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List of works by Neil Osheroff

(-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases

scientific article

1,4-Benzoquinone is a topoisomerase II poison

scientific article

A mutant yeast topoisomerase II (top2G437S) with differential sensitivity to anticancer drugs in the presence and absence of ATP.

scientific article

A mutation in yeast TOP2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli gyrA alters sensitivity to eukaryotic topoisomerase inhibitors

scientific article

A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases

scientific article

A two-drug model for etoposide action against human topoisomerase IIalpha

scientific article

A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.

scientific article published in January 1995

Ability of viral topoisomerase II to discern the handedness of supercoiled DNA: bimodal recognition of DNA geometry by type II enzymes

scientific article published on September 2006

Action of quinolones against Staphylococcus aureus topoisomerase IV: basis for DNA cleavage enhancement.

scientific article

Activities of gyrase and topoisomerase IV on positively supercoiled DNA.

scientific article

Activity of quinolone CP-115,955 against bacterial and human type II topoisomerases is mediated by different interactions

scientific article published on 23 January 2015

Amsacrine as a Topoisomerase II Poison: Importance of Drug–DNA Interactions ⬇️

scientific article published on February 10, 2012

Apurinic sites are position-specific topoisomerase II poisons

scientific article published in January 1997

Azatoxin Is a Mechanistic Hybrid of the Topoisomerase II-Targeted Anticancer Drugs Etoposide and Ellipticine ⬇️

scientific article published on October 21, 1997

Bacillus anthracis GrlAV96A topoisomerase IV, a quinolone resistance mutation that does not affect the water-metal ion bridge

scientific article

Bimodal Actions of a Naphthyridone/Aminopiperidine-Based Antibacterial That Targets Gyrase and Topoisomerase IV

scientific article published on 28 October 2019

Bimodal recognition of DNA geometry by human topoisomerase II alpha: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domain

scientific article published on December 2008

Binding of etoposide to topoisomerase II in the absence of DNA: decreased affinity as a mechanism of drug resistance

scientific article published on 01 March 1999

Biochemical mechanism of apoptotic execution.

scientific article published on May 2000

Bioflavonoids as poisons of human topoisomerase II alpha and II beta ⬇️

scientific article

Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanism

scientific article

Chiral discrimination and writhe-dependent relaxation mechanism of human topoisomerase IIα.

scientific article published on 18 March 2013

Chlorella virus Marburg topoisomerase II: high DNA cleavage activity as a characteristic of Chlorella virus type II enzymes

scientific article published in March 2005

Cleavage of plasmid DNA by eukaryotic topoisomerase II.

scientific article

Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme--drug--DNA complex.

scientific article

Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons

scientific article published on February 2009

Covalent Attachment of Ethidium to DNA Results in Enhanced Topoisomerase II-Mediated DNA Cleavage ⬇️

scientific article published on December 16, 1997

DNA abasic lesions in a different light: solution structure of an endogenous topoisomerase II poison

scientific article

DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA

scientific article

DNA ligation catalyzed by human topoisomerase II alpha

scientific article

DNA methylation impacts the cleavage activity of Chlorella virus topoisomerase II.

scientific article

DNA topoisomerase II as the target for the anticancer drug TOP-53: mechanistic basis for drug action

scientific article

DNA topoisomerase II in therapy-related acute promyelocytic leukemia.

scientific article published in April 2005

DNA topoisomerase IIalpha interacts with CAD nuclease and is involved in chromatin condensation during apoptotic execution

scientific article published in August 2000

DNA topoisomerases as targets for the anticancer drug TAS-103: DNA interactions and topoisomerase catalytic inhibition

scientific article published in November 1999

DNA topoisomerases as targets for the anticancer drug TAS-103: primary cellular target and DNA cleavage enhancement

scientific article published on 01 November 1999

Definitaion of cytochrome c binding domains by chemical modification. Reaction of carboxydinitrophenyl- and trinitrophenyl-cytochromes c with baker's yeast cytochrome c peroxidase ⬇️

scientific article (publication date: 25 September 1978)

Definition of cytochrome c binding domains by chemical modification. Interaction of horse cytochrome c with beef sulfite oxidase and analysis of steady state kinetics ⬇️

scientific article published on July 25, 1981

Definition of cytochrome c binding domains by chemical modification: Kinetics of reaction with beef mitochondrial reductase and functional organization of the respiratory chain ⬇️

scientific article published on January 1, 1979

Definition of enzymic interaction domains on cytochrome c. Purification and activity of singly substituted carboxydinitrophenyl-lysine 7, 25, 73, 86, and 99 cytochromes c ⬇️

scientific article published on September 10, 1980

Dietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancement

scientific article

Direct measurement of DNA bending by type IIA topoisomerases: implications for non-equilibrium topology simplification

scientific article

Drug Interactions with Bacillus anthracis Topoisomerase IV: Biochemical Basis for Quinolone Action and Resistance ⬇️

scientific article published on December 16, 2011

Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential

scientific article published in October 1993

Effects of Secondary Metabolites from the Fungus Septofusidium berolinense on DNA Cleavage Mediated by Human Topoisomerase IIα.

