List of works - Eric A Sobie

A Comparison of mRNA Sequencing with Random Primed and 3'-Directed Libraries.

scientific article published on 7 November 2017

A distinct molecular mechanism by which phenytoin rescues a novel long QT 3 variant

scientific article published on 24 April 2020

A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals

A network medicine approach to build a comprehensive atlas for the prognosis of human cancer.

scientific article

A privileged role for neuronal Na+ channels in regulating ventricular [Ca2+] and arrhythmias

scientific article published on 13 June 2018

A probability density approach to modeling local control of calcium-induced calcium release in cardiac myocytes

scientific article published on 19 January 2007

Allosteric activation of Na+-Ca2+ exchange by L-type Ca2+ current augments the trigger flux for SR Ca2+ release in ventricular myocytes

scientific article

Ambiguous interactions between diastolic and SR Ca2+ in the regulation of cardiac Ca2+ release.

scientific article published on 10 August 2017

An Introduction to Computational Modeling of Cardiac Electrophysiology and Arrhythmogenicity

scientific article published on 01 January 2018

An introduction to MATLAB

scientific article published on 13 September 2011

An introduction to dynamical systems

scientific article published on 13 September 2011

Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes

scientific article published on 23 August 2016

Bistability in biochemical signaling models

scientific article

Building Containerized Workflows Using the BioDepot-Workflow-Builder

scientific article published on 11 September 2019

Ca Cycling Impairment in Heart Failure Is Exacerbated by Fibrosis: Insights Gained From Mechanistic Simulations

scientific article published on 23 August 2018

Ca2+ sparks in heart muscle.

scientific article

Calcium biology of the transverse tubules in heart

scientific article

Calcium homeostasis in a local/global whole cell model of permeabilized ventricular myocytes with a Langevin description of stochastic calcium release.

scientific article

Complex and rate-dependent beat-to-beat variations in Ca2+ transients of canine Purkinje cells

scientific article

Comprehensive analyses of ventricular myocyte models identify targets exhibiting favorable rate dependence

scientific article (publication date: March 2014)

Computational modeling of the cell cycle

scientific article published on 20 September 2011

Computer simulation of voltage sensitive calcium ion channels in a dendritic spine

scientific article published on 30 August 2013

Cross-regulation of Phosphodiesterase 1 and Phosphodiesterase 2 Activities Controls Dopamine-mediated Striatal α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Trafficking

scientific article

Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes

scientific article

Decoding myocardial Ca²⁺ signals across multiple spatial scales: a role for sensitivity analysis

scientific article published on 28 September 2012

Differential roles of two delayed rectifier potassium currents in regulation of ventricular action potential duration and arrhythmia susceptibility.

scientific article published on 24 October 2016

Does the Goldilocks Principle apply to calcium release restitution in heart cells?

scientific article published on 28 October 2011

Dynamic local changes in sarcoplasmic reticulum calcium: physiological and pathophysiological roles

scientific article published on 13 July 2011

Dynamics of calcium sparks and calcium leak in the heart

scientific article

Excitation-contraction coupling gain in ventricular myocytes: insights from a parsimonious model

scientific article

Experimental and Computational Insight Into Human Mesenchymal Stem Cell Paracrine Signaling and Heterocellular Coupling Effects on Cardiac Contractility and Arrhythmogenicity.

scientific article published on 22 June 2017

Exploiting mathematical models to illuminate electrophysiological variability between individuals

scientific article

Expression of a sorcin missense mutation in the heart modulates excitation-contraction coupling

scientific article

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy

scientific article published on 10 November 2019

Getting heart cells on the same wavelength: infrared triggering of Ca2+ transients in cardiac myocytes ⬇️

scientific article published on March 2011

Holistic optimization of an RNA-seq workflow for multi-threaded environments

scientific article published on 01 October 2019

Human Mesenchymal Stem Cell Paracrine Signaling Counteracts Heterocellular Coupling Effects on Cardiac Contractility and Arrhythomgenicity

Hypertrophic phenotype in cardiac cell assemblies solely by structural cues and ensuing self-organization ⬇️

scientific article

I love it when a plan comes together: Insight gained through convergence of competing mathematical models.

