List of works by David T Scadden

A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia

scientific article published on 23 May 2019

A biomaterial-based vaccine eliciting durable tumour-specific responses against acute myeloid leukaemia

scientific article published on 14 January 2020

A hostel for the hostile: the bone marrow niche in hematologic neoplasms

scientific article

A microRNA regulating adult hematopoietic stem cells.

scientific article published on 28 September 2010

A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency

scientific article

A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy

scientific article published in June 2002

A point mutation in the signal peptide impairs the development of innate lymphoid cell subsets

scientific article published on 15 August 2018

A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood

scientific article published on January 2007

A randomized controlled trial of highly active antiretroviral therapy versus highly active antiretroviral therapy and chemotherapy in therapy-naive patients with HIV-associated Kaposi sarcoma in South Africa

scientific article

AIDS-related malignancies

scientific article published on 03 December 2001

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

scientific article

AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.

scientific article

Absence of biologically important Kaposi sarcoma-associated herpesvirus gene products and virus-specific cellular immune responses in multiple myeloma

scientific article published on July 2002

Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease

scientific article

Adult blood stem cell localization reflects the abundance of reported bone marrow niche cell types and their combinations

scientific article published on 07 August 2020

Adult stem cels and their niches

scientific article

Advances in the biology and therapy of chronic myeloid leukemia: proceedings from the 6th Post-ASH International Chronic Myeloid Leukemia and Myeloproliferative Neoplasms Workshop

scientific article published on 10 December 2012

Advancing stem cell biology toward stem cell therapeutics

scientific article published on February 2012

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers

scientific article published on 26 May 2020

Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells

scientific article published on 20 March 2017

An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation

scientific article published on 11 February 2019

Analysis of the hematopoietic stem cell niche

scientific article published on 01 November 2007

Anemia in HIV-infected adults: epidemiology, pathogenesis, and clinical management.

scientific article

Angiogenesis Inhibitor IM862 Is Ineffective Against AIDS-Kaposi's Sarcoma in a Phase III Trial, but Demonstrates Sustained, Potent Effect of Highly Active Antiretroviral Therapy: From the AIDS Malignancy Consortium and IM862 Study Team

article

Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells

scientific article published on August 2016

Antitumor activity of oral 9-cis-retinoic acid in HIV-associated Kaposi's sarcoma.

scientific article published on February 2002

BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression.

scientific article published on April 2013

BM mesenchymal stromal cell–derived exosomes facilitatemultiple myeloma progression

scientific article

Bayesian approach to single-cell differential expression analysis

scientific article

Biomimetic platforms for human stem cell research

scientific article

Blood and Bone.

scientific article

Blood loses it when nerves go bad

scientific article

Blood scent.

scientific article published in November 2013

Bone marrow drives central nervous system regeneration after radiation injury.

scientific article published on 4 December 2017

Bone marrow drives central nervous system regeneration after radiation injury.

scientific article

Bone marrow stem cells: current and emerging concepts

scientific article published on January 2015

Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease

scientific article

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia.

scientific article

Bone's dark side: mutated osteoblasts implicated in leukemia

scientific article published on 04 March 2014

C9orf72 suppresses systemic and neural inflammation induced by gut bacteria

scientific article published on 13 May 2020

CD133 expression defines a tumor initiating cell population in primary human ovarian cancer

scientific article published in December 2009

CXCR4 and CCR5 mediate homing of primitive bone marrow–derived hematopoietic cells to the postnatal thymus

Cancer stem cells refined

scientific article published on 01 July 2004

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

scientific article

Case records of the Massachusetts General Hospital. Case 30-2006. A 41-year-old man with dyspnea, fever, and lymphadenopathy.

scientific article published on September 2006

Cell Cycle Analysis of Hematopoietic Stem and Progenitor Cells by Multicolor Flow Cytometry

scientific article published on 18 October 2018

Cell cycle entry of hematopoietic stem and progenitor cells controlled by distinct cyclin-dependent kinase inhibitors

scientific article

Cell interactions in the bone marrow microenvironment affecting myeloid malignancies

scientific article published on 01 August 2020

Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis

scientific article

Cellular thrust and parry in the leukemic niche

scientific article published on 01 October 2014

Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms

scientific article

Correction: Tracking Single Cells in Live Animals Using a Photoconvertible Near-Infrared Cell Membrane Label

scientific article published on 13 November 2013

Corrigendum: Distinct bone marrow blood vessels differentially regulate haematopoiesis

scientific article published on 20 July 2016

Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification ⬇️

scientific article

D-cyclins repress apoptosis in hematopoietic cells by controlling death receptor Fas and its ligand FasL.

