List of works by Grant McFadden

10 M-T7: measuring chemokine-modulating activity

scientific article

A cautionary note on the selectivity of oncolytic poxviruses

A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit host inflammatory and apoptotic responses to infection

scientific article

A randomized controlled, phase 2 trial of the viral serpin Serp-1 in patients with acute coronary syndromes undergoing percutaneous coronary intervention.

scientific article

A secreted high-affinity inhibitor of human TNF from Tanapox virus

scholarly article

ATPS-65AN ONCOLYTIC MYXOMA VIRUS CONSTRUCT (M011L KNOCK-OUT) INDUCES APOPTOSIS AND IS A POTENT PRO-APOPTOTIC THERAPY IN BOTH HUMAN AND IMMUNOCOMPETENT MURINE GLIOBLASTOMA CANCER STEM CELLS MODELS.

scientific article

Acute myeloid leukemia targeting by myxoma virus in vivo depends on cell binding but not permissiveness to infection in vitro

scientific article

Adipose-derived stem cells as therapeutic delivery vehicles of an oncolytic virus for glioblastoma

scientific article

Analysis of an orf virus chemokine-binding protein: Shifting ligand specificities among a family of poxvirus viroceptors

scientific article

Analysis of vaccinia virus-host protein-protein interactions: validations of yeast two-hybrid screenings

scientific article

Anti-immunology: evasion of the host immune system by bacterial and viral pathogens

scientific article

Are we there yet? The smallpox research agenda using variola virus

scientific article published in May 2014

BAFfled by poxviruses?

scientific article published on 01 May 2007

Bugs and drugs: oncolytic virotherapy in combination with chemotherapy

scientific article published on July 2012

Building bridges between plant and animal viruses

scientific article published on 22 October 2011

Cellular factors promoting resistance to effective treatment of glioma with oncolytic myxoma virus.

scientific article

Chemokine-binding viral protein M-T7 prevents chronic rejection in rat renal allografts

scientific article

Co-regulation of NF-kappaB and inflammasome-mediated inflammatory responses by myxoma virus pyrin domain-containing protein M013

scientific article

Coinfections of Novel Polyomavirus, Anelloviruses and a Recombinant Strain of Myxoma Virus-MYXV-Tol Identified in Iberian Hares

scientific article published on 20 March 2020

Comparative genetic analysis of genomic DNA sequences of two human isolates of Tanapox virus

scientific article published on 14 June 2007

Complete genomic sequence and comparative analysis of the tumorigenic poxvirus Yaba monkey tumor virus

scientific article

Construction and testing of a novel host-range defective myxoma virus vaccine with the M063 gene inactivated that is non-permissive for replication in rabbit cells

scientific article published on 9 September 2008

Cowpox virus expresses a novel ankyrin repeat NF-kappaB inhibitor that controls inflammatory cell influx into virus-infected tissues and is critical for virus pathogenesis.

scientific article published on July 2009

Current Status for High Titre Poxvirus Stock Preparation in CEF Under Serum-Free Medium Conditions: Implication for Vaccine Development

scientific article published on June 2005

Cytokine determinants of viral tropism.

scientific article published on 21 August 2009

Cytokine synergy: an underappreciated contributor to innate anti-viral immunity

scientific article

Disruption of Erk-dependent type I interferon induction breaks the myxoma virus species barrier

scientific article published on 24 October 2004

Editorial overview: Oncolytic viruses--replicating virus therapeutics for the treatment of cancer

scientific article

Evidence for differential viral oncolytic efficacy in an in vitro model of epithelial ovarian cancer metastasis

scientific article published on 23 September 2015

Evolution and divergence of the mammalian SAMD9/SAMD9L gene family

scientific article (publication date: 12 June 2013)