scientific article published on 29 November 2016

Identification and purification of human induced pluripotent stem cell-derived atrial-like cardiomyocytes based on sarcolipin expression

scientific article

Identification of novel prognostic indicators for triple-negative breast cancer patients through integrative analysis of cancer genomics data and protein interactome data.

scientific article

Improving cardiomyocyte model fidelity and utility via dynamic electrophysiology protocols and optimization algorithms

scientific article published on 11 December 2015

Induction of autoimmune response to the extracellular loop of the HERG channel pore induces QTc prolongation in guinea-pigs.

scientific article published on 14 June 2016

Inquiry learning. Integrating content detail and critical reasoning by peer review

scientific article

Investigational treatments for COVID-19 may increase ventricular arrhythmia risk through drug interactions

scientific article published on 26 May 2020

Investigational treatments for COVID-19 may increase ventricular arrhythmia risk through drug interactions

scientific article published on 17 November 2020

Keeping the beat: life without SERCA--is it possible?

scientific article

Local Ca(2+) signaling and EC coupling in heart: Ca(2+) sparks and the regulation of the [Ca(2+)](i) transient

scientific article

Local recovery of Ca2+ release in rat ventricular myocytes

scientific article published on 7 April 2005

Mathematical model of the neonatal mouse ventricular action potential

scientific article

Maximal acceleration of Ca2+ release refractoriness by β-adrenergic stimulation requires dual activation of kinases PKA and CaMKII in mouse ventricular myocytes

scientific article published on 7 October 2014

Mechanistic Systems Modeling to Improve Understanding and Prediction of Cardiotoxicity Caused by Targeted Cancer Therapeutics.

scientific article published on 8 September 2017

Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes

scientific article

Models of cardiac excitation-contraction coupling in ventricular myocytes

scientific article published on 25 March 2010

Moment closure for local control models of calcium-induced calcium release in cardiac myocytes

scientific article published on 16 May 2008

Multifaceted roles of miR-1s in repressing the fetal gene program in the heart

scientific article

Mutations in a helix-1 motif of the ATP synthase c-subunit of Bacillus pseudofirmus OF4 cause functional deficits and changes in the c-ring stability and mobility on sodium dodecyl sulfate-polyacrylamide gel electrophoresis

scientific article

Na+ channel function, regulation, structure, trafficking and sequestration

scientific article

Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-κB pathway

scientific article

New insights into the structure and function of couplons

scientific article published on 01 August 2008

Novel approach to real-time flash photolysis and confocal [Ca2+] imaging

scientific article

Orphaned ryanodine receptors in the failing heart.

scholarly article

Parameter sensitivity analysis in electrophysiological models using multivariable regression

scientific article published on February 2009

Parameter sensitivity analysis of stochastic models provides insights into cardiac calcium sparks.

scientific article published on March 2013

Pathogenesis of the Novel Autoimmune-Associated Long-QT Syndrome

scientific article

Pharmacometrics and Systems Pharmacology 2030

scientific article published on 23 November 2019

Photochemical gating of intracellular Ca2+ release channels

scientific article

Physiologic gating properties of unitary cardiac L-type Ca2+ channels

scientific article

Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion

scientific article published on 14 October 2021

Population-based mechanistic modeling allows for quantitative predictions of drug responses across cell types.

scientific article published on 24 February 2018

Predicting local SR Ca(2+) dynamics during Ca(2+) wave propagation in ventricular myocytes.

scientific article

Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity

publication published on 20 January 2022

Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis

scientific article

Quantitative analysis of variability in an integrated model of human ventricular electrophysiology and β-adrenergic signaling

scientific article published on 21 April 2020

Recovery of cardiac calcium release is controlled by sarcoplasmic reticulum refilling and ryanodine receptor sensitivity

scientific article

Regression Analysis for Constraining Free Parameters in Electrophysiological Models of Cardiac Cells ⬇️

scientific article published on September 2, 2010

Regression methods for parameter sensitivity analysis: applications to cardiac arrhythmia mechanisms

scientific article published in January 2011

Restitution of Ca(2+) release and vulnerability to arrhythmias

scientific article

Slow Delayed Rectifier Current Protects Ventricular Myocytes From Arrhythmic Dynamics Across Multiple Species

