List of works by Gary S Stein

1,25-(OH)2-vitamin D3 suppresses the bone-related Runx2/Cbfa1 gene promoter

scientific article

1alpha,25-dihydroxy vitamin D(3) induces nuclear matrix association of the 1alpha,25-dihydroxy vitamin D(3) receptor in osteoblasts independently of its ability to bind DNA

scientific article

1alpha,25-dihydroxy vitamin D3-enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1alpha,25-dihydroxy vitamin D3 receptor-SRC-1 coactivator complex

scientific journal article

A Proteasome Inhibitor, Bortezomib, Inhibits Breast Cancer Growth and Reduces Osteolysis by Downregulating Metastatic Genes ⬇️

scientific article published on September 15, 2010

A RUNX2-HDAC1 co-repressor complex regulates rRNA gene expression by modulating UBF acetylation

scientific article

A Runx2 threshold for the cleidocranial dysplasia phenotype

scientific article

A central dinucleotide within vitamin D response elements modulates DNA binding and transactivation by the vitamin D receptor in cellular response to natural and synthetic ligands

scientific article

A functional N-terminal domain in C/EBPβ-LAP* is required for interacting with SWI/SNF and to repress Ric-8B gene transcription in osteoblasts

scientific article

A germline point mutation in Runx1 uncouples its role in definitive hematopoiesis from differentiation

scientific article published on 30 June 2013

A microRNA signature for a BMP2-induced osteoblast lineage commitment program

scientific article

A microRNA/Runx1/Runx2 network regulates prostate tumor progression from onset to adenocarcinoma in TRAMP mice

scientific article published on 13 September 2016

A network connecting Runx2, SATB2, and the miR-23a~27a~24-2 cluster regulates the osteoblast differentiation program

scientific article

A perspective on malignancy in the marrow

scientific article published on 16 February 2017

A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2

scientific journal article

Acidic fibroblast growth factor modulates gene expression in the rat thyroid in vivo

scientific article published on December 1, 1992

Activation of the bone-related Runx2/Cbfa1 promoter in mesenchymal condensations and developing chondrocytes of the axial skeleton

scientific article published in June 2002

Ajulemic acid, a nonpsychoactive cannabinoid acid, suppresses osteoclastogenesis in mononuclear precursor cells and induces apoptosis in mature osteoclast-like cells.

scientific article published in March 2008

Alterations in intranuclear localization of Runx2 affect biological activity

scientific article published on December 2006

Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network

scientific article

Altered chromatin modifications in AML1/RUNX1 breakpoint regions involved in (8;21) translocation.

scientific article published in February 2009

An AML1-ETO/miR-29b-1 regulatory circuit modulates phenotypic properties of acute myeloid leukemia cells

scientific article published on 24 May 2017

An architectural genetic and epigenetic perspective

scientific article published on 24 December 2010

An architectural perspective of cell-cycle control at the G1/S phase cell-cycle transition.

scientific article published on December 2006

An architectural perspective of vitamin D responsiveness.

scientific article published on 8 January 2007

Analysis of in vivo gene expression using epitope-tagged proteins

scientific article published on 01 January 2004

Antagonizing miR-218-5p attenuates Wnt signaling and reduces metastatic bone disease of triple negative breast cancer cells

scientific article published on 12 October 2016

Arachidonic acid, eicosanoids, and fracture repair

scientific article published on September 1, 2010

Architectural epigenetics: mitotic retention of mammalian transcriptional regulatory information

scientific article

Architectural genetic and epigenetic control of regulatory networks: compartmentalizing machinery for transcription and chromatin remodeling in nuclear microenvironments

scientific article

Author Correction: Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance

scientific article published on 20 April 2020

BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network.

scientific article published on 23 October 2006

Biological effects of the plant-derived polyphenol resveratrol in human articular cartilage and chondrosarcoma cells

scientific article published in October 2012

Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation

scientific article published on 02 April 2009

Bivalent Epigenetic Control of Oncofetal Gene Expression in Cancer

scientific article

Bone marrow-derived heparan sulfate potentiates the osteogenic activity of bone morphogenetic protein-2 (BMP-2)

scientific article

Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells

scientific journal article

Bookmarking target genes in mitosis: a shared epigenetic trait of phenotypic transcription factors and oncogenes?

scientific article published on 09 January 2014

Bookmarking the genome: maintenance of epigenetic information.

scientific article

Brg1, the ATPase subunit of the SWI/SNF chromatin remodeling complex, is required for myeloid differentiation to granulocytes

scientific article published on January 2006

C-ing the Genome: A Compendium of Chromosome Conformation Capture Methods to Study Higher-Order Chromatin Organization

scientific article

C/EBPβ binds the P1 promoter of the Runx2 gene and up-regulates Runx2 transcription in osteoblastic cells

scientific article published on November 2011

CBFβ and the leukemogenic fusion protein CBFβ-SMMHC associate with mitotic chromosomes to epigenetically regulate ribosomal genes

scientific article

CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression.

