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List of works by Richard F Loeser

A Comprehensive Histological Assessment of Osteoarthritis Lesions in Mice

scientific article

A comprehensive 3-year internal medicine residency research curriculum.

scientific article

A consensus-based framework for conducting and reporting osteoarthritis phenotype research

scientific article published on 20 March 2020

A machine learning approach to knee osteoarthritis phenotyping: data from the FNIH Biomarkers Consortium

scientific article published on 16 April 2019

A mouse model for chronic pain-induced increase in ethanol consumption

scientific article published on 30 November 2016

A precision medicine approach to develop and internally validate optimal exercise and weight loss treatments for overweight and obese adults with knee osteoarthritis

scientific article published on 07 March 2020

Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span

scientific article published on 24 March 2005

Age-related changes in the musculoskeletal system and the development of osteoarthritis

scientific article

Ageing and the pathogenesis of osteoarthritis.

scientific article published on 19 May 2016

Aging and osteoarthritis

scientific article

Aging and oxidative stress reduce the response of human articular chondrocytes to insulin-like growth factor 1 and osteogenic protein 1.

scientific article

Aging cartilage and osteoarthritis--what's the link?

scientific article published on 21 July 2004

Aging or osteoarthritis: which is the problem? ⬇️

scientific article published on November 1, 2003

Aging processes and the development of osteoarthritis ⬇️

scientific article published on January 1, 2013

Alterations in quadriceps muscle cellular and molecular properties in adults with moderate knee osteoarthritis

scientific article published on 23 May 2018

Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation

scientific article published on 27 February 2020

Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis

scientific article published on August 2005

Articular chondrocytes isolated from the knee and ankle joints of human tissue donors demonstrate similar redox-regulated MAP kinase and Akt signaling

scientific article published on 24 December 2018

Association of urinary metabolites with radiographic progression of knee osteoarthritis in overweight and obese adults: an exploratory study

scientific article

Basic fibroblast growth factor inhibits the anabolic activity of insulin-like growth factor 1 and osteogenic protein 1 in adult human articular chondrocytes

scientific article

Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes

scientific article

Biochemical markers of cartilage metabolism are associated with walking biomechanics 6-months following anterior cruciate ligament reconstruction

scientific article published on 2 February 2017

Biology and pathology of Rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes.

scientific article published on June 2010

Brief report: stress-inducible nuclear protein 1 regulates matrix metalloproteinase 13 expression in human articular chondrocytes

scientific article

Cell death in osteoarthritis

scientific article published on January 2008

Chondrocyte cell death mediated by reactive oxygen species-dependent activation of PKC-betaI.

scientific article

Cost-effectiveness of exercise and diet in overweight and obese adults with knee osteoarthritis

scientific article published on 01 June 2009

Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated With Fibronectin Fragments.

scientific article published on 28 August 2015

Deletion of c-Jun N-terminal Kinase Enhances Senescence in Joint Tissues and Increases the Severity of Age-Related Osteoarthritis in Mice

scientific article published on 17 May 2020

Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1.

scientific article published in September 2002

Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial

scientific article published in April 2004

Differential peroxiredoxin hyperoxidation regulates MAP kinase signaling in human articular chondrocytes

scientific article published on 09 January 2019

Disease progression and phasic changes in gene expression in a mouse model of osteoarthritis

scientific article

Does Joint Injury Make Young Joints Old?

scientific article published on 01 November 2018

Does high weight loss in older adults with knee osteoarthritis affect bone-on-bone joint loads and muscle forces during walking?

scientific article

Editorial: inflammatory activity in symptomatic knee osteoarthritis: not all inflammation is local

scientific article published on 5 August 2015

Effect of an exercise and dietary intervention on serum biomarkers in overweight and obese adults with osteoarthritis of the knee

scientific article published on 24 March 2008

Effect of intensive diet and exercise on self-efficacy in overweight and obese adults with knee osteoarthritis: The IDEA randomized clinical trial.

scientific article

Effects of aging on articular cartilage homeostasis

scientific article

Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints.

scientific article published in December 2006

Effects of dietary weight loss with and without exercise on interstitial matrix turnover and tissue inflammation biomarkers in adults with knee osteoarthritis: the Intensive Diet and Exercise for Arthritis trial (IDEA).

