List of works - James E Bear

A Reaction-Diffusion Model Explains Amplification of the PLC/PKC Pathway in Fibroblast Chemotaxis

scientific article published in July 2017

A circle RNA regulatory axis promotes lung squamous metastasis via CDR1-mediated regulation of Golgi trafficking

scientific article published on 25 September 2020

Abstract 437: Mena at the nexus of chemotaxis and haptotaxis during tumor progression

article by Madeleine J. Oudin et al published 1 August 2015 in Cancer Research

Abstract C14: Loss of haptotaxis facilitates invasion in LKB1-deficient melanoma

article by Keefe T. Chan et al published 1 February 2013 in Cancer Research

Altered T-cell entry and egress in the absence of Coronin 1A attenuates murine acute graft versus host disease

scientific article

An optogenetic switch for the Set2 methyltransferase provides evidence for transcription-dependent and -independent dynamics of H3K36 methylation

scientific article published on 05 October 2020

Arp2/3 Complex Is Required for Macrophage Integrin Functions but Is Dispensable for FcR Phagocytosis and In Vivo Motility

scientific article published on 29 August 2017

Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis

scientific article

Automated analysis of invadopodia dynamics in live cells.

scientific article published on July 2014

CD200 is induced by ERK and is a potential therapeutic target in melanoma

scientific article

Cells lay their own tracks - optogenetic Cdc42 activation stimulates fibronectin deposition supporting directed migration

scientific article published on 28 July 2017

Competition and collaboration between different actin assembly pathways allows for homeostatic control of the actin cytoskeleton

scientific article published on 2 October 2015

Contribution of Ena/VASP proteins to intracellular motility of listeria requires phosphorylation and proline-rich core but not F-actin binding or multimerization

scientific article

Control of Protein Activity and Cell Fate Specification via Light-Mediated Nuclear Translocation

scientific article (publication date: 2015)

Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia

scientific article

Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin

scientific article

Coronin 1C inhibits melanoma metastasis through regulation of MT1-MMP-containing extracellular vesicle secretion

scientific article published on 20 July 2020

Correlating in Vitro and in Vivo Activities of Light-Inducible Dimers: A Cellular Optogenetics Guide

scientific article published on 16 October 2015

Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration

scientific article

Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice

scientific article published on 01 August 2017

Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet

scientific article published on 05 July 2014

Emergent spatiotemporal dynamics of the actomyosin network in the presence of chemical gradients

scientific article published on 01 June 2019

Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins

scientific article

Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction

scientific article published on 19 January 2018

Evading immune cell uptake and clearance requires PEG grafting at densities substantially exceeding the minimum for brush conformation.

scientific article

F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling

scientific article

GMFβ controls branched actin content and lamellipodial retraction in fibroblasts.

scientific article

IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma

scientific article published on May 2015

Intravital imaging of a spheroid-based orthotopic model of melanoma in the mouse ear skin

scientific article

Intravital imaging of donor allogeneic effector and regulatory T cells with host dendritic cells during GVHD.

scientific article

LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues.

scientific article

LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma

scientific article published on June 2012

Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma

scientific article published on February 2007

Lack of myeloid Fatp1 increases atherosclerotic lesion size in Ldlr-/- mice

scientific article published on 7 October 2017

Lamellipodia are crucial for haptotactic sensing and response

scientific article published on 12 May 2016

Light-induced nuclear export reveals rapid dynamics of epigenetic modifications

scientific article published on 18 April 2016

Loss of Arp2/3 induces an NF-κB-dependent, nonautonomous effect on chemotactic signaling

scientific article

Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing

scientific article published on 07 April 2020

Megakaryocytes use in vivo podosome-like structures working collectively to penetrate the endothelial barrier of bone marrow sinusoids

scientific article published on 23 July 2020

MenaINV mediates synergistic cross-talk between signaling pathways driving chemotaxis and haptotaxis.

scientific article published on 24 August 2016

Mesenchymal chemotaxis requires selective inactivation of myosin II at the leading edge via a noncanonical PLCγ/PKCα pathway

scientific article

Metastasis in an orthotopic murine model of melanoma is independent of RAS/RAF mutation

scientific article

Myeloid -Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1

scientific article published on 18 January 2019

Nanoparticle clearance is governed by Th1/Th2 immunity and strain background

scientific article

New Mechanisms of Resistance to MEK Inhibitors in Melanoma Revealed by Intravital Imaging

scientific article published on 27 November 2017

New insights into the regulation and cellular functions of the ARP2/3 complex

scientific article published on 05 December 2012

PEGylated PRINT Nanoparticles: The Impact of PEG Density on Protein Binding, Macrophage Association, Biodistribution, and Pharmacokinetics ⬇️

scientific article published on September 5, 2012

Peering deeply inside the branch

scientific article

Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility

scientific article

Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation

scientific article

Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways

scientific article

Quantitative analysis of B-lymphocyte migration directed by CXCL13

scientific article published on August 2016

Self-sorting of nonmuscle myosins IIA and IIB polarizes the cytoskeleton and modulates cell motility.