scientific article published on 19 October 2001

CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P

scientific article

Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility ⬇️

scientific article

Canonical WNT Signaling Promotes Osteogenesis by Directly StimulatingRunx2Gene Expression

scientific article published in Journal of Biological Chemistry

Cbfbeta interacts with Runx2 and has a critical role in bone development

scientific journal article

Cell cycle dependent phosphorylation and subnuclear organization of the histone gene regulator p220(NPAT) in human embryonic stem cells.

scientific article published on October 2007

Cell cycle gene expression networks discovered using systems biology: Significance in carcinogenesis

scientific article published on October 2015

Cell cycle related modulations in Runx2 protein levels are independent of lymphocyte enhancer-binding factor 1 (Lef1) in proliferating osteoblasts

scientific article published on 21 September 2007

Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblasts ⬇️

scientific article published on September 1, 2003

Chromatin dynamics regulate mesenchymal stem cell lineage specification and differentiation to osteogenesis

scientific article published on 8 January 2017

Chromatin immunoprecipitation

scientific article published on 01 January 2004

Chromatin immunoprecipitation assays: application of ChIP-on-chip for defining dynamic transcriptional mechanisms in bone cells.

scientific article

Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells

scientific article

Chromatin remodeling and transcriptional activity of the bone-specific osteocalcin gene require CCAAT/enhancer-binding protein beta-dependent recruitment of SWI/SNF activity

scientific article

Chromatin remodeling by SWI/SNF results in nucleosome mobilization to preferential positions in the rat osteocalcin gene promoter

scientific article published on February 2007

Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus.

scientific article published on 20 July 2015

Co-stimulation of the bone-related Runx2 P1 promoter in mesenchymal cells by SP1 and ETS transcription factors at polymorphic purine-rich DNA sequences (Y-repeats)

scientific article

Combinatorial organization of the transcriptional regulatory machinery in biological control and cancer

scientific article

Conditional inactivation of the mouse Wwox tumor suppressor gene recapitulates the null phenotype

scientific article published on July 2013

Control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2.

scientific article

Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130.

scientific article

Coordinate control and selective expression of the full complement of replication-dependent histone H4 genes in normal and cancer cells

scientific article published on 29 August 2005

Core Binding Factor β of Osteoblasts Maintains Cortical Bone Mass Via Stabilization of Runx2 in Mice

scientific article published on 01 October 2015

Core Binding Factor β of Osteoblasts Maintains Cortical Bone Mass via Stabilization of Runx2 in Mice

scientific article published on 26 June 2015

Core binding factor β (CBFβ) is retained in the midbody during cytokinesis

scientific article

Core binding factor β of osteoblasts maintains cortical bone mass via stabilization of Runx2 in mice.

scientific article published in April 2015

Correction: Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation.

scientific article published in June 2019

Corrigendum to "Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain" [GENE 655 (2018) 1-12]

scientific article published on 12 June 2018

Could lncRNAs be the missing links in control of mesenchymal stem cell differentiation?

scientific article

Cover Image, Volume 232, Number 12, December 2017.

scientific article

Crystallization and preliminary X-ray analysis of a domain in the Runx2 transcription factor that interacts with the 1α,25 dihydroxy vitamin D3 receptor

scientific article published on 01 June 2007

Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cells

scientific article

Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation.

scientific article

Development of a predictive miRNA signature for breast cancer risk among high-risk women

scientific article published on 28 November 2017

Development of an Experimental Animal Model for Lower Back Pain by Percutaneous Injury-Induced Lumbar Facet Joint Osteoarthritis

scientific article published in November 2015

Dicer inactivation in osteoprogenitor cells compromises fetal survival and bone formation, while excision in differentiated osteoblasts increases bone mass in the adult mouse

scientific article

Differential gene expression analysis using paraffin-embedded tissues after laser microdissection

scientific article published in December 2003

Disruption of Broad Epigenetic Domains in PDAC Cells by HAT Inhibitors

scientific article published on 02 June 2019

Dissection of Individual Prostate Lobes in Mouse Models of Prostate Cancer to Obtain High Quality RNA.

scientific article published on 18 March 2016

Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene.

scientific article published on October 2004

Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression

scientific article published on 18 August 2009

Effects of miR-335-5p in modulating osteogenic differentiation by specifically downregulating Wnt antagonist DKK1

scientific article published on August 2011

Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications.

scientific article published on June 2009

Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma.

scientific article

Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: a novel role of the cysteinyl LT-1 receptor

scientific article published on October 2009

Enhancer of Zeste Homolog 2 Inhibition Stimulates Bone Formation and Mitigates Bone Loss Caused by Ovariectomy in Skeletally Mature Mice

scientific article published on 10 October 2016

Environmental disruption of circadian rhythm predisposes mice to osteoarthritis-like changes in knee joint

scientific article published on September 2015

Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2

scientific article

Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B.

scientific article published on 9 October 2015

Epigenetic Modulation in Periodontitis: Interaction of Adiponectin and JMJD3-IRF4 Axis in Macrophages

scientific article published on 24 September 2015

Epigenetic control of cell cycle-dependent histone gene expression is a principal component of the abbreviated pluripotent cell cycle.