scientific article published on 31 July 2014

Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

scientific article published on February 2008

Deconstructing the complexity of a microenvironmental niche

scientific article published on March 2012

Deep diving in the blood stem cell-ome

scientific article published on 4 September 2014

Defective immune function of primary effusion lymphoma cells is associated with distinct KSHV gene expression profiles.

scientific article published in June 2004

Defining the hematopoietic stem cell niche

scientific article published on 01 April 2004

Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia

scientific article

Diabetes impairs hematopoietic stem cell mobilization by altering niche function

scientific article

Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy

scientific article published on March 2006

Differential H3K4 methylation identifies developmentally poised hematopoietic genes

scientific article

Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels

scientific article

Differential niche and Wnt requirements during acute myeloid leukemia progression

scientific article

Differential regulation of myeloid leukemias by the bone marrow microenvironment

scientific article published on 27 October 2013

Differential stem- and progenitor-cell trafficking by prostaglandin E2.

scientific article published on 13 March 2013

Differential targeting and shifts in the immunodominance of Epstein-Barr virus--specific CD8 and CD4 T cell responses during acute and persistent infection

scientific article

Differentiation and characterization of T cells

scientific article published on 01 November 2005

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

scientific article published on 25 January 2004

Direct measurement of local oxygen concentration in the bone marrow of live animals

scientific article published on 02 March 2014

Direct vascular delivery of primitive hematopoietic cells to bone marrow improves localization but not engraftment

scientific article published on 01 June 2004

Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia

Distinct bone marrow blood vessels differentially regulate haematopoiesis.

scientific article published on 13 April 2016

Distinctive Mesenchymal-Parenchymal Cell Pairings Govern B Cell Differentiation in the Bone Marrow

scientific article published on 20 July 2016

Divided within: heterogeneity within adult stem cell pools.

scientific article published in December 2008

Dose-reduced busulfan, cyclophosphamide, and autologous stem cell transplantation for human immunodeficiency virus-associated lymphoma: AIDS Malignancy Consortium study 020.

scientific article published in January 2008

E 7 (CD103) Expression Identifies a Highly Active, Tonsil-Resident Effector-Memory CTL Population

scientific article published on 01 October 2005

Effective Multi-lineage Engraftment in a Mouse Model of Fanconi Anemia Using Non-genotoxic Antibody-Based Conditioning

scientific article published on 08 February 2020

Efficacy and safety of anti-CD45-Saporin as conditioning agent for RAG deficiency

scientific article published on 05 May 2020

Embryonic stem cells make human T cells

scholarly article

Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration.

scientific article published on March 2012

Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy

scientific article published on 29 February 2016

Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo.

scientific article

Engineering pulmonary vasculature in decellularized rat and human lungs.

scientific article published on 14 September 2015

Ephrin receptor, EphB4, regulates ES cell differentiation of primitive mammalian hemangioblasts, blood, cardiomyocytes, and blood vessels

scientific article published on 4 September 2003

Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells

scientific article

Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells.

scientific article

Erratum: Corrigendum: Therapeutic targeting of a stem cell niche

scholarly article by Gregor B Adams et al published February 2008 in Nature Biotechnology

Erratum: Corrigendum: Therapeutic targeting of a stem cell niche

scholarly article by Gregor B Adams et al published August 2007 in Nature Biotechnology

Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors

scientific article published on 8 December 2005

Evolving concepts on the microenvironmental niche for hematopoietic stem cells

scientific article published on July 2008

Ex vivo targeting of p21Cip1/Waf1 permits relative expansion of human hematopoietic stem cells ⬇️

scientific article published on April 17, 2003

Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells

scientific article published on 07 November 2019

Fate through fat: lipid metabolism determines stem cell division outcome

scientific article published on October 2012

Flow electroporation with pulsed electric fields for purging tumor cells

scientific article published on 01 January 2008

Flowing cells through pulsed electric fields efficiently purges stem cell preparations of contaminating myeloma cells while preserving stem cell function

scientific article published on 03 August 2004

Forward RNAi screens in primary human hematopoietic stem/progenitor cells

scientific article

From quiescence to senescence

scientific article

Functional analyses of the cancer stem cell-like properties of human endometrial tumor initiating cells.