scientific article

Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial

scientific article published on September 2013

Effects of long-term estrogen replacement therapy on articular cartilage IGFBP-2, IGFBP-3, collagen and proteoglycan levels in ovariectomized cynomolgus monkeys

scientific article published on 01 February 2004

Effects of long-term estrogen replacement therapy on osteoarthritis severity in cynomolgus monkeys

scientific article published on 01 July 2002

Effects of total and regional fat loss on plasma CRP and IL-6 in overweight and obese, older adults with knee osteoarthritis

scientific article

Endogenous production of reactive oxygen species is required for stimulation of human articular chondrocyte matrix metalloproteinase production by fibronectin fragments

scientific article published on 24 January 2007

Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial

scientific article

Exercise and weight loss in obese older adults with knee osteoarthritis: a preliminary study

scientific article published in September 2000

Expression of p16INK 4a is a biomarker of chondrocyte aging but does not cause osteoarthritis

scientific article published on 09 May 2018

Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes ⬇️

scientific article published on January 30, 2012

Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway

scientific article

Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes

scientific article published in September 2002

Functional integrin subunits regulating cell-matrix interactions in the intervertebral disc

scientific article published in June 2007

Glucosamine/chondroitin combined with exercise for the treatment of knee osteoarthritis: a preliminary study

scientific article published on 11 June 2007

H2O2 oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes

scientific article published on 06 September 2018

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is increased in osteoarthritis and regulates chondrocyte catabolic and anabolic activities

scientific article published on 29 April 2015

High fat-diet and saturated fatty acid palmitate inhibits IGF-1 function in chondrocytes

scientific article published on 22 May 2017

Histopathology of naturally occurring and surgically induced osteoarthritis in mice ⬇️

scientific article published on May 14, 2012

Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13.

scientific article published on 20 February 2008

IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK.

scientific article published on August 2005

Impact of Diet and/or Exercise Intervention on Infrapatellar Fat Pad Morphology: Secondary Analysis from the Intensive Diet and Exercise for Arthritis (IDEA) Trial

scientific article published on 22 February 2017

Impaired Annulus Fibrosus Development and Vertebral Fusion Cause Severe Scoliosis in Mice with Deficiency of c-Jun NH2-Terminal Kinases 1 and 2

scientific article published on 19 January 2019

Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products.

scientific article

Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis

scientific article published on February 2009

Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes in response to catabolic stimuli

scientific article

Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels

scientific article published in December 2003

Inflammatory biomarkers and physical function in older, obese adults with knee pain and self-reported osteoarthritis after intensive weight-loss therapy

scientific article

Inflammatory cytokines mediate the effects of diet and exercise on pain and function in knee osteoarthritis independent of BMI

scientific article published on 20 April 2019

Influences of alignment and obesity on knee joint loading in osteoarthritic gait

scientific article

Inhibitory Effects of Insulin-like Growth Factor-1 and Osteogenic Protein-1 on Fibronectin Fragment- and Interleukin-1β-stimulated Matrix Metalloproteinase-13 Expression in Human Chondrocytes ⬇️

scientific article published on May 6, 2003

Integration of gene expression data with network-based analysis to identify signaling and metabolic pathways regulated during the development of osteoarthritis

scientific article

Integrin-mediated adhesion of human articular chondrocytes to cartilage

scientific article published in January 2003

Integrins and cell signaling in chondrocytes.

scientific article

Integrins and chondrocyte-matrix interactions in articular cartilage

scientific article

Intensive weight loss program improves physical function in older obese adults with knee osteoarthritis

scientific article published in July 2006

Intentional Weight Loss in Overweight and Obese Patients With Knee Osteoarthritis: Is More Better?

scientific article published on 01 November 2018

Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes

scientific article published on March 2009

Ionizing radiation causes active degradation and reduces matrix synthesis in articular cartilage ⬇️

scientific article published on December 12, 2012

Is osteoarthritis one disease or a collection of many?

scientific article published on 15 December 2017

Is serum leptin related to physical function and is it modifiable through weight loss and exercise in older adults with knee osteoarthritis?

scientific article published on 01 November 2004

Knee joint loading in knee osteoarthritis: influence of abdominal and thigh fat.

scientific article

Magnetic resonance imaging of the craniovertebral junction in rheumatoid arthritis.

scientific article published in September 1988

Mechanisms and therapeutic implications of cellular senescence in osteoarthritis

scientific article published on 18 November 2020

Methylation of the OP-1 promoter: potential role in the age-related decline in OP-1 expression in cartilage

scientific article published on 30 September 2008

Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice

scientific article published on March 2012

Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice.