scientific article

Epigenetic landscape during osteoblastogenesis defines a differentiation-dependent Runx2 promoter region.

scientific article

Epigenetic mechanisms in leukemia

scientific article published on 24 May 2012

Epigenetic pathways regulating bone homeostasis: potential targeting for intervention of skeletal disorders

scientific article

Epigenetic regulation of early osteogenesis and mineralized tissue formation by a HOXA10-PBX1-associated complex

scientific article

Epithelial-to-mesenchymal transition and cancer stem cells contribute to breast cancer heterogeneity

scientific article published on 03 July 2018

Establishment of histone gene regulation and cell cycle checkpoint control in human embryonic stem cells

scientific article published in February 2007

Estrogen Receptor-α Is Developmentally Regulated during Osteoblast Differentiation and Contributes to Selective Responsiveness of Gene Expression

Estrogen receptor α mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor β.

scientific article published on 29 January 2013

Ethanol Extract of Cissus quadrangularis Enhances Osteoblast Differentiation and Mineralization of Murine Pre-Osteoblastic MC3T3-E1 Cells

scientific article published on 5 June 2016

Ethyl acetate and n-butanol fraction of Cissus quadrangularis promotes the mineralization potential of murine pre-osteoblast cell line MC3T3-E1 (sub-clone 4)

scientific article published on 15 November 2018

Expression of Ribosomal RNA and Protein Genes in Human Embryonic Stem Cells Is Associated With the Activating H3K4me3 Histone Mark

scientific article published on 11 January 2016

Expression of Runx2 transcription factor in non-skeletal tissues, sperm and brain

scientific article

Expression of secreted frizzled related protein 1, a Wnt antagonist, in brain, kidney, and skeleton is dispensable for normal embryonic development

scientific article published on October 2008

Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1

scientific article published in September 2015

Expression of the ectodomain-releasing protease ADAM17 is directly regulated by the osteosarcoma and bone-related transcription factor RUNX2

scientific article published on 19 June 2018

Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha

scientific article

Ezh2-dependent H3K27me3 modification dynamically regulates vitamin D3-dependent epigenetic control of CYP24A1 gene expression in osteoblastic cells

scientific article published on 07 January 2020

Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease.

scientific article published on July 2004

Fidelity of histone gene regulation is obligatory for genome replication and stability

scientific article

Forced expression of the interferon regulatory factor 2 oncoprotein causes polyploidy and cell death in FDC-P1 myeloid hematopoietic progenitor cells

scientific article

Four novel RUNX2 mutations including a splice donor site result in the cleidocranial dysplasia phenotype.

scientific article published in April 2006

Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression

scientific article

Functional architecture of the nucleus: organizing the regulatory machinery for gene expression, replication and repair.

scientific article published on November 2003

Functional characterization of a human histone gene cluster duplication

scientific article

Functional coupling of transcription factor HiNF-P and histone H4 gene expression during pre- and post-natal mouse development.

scientific article

Gene profiling of cell cycle progression through S-phase reveals sequential expression of genes required for DNA replication and nucleosome assembly

scientific article

Genetic ablation of the CDP/Cux protein C terminus results in hair cycle defects and reduced male fertility

scientific journal article

Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer

scientific article published on August 2008

Genome-Wide Studies Reveal that H3K4me3 Modification in Bivalent Genes Is Dynamically Regulated during the Pluripotent Cell Cycle and Stabilized upon Differentiation.

scientific article published on 07 December 2015

Genome-wide DNase hypersensitivity, and occupancy of RUNX2 and CTCF reveal a highly dynamic gene regulome during MC3T3 pre-osteoblast differentiation

scientific article published on 27 November 2017

Genome-wide co-occupancy of AML1-ETO and N-CoR defines the t(8;21) AML signature in leukemic cells

scientific article published on 17 April 2015

Genome-wide screening in human growth plates during puberty in one patient suggests a role for RUNX2 in epiphyseal maturation.

scientific article published on 09 February 2011

Genomic occupancy of HLH, AP1 and Runx2 motifs within a nuclease sensitive site of the Runx2 gene

scientific article published on February 2013

Genomic occupancy of Runx2 with global expression profiling identifies a novel dimension to control of osteoblastogenesis.

scientific article published on 21 March 2014

Genomic promoter occupancy of runt-related transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motility

scientific article published on 9 December 2011

Glycosaminoglycans modulate RANKL-induced osteoclastogenesis

scientific article

HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes.

scientific article published on 26 February 2007

Heparan sulfate enhances the self-renewal and therapeutic potential of mesenchymal stem cells from human adult bone marrow

scientific article

Heparan sulfate proteoglycans and human breast cancer epithelial cell tumorigenicity

scientific article

Heparan sulfate regulates the anabolic activity of MC3T3-E1 preosteoblast cells by induction of Runx2.

scientific article published on January 2007

HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition.

scientific article

HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription

scientific article

High throughput analysis of differential gene expression

scientific article published in January 1998

High-resolution molecular validation of self-renewal and spontaneous differentiation in clinical-grade adipose-tissue derived human mesenchymal stem cells.