scientific article published on 24 October 2007

GATA-2 regulates granulocyte-macrophage progenitor cell function

scientific article published on 7 October 2008

Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells.

scientific article

Generic antiretroviral efficacy in AIDS-associated Kaposi's sarcoma in sub-Saharan Africa

scientific article

Genome-wide map of nuclear protein degradation shows NCoR1 turnover as a key to mitochondrial gene regulation

scientific journal article

Global transcriptome analysis of T-competent progenitors in the bone marrow

scientific article published on 5 June 2015

Glucocorticoids Regulate Bone Marrow B Lymphopoiesis After Stroke

scientific article published on 01 April 2019

Good, bad and reformable

scientific article published in Nature

Growing old in the age of heterogeneity: the perils of shifting clonality

scientific article published on 01 July 2019

Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells

scientific article

HOXB4-induced self-renewal of hematopoietic stem cells is significantly enhanced by p21 deficiency

scientific article

Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow

scientific article

Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis

scientific journal article

Harnessing the apoptotic programs in cancer stem-like cells

scientific article (publication date: September 2015)

Hematopoiesis: Reconciling Historic Controversies about the Niche

scientific article published in May 2017

Hematopoietic Stem Cell Niche in Health and Disease

scientific article published on May 2016

Hematopoietic stem cell responsiveness to exogenous signals is limited by caspase-3.

scientific article

Heterogeneity of the bone marrow niche.

scientific article published on 12 May 2016

Heterologous cells cooperate to augment stem cell migration, homing, and engraftment.

scientific article published on 22 August 2002

Homing of hematopoietic cells to the bone marrow

scientific article published on 18 March 2009

Human HTm4 is a hematopoietic cell cycle regulator

scientific article

Identification of Functionally Distinct Mx1+αSMA+ Periosteal Skeletal Stem Cells

scientific article published on 01 December 2019

Immune reconstitution in HIV infection and its relationship to cancer

scientific article

Impact of Kaposi Sarcoma–Associated Herpesvirus (KSHV) Burden and HIV Coinfection on the Detection of T Cell Responses to KSHV ORF73 and ORF65 Proteins

article

In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling

scientific article published on 13 June 2013

In vivo and in vitro effects of a novel anti-Dkk1 neutralizing antibody in multiple myeloma.

scientific article published on 17 January 2013

In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies

scientific article published in 2022

In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche.

scientific article published on 08 June 2011

In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

scientific article

In vivo imaging of transplanted hematopoietic stem and progenitor cells in mouse calvarium bone marrow

scientific article published on 9 December 2010

In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C.

scientific article

Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance

scientific article published on 30 July 2020

Influenza, but not HIV-specific CTL epitopes, elicits delayed-type hypersensitivity (DTH) reactions in HIV-infected patients

article

Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning

scientific article

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.

scientific article

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation

scientific article

Interview with David Scadden. Interview by Joseph Glorioso and Jenny Jacoby

scientific article

Ischemic stroke activates hematopoietic bone marrow stem cells

scientific article

Isolation and transplantation of hematopoietic stem cells (HSCs)

scientific article published on 25 February 2007

Kaposi's sarcoma-associated herpesvirus-specific immune reconstitution and antiviral effect of combined HAART/chemotherapy in HIV clade C-infected individuals with Kaposi's sarcoma

scientific article

Kinetic expression of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) during embryonic stem cell differentiation

scientific article

Lack of antitumor activity and intolerance of interleukin-4 in patients with advanced HIV disease and Kaposi's sarcoma

scientific article published on November 2002

Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress

scientific article published on 01 September 2020

Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment

scientific article published on 26 October 2016

Limiting factors in murine hematopoietic stem cell assays.

scientific article published on September 2007

Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress

scientific article published on 18 April 2019

Lineage-negative side-population (SP) cells with restricted hematopoietic capacity circulate in normal human adult blood: immunophenotypic and functional characterization

scientific article published in January 2002

Lipid availability determines fate of skeletal progenitor cells via SOX9

scientific article published on 26 February 2020

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche

scientific article

Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes

scientific article published on 28 February 2007

Matrix metalloproteinase inhibitor COL-3 in the treatment of AIDS-related Kaposi's sarcoma: a phase I AIDS malignancy consortium study

scientific article published in January 2002

Mesenchymal cell contributions to the stem cell niche

scientific article

Metcalf Lecture Award: Applying niche biology to engineer T-cell regenerative therapies

scientific article published on 23 November 2019

MicroRNA miR-125a controls hematopoietic stem cell number

scientific article

MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors

scientific article

Modeling human hematopoietic stem cell biology in the mouse

scientific article published on April 2013

Modulating Bone Marrow Hematopoietic Lineage Potential to Prevent Bone Metastasis in Breast Cancer

scientific article published on 31 July 2018

Multicenter trial of low-dose paclitaxel in patients with advanced AIDS-related Kaposi sarcoma.

