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List of works by Juergen Loeffler

40-O -[2-Hydroxyethyl]rapamycin modulates human dendritic cell function during exposure to Aspergillus fumigatus

scientific article published on 21 July 2011

A CTL epitope from human cytomegalovirus IE1 defined by combining prediction of HLA binding and proteasomal processing is the target of dominant immune responses in patients after allogeneic stem cell transplantation

scientific article published on October 2003

A Comparison of Aspergillus and Mucorales PCR Testing of Different Bronchoalveolar Lavage Fluid Fractions from Patients with Suspected Invasive Pulmonary Fungal Disease

scientific article

A novel extraction method combining plasma with a whole-blood fraction shows excellent sensitivity and reproducibility for patients at high risk for invasive aspergillosis.

scientific article

A prospective study of fungal biomarkers to improve management of invasive fungal diseases in a mixed specialty critical care unit

scientific article published on 30 March 2017

AXT914 a novel, orally-active parathyroid hormone-releasing drug in two early studies of healthy volunteers and postmenopausal women

scientific article

Analytical Comparison of In Vitro-Spiked Human Serum and Plasma for PCR-Based Detection of Aspergillus fumigatus DNA: a Study by the European Aspergillus PCR Initiative

scientific article

Antifungal drug resistance

scientific article

Antifungal-resistant Mucorales in different indoor environments

scientific article published on 26 November 2018

Aspergillus PCR formidable challenges and progress

scientific article published on 27 February 2009

Aspergillus PCR: one step closer to standardization.

scientific article

Aspergillus fumigatus antigens activate innate immune cells via toll-like receptors 2 and 4.

scientific article published on May 2004

Automated RNA extraction by MagNA Pure followed by rapid quantification of cytokine and chemokine gene expression with use of fluorescence resonance energy transfer.

scientific article

Automated extraction of genomic DNA from medically important yeast species and filamentous fungi by using the MagNA Pure LC system

scientific article published on June 2002

CD56 Is a Pathogen Recognition Receptor on Human Natural Killer Cells.

scientific article published on 21 July 2017

Chronic Occupational Mold Exposure Drives Expansion of Aspergillus-Reactive Type 1 and Type 2 T-Helper Cell Responses

scientific article published in 2021

Clinical Performance of Aspergillus PCR for Testing Serum and Plasma: a Study by the European Aspergillus PCR Initiative.

scientific article

Clinical evaluation of a Mucorales-specific real-time PCR assay in tissue and serum samples

scientific article

Clinical experience with daptomycin in Europe: the first 2.5 years ⬇️

scientific article published on January 25, 2011

Combined real-time PCR and galactomannan surveillance improves diagnosis of invasive aspergillosis in high risk patients with haematological malignancies

scientific article published on 11 March 2013

Combining standard clinical methods with PCR showed improved diagnosis of invasive pulmonary aspergillosis in patients with hematological malignancies and prolonged neutropenia

scientific article published on July 2015

Comment on: T2Candida MR as a predictor of outcome in patients with suspected invasive candidiasis starting empirical antifungal treatment: a prospective pilot study

scientific article published on 01 February 2019

Comparative Analysis of Inflammatory Cytokine Release and Alveolar Epithelial Barrier Invasion in a Transwell® Bilayer Model of Mucormycosis

article

Comparison of Nonculture Blood-Based Tests for Diagnosing Invasive Aspergillosis in an Animal Model

scientific article published on 20 January 2016

Comparison of the pharmacokinetics, safety and tolerability of daptomycin in healthy adult volunteers following intravenous administration by 30 min infusion or 2 min injection

scientific article published on 22 April 2009

Critical stages of extracting DNA from Aspergillus fumigatus in whole-blood specimens

scientific article

Cross-protective TH1 immunity against Aspergillus fumigatus and Candida albicans

scientific article published on 25 March 2011

Detection of Fusarium Species in Clinical Specimens by Probe-Based Real-Time PCR

scientific article published on 12 November 2019

Determining the analytical specificity of PCR-based assays for the diagnosis of IA: What is Aspergillus?

scientific article published on 7 October 2016

Development and Evaluation of a Calibrator Material for Nucleic Acid-Based Assays for Diagnosing Aspergillosis ⬇️

scientific article published on April 24, 2013

Development and evaluation of a whole blood-based approach for flow cytometric quantification of CD154+ mould-reactive T cells

scientific article published on 01 February 2020

Development and evaluation of the nuclisens basic kit NASBA for the detection of RNA from Candida species frequently resistant to antifungal drugs

scientific article published on 01 March 2003

Diagnosis of aspergillosis by PCR: Clinical considerations and technical tips

scientific article published on 26 October 2017

Diminished phagocytosis-induced cell death (PICD) in neonatal monocytes upon infection with Escherichia coli

scientific article published on January 2008

Direct interaction studies between Aspergillus fumigatus and human immune cells; what have we learned about pathogenicity and host immunity? ⬇️

scientific article published on December 3, 2012

Effectiveness and safety of daptomycin in complicated skin and soft-tissue infections and bacteraemia in clinical practice: Results of a large non-interventional study ⬇️

scientific article published on February 24, 2013

Evaluation of Aspergillus PCR protocols for testing serum specimens

scientific article published on 21 September 2011

Fever-range temperature modulates activation and function of human dendritic cells stimulated with the pathogenic mould Aspergillus fumigatus

scientific article published on 8 April 2014

First Insights in NK-DC Cross-Talk and the Importance of Soluble Factors During Infection With

scholarly article by Esther Weiss et al published 2018 in Frontiers in cellular and infection microbiology

Functional Analysis Is a Paramount Prerequisite for Understanding the In Vitro Interaction of Human Natural Killer Cells With Aspergillus fumigatus ⬇️

scientific article published on January 25, 2012

Gene expression profiles of human dendritic cells interacting with Aspergillus fumigatus in a bilayer model of the alveolar epithelium/endothelium interface

scientific article

Genetic polymorphisms in the cytokine and chemokine system: their possible importance in allogeneic stem cell transplantation.

scientific article published on January 2010

Genetic susceptibility to Aspergillus fumigatus infections ⬇️

scientific article published on 08 May 2011

Genetic susceptibility to infections with Aspergillus fumigatus

scientific article published on May 2010

Genetic variants of folate and methionine metabolism and PCNSL incidence in a German patient population

scientific article published on 17 March 2010

Human Invariant Natural Killer T cells possess immune-modulating functions during Aspergillus infection

scientific article published on 18 October 2015

Human NK cells adapt their immune response towards increasing multiplicities of infection of Aspergillus fumigatus

scholarly article by Lothar Marischen et al published 18 December 2018 in BMC Immunology

Human NK cells display important antifungal activity against Aspergillus fumigatus, which is directly mediated by IFN-γ release

scientific article

Human and Murine Innate Immune Cell Populations Display Common and Distinct Response Patterns during Their In Vitro Interaction with the Pathogenic Mold Aspergillus fumigatus

scientific article published on 6 December 2017

Human dendritic cell subsets display distinct interactions with the pathogenic mould Aspergillus fumigatus.

scientific article published on 18 August 2014

Human primary myeloid dendritic cells interact with the opportunistic fungal pathogen Aspergillus fumigatus via the C-type lectin receptor Dectin-1.

scientific article

Immune responses of human immature dendritic cells can be modulated by the recombinant Aspergillus fumigatus antigen Aspf1.

scientific article published on 12 August 2009

Immunological Aspects ofCandidaandAspergillusSystemic Fungal Infections ⬇️

scientific article published on January 21, 2013

Immunomodulation as a Therapy for Aspergillus Infection: Current Status and Future Perspectives

scientific article published on 14 December 2018

Impact of immunosuppressive and antifungal drugs on PBMC- and whole blood-based flow cytometric CD154+Aspergillus fumigatus specific T-cell quantification

scientific article published on 31 March 2020

Impact of mycophenolic acid on the functionality of human polymorphonuclear neutrophils and dendritic cells during interaction with Aspergillus fumigatus

scientific article published on 21 April 2008

Infectious pulmonary complications after stem cell transplantation or chemotherapy: diagnostic yield of bronchoalveolar lavage.

scientific article

Interaction analyses of human monocytes co-cultured with different forms of Aspergillus fumigatus

scientific article published on 01 January 2009

Interlaboratory comparison of PCR-based identification of Candida and Aspergillus DNA in spiked blood samples

scientific article published on 16 January 2012

Molecular detection and identification of zygomycetes species from paraffin-embedded tissues in a murine model of disseminated zygomycosis: a collaborative European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Fungal Infection S

scientific article

Molecular methods in the diagnosis of infections in the immunocompromised host

scientific article published on 01 August 2000

Molecular techniques in the diagnosis of deep and systemic mycosis

scientific article

Multicenter comparison of serum and whole-blood specimens for detection of Aspergillus DNA in high-risk hematological patients.