scientific article

Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer

scientific article published on 15 March 2019

Higher order genomic organization and regulatory compartmentalization for cell cycle control at the G1/S-phase transition

scientific article published on 10 May 2018

Histone H3 lysine 4 acetylation and methylation dynamics define breast cancer subtypes

scientific article published on 15 January 2016

Histone H4 Methyltransferase Suv420h2 Maintains Fidelity of Osteoblast Differentiation

scientific article published on 9 November 2016

Histone acetylation in vivo at the osteocalcin locus is functionally linked to vitamin D-dependent, bone tissue-specific transcription

scientific article

Histone deacetylase inhibition destabilizes the multi-potent state of uncommitted adipose-derived mesenchymal stromal cells

scientific article

Human embryonic stem cell registries: value, challenges and opportunities

scientific article published on October 2008

Human embryonic stem cells are pre-mitotically committed to self-renewal and acquire a lengthened G1 phase upon lineage programming

scientific article

Hyaluronic acid-based hydrogels functionalized with heparin that support controlled release of bioactive BMP-2

scientific article published on 9 June 2012

Identification of HiNF-P, a Key Activator of Cell Cycle-Controlled Histone H4 Genes at the Onset of S Phase ⬇️

scientific article published on November 1, 2003

Identification of RUNX3 as a component of the MST/Hpo signaling pathway

scientific article published on February 2012

Identification of novel protein/DNA interactions within the promoter of the bone-related transcription factor Runx2/Cbfa1.

scientific article published on January 2002

Identification of tRNA-derived small RNA (tsRNA) responsive to the tumor suppressor, RUNX1, in breast cancer

scientific article published on 10 January 2020

Identifying Nuclear Matrix-Attached DNA Across the Genome

scientific article published on 14 September 2016

Immunofluorescence analysis using epitope-tagged proteins: in vitro system

scientific article published on 01 January 2004

Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfbeta in osteosarcoma cells

scientific article

Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo.

scientific article

In situ immunofluorescence analysis: analyzing RNA synthesis by 5-bromouridine-5'-triphosphate labeling

scientific article

In situ immunofluorescence analysis: immunofluorescence microscopy

scientific article published on 01 January 2004

In situ nuclear organization of regulatory machinery

scientific article published on 01 January 2008

Inhibition of the RUNX1-CBFβ transcription factor complex compromises mammary epithelial cell identity: a phenotype potentially stabilized by mitotic gene bookmarking

scientific article published on 30 June 2020

Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites

scientific article

Integrin αvβ6 promotes an osteolytic program in cancer cells by upregulating MMP2.

scientific article published on 02 January 2014

Interaction of the 1alpha,25-dihydroxyvitamin D3 receptor at the distal promoter region of the bone-specific osteocalcin gene requires nucleosomal remodelling

scientific journal article

International stem cell registries.

scientific article published on 23 February 2010

Intranuclear Trafficking: Organization and Assembly of Regulatory Machinery for Combinatorial Biological Control

scientific article (publication date: 23 July 2004)

Intranuclear and higher-order chromatin organization of the major histone gene cluster in breast cancer.

scientific article

Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer

scientific article

Intranuclear trafficking of transcription factors: Requirements for vitamin D-mediated biological control of gene expression.

scientific article

Intricate gene regulatory networks of helix-loop-helix (HLH) proteins support regulation of bone-tissue related genes during osteoblast differentiation

scientific article published on October 2008

Lineage-Specific Early Differentiation of Human Embryonic Stem Cells Requires a G2 Cell Cycle Pause.

scientific article published on 06 March 2016

Linkages of nuclear architecture to biological and pathological control of gene expression

scientific article published in January 1998

Live cell imaging of the cancer-related transcription factor RUNX2 during mitotic progression

scientific article

Loss of RUNX1 is associated with aggressive lung adenocarcinomas.

scientific article published on 19 September 2017

Lymphocyte enhancer-binding factor 1 (Lef1) inhibits terminal differentiation of osteoblasts.

scientific article published in April 2006

Maintenance of open chromatin and selective genomic occupancy at the cell cycle-regulated histone H4 promoter during differentiation of HL-60 promyelocytic leukemia cells

scientific article

Maternal expression and early induction of histone gene transcription factor Hinfp sustains development in pre-implantation embryos

scientific article

Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2

scientific article published on 16 January 2020

Metastatic bone disease: role of transcription factors and future targets

scientific article

MicroRNA control of bone formation and homeostasis

scientific article published on 31 January 2012

MicroRNA functions in osteogenesis and dysfunctions in osteoporosis

scientific article published on June 2013

MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma

scientific article published on 29 May 2013

MicroRNA-378-mediated suppression of Runx1 alleviates the aggressive phenotype of triple-negative MDA-MB-231 human breast cancer cells.

scientific article published on 09 January 2016

MicroRNA-466 inhibits tumor growth and bone metastasis in prostate cancer by direct regulation of osteogenic transcription factor RUNX2.

scientific article published on 26 January 2017

MicroRNAs 221 and 222 bypass quiescence and compromise cell survival

scientific article

MicroRNAs in the control of metastatic bone disease

scientific article

Microtubule-dependent nuclear-cytoplasmic shuttling of Runx2.