Evolution of viral sensing RIG-I-like receptor genes in Leporidae genera Oryctolagus, Sylvilagus, and Lepus

scientific article published on 13 November 2013

Ex vivo virotherapy with myxoma virus does not impair hematopoietic stem and progenitor cells

scientific article published on March 2016

Expression profiling of herpesvirus and vaccinia virus proteins using a high-throughput baculovirus screening system

scientific article published on November 2005

Ex Vivo Oncolytic Virotherapy with Myxoma Virus Arms Multiple Allogeneic Bone Marrow Transplant Leukocytes to Enhance Graft versus Tumor

scientific article published on 14 December 2016

Gene delivery of a viral anti-inflammatory protein to combat ocular inflammation

scientific article

Genetic Characterization of a Recombinant Myxoma Virus in the Iberian Hare (Lepus granatensis)

scientific article published on 07 June 2019

Gleevec casts a pox on poxviruses

scientific article published in July 2005

Heparin alters viral serpin, serp-1, anti-thrombolytic activity to anti-thrombotic activity.

scientific article published on 6 February 2008

Histological evaluation of intratumoral myxoma virus treatment in an immunocompetent mouse model of melanoma

scientific article

Human cancer cells have specifically lost the ability to induce the synergistic state caused by tumor necrosis factor plus interferon-beta

scientific article

Identification of a Novel Myxoma Virus C7-Like Host Range Factor That Enabled a Species Leap from Rabbits to Hares

scientific article published on 30 March 2022

Identification of host DEAD-box RNA helicases that regulate cellular tropism of oncolytic Myxoma virus in human cancer cells

scientific article published on 16 November 2017

Identification of host range mutants of myxoma virus with altered oncolytic potential in human glioma cells

scientific article published in December 2007

Identification of myxomaviral serpin reactive site loop sequences that regulate innate immune responses

scientific article

Immune responses to myxoma virus

scientific article

Immunopathogenesis of poxvirus infections: forecasting the impending storm

scientific article published on 16 January 2007

In vitro screen of a small molecule inhibitor drug library identifies multiple compounds that synergize with oncolytic myxoma virus against human brain tumor-initiating cells

scientific article published on 20 January 2015

Induction of alpha/beta interferon by myxoma virus is selectively abrogated when primary mouse embryo fibroblasts become immortalized

scientific article published on 18 March 2009

Induction of indefinite cardiac allograft survival correlates with toll-like receptor 2 and 4 downregulation after serine protease inhibitor-1 (Serp-1) treatment.

scientific article

Infection of human cancer cells with myxoma virus requires Akt activation via interaction with a viral ankyrin-repeat host range factor.

scholarly article

Inhibition of chemokine-glycosaminoglycan interactions in donor tissue reduces mouse allograft vasculopathy and transplant rejection

scientific article (publication date: 6 May 2010)

Inhibition of macrophage activation by the myxoma virus M141 protein (vCD200)

scientific article

Innate immune response of human plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain

scientific article

Innate immunity, tumor microenvironment and oncolytic virus therapy: friends or foes?

scientific article published on February 2008

Interaction analysis of viral cytokine-binding proteins using surface plasmon resonance

scientific article published on January 2004

Interaction of human TNF and beta2-microglobulin with Tanapox virus-encoded TNF inhibitor, TPV-2L.

scientific article

Interleukin-15 (IL-15) and IL-15 receptor alpha fusion protein enhances antitumor activity of myxoma virus

scientific article published on 7 November 2013

Interplay between poxviruses and the cellular ubiquitin/ubiquitin-like pathways

scientific article published on 25 January 2009

Intraventricular injection of myxoma virus results in transient expression of viral protein in mouse brain ependymal and subventricular cells.

scientific article published on 22 September 2010

Killing a killer: what next for smallpox?

scientific article

Leporipoxvirus Cu-Zn superoxide dismutase homologs inhibit cellular superoxide dismutase, but are not essential for virus replication or virulence

scientific article published on April 2002

M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A

scientific article

M011L-deficient oncolytic myxoma virus induces apoptosis in brain tumor-initiating cells and enhances survival in a novel immunocompetent mouse model of glioblastoma

scientific article published on 8 March 2016

M062 is a host range factor essential for myxoma virus pathogenesis and functions as an antagonist of host SAMD9 in human cells

scientific article

M135R is a novel cell surface virulence factor of myxoma virus

scientific article published on 25 October 2006

Modulation of NF-κB signalling by microbial pathogens

scientific article (publication date: April 2011)