scientific article published on 01 October 2018

Spontaneous Ca2+ sparks and Ca2+ homeostasis in a minimal model of permeabilized ventricular myocytes ⬇️

scientific article published on September 17, 2010

Stochastic simulation of cardiac ventricular myocyte calcium dynamics and waves

scientific article published on January 2011

Systems biology--biomedical modeling

scientific article published on 06 September 2011

Teaching resources. Using web-based discussion forums as a model of the peer-review process and a tool for assessment

scientific article published on January 2008

Termination of cardiac Ca(2+) sparks: an investigative mathematical model of calcium-induced calcium release

scientific article

The Ca 2+ leak paradox and rogue ryanodine receptors: SR Ca 2+ efflux theory and practice

scientific article

The Contribution of Ionic Currents to Rate-Dependent Action Potential Duration and Pattern of Reentry in a Mathematical Model of Human Atrial Fibrillation.

scientific article

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

scientific article published on 24 November 2017

The challenge of molecular medicine: complexity versus Occam's razor

scientific article

The role of β-adrenergic system remodeling in human heart failure: A mechanistic investigation

scientific article published on 13 December 2020

The ryanodine receptor patchwork: knitting calcium spark dynamics

scientific article

There and back again: Iterating between population-based modeling and experiments reveals surprising regulation of calcium transients in rat cardiac myocytes.

scientific article published on 30 July 2015

Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity

scientific article published on 23 September 2020

Twenty years of calcium imaging: cell physiology to dye for.

scientific article

Unique properties of the ATP-sensitive K⁺ channel in the mouse ventricular cardiac conduction system

scientific article published on 9 October 2011

Yoga for the sinoatrial node: sarcoplasmic reticulum calcium release confers flexibility.

scientific article published on 28 April 2013

beta-Adrenergic receptor activation induces internalization of cardiac Cav1.2 channel complexes through a beta-arrestin 1-mediated pathway

scientific article published on 5 May 2008

List of works by Eric A Sobie

A Comparison of mRNA Sequencing with Random Primed and 3'-Directed Libraries.

A distinct molecular mechanism by which phenytoin rescues a novel long QT 3 variant

A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals

A network medicine approach to build a comprehensive atlas for the prognosis of human cancer.

A privileged role for neuronal Na+ channels in regulating ventricular [Ca2+] and arrhythmias

A probability density approach to modeling local control of calcium-induced calcium release in cardiac myocytes

Allosteric activation of Na+-Ca2+ exchange by L-type Ca2+ current augments the trigger flux for SR Ca2+ release in ventricular myocytes

Ambiguous interactions between diastolic and SR Ca2+ in the regulation of cardiac Ca2+ release.

An Introduction to Computational Modeling of Cardiac Electrophysiology and Arrhythmogenicity

An introduction to MATLAB

An introduction to dynamical systems

Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes

Bistability in biochemical signaling models

Building Containerized Workflows Using the BioDepot-Workflow-Builder

Ca Cycling Impairment in Heart Failure Is Exacerbated by Fibrosis: Insights Gained From Mechanistic Simulations

Ca2+ sparks in heart muscle.

Calcium biology of the transverse tubules in heart

Calcium homeostasis in a local/global whole cell model of permeabilized ventricular myocytes with a Langevin description of stochastic calcium release.

Complex and rate-dependent beat-to-beat variations in Ca2+ transients of canine Purkinje cells

Comprehensive analyses of ventricular myocyte models identify targets exhibiting favorable rate dependence

Computational modeling of the cell cycle

Computer simulation of voltage sensitive calcium ion channels in a dendritic spine

Cross-regulation of Phosphodiesterase 1 and Phosphodiesterase 2 Activities Controls Dopamine-mediated Striatal α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Trafficking

Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes

Decoding myocardial Ca²⁺ signals across multiple spatial scales: a role for sensitivity analysis

Differential roles of two delayed rectifier potassium currents in regulation of ventricular action potential duration and arrhythmia susceptibility.

Does the Goldilocks Principle apply to calcium release restitution in heart cells?