scientific article published on February 2006

Mitotic Gene Bookmarking: An Epigenetic Mechanism for Coordination of Lineage Commitment, Cell Identity and Cell Growth

scientific article published in January 2017

Mitotic Gene Bookmarking: An Epigenetic Program to Maintain Normal and Cancer Phenotypes

scientific article published on 12 July 2018

Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor Runx2 in Progeny of Osteoblastic Cells.

scientific article published on 7 September 2015

Mitotic bookmarking of genes: a novel dimension to epigenetic control.

scientific article

Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cells

scientific article published on April 2007

Mitotic gene bookmarking by RUNX1 contributes to stabilization of the normal mammary epithelial phenotype

article

Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2.

scientific article

Mitotic partitioning and selective reorganization of tissue-specific transcription factors in progeny cells

scientific journal article

Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2.

scholarly article

Mitotically-associated lncRNA (MANCR) Affects Genomic Stability and Cell Division in Aggressive Breast Cancer.

scientific article

Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 in osteoblasts

scientific article published on 07 September 2018

Molecular switches involving homeodomain proteins, HOXA10 and RUNX2 regulate osteoblastogenesis

scientific article published on 14 August 2008

Molecular targets for radiation oncology in prostate cancer.

scientific article published on 13 July 2011

Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis

scientific article

Multiple levels of epigenetic control for bone biology and pathology

scientific article

Multiple subnuclear targeting signals of the leukemia-related AML1/ETO and ETO repressor proteins

scientific article

Nanoparticle-based targeted cancer strategies for non-invasive prostate cancer intervention.

scientific article published on 16 April 2018

Networks and hubs for the transcriptional control of osteoblastogenesis.

scientific article published on June 2006

Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation

scientific journal article

Nomenclature for Runt-related (RUNX) proteins

scientific article

Non-coding RNAs: Epigenetic regulators of bone development and homeostasis

scientific article published on 31 May 2015

Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing

scientific article

Nuclear microenvironments and cancer

scientific article published on 01 August 2008

Nuclear microenvironments in biological control and cancer.

scientific article published on June 2007

Nuclear microenvironments support assembly and organization of the transcriptional regulatory machinery for cell proliferation and differentiation

scientific article published on February 2004

Nuclear microenvironments support physiological control of gene expression

scientific article published in January 2003

Nuclear organization mediates cancer-compromised genetic and epigenetic control

scientific article published on 09 May 2018

Nucleosome organization and targeting of SWI/SNF chromatin-remodeling complexes: contributions of the DNA sequence

scientific article published on August 2007

Oncofetal Epigenetic Bivalency in Breast Cancer Cells: H3K4 and H3K27 Tri-Methylation as a Biomarker for Phenotypic Plasticity

scientific article published on 24 February 2016

Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells

scientific article published on August 2013

Oncogenic epigenetic control.

scientific article

Organization of transcriptional regulatory machinery in nuclear microenvironments: implications for biological control and cancer

scientific article published on 23 March 2007

Organization of transcriptional regulatory machinery in osteoclast nuclei: compartmentalization of Runx1.

scientific article published in September 2005

Organization, integration, and assembly of genetic and epigenetic regulatory machinery in nuclear microenvironments: implications for biological control in cancer

scientific article published on February 2009

Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling

scientific article

Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells

scientific article (publication date: 15 May 2003)

Osteocalcin gene promoter: Unlocking the secrets for regulation of osteoblast growth and differentiation

scientific article published in January 1998

Osteogenic potential of hexane and dichloromethane fraction of Cissus quadrangularis on murine preosteoblast cell line MC3T3-E1 (subclone 4)

scientific article published on 26 May 2019

Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development

scientific journal article

Participation of integrin β3 in osteoblast differentiation induced by titanium with nano or microtopography

scientific article published on 23 February 2019

Pbx1 represses osteoblastogenesis by blocking Hoxa10-mediated recruitment of chromatin remodeling factors

scientific article

Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice

scientific article

Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain.

scientific article published on 20 February 2018

Phenotype discovery by gene expression profiling: mapping of biological processes linked to BMP-2-mediated osteoblast differentiation

scientific article

Phenotypic transcription factors epigenetically mediate cell growth control.

scholarly article

Phosphorylation at serine 208 of the 1alpha,25-dihydroxy Vitamin D3 receptor modulates the interaction with transcriptional coactivators

scientific article published on March 2007

Pin1-mediated Runx2 modification is critical for skeletal development

scientific article

Planar cell polarity aligns osteoblast division in response to substrate strain

scientific article

Pluripotency: toward a gold standard for human ES and iPS cells

scientific article published on July 2009

Point mutation in AML1 disrupts subnuclear targeting, prevents myeloid differentiation, and effects a transformation-like phenotype.

scientific article

Polyalanine repeat polymorphism in RUNX2 is associated with site-specific fracture in post-menopausal females

scientific article

Positive association between nuclear Runx2 and oestrogen-progesterone receptor gene expression characterises a biological subtype of breast cancer.

scientific article published on 24 July 2009

Post-proliferative cyclin E-associated kinase activity in differentiated osteoblasts: Inhibition by proliferating osteoblasts and osteosarcoma cells

scholarly article by Elisheva Smith published in August 1997

Preclinical characterization of mitochondria-targeted small molecule hsp90 inhibitors, gamitrinibs, in advanced prostate cancer

scientific article

Precocious Phenotypic Transcription-Factor Expression During Early Development.

scientific article published on 3 September 2016

Primary mouse embryonic fibroblasts: A model of mesenchymal cartilage formation

article

Profiling of human epigenetic regulators using a semi-automated real-time qPCR platform validated by next generation sequencing

scientific article

Prostate cancer regulatory networks

scientific article

Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention

scientific article published on June 2008

Protein-deoxyribonucleic acid interactions linked to gene expression: DNase I digestion.

scientific article published on January 2004

Protein-deoxyribonucleic acid interactions linked to gene expression: electrophoretic mobility shift assay

scientific article published on 01 January 2004

Protein-deoxyribonucleic acid interactions linked to gene expression: ligation-mediated polymerase chain reaction

scientific article published on 01 January 2004

Proteomic Analysis of Exosomes and Exosome-Free Conditioned Media From Human Osteosarcoma Cell Lines Reveals Secretion of Proteins Related to Tumor Progression.

scientific article published on 30 June 2016

Quantitative signature for architectural organization of regulatory factors using intranuclear informatics.

scientific article published on 14 September 2004

RUNX1 and RUNX2 transcription factors function in opposing roles to regulate breast cancer stem cells

scientific article published on 17 March 2020

RUNX1 contributes to higher-order chromatin organization and gene regulation in breast cancer cells.

scientific article published on 8 August 2016

RUNX1-dependent mechanisms in biological control and dysregulation in cancer

scientific article published on 04 December 2018

Real-time detection of breast cancer at the cellular level

scientific article published on 26 October 2018

Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation

scientific article published on February 2007

Recruitment and subnuclear distribution of the regulatory machinery during 1alpha,25-dihydroxy vitamin D3-mediated transcriptional upregulation in osteoblasts

scientific article

Redefining the activity of a bone-specific transcription factor: novel insights for understanding bone formation

scientific article published in October 2013

Reduced CpG methylation is associated with transcriptional activation of the bone-specific rat osteocalcin gene in osteoblasts

scientific article

Regulation of osteogenesis by long noncoding RNAs: An epigenetic mechanism contributing to bone formation

scientific article published on 01 December 2018

Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity

scientific journal article

Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors

scientific article

Reprogramming the pluripotent cell cycle: restoration of an abbreviated G1 phase in human induced pluripotent stem (iPS) cells

scientific article

Resolution of inflammation induces osteoblast function and regulates the Wnt signaling pathway

scientific article published on May 2012

Ribonucleoprotein immunoprecipitation (RNP-IP): a direct in vivo analysis of microRNA-targets

scientific article published in July 2010

Role of the WWOX tumor suppressor gene in bone homeostasis and the pathogenesis of osteosarcoma

scientific article published on 03 April 2011

Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination

scientific article

Runx1 Activities in Superficial Zone Chondrocytes, Osteoarthritic Chondrocyte Clones and Response to Mechanical Loading

scientific article published on February 2015

Runx1 is associated with breast cancer progression in MMTV-PyMT transgenic mice and its depletion in vitro inhibits migration and invasion

scientific article published on October 2015

Runx1 stabilizes the mammary epithelial cell phenotype and prevents epithelial to mesenchymal transition

scientific article

Runx1/AML1 hematopoietic transcription factor contributes to skeletal development in vivo.

scientific article published in August 2003

Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter

scientific article

Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

scientific article published on May 2004

Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential.

scholarly article

Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice

scientific article published on 28 January 2009

Runx2 mediates epigenetic silencing of the bone morphogenetic protein-3B (BMP-3B/GDF10) in lung cancer cells

scientific article

Runx2 protein expression utilizes the Runx2 P1 promoter to establish osteoprogenitor cell number for normal bone formation

scientific article

Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice

scientific article published on 7 January 2013

Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors

scientific article

Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells

scientific article published on October 2008

Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre-chemotherapeutic osteosarcoma cell line (OS1).

scientific article published on December 2009

Runx2-Smad signaling impacts the progression of tumor-induced bone disease

scientific article

Runx2/Cbfa1 functions: diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions

scientific article

Runx2/DICER/miRNA Pathway in Regulating Osteogenesis

scientific article published on 11 April 2016

SAT-573 Characterization of the Gene Expression Program of a Mutant Thyroid Hormone Receptor in Anaplastic Thyroid Cancer

SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells

scientific article published on 19 July 2016

SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation

scientific journal article

SWI/SNF-independent nuclease hypersensitivity and an increased level of histone acetylation at the P1 promoter accompany active transcription of the bone master gene Runx2.

scientific article published on August 2009

Secreted frizzled related protein 1 is a target to improve fracture healing

scientific article published on July 2009

Secreted frizzled related protein 1 regulates Wnt signaling for BMP2 induced chondrocyte differentiation.