Modulation of tumor necrosis factor by microbial pathogens

scientific article published in February 2006

Myxoma Virus-Encoded Host Range Protein M029: A Multifunctional Antagonist Targeting Multiple Host Antiviral and Innate Immune Pathways

scientific article published on 23 May 2020

Myxoma and vaccinia viruses bind differentially to human leukocytes

scientific article published on 6 February 2013

Myxoma and vaccinia viruses exploit different mechanisms to enter and infect human cancer cells.

scientific article published on 24 March 2010

Myxoma virus M013 protein antagonizes NF-κB and inflammasome pathways via distinct structural motifs

scientific article published on 02 April 2019

Myxoma virus M063R is a host range gene essential for virus replication in rabbit cells

scientific article published on 20 December 2006

Myxoma virus M064 is a novel member of the poxvirus C7L superfamily of host range factors that controls the kinetics of myxomatosis in European rabbits

scientific article

Myxoma virus M11L blocks apoptosis through inhibition of conformational activation of Bax at the mitochondria

scientific article published on February 2006

Myxoma virus M11L prevents apoptosis through constitutive interaction with Bak.

scientific article published on July 2004

Myxoma virus M128L is expressed as a cell surface CD47-like virulence factor that contributes to the downregulation of macrophage activation in vivo

scientific article

Myxoma virus M130R is a novel virulence factor required for lethal myxomatosis in rabbits

scientific article

Myxoma virus M141R expresses a viral CD200 (vOX-2) that is responsible for down-regulation of macrophage and T-cell activation in vivo

scientific article

Myxoma virus M156 is a specific inhibitor of rabbit PKR but contains a loss-of-function mutation in Australian virus isolates

scientific article published on 22 February 2016

Myxoma virus and oncolytic virotherapy: a new biologic weapon in the war against cancer

scientific article published on September 2007

Myxoma virus combined with rapamycin treatment enhances adoptive T cell therapy for murine melanoma brain tumors

scientific article published on 9 June 2011

Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity

scientific article

Myxoma virus expressing human interleukin-12 does not induce myxomatosis in European rabbits

scientific article

Myxoma virus expressing interleukin-15 fails to cause lethal myxomatosis in European rabbits.

scientific article

Myxoma virus in the European rabbit: interactions between the virus and its susceptible host

scientific article published on 13 February 2007

Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent pathway

scientific article

Myxoma virus infection of primary human fibroblasts varies with cellular age and is regulated by host interferon responses.

scientific article published on February 2005

Myxoma virus infection promotes NK lysis of malignant gliomas in vitro and in vivo.

scientific article

Myxoma virus is a novel oncolytic virus with significant antitumor activity against experimental human gliomas

scientific article

Myxoma virus is oncolytic for human pancreatic adenocarcinoma cells

scientific article

Myxoma virus lacking the pyrin-like protein M013 is sensed in human myeloid cells by both NLRP3 and multiple Toll-like receptors, which independently activate the inflammasome and NF-κB innate response pathways

scientific article published on 28 September 2011

Myxoma virus oncolysis of primary and metastatic B16F10 mouse tumors in vivo.

scientific article

Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replication

scientific article

Myxoma virus selectively disrupts type I interferon signaling in primary human fibroblasts by blocking the activation of the Janus kinase Tyk2.

scientific article published on 28 February 2009

Myxoma virus sensitizes cancer cells to gemcitabine and is an effective oncolytic virotherapeutic in models of disseminated pancreatic cancer

scientific article published on 10 January 2012

Myxoma virus suppresses proliferation of activated T lymphocytes yet permits oncolytic virus transfer to cancer cells

scientific article published on 22 April 2015

Myxoma virus virotherapy for glioma in immunocompetent animal models: optimizing administration routes and synergy with rapamycin

scientific article

Myxoma virus-mediated oncolysis of ascites-derived human ovarian cancer cells and spheroids is impacted by differential AKT activity

scientific article

Myxoma virus: propagation, purification, quantification, and storage

scientific article

Myxomaviral Anti-Inflammatory Serpin Reduces Myeloid-Derived Suppressor Cells and Human Pancreatic Cancer Cell Growth in Mice

scientific article

Myxomavirus-derived serpin prolongs survival and reduces inflammation and hemorrhage in an unrelated lethal mouse viral infection

scientific article published on 17 June 2013

Myxoma Virus dsRNA Binding Protein M029  Inhibits the Type I IFN-Induced Antiviral State in a  Highly Species-Specific Fashion

scientific article published on 02 February 2017

NFkB inhibitors: strategies from poxviruses

scientific article published on October 2009

Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps.

