List of works - Tom Taghon

A DL-4- and TNFα-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors

scientific article published on 11 June 2021

A Murine Intestinal Intraepithelial NKp46-Negative Innate Lymphoid Cell Population Characterized by Group 1 Properties.

scientific article published on May 2017

A Tumor Suppressor Enhancer of in T-cell development and leukemia

A cell atlas of human thymic development defines T cell repertoire formation

scientific article published on 01 February 2020

A cell atlas of human thymic development defines T cell repertoire formation

A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing

scientific article published on 28 June 2018

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).

scientific article

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.

scientific article

A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network.

scientific article published on 06 September 2016

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

scientific article published on 9 October 2014

Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function

scientific article

Active form of Notch imposes T cell fate in human progenitor cells

scientific article published on September 2002

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia

scientific article published on 23 September 2020

An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells

scientific article published on 3 December 2008

Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities

scientific article published on 19 January 2017

Approaches to Study Human T Cell Development

scientific article published on January 2016

CD27-deficient mice show normal NK-cell differentiation but impaired function upon stimulation

scientific article published in February 2011

Characterization and Isolation of Human T Cell Progenitors

scientific article published in January 2016

Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia

scientific article

Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia

scientific article

Comprehensive miRNA expression profiling in human T-cell acute lymphoblastic leukemia by small RNA-sequencing

scientific article published on 11 August 2017

Continuous CD27 triggering in vivo strongly reduces NK cell numbers

scientific article published in April 2010

Contribution of the Ly49E natural killer receptor in the immune response to Plasmodium berghei infection and control of hepatic parasite development

scientific article published on 30 January 2014

Conventional and Computational Flow Cytometry Analyses Reveal Sustained Human Intrathymic T Cell Development From Birth Until Puberty

scientific article published on 04 August 2020

Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation

scientific article published on 28 September 2018

Developmental and molecular characterization of emerging beta- and gammadelta-selected pre-T cells in the adult mouse thymus

scientific article published in January 2006

Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial γδ T cells

scientific article

Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development

scientific article published on 07 April 2020

Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development

scientific article published on 27 July 2020

EVI1-mediated down regulation of MIR449A is essential for the survival of EVI1 positive leukaemic cells

scientific article published on 14 May 2011

Epigenetics in T-cell acute lymphoblastic leukemia

scientific article

Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours.

scientific article published on 29 July 2016

Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells

scientific article published on October 2009

GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate

scientific article published on 6 April 2016

Generation of T cells from human embryonic stem cell-derived hematopoietic zones

scientific article published in June 2009

Generation of adult human T-cell progenitors for immunotherapeutic applications

scientific article published on 2 December 2017

HES1 and HES4 have non-redundant roles downstream of Notch during early human T cell development

scientific article published on 09 January 2020

HOX-A10 regulates hematopoietic lineage commitment: evidence for a monocyte-specific transcription factor

scientific article published in February 2002

Human T cell development notched up a level

scientific article

Human Thymic CD10+ PD-1+ Intraepithelial Lymphocyte Precursors Acquire Interleukin-15 Responsiveness at the CD1a- CD95+ CD28- CCR7- Developmental Stage

scientific article published on 20 November 2020

Humanized Mice to Study Human T Cell Development.

scientific article published in January 2016

In vitro generation of immune cells from pluripotent stem cells

scientific article published on January 2011

In vitro generation of mature, naive antigen-specific CD8(+) T cells with a single T-cell receptor by agonist selection

scientific article published on 4 October 2013

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis

scientific article published on 7 November 2014

Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes

scientific article

Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes

scientific article published on 13 April 2020

Integrative genomic and transcriptomic analysis identified candidate genes implicated in the pathogenesis of hepatosplenic T-cell lymphoma

scientific article

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions

scientific article published on 3 March 2011

Langerhans cells are not required for epidermal Vgamma3 T cell homeostasis and function

scientific article published on 12 April 2011

Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes

scientific article published on 01 December 2020

Long noncoding RNA signatures define oncogenic subtypes in T-cell acute lymphoblastic leukemia.

