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List of works by James J Hickman

A defined long-term in vitro tissue engineered model of neuromuscular junctions

scientific article

A defined system to allow skeletal muscle differentiation and subsequent integration with silicon microstructures

scientific article

A functional hiPSC-cortical neuron differentiation and maturation model and its application to neurological disorders

scientific article

A functional long-term 2D serum-free human hepatic in vitro system for drug evaluation

scientific article published on 23 August 2020

A human in vitro platform for the evaluation of pharmacology strategies in cardiac ischemia

scientific article published on 13 August 2019

A human induced pluripotent stem cell-derived cortical neuron human-on-a chip system to study Aβ42 and tau-induced pathophysiological effects on long-term potentiation

scientific article published on 27 May 2020

A multiplexed in vitro assay system for evaluating human skeletal muscle functionality in response to drug treatment

scientific article published on 13 December 2019

A new target for amyloid beta toxicity validated by standard and high-throughput electrophysiology

scientific article

A phenotypic culture system for the molecular analysis of CNS myelination in the spinal cord

scientific article

A phenotypic in vitro model for the main determinants of human whole heart function.

scientific article published on 14 May 2015

ALS mutations in both human skeletal muscle and motoneurons differentially affects neuromuscular junction integrity and function

scientific article published in 2022

Addition of glutamate to serum-free culture promotes recovery of electrical activity in adult hippocampal neurons in vitro

scientific article

Adrenergic deficiency leads to impaired electrical conduction and increased arrhythmic potential in the embryonic mouse heart

scientific article published on 7 June 2012

Adult rat spinal cord culture on an organosilane surface in a novel serum-free medium

scientific article published in November 2005

Altered calcium dynamics in cardiac cells grown on silane-modified surfaces

scientific article published on 13 October 2009

Analysis of toxin-induced changes in action potential shape for drug development

scientific article published on December 2009

Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

scientific article

Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons.

scientific article published on 27 July 2018

Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons

scientific article published on 12 January 2007

Body-on-a-chip systems for animal-free toxicity testing

scientific article

Characterization of Functional Human Skeletal Myotubes and Neuromuscular Junction Derived-From the Same Induced Pluripotent Stem Cell Source

scientific article published on 22 October 2020

Characterization of a human fetal spinal cord stem cell line, NSI-566RSC, and its induction to functional motoneurons

scientific article

Coexpression of glutamate vesicular transporter (VGLUT1) and choline acetyltransferase (ChAT) proteins in fetal rat hippocampal neurons in culture

scientific article published on 15 July 2010

Comparison of NMDA and AMPA Channel Expression and Function between Embryonic and Adult Neurons Utilizing Microelectrode Array Systems

scientific article published on 13 November 2017

Construction of high-density bacterial colony arrays and patterns by the ink-jet method

scientific article published in January 2004

Derivation of sensory neurons and neural crest stem cells from human neural progenitor hNP1

scientific article published on 15 March 2013

Developing a novel serum-free cell culture model of skeletal muscle differentiation by systematically studying the role of different growth factors in myotube formation

scientific article published on 09 May 2009

Differential Monocyte Actuation in a Three-Organ Functional Innate Immune System-on-a-Chip

scientific article published on 02 June 2020

Differentiation of Intrafusal Fibers from Human Induced Pluripotent Stem Cells

scientific article published on 19 March 2020

Differentiation of skeletal muscle and integration of myotubes with silicon microstructures using serum-free medium and a synthetic silane substrate

scientific article published in January 2007

Direct patterning of coplanar polyethylene glycol alkylsilane monolayers by deep-ultraviolet photolithography as a general method for high fidelity, long-term cell patterning and culture ⬇️

scientific article published on March 10, 2011

Electrophysiological and immunocytochemical characterization of DRG neurons on an organosilane surface in serum-free medium

scientific article published on 14 May 2008

Electrophysiological and morphological characterization of rat embryonic motoneurons in a defined system

scientific article

Electrophysiological characterization of embryonic hippocampal neurons cultured in a 3D collagen hydrogel

scientific article

Evaluation of Holistic Treatment for ALS Reveals Possible Mechanism and Therapeutic Potential

scientific article published on 30 December 2017

Functional analysis of human intrafusal fiber innervation by human γ-motoneurons.

scientific article published on 8 December 2017

Functional myotube formation from adult rat satellite cells in a defined serum-free system

scientific article published on 16 February 2015

Functional skeletal muscle model derived from SOD1-mutant ALS patient iPSCs recapitulates hallmarks of disease progression

scientific article published on 31 August 2020

Growth and electrophysiological properties of rat embryonic cardiomyocytes on hydroxyl- and carboxyl-modified surfaces

scientific article published on January 2008

How multi-organ microdevices can help foster drug development

scientific article

In vitro Differentiation of Functional Human Skeletal Myotubes in a Defined System

scientific article

Integration of functional myotubes with a Bio-MEMS device for non-invasive interrogation

scientific article

Inverse Liquid Solid Chromatography to Evaluate Drug Interactions with Organosilane Modified Polydimethylsiloxane for use in Body-on-a-Chip Systems