scientific article

On the road to systems biology of host-pathogen interactions

scientific article published in February 2010

Oncolytic Poxviruses

scientific article

Oncolytic Virus-Mediated RAS Targeting in Rhabdomyosarcoma

Oncolytic efficacy of recombinant vesicular stomatitis virus and myxoma virus in experimental models of rhabdoid tumors

scientific article

Oncolytic myxoma virus: the path to clinic

scientific article published on 29 May 2013

Oncolytic viral purging of leukemic hematopoietic stem and progenitor cells with Myxoma virus

scientific article

Oncolytic virotherapy for hematological malignancies

scientific article published on 29 October 2011

Oncolytic virotherapy for ovarian cancer

scientific article published on August 2012

Oncolytic virotherapy for pancreatic cancer

scientific article published on 18 May 2011

Oncolytic virotherapy synergism with signaling inhibitors: Rapamycin increases myxoma virus tropism for human tumor cells

scientific article published on 15 November 2006

Optimization of codon usage of poxvirus genes allows for improved transient expression in mammalian cells

scientific article published on August 2006

Pharmacological manipulation of the akt signaling pathway regulates myxoma virus replication and tropism in human cancer cells

scientific article published on 27 January 2010

Positive evolutionary selection on the RIG-I-like receptor genes in mammals

scientific article

Poxvirus cancer therapy

scientific article

Poxvirus host range genes

scientific article published on January 2008

Poxvirus immunomodulatory strategies: current perspectives

scientific article

Poxvirus proteomics and virus-host protein interactions

scientific article published on December 2009

Poxvirus tropism

scientific article (publication date: March 2005)

Poxvirus tumor necrosis factor receptor (TNFR)-like T2 proteins contain a conserved preligand assembly domain that inhibits cellular TNFR1-induced cell death.

scientific article published on September 2006

Poxviruses and apoptosis: a time to die.

scientific article

Poxviruses and immune evasion

scientific article

Poxviruses and the evolution of host range and virulence

scientific article (publication date: 2014)

Prevention of EBV lymphoma development by oncolytic myxoma virus in a murine xenograft model of post-transplant lymphoproliferative disease.

scientific article published on 2 April 2015

Prevention of chronic renal allograft rejection by SERP-1 protein

scientific article published on 01 March 2006

Production of Myxoma virus gateway entry and expression libraries and validation of viral protein expression

scientific article

Proteomic screening of variola virus reveals a unique NF-kappaB inhibitor that is highly conserved among pathogenic orthopoxviruses

scientific article

RIG-I mediates the co-induction of tumor necrosis factor and type I interferon elicited by myxoma virus in primary human macrophages

scientific article

Recombinant myxoma virus lacking all poxvirus ankyrin-repeat proteins stimulates multiple cellular anti-viral pathways and exhibits a severe decrease in virulence

scientific article published on 26 July 2014

Resistance to oncolytic myxoma virus therapy in nf1(-/-)/trp53(-/-) syngeneic mouse glioma models is independent of anti-viral type-I interferon.

scientific article

Role of the serine-threonine kinase PAK-1 in myxoma virus replication

scientific article

SAMD9 is an innate antiviral host factor with stress response properties that can be antagonized by poxviruses.

scientific article published on 26 November 2014

Secreted immunomodulatory viral proteins as novel biotherapeutics

scientific article

Selective purging of human multiple myeloma cells from autologous stem cell transplantation grafts using oncolytic myxoma virus

scientific article published on 16 April 2012

Serp-1, a viral anti-inflammatory serpin, regulates cellular serine proteinase and serpin responses to vascular injury

scientific article

Simultaneous Tumor and Stroma Targeting by Oncolytic Viruses

scientific article published on 05 November 2020

Smallpox: an ancient disease enters the modern era of virogenomics

scholarly article

Smallpox: anything to declare?