scientific article

Multiple measures of HIV burden in blood and tissue are correlated with each other but not with clinical parameters in aviremic subjects

scientific article published in January 2003

Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias

scientific article published on 25 February 2008

Myeloid Expression of Cytochrome P450 4F3 Is Determined by a Lineage-specific Alternative Promoter ⬇️

scientific article published on April 22, 2003

Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling

scientific article published on 16 November 2012

Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells

scientific article published on May 2015

NF-Y is necessary for hematopoietic stem cell proliferation and survival

scientific article published on 9 November 2011

Nervous activity in a stem cell niche

scientific article

Nf2/merlin regulates hematopoietic stem cell behavior by altering microenvironmental architecture

scientific article

Nice neighborhood: emerging concepts of the stem cell niche

scientific article

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.

scientific article published on 4 February 2015

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

scientific article

Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin.

scientific article published on 06 June 2016

Not All Created Equal: Lineage Hard-Wiring in the Production of Blood

scientific article published on December 2015

Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention

scientific article published on 13 May 2015

Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome

scientific article published on April 2002

Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood

scientific article

Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways

scholarly article

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils

scientific article published in December 2017

Osteoclasts eat stem cells out of house and home

scientific article published on 01 June 2006

Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size

scientific article

P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells

scientific article

PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.

scientific article published on September 2016

Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice

scientific article

Plasmablastic lymphoma in HIV-positive patients: an aggressive Epstein-Barr virus-associated extramedullary plasmacytic neoplasm

scientific article

Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1.

scientific article published in October 2017

Primitive hematopoietic cells resist HIV-1 infection via p21

scientific article

Programmable microencapsulation for enhanced mesenchymal stem cell persistence and immunomodulation

scientific article published on 16 July 2019

Progression signature underlies clonal evolution and dissemination of multiple myeloma

scientific article published on 04 November 2020

Prospects for stem cell-based therapy

scientific article published in February 2008

Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation

scientific article published on 30 August 2013

Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators

scientific article

Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics

scientific article published on 14 March 2019

Purinergic P2Y₁₄ receptor modulates stress-induced hematopoietic stem/progenitor cell senescence

scientific article

Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo

scientific article published on 08 May 2005

Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell

scientific article

Receptor tyrosine kinase, EphB4 (HTK), accelerates differentiation of select human hematopoietic cells

scientific article published on April 2002

Regenerative response in ischemic brain restricted by p21cip1/waf1

scientific article

Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells

scientific article

Rethinking stroma: lessons from the blood

scientific article (publication date: 14 June 2012)

Rituximab does not improve clinical outcome in a randomized phase 3 trial of CHOP with or without rituximab in patients with HIV-associated non-Hodgkin lymphoma: AIDS-Malignancies Consortium Trial 010.

scientific article published on 24 May 2005

Role of the osteoblast lineage in the bone marrow hematopoietic niches

scientific article published on May 2009

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin.

scientific article published on 30 January 2013

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin.

scientific article published on 5 March 2013

SIRT3 reverses aging-associated degeneration

scientific article published on 31 January 2013

Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation

scientific article published in Nature Communications

Sequential in vivo imaging of osteogenic stem/progenitor cells during fracture repair.

scientific article

Sex steroid blockade enhances thymopoiesis by modulating Notch signaling

scientific article

Shipping mouse bone marrow: Keep it in the bone

scientific article published on 30 December 2016

Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1(STEM) Mouse

scientific article

SnapShot: The hematopoietic stem cell niche

scientific article published on 01 July 2014

Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia

scientific article

Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow.

