List of works - Annemieke Kavelaars

A dual role of the NF-kappaB pathway in neonatal hypoxic-ischemic brain damage

scientific article

Alternate pathways preserve tumor necrosis factor-alpha production after nuclear factor-kappaB inhibition in neonatal cerebral hypoxia-ischemia

scientific article

Angiopoietin-1 treatment reduces inflammation but does not prevent ventilator-induced lung injury

scientific article

Assessment of long-term safety and efficacy of intranasal mesenchymal stem cell treatment for neonatal brain injury in the mouse

scientific article

Astrocyte GRK2 as a novel regulator of glutamate transport and brain damage

scientific article published on 8 January 2013

Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.

scientific article

Bilateral molecular changes in a neonatal rat model of unilateral hypoxic-ischemic brain damage

scientific article published in March 2006

CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain.

scientific article published on October 2016

CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines.

scientific article

Cell-specific roles of GRK2 in onset and severity of hypoxic-ischemic brain damage in neonatal mice

scientific article

Central administration of lipopolysaccharide induces depressive-like behavior in vivo and activates brain indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures

scientific article

Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1.

scientific article published on 29 February 2016

Cytokine production by leukocytes of military personnel with depressive symptoms after deployment to a combat-zone: a prospective, longitudinal study

scientific article

Dexamethasone attenuates VEGF expression and inflammation but not barrier dysfunction in a murine model of ventilator-induced lung injury

scientific article

Dorsal Root Ganglion Infiltration by Macrophages Contributes to Paclitaxel Chemotherapy-Induced Peripheral Neuropathy

scientific article published on 12 March 2016

Effects of murine and human bone marrow-derived mesenchymal stem cells on cuprizone induced demyelination

scientific article published on 26 July 2013

Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos

scientific article (publication date: 2012)

Expression of nitric oxide synthase isoforms and nitrotyrosine formation after hypoxia-ischemia in the neonatal rat brain

scientific article

Extent of bilateral neuronal network reorganization and functional recovery in relation to stroke severity

scientific article published in March 2012

G protein-coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration

scientific article published on 14 March 2013

G protein-coupled receptor kinase 2 positively regulates epithelial cell migration

scientific article

G protein-coupled receptor kinase 6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting phosphatidylinositol 3-kinase and inhibiting p38 signaling.

scientific article

GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain

scientific article

GRKs and arrestins: regulators of migration and inflammation

scientific article published on 30 August 2006

Gender-dependent pathways of hypoxia-ischemia-induced cell death and neuroprotection in the immature P3 rat.

scientific article published in January 2007

Gender-specific neuroprotection by 2-iminobiotin after hypoxia-ischemia in the neonatal rat via a nitric oxide independent pathway

scientific article

Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region

scientific article

Hematopoietic G-protein-coupled receptor kinase 2 deficiency decreases atherosclerotic lesion formation in LDL receptor-knockout mice

scientific article

IL-1β reactivity and the development of severe fatigue after military deployment: a longitudinal study

scientific article

IL4-10 Fusion Protein Is a Novel Drug to Treat Persistent Inflammatory Pain.

scientific article published on July 2016

Impaired neuroendocrine and immune response to acute stress in medication-naive patients with a first episode of psychosis

scientific article published on 17 June 2010

Inhibition of Mitochondrial p53 Accumulation by PFT-μ Prevents Cisplatin-Induced Peripheral Neuropathy

scientific article

Inhibition of the JNK/AP-1 pathway reduces neuronal death and improves behavioral outcome after neonatal hypoxic-ischemic brain injury

scientific article published on 17 September 2009

Intranasal administration of human MSC for ischemic brain injury in the mouse: in vitro and in vivo neuroregenerative functions

scientific article

Intranasal mesenchymal stem cell treatment for neonatal brain damage: long-term cognitive and sensorimotor improvement

scientific article

Intranasally administered mesenchymal stem cells promote a regenerative niche for repair of neonatal ischemic brain injury

scientific article published on 16 June 2014

Long-term neuroprotection with 2-iminobiotin, an inhibitor of neuronal and inducible nitric oxide synthase, after cerebral hypoxia-ischemia in neonatal rats

scientific article

Low endogenous G-protein-coupled receptor kinase 2 sensitizes the immature brain to hypoxia-ischemia-induced gray and white matter damage.

scientific article published in March 2008

Mechanisms of chemotherapy-induced behavioral toxicities

scientific article

Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice

scientific article

MicroRNA-124 as a novel treatment for persistent hyperalgesia ⬇️

scientific article published on June 25, 2012

Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling.

scientific article

Mitochondrial JNK phosphorylation as a novel therapeutic target to inhibit neuroinflammation and apoptosis after neonatal ischemic brain damage

scientific article

Monocytes/Macrophages control resolution of transient inflammatory pain.

scientific article

NF-kappaB inhibition after neonatal cerebral hypoxia-ischemia improves long-term motor and cognitive outcome in rats

scientific article published on 2 February 2010

Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation

scientific article

Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss

scientific article

Neuroprotective properties and mechanisms of erythropoietin in in vitro and in vivo experimental models for hypoxia/ischemia.

scientific article

Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice.

scientific article published on 28 January 2015

Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-μ.

scientific article published on November 2015

Regulated expression of alpha-1 adrenergic receptors in the immune system

scientific article

Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2.

scientific article

Role and modulation of G protein-coupled receptor signaling in inflammatory processes

scientific article

Sickness behavior induced by cisplatin chemotherapy and radiotherapy in a murine head and neck cancer model is associated with altered mitochondrial gene expression

scientific article

Stress, genetics, and immunity

scientific article

Strong neuroprotection by inhibition of NF-kappaB after neonatal hypoxia-ischemia involves apoptotic mechanisms but is independent of cytokines

scientific article

Targeting the p53 pathway to protect the neonatal ischemic brain.