scientific article published on 19 February 2016

Effects of benzene metabolites on DNA cleavage mediated by human topoisomerase II alpha: 1,4-hydroquinone is a topoisomerase II poison

scientific article published in April 2005

Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group ⬇️

scientific article published on April 1, 1992

Electrostatic interactions in cytochrome c. The role of interactions between residues 13 and 90 and residues 79 and 47 in stabilizing the heme crevice structure ⬇️

scientific article published on February 25, 1980

Epimerization of green tea catechins during brewing does not affect the ability to poison human type II topoisomerases

scientific article published on 04 April 2013

Etoposide quinone is a covalent poison of human topoisomerase IIβ.

scientific article published on 2 May 2014

Etoposide quinone is a redox-dependent topoisomerase II poison

scientific article

Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia

scientific article

Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells.

scientific article published on March 2005

Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase

scientific article published on 20 January 2016

From Theory to Practice: Utilizing Competency-based Milestones to Assess Professional Growth and Development in the Foundational Science Blocks of a Pre-Clerkship Medical School Curriculum

scientific article published on 7 June 2016

Genome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci

scientific article

Human topoisomerase IIalpha possesses an intrinsic nucleic acid specificity for DNA ligation. Use of 5' covalently activated oligonucleotide substrates to study enzyme mechanism

scientific article

Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage

scientific article published on 24 July 2008

Impact of the C-terminal domain of topoisomerase IIalpha on the DNA cleavage activity of the human enzyme

scientific article published on August 2005

In vitro evolution of preferred topoisomerase II DNA cleavage sites

scientific article

Increased drug affinity as the mechanistic basis for drug hypersensitivity of a mutant type II topoisomerase

scientific article

Inhibition of human DNA topoisomerase IIα by two novel ellipticine derivatives

scientific article published on 15 February 2016

Integrating Foundational Sciences in a Clinical Context in the Post-Clerkship Curriculum

scientific article published on 2 January 2018

Interactions between Quinolones and Bacillus anthracis Gyrase and the Basis of Drug Resistance

scientific article published on 14 July 2017

Interactions between the Etoposide Derivative F14512 and Human Type II Topoisomerases: Implications for the C4 Spermine Moiety in Promoting Enzyme-Mediated DNA Cleavage ⬇️

scientific article published on March 28, 2011

Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events

scientific article

Intrinsic intermolecular DNA ligation activity of eukaryotic topoisomerase II. Potential roles in recombination ⬇️

scientific article published on June 15, 1992

Lactoperoxidase-catalyzed iodination of horse cytochrome c:monoiodotyrosyl 74 cytochrome c ⬇️

scientific article published on November 10, 1977

MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisom

scientific article

Mapping of anion binding sites on cytochrome c by differential chemical modification of lysine residues ⬇️

scientific article published on August 1, 1980

Mapping of the interaction domain for purified cytochromec1on cytochromec ⬇️

scientific article published on March 10, 1980

Mechanism of Action of Mycobacterium tuberculosis Gyrase Inhibitors: A Novel Class of Gyrase Poisons

scientific article published on 17 May 2018

Mechanism of quinolone action and resistance

scientific article published on 07 March 2014

Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase

scientific article published on 28 February 2019

Merbarone Inhibits the Catalytic Activity of Human Topoisomerase IIα by Blocking DNA Cleavage ⬇️

scientific article published on July 10, 1998

Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha

scientific article published on September 2009

Metnase promotes restart and repair of stalled and collapsed replication forks

scientific article

Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis

scientific article

Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides

scientific article

N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison

scientific article published on March 2004

Natural products as topoisomerase II poisons: effects of thymoquinone on DNA cleavage mediated by human topoisomerase IIα

scientific article

Novel 1-8-bridged chiral quinolones with activity against topoisomerase II: stereospecificity of the eukaryotic enzyme

scientific article published on April 1993

Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα.

scientific article published on 8 September 2017

Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β

scientific article published on 20 October 2020

Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions.