scientific article published on 12 July 2017

Subtumoral analysis of PRINT nanoparticle distribution reveals targeting variation based on cellular and particle properties

scientific article

The Ena/VASP enigma

scientific article

The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency

scientific article

Tropomyosin Promotes Lamellipodial Persistence by Collaborating with Arp2/3 at the Leading Edge

scientific article published on 20 April 2016

Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression

scientific article published on 25 January 2016

Tumor Presence Induces Global Immune Changes and Enhances Nanoparticle Clearance

scientific article published on 23 November 2015

Tuning the Binding Affinities and Reversion Kinetics of a Light Inducible Dimer Allows Control of Transmembrane Protein Localization

scientific article published on 16 August 2016

Unraveling the enigma: progress towards understanding the coronin family of actin regulators.

scientific article published on June 2011

Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles

scientific article

β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion.

scientific article

List of works by James E Bear

A Reaction-Diffusion Model Explains Amplification of the PLC/PKC Pathway in Fibroblast Chemotaxis

A circle RNA regulatory axis promotes lung squamous metastasis via CDR1-mediated regulation of Golgi trafficking

Abstract 437: Mena at the nexus of chemotaxis and haptotaxis during tumor progression

Abstract C14: Loss of haptotaxis facilitates invasion in LKB1-deficient melanoma

Altered T-cell entry and egress in the absence of Coronin 1A attenuates murine acute graft versus host disease

An optogenetic switch for the Set2 methyltransferase provides evidence for transcription-dependent and -independent dynamics of H3K36 methylation

Arp2/3 Complex Is Required for Macrophage Integrin Functions but Is Dispensable for FcR Phagocytosis and In Vivo Motility

Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis

Automated analysis of invadopodia dynamics in live cells.

CD200 is induced by ERK and is a potential therapeutic target in melanoma

Cells lay their own tracks - optogenetic Cdc42 activation stimulates fibronectin deposition supporting directed migration

Competition and collaboration between different actin assembly pathways allows for homeostatic control of the actin cytoskeleton

Contribution of Ena/VASP proteins to intracellular motility of listeria requires phosphorylation and proline-rich core but not F-actin binding or multimerization

Control of Protein Activity and Cell Fate Specification via Light-Mediated Nuclear Translocation

Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia

Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin

Coronin 1C inhibits melanoma metastasis through regulation of MT1-MMP-containing extracellular vesicle secretion

Correlating in Vitro and in Vivo Activities of Light-Inducible Dimers: A Cellular Optogenetics Guide

Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration

Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice

Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet

Emergent spatiotemporal dynamics of the actomyosin network in the presence of chemical gradients

Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins

Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction

Evading immune cell uptake and clearance requires PEG grafting at densities substantially exceeding the minimum for brush conformation.

F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling

GMFβ controls branched actin content and lamellipodial retraction in fibroblasts.

IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma

Intravital imaging of a spheroid-based orthotopic model of melanoma in the mouse ear skin

Intravital imaging of donor allogeneic effector and regulatory T cells with host dendritic cells during GVHD.

LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues.

LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma

Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma

Lack of myeloid Fatp1 increases atherosclerotic lesion size in Ldlr-/- mice

Lamellipodia are crucial for haptotactic sensing and response

Light-induced nuclear export reveals rapid dynamics of epigenetic modifications

Loss of Arp2/3 induces an NF-κB-dependent, nonautonomous effect on chemotactic signaling

Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing

Megakaryocytes use in vivo podosome-like structures working collectively to penetrate the endothelial barrier of bone marrow sinusoids

MenaINV mediates synergistic cross-talk between signaling pathways driving chemotaxis and haptotaxis.

Mesenchymal chemotaxis requires selective inactivation of myosin II at the leading edge via a noncanonical PLCγ/PKCα pathway

Metastasis in an orthotopic murine model of melanoma is independent of RAS/RAF mutation

Myeloid -Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1

Nanoparticle clearance is governed by Th1/Th2 immunity and strain background

New Mechanisms of Resistance to MEK Inhibitors in Melanoma Revealed by Intravital Imaging

New insights into the regulation and cellular functions of the ARP2/3 complex

PEGylated PRINT Nanoparticles: The Impact of PEG Density on Protein Binding, Macrophage Association, Biodistribution, and Pharmacokinetics ⬇️

Peering deeply inside the branch

Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility

Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation

Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways

Quantitative analysis of B-lymphocyte migration directed by CXCL13

Self-sorting of nonmuscle myosins IIA and IIB polarizes the cytoskeleton and modulates cell motility.

Subtumoral analysis of PRINT nanoparticle distribution reveals targeting variation based on cellular and particle properties

The Ena/VASP enigma

The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency

Tropomyosin Promotes Lamellipodial Persistence by Collaborating with Arp2/3 at the Leading Edge

Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression

Tumor Presence Induces Global Immune Changes and Enhances Nanoparticle Clearance

Tuning the Binding Affinities and Reversion Kinetics of a Light Inducible Dimer Allows Control of Transmembrane Protein Localization

Unraveling the enigma: progress towards understanding the coronin family of actin regulators.

Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles

β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion.