 regulates plasmacytoid dendritic cell homeostasis

LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L.

LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes.

Lymphocyte Activation Gene-3 (LAG-3) negatively regulates environmentally-induced autoimmunity

Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo

Membrane association of the CD3ε signaling domain is required for optimal T cell development and function.

Metalloproteases regulate T-cell proliferation and effector function via LAG-3

Mutational analysis of TRAF6 reveals a conserved functional role of the RING dimerization interface and a potentially necessary but insufficient role of RING-dependent TRAF6 polyubiquitination towards NF-κB activation

Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity

Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development

Once a Treg, always a Treg?

Organization of proximal signal initiation at the TCR:CD3 complex

Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3).

Prevention of autoimmune diabetes by ectopic pancreatic β-cell expression of interleukin-35.

Publisher Correction: Immune landscape in invasive ductal and lobular breast cancer reveals a divergent macrophage-driven microenvironment

Rapid identification of MHC class I-restricted antigens relevant to autoimmune diabetes using retrogenic T cells

Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding

Role of LAG-3 in regulatory T cells.

Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis.

Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses

T cell-driven initiation and propagation of autoimmune diabetes

TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential.

The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells

The battle against immunopathology: infectious tolerance mediated by regulatory T cells

The composition and signaling of the IL-35 receptor are unconventional

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

The plasticity of regulatory T cell function

Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice

Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell development

Type 1 diabetes: translating mechanistic observations into effective clinical outcomes