scientific article published on 27 April 2015

Stem Cell Transplant Approaches for Patients With Blood Cancers

scientific article published on 01 March 2019

Stem Cell-Based Medicine

scientific article

Stem Cells Remember Their Grade

scientific article published on 01 August 2007

Stem Cells and DNA Damage: Persist or Perish? ⬇️

scientific article published on 01 August 2010

Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor

scientific article

Stem cells and immune reconstitution in AIDS ⬇️

scientific article published on December 1, 2003

Stem cells traffic in time

scientific article published on 01 March 2008

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

scientific article published in Nature

Stem-cell ecology and stem cells in motion

scientific article published on April 2008

Stress hematopoiesis is regulated by the Krüppel-like transcription factor ZBP-89.

scientific article

Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping

scientific article published on 03 July 2019

Stromal cell-derived factor-1/CXCR4 signaling modifies the capillary-like organization of human embryonic stem cell-derived endothelium in vitro

scientific article published on 12 October 2006

Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients

scientific article published in November 2005

Targeting the Warburg effect for leukemia therapy: Magnitude matters

scientific article published on 6 May 2015

The HSC niche concept has turned 31. Has our knowledge matured?

scientific article published on March 2010

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

scientific article

The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model

article

The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow.

scientific article

The bone marrow at the crossroads of blood and immunity

scientific article

The bone marrow niche for haematopoietic stem cells

scientific article published in January 2014

The cell cycle associated protein, HTm4, is expressed in differentiating cells of the hematopoietic and central nervous system in mice

scientific journal article

The contribution of cytotoxic and noncytotoxic function by donor T-cells that support engraftment after allogeneic bone marrow transplantation.

scientific article

The haematopoietic stem cell niche at a glance.

scientific article published on November 2011

The hematopoietic stem cell in its place

scientific article

The hematopoietic stem cell niche

scientific article published on 9 July 2010

The hematopoietic stem cell niche--home for friend and foe?

scientific article published on 26 December 2012

The hematopoietic stem cell niche.

scientific article

The leukemic stem cell niche: current concepts and therapeutic opportunities

scientific article published on 28 April 2009

The level of MEF but not ELF-1 correlates with FAB subtype of acute myeloid leukemia and is low in good prognosis cases

scientific article published on 01 May 2003

The malignant side of successful transplantation

scientific article published on 01 February 2004

The metabolic regulator mTORC1 controls terminal myeloid differentiation.

scientific article published in May 2017

The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies

scientific article published on 02 April 2019

The protease inhibitor ritonavir inhibits the functional activity of the multidrug resistance related-protein 1 (MRP-1).

scientific article published in September 2002

The secrets of the bone marrow niche: Metabolic priming for AML.

scientific article

The stem cell niche in health and leukemic disease

scientific article published on March 2007

The stem cell niche: tissue physiology at a single cell level

scientific article

The stem-cell niche as an entity of action

scientific article

The weight of cell identity

scientific article published on December 2007

Therapeutic targeting of a stem cell niche

scientific article published on 21 January 2007

Thymocyte emigration is mediated by active movement away from stroma-derived factors

scientific article

Tic-TACs: refreshing hair growth

scientific article published on May 2014

Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway

scientific article published on February 2016

Toward cellular-based therapies for HIV infection

scientific article

Tracking single cells in live animals using a photoconvertible near-infrared cell membrane label ⬇️

scientific article

Transcriptome comparison of distinct osteolineage subsets in the hematopoietic stem cell niche using a triple fluorescent transgenic mouse model

scientific article published on 5 June 2015

Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors

scientific article published on 25 September 2014

Tumor necrosis factor-alpha and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation

scientific article

Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes

scientific article published in September 2006

VEGF-C Protects the Integrity of Bone Marrow Perivascular Niche

scientific article published on 25 August 2020

VEGFR2+PDGFRbeta+ circulating precursor cells participate in capillary restoration after hyperoxia acute lung injury (HALI).

scientific article published on 6 May 2009

Vitamin D receptor deletion leads to increased hematopoietic stem and progenitor cells residing in the spleen ⬇️

scientific article published on July 27, 2010

Will stem cells finally deliver?

scientific article published on 01 December 2008

Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo.

scientific article

Written in bone: young bone makes young blood.

scientific article published on 13 March 2017

Xist RNA is a potent suppressor of hematologic cancer in mice

scientific article published on February 2013

ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells.

scientific article

deficiency-induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm

dropEst: pipeline for accurate estimation of molecular counts in droplet-based single-cell RNA-seq experiments.

scientific article published on 19 June 2018

mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis

scientific article published on September 2012

p27Kip1 constrains proliferation of neural progenitor cells in adult brain under homeostatic and ischemic conditions.

scientific article published on April 2009

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