scientific article published on 10 May 2016

Ly49E expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases

scientific article

Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator.

scientific article published on 10 September 2008

Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3

scientific journal article

MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia

scientific article

MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia

scientific article

Molecular dissection of prethymic progenitor entry into the T lymphocyte developmental pathway

scientific article

Molecular genetics of T cell development

scientific article

Molecular mechanisms that control mouse and human TCR-alphabeta and TCR-gammadelta T cell development

scientific article published on 17 October 2008

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20.

scientific article published on 22 August 2016

Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway.

scientific article published on 4 November 2011

Notch signaling during human T cell development

scientific article published on January 2012

Notch signaling induces cytoplasmic CD3 epsilon expression in human differentiating NK cells

scientific article published on 13 July 2007

Notch signaling is required for proliferation but not for differentiation at a well-defined beta-selection checkpoint during human T-cell development

scientific article published on 23 October 2008

Notch/Delta signaling constrains reengineering of pro-T cells by PU.1.

scholarly article

Notch3 activation is sufficient but not required for inducing human T-lineage specification

scientific article published on 7 November 2014

PHF6 Expression Levels Impact Human Hematopoietic Stem Cell Differentiation

scientific article published on 04 November 2020

PHF6 mutations in T-cell acute lymphoblastic leukemia

scientific article (publication date: 14 March 2010)

PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis

scientific article published on 30 June 2020

Persistent rotavirus diarrhea post-transplant in a novel JAK3-SCID patient after vaccination.

scientific article published on 6 August 2015

Posttranslational regulation of the exon skipping machinery controls aberrant splicing in leukemia

scientific article published on 22 May 2020

Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms

scientific article

Progression of regulatory gene expression states in fetal and adult pro-T-cell development

scientific article

Quantification of reverse transcriptase activity by real-time PCR as a fast and accurate method for titration of HIV, lenti- and retroviral vectors

scientific article

RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia

scientific article

Rapid and Effective Generation of Nanobody Based CARs using PCR and Gibson Assembly

scientific article published on 30 January 2020

SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival

scientific article published in Nature Communications

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition

scientific article published on 01 May 2019

Single cell profiling of immature human postnatal thymocytes resolves the complexity of intra-thymic lineage differentiation and thymus seeding precursors ⬇️

journal article from 'bioRxiv' published in 2020

Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.

scientific article published on 25 March 2013

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche

scientific article published on 24 September 2019

T-ALL and thymocytes: a message of noncoding RNAs

scientific article published on 7 March 2017

T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development

scientific article published on 04 December 2018

T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources

scientific article published on 17 February 2020

T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38-/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells

scientific article published on 17 February 2011

Targeting cytokine and therapy induced PIM1 activation in T-cell acute lymphoblastic leukemia and lymphoma

scientific article published on 13 February 2020

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

scientific article

The Ly49E Receptor Inhibits the Immune Control of Acute Trypanosoma cruzi Infection.

scientific article

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

scientific article

The RNA Atlas, a single nucleotide resolution map of the human transcriptome

The checkpoint for agonist selection precedes conventional selection in human thymus.

scientific article published on February 2017

The role of Ly49E receptor expression on murine intraepithelial lymphocytes in intestinal cancer development and progression.

scientific article

The transcription factor ETS1 is an important regulator of human NK cell development and terminal differentiation

scientific article published on 29 April 2020

Treatment of a patient with severe cytomegalovirus (CMV) infection after haploidentical stem cell transplantation with donor-derived CMV-specific T cells

scientific article published on 14 April 2020

Tumor necrosis factor promotes T-cell at the expense of B-cell lymphoid development from cultured human CD34+ cord blood cells

scientific article published on 5 June 2007

ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms

scientific article published on 24 January 2019

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.

scientific article

ZEB2 in T-cells and T-ALL

scientific article published on 27 July 2019

hsa-miR-20b-5p and hsa-miR-363-3p Affect Expression of PTEN and BIM Tumor Suppressor Genes and Modulate Survival of T-ALL Cells In Vitro

scientific article published on 05 May 2020

List of works by Tom Taghon

A DL-4- and TNFα-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors

A Murine Intestinal Intraepithelial NKp46-Negative Innate Lymphoid Cell Population Characterized by Group 1 Properties.