scientific article published on 14 July 2020

Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system

scientific article published on 04 August 2018

Ion channel dysfunction and altered motoneuron excitability in ALS

scientific article published on 30 July 2019

Long-Term Electrical and Mechanical Function Monitoring of a Human-on-a-Chip System

scientific article published on 14 December 2018

Long-term culture of embryonic rat cardiomyocytes on an organosilane surface in a serum-free medium

scientific article

Measurement of contractile stress generated by cultured rat muscle on silicon cantilevers for toxin detection and muscle performance enhancement

scientific article

Microfabricated mammalian organ systems and their integration into models of whole animals and humans

scientific article

Microphysiological heart-liver body-on-a-chip system with a skin mimic for evaluating topical drug delivery

scientific article published on 23 January 2020

Microphysiological systems

scientific article published on 29 October 2019

Microphysiological systems and low-cost microfluidic platform with analytics

scientific article

Modeling Barrier Tissues In Vitro: Methods, Achievements, and Challenges

scientific article

Modeling of action potential generation in NG108-15 cells

scientific article published on 01 January 2007

Morphological and functional characterization of human induced pluripotent stem cell-derived neurons (iCell Neurons) in defined culture systems

scientific article published on 28 August 2015

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

scientific article

Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics

scientific article published on 01 June 2019

Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges

scientific article published on 4 December 2017

Myelination and node of Ranvier formation in a human motoneuron - Schwann cell serum-free co-culture

scientific article published on 28 July 2020

Myelination and node of Ranvier formation on sensory neurons in a defined in vitro system

scientific article published on 16 August 2013

Neuromuscular junction formation between human stem cell-derived motoneurons and human skeletal muscle in a defined system ⬇️

scientific article published on September 23, 2011

Neuromuscular junction formation between human stem-cell-derived motoneurons and rat skeletal muscle in a defined system

scientific article

Node of Ranvier formation on motoneurons in vitro

scientific article published on 10 April 2009

On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships

scientific article published on 03 July 2019

Patterned cardiomyocytes on microelectrode arrays as a functional, high information content drug screening platform ⬇️

scientific article published on March 31, 2011

Photolithographic patterning of C2C12 myotubes using vitronectin as growth substrate in serum-free medium

scientific article published on January 2007

Physiological Aβ Concentrations Produce a More Biomimetic Representation of the Alzheimer's Disease Phenotype in iPSC Derived Human Neurons

scientific article published on 22 May 2018

Polarity Induced in Human Stem Cell Derived Motoneurons on Patterned Self-Assembled Monolayers

scientific article published on 22 May 2019

Rat Cortical Oligodendrocyte-Embryonic Motoneuron Co-Culture: An In Vitro Axon-Oligodendrocyte Interaction Model

scientific article published on September 2012

Recent Advances in Body-on-a-Chip Systems

scientific article published on 11 December 2018

Regeneration and characterization of adult mouse hippocampal neurons in a defined in vitro system.

scientific article published on 7 October 2008

Self-contained, low-cost Body-on-a-Chip systems for drug development

scientific article published on 17 February 2017

Skeletal muscle tissue engineering: a maturation model promoting long-term survival of myotubes, structural development of the excitation-contraction coupling apparatus and neonatal myosin heavy chain expression

scientific article

Small Molecule Induction of Human Umbilical Stem Cells into MBP-positive Oligodendrocytes in a Defined Three-Dimensional Environment

scientific article

Stem cell derived phenotypic human neuromuscular junction model for dose response evaluation of therapeutics

scientific article published on 27 February 2018

Synaptic connectivity in engineered neuronal networks

scientific article published in January 2007

Synaptic connectivity in engineered neuronal networks

scientific article published in January 2014

Temporal Characterization of Neuronal Migration Behavior on Chemically Patterned Neuronal Circuits in a Defined in Vitro Environment

scientific article published on 27 August 2018

Temporal neurotransmitter conditioning restores the functional activity of adult spinal cord neurons in long-term culture

scientific article

Tissue engineering intrafusal fibers: dose- and time-dependent differentiation of nuclear bag fibers in a defined in vitro system using neuregulin 1-beta-1.

scientific article published on March 2008

Tissue engineering the mechanosensory circuit of the stretch reflex arc with human stem cells: Sensory neuron innervation of intrafusal muscle fibers

scientific article published on 3 January 2017

Tissue engineering the mechanosensory circuit of the stretch reflex arc: sensory neuron innervation of intrafusal muscle fibers

scientific article

Tissue engineering the monosynaptic circuit of the stretch reflex arc with co-culture of embryonic motoneurons and proprioceptive sensory neurons ⬇️

scientific article published on May 15, 2012

Toxin detection based on action potential shape analysis using a realistic mathematical model of differentiated NG108-15 cells.

scientific article published on 3 February 2006

Two cell circuits of oriented adult hippocampal neurons on self-assembled monolayers for use in the study of neuronal communication in a defined system

scientific article published on 20 May 2013

Using physiologically-based pharmacokinetic-guided "body-on-a-chip" systems to predict mammalian response to drug and chemical exposure

scientific article

Utilization of microscale silicon cantilevers to assess cellular contractile function in vitro

scientific article

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