scientific article

Strategies that modulate inflammasomes: insights from host-pathogen interactions

scientific article published on 24 August 2007

Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2

scientific article

Suppression of collagen-induced arthritis with a serine proteinase inhibitor (serpin) derived from myxoma virus

scientific article published on 17 May 2014

Targeting gallbladder cancer: oncolytic virotherapy with myxoma virus is enhanced by rapamycin in vitro and further improved by hyaluronan in vivo

scientific article

Targeting human medulloblastoma: oncolytic virotherapy with myxoma virus is enhanced by rapamycin.

scientific article

Technical knockout: understanding poxvirus pathogenesis by selectively deleting viral immunomodulatory genes

scientific article published in August 2004

The 'supervirus'? Lessons from IL-4-expressing poxviruses.

scientific article

The Complete DNA Sequence of Myxoma Virus

scientific article (publication date: November 1999)

The PHD/LAP-domain protein M153R of myxomavirus is a ubiquitin ligase that induces the rapid internalization and lysosomal destruction of CD4

scientific article

The addition of tumor necrosis factor plus beta interferon induces a novel synergistic antiviral state against poxviruses in primary human fibroblasts ⬇️

scientific article published on 29 October 2008

The current status and future directions of myxoma virus, a master in immune evasion

scientific article published on 09 June 2011

The immunoregulatory properties of oncolytic myxoma virus and their implications in therapeutics.

scientific article published on 09 September 2010

The myxoma poxvirus protein, M11L, prevents apoptosis by direct interaction with the mitochondrial permeability transition pore.

scientific article

The myxoma virus m-t5 ankyrin repeat host range protein is a novel adaptor that coordinately links the cellular signaling pathways mediated by Akt and Skp1 in virus-infected cells

scientific article published on 23 September 2009

The poxvirus C7L host range factor superfamily

scientific article

The role of cell signaling in poxvirus tropism: the case of the M-T5 host range protein of myxoma virus

scientific article published on 14 August 2007

The serpin saga; development of a new class of virus derived anti-inflammatory protein immunotherapeutics

scientific article published on January 2009

The serpin solution; targeting thrombotic and thrombolytic serine proteases in inflammation

scientific article published on August 2013

The tanapoxvirus 15L protein is a virus-encoded neuregulin that promotes viral replication in human endothelial cells

scientific article published on 26 December 2012

The α2,3-sialyltransferase encoded by myxoma virus is a virulence factor that contributes to immunosuppression

scientific article (publication date: 2015)

Therapeutics for Graft-versus-Host Disease: From Conventional Therapies to Novel Virotherapeutic Strategies

scientific article

Treating brain tumor-initiating cells using a combination of myxoma virus and rapamycin

scientific article published on 12 April 2013

Tropism of Tanapox virus infection in primary human cells

scientific article published on 16 July 2007

Tumor necrosis factor and interferon: cytokines in harmony

scientific article published on July 2008

Tumor necrosis factor inhibitors from poxviruses with an emphasis on tanapoxvirus-2L protein

scientific article published on August 2011

Vaccinia virus dissemination requires p21-activated kinase 1.

scientific article published on 27 July 2016

Variation in ligand binding specificities of a novel class of poxvirus-encoded tumor necrosis factor-binding protein.

scientific article published on 16 June 2006

Viral TNF inhibitors as potential therapeutics

scientific article published on January 2009

Viral chemokine-binding proteins

scientific article

Viral chemokine-binding proteins inhibit inflammatory responses and aortic allograft transplant vasculopathy in rat models

scientific article published in June 2004

Viral serpin therapeutics from concept to clinic.

scientific article published on January 2011

Virotherapy using myxoma virus prevents lethal graft-versus-host disease following xeno-transplantation with primary human hematopoietic stem cells.

scientific article

Viruses for tumor therapy

scientific article

When good vaccines go wild: Feral Orthopoxvirus in developing countries and beyond

scientific article

White paper on microbial anti-cancer therapy and prevention

article

Yaba monkey tumor virus encodes a functional inhibitor of interleukin-18

scientific article

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