scientific article published on 30 September 2013

Oxidative Transformation of Demethoxy- and Bisdemethoxycurcumin: Products, Mechanism of Formation, and Poisoning of Human Topoisomerase IIα

scientific article published in 2015

Oxidative metabolites of curcumin poison human type II topoisomerases

scientific article published in 2012

Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase IIα and IIβ

scholarly article by Alexandria A Oviatt published in September 2018

Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate

scientific article

Preferred sites for electron transfer between cytochrome c and iron and cobalt complexes ⬇️

scientific article published on May 25, 1983

Preferred sites on cytochrome c for electron transfer with two positively charged blue copper proteins, Anabaena variabilis plastocyanin and stellacyanin

scientific article published on November 1986

Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome

scientific article published on 14 January 2008

Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate

scientific article

Purification of DNA topoisomerase II from Drosophila melanogaster

scientific article published in January 1999

Quinolone action against human topoisomerase IIalpha: stimulation of enzyme-mediated double-stranded DNA cleavage

scientific article

Quinolones inhibit DNA religation mediated by Staphylococcus aureus topoisomerase IV. Changes in drug mechanism across evolutionary boundaries

scientific article published on 01 December 1999

Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs

scientific article published on March 1997

Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405.

scientific article

Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further process

scientific article published in November 2003

Recognition of DNA Supercoil Geometry by Mycobacterium tuberculosis Gyrase.

scientific article published on 18 September 2017

Role of the water-metal ion bridge in mediating interactions between quinolones and Escherichia coli topoisomerase IV.

scientific article

Selection of DNA Cleavage Sites by Topoisomerase II Results from Enzyme-Induced Flexibility of DNA

scientific article published on 31 January 2019

Site-specific DNA cleavage by Chlorella virus topoisomerase II.

scientific article published on October 2002

Site-specific anti-cytochrome c antibodies. Inhibition of the reactions between cytochrome c and its respiratory chain electron exchange partners ⬇️

scientific article published on December 25, 1979

Site-specific cleavage of a DNA hairpin by topoisomerase II. DNA secondary structure as a determinant of enzyme recognition/cleavage.

scientific article published in March 1994

Smoothed Potential MD Simulations for Dissociation Kinetics of Etoposide To Unravel Isoform Specificity in Targeting Human Topoisomerase II

scientific article published on 09 September 2019

Spontaneous DNA lesions poison human topoisomerase IIalpha and stimulate cleavage proximal to leukemic 11q23 chromosomal breakpoints

scientific article published on 01 May 1997

Stimulation of topoisomerase II-mediated DNA cleavage by benzene metabolites

scientific article published on 25 April 2005

Structure of a topoisomerase II–DNA–nucleotide complex reveals a new control mechanism for ATPase activity ⬇️

scientific article published on September 30, 2012

Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.

scientific article published on 21 March 2008

Synthesis and evaluation of ether-linked demethylepipodophyllotoxin dimers

scientific article published on November 2014

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

scientific article

The bis(naphthalimide) DMP-840 causes cytotoxicity by its action against eukaryotic topoisomerase II.

scientific article

The efficacy of topoisomerase II-targeted anticancer agents reflects the persistence of drug-induced cleavage complexes in cells

scientific article published on 16 October 2008

The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I ⬇️

scientific article published on September 19, 2010

The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs

scientific article published on March 2006

The presteady state reaction of chemically modified cytochromes c with cytochrome oxidase ⬇️

scientific article published on May 10, 1983

The reaction of primate cytochromes c with cytochrome c oxidase. Analysis of the polarographic assay ⬇️

scientific article published on May 10, 1983

The use of divalent metal ions by type II topoisomerases.

scientific article

Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme.

scientific article

Topoisomerase II and leukemia

scientific article published on 03 February 2014

Topoisomerase II and the etiology of chromosomal translocations

scientific article published on 20 July 2006

Topoisomerase II from Chlorella virus PBCV-1 has an exceptionally high DNA cleavage activity

scientific article published on 25 April 2001

Topoisomerase II from Chlorella virus PBCV-1. Characterization of the smallest known type II topoisomerase

scientific article published in March 2000

Topoisomerase II-catalyzed relaxation and catenation of plasmid DNA.

scientific article published in January 2001

Topoisomerase II-mediated cleavage of plasmid DNA.

scientific article published in January 2001

Topoisomerase II.etoposide interactions direct the formation of drug-induced enzyme-DNA cleavage complexes

scientific article published in November 1996

Topoisomerase IV Catalysis and the Mechanism of Quinolone Action ⬇️

scientific article published on July 10, 1998

Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance ⬇️

scientific article published on March 4, 2013

Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal

scientific article

Type II topoisomerases as targets for quinolone antibacterials: turning Dr. Jekyll into Mr. Hyde

scientific article

Uncoupling the DNA cleavage and religation activities of topoisomerase II with a single-stranded nucleic acid substrate: evidence for an active enzyme-cleaved DNA intermediate

scientific article

Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV ⬇️

scientific article published on February 7, 2011

Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.

scientific article published on March 2009

Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha

scientific article published on 05 March 2008

Using Small Case-Based Learning Groups as a Setting for Teaching Medical Students How to Provide and Receive Peer Feedback

scientific article published on 20 September 2017

Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II

scientific article

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