A Tumor Suppressor Enhancer of in T-cell development and leukemia

A cell atlas of human thymic development defines T cell repertoire formation

A cell atlas of human thymic development defines T cell repertoire formation

A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.

A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network.

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function

Active form of Notch imposes T cell fate in human progenitor cells

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia

An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells

Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities

Approaches to Study Human T Cell Development

CD27-deficient mice show normal NK-cell differentiation but impaired function upon stimulation

Characterization and Isolation of Human T Cell Progenitors

Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia

Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia

Comprehensive miRNA expression profiling in human T-cell acute lymphoblastic leukemia by small RNA-sequencing

Continuous CD27 triggering in vivo strongly reduces NK cell numbers

Contribution of the Ly49E natural killer receptor in the immune response to Plasmodium berghei infection and control of hepatic parasite development

Conventional and Computational Flow Cytometry Analyses Reveal Sustained Human Intrathymic T Cell Development From Birth Until Puberty

Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation

Developmental and molecular characterization of emerging beta- and gammadelta-selected pre-T cells in the adult mouse thymus

Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial γδ T cells

Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development

Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development

EVI1-mediated down regulation of MIR449A is essential for the survival of EVI1 positive leukaemic cells

Epigenetics in T-cell acute lymphoblastic leukemia

Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours.

Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells

GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate

Generation of T cells from human embryonic stem cell-derived hematopoietic zones

Generation of adult human T-cell progenitors for immunotherapeutic applications

HES1 and HES4 have non-redundant roles downstream of Notch during early human T cell development

HOX-A10 regulates hematopoietic lineage commitment: evidence for a monocyte-specific transcription factor

Human T cell development notched up a level

Human Thymic CD10+ PD-1+ Intraepithelial Lymphocyte Precursors Acquire Interleukin-15 Responsiveness at the CD1a- CD95+ CD28- CCR7- Developmental Stage

Humanized Mice to Study Human T Cell Development.

In vitro generation of immune cells from pluripotent stem cells

In vitro generation of mature, naive antigen-specific CD8(+) T cells with a single T-cell receptor by agonist selection

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis

Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes

Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes

Integrative genomic and transcriptomic analysis identified candidate genes implicated in the pathogenesis of hepatosplenic T-cell lymphoma

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions

Langerhans cells are not required for epidermal Vgamma3 T cell homeostasis and function

Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes

Long noncoding RNA signatures define oncogenic subtypes in T-cell acute lymphoblastic leukemia.

Ly49E expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases

Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator.

Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3

MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia

MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia

Molecular dissection of prethymic progenitor entry into the T lymphocyte developmental pathway

Molecular genetics of T cell development

Molecular mechanisms that control mouse and human TCR-alphabeta and TCR-gammadelta T cell development

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20.

Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway.

Notch signaling during human T cell development

Notch signaling induces cytoplasmic CD3 epsilon expression in human differentiating NK cells

Notch signaling is required for proliferation but not for differentiation at a well-defined beta-selection checkpoint during human T-cell development

Notch/Delta signaling constrains reengineering of pro-T cells by PU.1.

Notch3 activation is sufficient but not required for inducing human T-lineage specification

PHF6 Expression Levels Impact Human Hematopoietic Stem Cell Differentiation

PHF6 mutations in T-cell acute lymphoblastic leukemia

PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis

Persistent rotavirus diarrhea post-transplant in a novel JAK3-SCID patient after vaccination.

Posttranslational regulation of the exon skipping machinery controls aberrant splicing in leukemia

Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms

Progression of regulatory gene expression states in fetal and adult pro-T-cell development

Quantification of reverse transcriptase activity by real-time PCR as a fast and accurate method for titration of HIV, lenti- and retroviral vectors

RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia

Rapid and Effective Generation of Nanobody Based CARs using PCR and Gibson Assembly

SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition

Single cell profiling of immature human postnatal thymocytes resolves the complexity of intra-thymic lineage differentiation and thymus seeding precursors ⬇️