scientific article published on 20 February 2013

Multiplex PCR Based Strategy for Detection of Fungal Pathogen DNA in Patients with Suspected Invasive Fungal Infections

scientific article published on 23 November 2020

Pathogen-specific DNA enrichment does not increase sensitivity of PCR for diagnosis of invasive aspergillosis in neutropenic patients

scientific article

Pathogenic fungi regulate immunity by inducing neutrophilic myeloid-derived suppressor cells

scientific article

Polymerase Chain Reaction Detection ofAspergillusDNA in Experimental Models of Invasive Aspergillosis

scientific article published on 01 April 2002

Polymerase chain reaction blood tests for the diagnosis of invasive aspergillosis in immunocompromised patients

scientific article

Polymerase chain reaction blood tests for the diagnosis of invasive aspergillosis in immunocompromised people

scientific article (publication date: October 2015)

Polymerase chain reaction blood tests for the diagnosis of invasive aspergillosis in immunocompromised people

scientific article

Polymerase chain reaction blood tests for the diagnosis of invasive aspergillosis in immunocompromised people

scientific article published on 03 September 2019

Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation

scientific article

Polymorphisms within the <i>TNFSF4</i> and <i>MAPKAPK2</i> Loci Influence the Risk of Developing Invasive Aspergillosis: A Two-Stage Case Control Study in the Context of the aspBIOmics Consortium

scientific article published on 23 December 2020

Polymorphonuclear neutrophils and granulocytic myeloid-derived suppressor cells inhibit natural killer cell activity toward Aspergillus fumigatus

scientific article published on 30 May 2015

Proinflammatory response of immature human dendritic cells is mediated by dectin-1 after exposure to Aspergillus fumigatus germ tubes.

scientific article

Prospective Biomarker Screening for Diagnosis of Invasive Aspergillosis in High-Risk Pediatric Patients.

scientific article published on 19 October 2016

Proteome Analysis Reveals the Conidial Surface Protein CcpA Essential for Virulence of the Pathogenic Fungus

article

Quantification of T-cell receptor excision circle DNA using fluorescence resonance energy transfer and the LightCycler system

scientific article published on 01 December 2002

Real-time PCR and quantitative culture for monitoring of experimental Aspergillus fumigatus intracranial infection in neutropenic mice

scientific article

Reconstituting NK Cells After Allogeneic Stem Cell Transplantation Show Impaired Response to the Fungal Pathogen Aspergillus fumigatus

scientific article published on 10 September 2020

Role of glycogen synthase kinase 3 (GSK-3) in innate immune response of human immature dendritic cells to Aspergillus fumigatus

scientific article

Sensitive detection of human cytomegalovirus peptide-specific cytotoxic T-lymphocyte responses by interferon-gamma-enzyme-linked immunospot assay and flow cytometry in healthy individuals and in patients after allogeneic stem cell transplantation

scientific article

Small interfering RNA targeting HIF-1α reduces hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitro ⬇️

scientific article published on March 25, 2011

Stimulating surface molecules, Th1-polarizing cytokines, proven trafficking--a new protocol for the generation of clinical-grade dendritic cells.

scientific article published on April 2013

TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell transplantation.

scientific article

The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model

scientific article

The Fungal PCR Initiative's evaluation of in-house and commercial Pneumocystis jirovecii qPCR assays: Toward a standard for a diagnostics assay

scientific article published on 23 November 2019

The temporal dynamics of differential gene expression in Aspergillus fumigatus interacting with human immature dendritic cells in vitro

scientific article

Toll-like receptor 3 has no critical role during early immune response of human monocyte-derived dendritic cells after infection with the human cytomegalovirus strain TB40E.

scientific article

Triacetylfusarinine C: A urine biomarker for diagnosis of invasive aspergillosis

scientific article published on 26 September 2018

Triple RNA-Seq Reveals Synergy in a Human Virus-Fungus Co-infection Model

scientific article published on 01 November 2020

Use of PCR for diagnosis of invasive aspergillosis: systematic review and meta-analysis

scientific article published on February 2009

Validation of a simplified in vitro Transwell® model of the alveolar surface to assess host immunity induced by different morphotypes of Aspergillus fumigatus

scientific article published on 03 September 2018

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