scientific article published in July 2006

Selective expression of long non-coding RNAs in a breast cancer cell progression model

scientific article published on 10 May 2017

Self-renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase

scientific article published on December 2006

Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription.

scientific article

Species-specific biological effects of FGF-2 in articular cartilage: implication for distinct roles within the FGF receptor family

scientific article

Specific residues of RUNX2 are obligatory for formation of BMP2-induced RUNX2-SMAD complex to promote osteoblast differentiation.

scientific article published on 26 August 2008

Staged assembly of histone gene expression machinery at subnuclear foci in the abbreviated cell cycle of human embryonic stem cells

scholarly article

Standardizing analysis of circulating microRNA: clinical and biological relevance

scientific article published on May 2014

Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal.

scientific article

Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts.

scientific article

Subnuclear domain proteins in cancer cells support the functions of RUNX2 in the DNA damage response

scientific article

Subnuclear localization and intranuclear trafficking of transcription factors

scientific article published on January 2010

Subnuclear targeting of Runx1 is required for synergistic activation of the myeloid specific M-CSF receptor promoter by PU.1.

scientific article published on November 2005

Subnuclear targeting of the Runx3 tumor suppressor and its epigenetic association with mitotic chromosomes.

scientific article

Sulfated glycosaminoglycans mediate the effects of FGF2 on the osteogenic potential of rat calvarial osteoprogenitor cells

scientific journal article

Survival responses of human embryonic stem cells to DNA damage

scientific article

Switches in histone modifications epigenetically control vitamin D3-dependent transcriptional upregulation of the CYP24A1 gene in osteoblastic cells

scientific article published on 23 December 2019

Synergism between Wnt3a and heparin enhances osteogenesis via a phosphoinositide 3-kinase/Akt/RUNX2 pathway

scientific article

TIEG1/KLF10 modulates Runx2 expression and activity in osteoblasts

scientific article

TRAP-1, the mitochondrial Hsp90.

scientific article published on 22 August 2011

Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis

scientific article published on 30 October 2008

Targeted deletion of Wwox reveals a tumor suppressor function

scientific article

Targeting deregulated epigenetic control in cancer

scientific article

Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease

scientific article

Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: The C-terminus is a principal determinant for nuclear trafficking

scientific article (publication date: 15 March 1998)

Temporal and spatial parameters of skeletal gene expression: targeting RUNX factors and their coregulatory proteins to subnuclear domains

scientific article

Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance

scientific article published on 03 April 2019

The 1alpha,25-dihydroxy Vitamin D3 receptor preferentially recruits the coactivator SRC-1 during up-regulation of the osteocalcin gene

scientific article

The BRG1 ATPase of human SWI/SNF chromatin remodeling enzymes as a driver of cancer

scientific article published on 19 May 2017

The BRG1 chromatin remodeling enzyme links cancer cell metabolism and proliferation

scientific article

The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes

scientific article

The Notch-responsive transcription factor Hes-1 attenuates osteocalcin promoter activity in osteoblastic cells

scientific journal article

The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion

scientific article

The Runx2 transcription factor plays a key role in the 1alpha,25-dihydroxy Vitamin D3-dependent upregulation of the rat osteocalcin (OC) gene expression in osteoblastic cells

scientific article published in May 2004

The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation

scientific article

The Thyroid Hormone Receptor-RUNX2 Axis: A Novel Tumor Suppressive Pathway in Breast Cancer

scientific article published on 21 December 2019

The Ultrastructural Signature of Human Embryonic Stem Cells

scientific article published on 15 September 2016

The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism

scientific journal article

The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis

scientific article

The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

scientific journal article

The abbreviated pluripotent cell cycle.

scientific article published on January 2013

The architectural organization of human stem cell cycle regulatory machinery

scientific journal article

The bone-related Zn finger transcription factor Osterix promotes proliferation of mesenchymal cells

scientific article

The bone-specific Runx2-P1 promoter displays conserved three-dimensional chromatin structure with the syntenic Supt3h promoter.

scientific article

The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts

scientific article

The cancer-related Runx2 protein enhances cell growth and responses to androgen and TGFbeta in prostate cancer cells.

scientific article

The cancer-related transcription factor RUNX2 modulates expression and secretion of the matricellular protein osteopontin in osteosarcoma cells to promote adhesion to endothelial pulmonary cells and lung metastasis

scientific article published on 13 January 2019

The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines

scientific article published on April 2013

The classic receptor for 1alpha,25-dihydroxy vitamin D3 is required for non-genomic actions of 1alpha,25-dihydroxy vitamin D3 in osteosarcoma cells

scientific article published on 01 November 2006

The cleidocranial dysplasia-related R131G mutation in the Runt-related transcription factor RUNX2 disrupts binding to DNA but not CBF-beta

scientific article

The connection between BRG1, CTCF and topoisomerases at TAD boundaries

scientific article published on 6 January 2017

The core-binding factor beta subunit is required for bone formation and hematopoietic maturation

scientific journal article

The dynamic architectural and epigenetic nuclear landscape: developing the genomic almanac of biology and disease.