Dynamic local changes in sarcoplasmic reticulum calcium: physiological and pathophysiological roles

Dynamics of calcium sparks and calcium leak in the heart

Excitation-contraction coupling gain in ventricular myocytes: insights from a parsimonious model

Experimental and Computational Insight Into Human Mesenchymal Stem Cell Paracrine Signaling and Heterocellular Coupling Effects on Cardiac Contractility and Arrhythmogenicity.

Exploiting mathematical models to illuminate electrophysiological variability between individuals

Expression of a sorcin missense mutation in the heart modulates excitation-contraction coupling

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy

Getting heart cells on the same wavelength: infrared triggering of Ca2+ transients in cardiac myocytes ⬇️

Holistic optimization of an RNA-seq workflow for multi-threaded environments

Human Mesenchymal Stem Cell Paracrine Signaling Counteracts Heterocellular Coupling Effects on Cardiac Contractility and Arrhythomgenicity

Hypertrophic phenotype in cardiac cell assemblies solely by structural cues and ensuing self-organization ⬇️

I love it when a plan comes together: Insight gained through convergence of competing mathematical models.

Identification and purification of human induced pluripotent stem cell-derived atrial-like cardiomyocytes based on sarcolipin expression

Identification of novel prognostic indicators for triple-negative breast cancer patients through integrative analysis of cancer genomics data and protein interactome data.

Improving cardiomyocyte model fidelity and utility via dynamic electrophysiology protocols and optimization algorithms

Induction of autoimmune response to the extracellular loop of the HERG channel pore induces QTc prolongation in guinea-pigs.

Inquiry learning. Integrating content detail and critical reasoning by peer review

Investigational treatments for COVID-19 may increase ventricular arrhythmia risk through drug interactions

Investigational treatments for COVID-19 may increase ventricular arrhythmia risk through drug interactions

Keeping the beat: life without SERCA--is it possible?

Local Ca(2+) signaling and EC coupling in heart: Ca(2+) sparks and the regulation of the [Ca(2+)](i) transient

Local recovery of Ca2+ release in rat ventricular myocytes

Mathematical model of the neonatal mouse ventricular action potential

Maximal acceleration of Ca2+ release refractoriness by β-adrenergic stimulation requires dual activation of kinases PKA and CaMKII in mouse ventricular myocytes

Mechanistic Systems Modeling to Improve Understanding and Prediction of Cardiotoxicity Caused by Targeted Cancer Therapeutics.

Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes

Models of cardiac excitation-contraction coupling in ventricular myocytes

Moment closure for local control models of calcium-induced calcium release in cardiac myocytes

Multifaceted roles of miR-1s in repressing the fetal gene program in the heart

Mutations in a helix-1 motif of the ATP synthase c-subunit of Bacillus pseudofirmus OF4 cause functional deficits and changes in the c-ring stability and mobility on sodium dodecyl sulfate-polyacrylamide gel electrophoresis

Na+ channel function, regulation, structure, trafficking and sequestration

Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-κB pathway

New insights into the structure and function of couplons

Novel approach to real-time flash photolysis and confocal [Ca2+] imaging

Orphaned ryanodine receptors in the failing heart.

Parameter sensitivity analysis in electrophysiological models using multivariable regression

Parameter sensitivity analysis of stochastic models provides insights into cardiac calcium sparks.

Pathogenesis of the Novel Autoimmune-Associated Long-QT Syndrome

Pharmacometrics and Systems Pharmacology 2030

Photochemical gating of intracellular Ca2+ release channels

Physiologic gating properties of unitary cardiac L-type Ca2+ channels

Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion

Population-based mechanistic modeling allows for quantitative predictions of drug responses across cell types.

Predicting local SR Ca(2+) dynamics during Ca(2+) wave propagation in ventricular myocytes.

Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity

Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis

Quantitative analysis of variability in an integrated model of human ventricular electrophysiology and β-adrenergic signaling

Recovery of cardiac calcium release is controlled by sarcoplasmic reticulum refilling and ryanodine receptor sensitivity

Regression Analysis for Constraining Free Parameters in Electrophysiological Models of Cardiac Cells ⬇️

Regression methods for parameter sensitivity analysis: applications to cardiac arrhythmia mechanisms

Restitution of Ca(2+) release and vulnerability to arrhythmias

Slow Delayed Rectifier Current Protects Ventricular Myocytes From Arrhythmic Dynamics Across Multiple Species