scientific article published on 14 June 2011

The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model

scientific article (publication date: 2014)

The endogenous regenerative capacity of the damaged newborn brain: boosting neurogenesis with mesenchymal stem cell treatment.

scientific article published on 13 February 2013

The rodent endovascular puncture model of subarachnoid hemorrhage: mechanisms of brain damage and therapeutic strategies.

scientific article published on 03 January 2014

Tumour necrosis factor-alpha stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-kappaB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b

scientific article

Type D personality, temperament, and mental health in military personnel awaiting deployment

scientific article

List of works by Annemieke Kavelaars

A dual role of the NF-kappaB pathway in neonatal hypoxic-ischemic brain damage

Alternate pathways preserve tumor necrosis factor-alpha production after nuclear factor-kappaB inhibition in neonatal cerebral hypoxia-ischemia

Angiopoietin-1 treatment reduces inflammation but does not prevent ventilator-induced lung injury

Assessment of long-term safety and efficacy of intranasal mesenchymal stem cell treatment for neonatal brain injury in the mouse

Astrocyte GRK2 as a novel regulator of glutamate transport and brain damage

Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.

Bilateral molecular changes in a neonatal rat model of unilateral hypoxic-ischemic brain damage

CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain.

CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines.

Cell-specific roles of GRK2 in onset and severity of hypoxic-ischemic brain damage in neonatal mice

Central administration of lipopolysaccharide induces depressive-like behavior in vivo and activates brain indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures

Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1.

Cytokine production by leukocytes of military personnel with depressive symptoms after deployment to a combat-zone: a prospective, longitudinal study

Dexamethasone attenuates VEGF expression and inflammation but not barrier dysfunction in a murine model of ventilator-induced lung injury

Dorsal Root Ganglion Infiltration by Macrophages Contributes to Paclitaxel Chemotherapy-Induced Peripheral Neuropathy

Effects of murine and human bone marrow-derived mesenchymal stem cells on cuprizone induced demyelination

Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos

Expression of nitric oxide synthase isoforms and nitrotyrosine formation after hypoxia-ischemia in the neonatal rat brain

Extent of bilateral neuronal network reorganization and functional recovery in relation to stroke severity

G protein-coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration

G protein-coupled receptor kinase 2 positively regulates epithelial cell migration

G protein-coupled receptor kinase 6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting phosphatidylinositol 3-kinase and inhibiting p38 signaling.

GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain

GRKs and arrestins: regulators of migration and inflammation

Gender-dependent pathways of hypoxia-ischemia-induced cell death and neuroprotection in the immature P3 rat.

Gender-specific neuroprotection by 2-iminobiotin after hypoxia-ischemia in the neonatal rat via a nitric oxide independent pathway

Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region

Hematopoietic G-protein-coupled receptor kinase 2 deficiency decreases atherosclerotic lesion formation in LDL receptor-knockout mice

IL-1β reactivity and the development of severe fatigue after military deployment: a longitudinal study

IL4-10 Fusion Protein Is a Novel Drug to Treat Persistent Inflammatory Pain.

Impaired neuroendocrine and immune response to acute stress in medication-naive patients with a first episode of psychosis

Inhibition of Mitochondrial p53 Accumulation by PFT-μ Prevents Cisplatin-Induced Peripheral Neuropathy

Inhibition of the JNK/AP-1 pathway reduces neuronal death and improves behavioral outcome after neonatal hypoxic-ischemic brain injury

Intranasal administration of human MSC for ischemic brain injury in the mouse: in vitro and in vivo neuroregenerative functions

Intranasal mesenchymal stem cell treatment for neonatal brain damage: long-term cognitive and sensorimotor improvement

Intranasally administered mesenchymal stem cells promote a regenerative niche for repair of neonatal ischemic brain injury

Long-term neuroprotection with 2-iminobiotin, an inhibitor of neuronal and inducible nitric oxide synthase, after cerebral hypoxia-ischemia in neonatal rats

Low endogenous G-protein-coupled receptor kinase 2 sensitizes the immature brain to hypoxia-ischemia-induced gray and white matter damage.

Mechanisms of chemotherapy-induced behavioral toxicities

Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice

MicroRNA-124 as a novel treatment for persistent hyperalgesia ⬇️

Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling.

Mitochondrial JNK phosphorylation as a novel therapeutic target to inhibit neuroinflammation and apoptosis after neonatal ischemic brain damage

Monocytes/Macrophages control resolution of transient inflammatory pain.

NF-kappaB inhibition after neonatal cerebral hypoxia-ischemia improves long-term motor and cognitive outcome in rats

Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation

Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss

Neuroprotective properties and mechanisms of erythropoietin in in vitro and in vivo experimental models for hypoxia/ischemia.

Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice.

Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-μ.

Regulated expression of alpha-1 adrenergic receptors in the immune system

Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2.

Role and modulation of G protein-coupled receptor signaling in inflammatory processes

Sickness behavior induced by cisplatin chemotherapy and radiotherapy in a murine head and neck cancer model is associated with altered mitochondrial gene expression

Stress, genetics, and immunity

Strong neuroprotection by inhibition of NF-kappaB after neonatal hypoxia-ischemia involves apoptotic mechanisms but is independent of cytokines

Targeting the p53 pathway to protect the neonatal ischemic brain.

The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model

The endogenous regenerative capacity of the damaged newborn brain: boosting neurogenesis with mesenchymal stem cell treatment.

The rodent endovascular puncture model of subarachnoid hemorrhage: mechanisms of brain damage and therapeutic strategies.

Tumour necrosis factor-alpha stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-kappaB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b

Type D personality, temperament, and mental health in military personnel awaiting deployment