scientific article published on June 2014

The dynamic organization of gene-regulatory machinery in nuclear microenvironments

scientific article

The epigenetic reader Brd4 is required for osteoblast differentiation

scientific article published on 23 December 2019

The gene for aromatase, a rate-limiting enzyme for local estrogen biosynthesis, is a downstream target gene of Runx2 in skeletal tissues

scientific article

The heparan sulfate proteoglycan (HSPG) glypican-3 mediates commitment of MC3T3-E1 cells toward osteogenesis.

scientific article published on September 2009

The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss

scientific article

The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles

scientific journal article

The histone gene cell cycle regulator HiNF-P is a unique zinc finger transcription factor with a novel conserved auxiliary DNA-binding motif

scientific article

The histone gene transcription factor HiNF-P stabilizes its cell cycle regulatory co-activator p220NPAT.

scientific article published on December 2006

The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes

scientific article

The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing

scientific article

The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes.

scientific article

The osteogenic transcription factor Runx2 regulates components of the fibroblast growth factor/proteoglycan signaling axis in osteoblasts

scientific article

The osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism, including CYP11A1 in osteoblasts

scientific article published on 02 April 2009

The role of Runx2 in facilitating autophagy in metastatic breast cancer cells

scientific article published on 27 March 2017

The role of cell adhesion in hematopoiesis and leukemogenesis

scientific article published on 13 April 2019

The subnuclear organization of histone gene regulatory proteins and 3' end processing factors of normal somatic and embryonic stem cells is compromised in selected human cancer cell types

scientific article

The tumor suppressor interferon regulatory factor 1 interferes with SP1 activation to repress the human CDK2 promoter

scientific article published on 5 May 2003

The tyrosine phosphatase, OST-PTP, is expressed in mesenchymal progenitor cells early during skeletogenesis in the mouse

scientific article published in November 2004

The vitamin D response element in the distal osteocalcin promoter contributes to chromatin organization of the proximal regulatory domain

scientific article

Thyroid Hormone Receptor β Suppression of RUNX2 Is Mediated by Brahma-Related Gene 1-Dependent Chromatin Remodeling

scientific article published on 01 June 2018

Thyroid Hormone Receptor-β (TRβ) Mediates Runt-Related Transcription Factor 2 (Runx2) Expression in Thyroid Cancer Cells: A Novel Signaling Pathway in Thyroid Cancer

scientific article published on 2 June 2016

Towards a more precise and individualized assessment of breast cancer risk

scientific article published on 01 February 2019

Transcription factor-mediated epigenetic regulation of cell growth and phenotype for biological control and cancer

scientific article

Transcription factors RUNX1/AML1 and RUNX2/Cbfa1 dynamically associate with stationary subnuclear domains.

scientific article published in November 2002

Transcription-factor-mediated epigenetic control of cell fate and lineage commitment

scientific article published on February 2009

Transcriptional Auto-Regulation of RUNX1 P1 Promoter

scientific article

Transcriptional activation of the histone nuclear factor P (HiNF-P) gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT defines a novel autoregulatory loop at the G1/S phase transition

scientific article

Transcriptional corepressor TLE1 functions with Runx2 in epigenetic repression of ribosomal RNA genes

scientific article

Transcriptional induction of the osteocalcin gene during osteoblast differentiation involves acetylation of histones h3 and h4.

scientific article

Transient RUNX1 Expression during Early Mesendodermal Differentiation of hESCs Promotes Epithelial to Mesenchymal Transition through TGFB2 Signaling

scientific article published on 05 October 2016

Tumor suppressor pRB functions as a co-repressor of the CCAAT displacement protein (CDP/cut) to regulate cell cycle controlled histone H4 transcription

scientific article (publication date: September 2003)

Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription

scientific article published on 12 February 2004

Unique Regulatory Mechanisms for the Human Embryonic Stem Cell Cycle.

scientific article published on 17 August 2016

Vitamin D control of gene expression: temporal and spatial parameters for organization of the regulatory machinery

scientific article published on January 2008

WWOX and p53 Dysregulation Synergize to Drive the Development of Osteosarcoma

scientific article published on 22 August 2016

Wnt/β-Catenin Signaling Activates Expression of the Bone-Related Transcription Factor RUNX2 in Select Human Osteosarcoma Cell Types

scientific article published on 28 March 2017

X-inactivation reveals epigenetic anomalies in most hESC but identifies sublines that initiate as expected

scientific article

hsa-mir-30c promotes the invasive phenotype of metastatic breast cancer cells by targeting NOV/CCN3.

scientific article

miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells

scientific article

miRNA signatures associate with pathogenesis and progression of osteosarcoma

scientific article published on 20 February 2012

microRNA-mediated survivin control of pluripotency

scientific article

p53 checkpoint ablation exacerbates the phenotype of Hinfp dependent histone H4 deficiency

scientific article

p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation

scientific article

tsRNA signatures in cancer

scientific article published on 10 July 2017

α(V)β(6) integrin expression is induced in the POET and Pten(pc-/-) mouse models of prostatic inflammation and prostatic adenocarcinoma.

scientific article

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