scientific article published on 11 October 2010

Mitogen-activated protein kinases as therapeutic targets in osteoarthritis

scientific article published on September 2008

Modifiers of change in physical functioning in older adults with knee pain: the Observational Arthritis Study in Seniors (OASIS)

scientific article published on 01 August 2001

Molecular mechanisms of cartilage destruction: mechanics, inflammatory mediators, and aging collide

scientific article published in May 2006

NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments

scientific article

Naturally occurring osteoarthritis in male mice with an extended lifespan

scientific article published on 18 September 2019

Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species

scientific article published in February 2002

Osteoarthritic changes in vervet monkey knees correlate with meniscus degradation and increased matrix metalloproteinase and cytokine secretion

scientific article

Osteoarthritis

scientific article published on 01 September 2004

Osteoarthritis in cynomolgus macaques II. Detection of modulated proteoglycan epitopes in cartilage and synovial fluid

Osteoarthritis induced by destabilization of the medial meniscus is reduced in germ-free mice

scientific article published on 30 May 2018

Osteoarthritis of the knee: effects on gait, strength, and flexibility

scientific article published on 01 January 1992

Osteoarthritis: a disease of the joint as an organ

scientific article

Overexpression of Peroxiredoxin 3 in Cartilage Reduces the Severity of Age-Related Osteoarthritis But Not Surgically Induced Osteoarthritis in Mice

publication published on 22 February 2022

Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes.

scientific article published on 21 January 2016

Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways

scientific article

Phenotypes of osteoarthritis: current state and future implications

scientific article published on 01 September 2019

Pro-inflammatory stimulation of meniscus cells increases production of matrix metalloproteinases and additional catabolic factors involved in osteoarthritis pathogenesis

scientific article published on 04 December 2013

Prolonged treatment of human osteoarthritic chondrocytes with insulin-like growth factor-I stimulates proteoglycan synthesis but not proteoglycan matrix accumulation in alginate cultures.

scientific article

Rac1 Is Required for Matrix Metalloproteinase 13 Production by Chondrocytes in Response to Fibronectin Fragments ⬇️

scientific article published on June 1, 2013

Reactive oxygen species, aging and articular cartilage homeostasis

scientific article published on 31 August 2018

Redox regulation of Rac1 by thiol oxidation.

scientific article

Reduced Osteoarthritis Severity in Aged Mice With Deletion of Macrophage Migration Inhibitory Factor

scientific article published on 26 August 2016

Reduced response of human meniscal cells to Osteogenic Protein 1 during osteoarthritis and pro-inflammatory stimulation.

scientific article published on 08 January 2016

Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease

scientific article published on 01 September 2000

Regulation of chondrocyte gene expression by osteogenic protein-1 ⬇️

scientific article published on March 29, 2011

Relationship between Thigh Fat Depots and Knee Joint Loads in Knee Osteoarthritis: A Preliminary Study

article by Stephen P. Messier et al published May 2010 in Medicine and Science in Sports and Exercise

Relationship of Objectively-Measured Habitual Physical Activity to Chronic Inflammation and Fatigue in Middle-Aged and Older Adults

scientific article published on 5 July 2016

Response to Berge et al.: Comment on the Importance of S100A4 in Regulation of MMP-13.

scientific article

Role of the Hypoxia-Inducible Factor Pathway in Normal and Osteoarthritic Meniscus and in Mice after Destabilization of the Medial Meniscus

scientific article published on 17 September 2020

Strength Training for Arthritis Trial (START): design and rationale

scientific article

Sufficient vitamin K status combined with sufficient vitamin D status is associated with better lower extremity function: a prospective analysis of two knee osteoarthritis cohorts

scientific article

Sumoylation and Nuclear Translocation of S100A4 Regulate IL-1β-mediated Production of Matrix Metalloproteinase-13 ⬇️

scientific article published on August 4, 2010

Systemic and local regulation of articular cartilage metabolism: Where does leptin fit in the puzzle? ⬇️

scientific article published on 01 November 2003

TGF-β type 2 receptor-mediated modulation of the IL-36 family can be therapeutically targeted in osteoarthritis

scientific article published on 01 May 2019

Targeting aging for disease modification in osteoarthritis

scientific article

The ?5?1 integrin provides matrix survival signals for normal and osteoarthritic human articular chondrocytes in vitro

scientific article (publication date: June 2002)

The Arthritis, Diet and Activity Promotion Trial (ADAPT): design, rationale, and baseline results

scientific article

The Intensive Diet and Exercise for Arthritis (IDEA) trial: 18-month radiographic and MRI outcomes

scientific article published on 15 April 2015

The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale

scientific article

The OMERACT-OARSI Core Domain Set for Measurement in Clinical Trials of Hip and/or Knee Osteoarthritis ⬇️

The Role of Aging in the Development of Osteoarthritis

scientific article published on January 2017

The association between vitamin K status and knee osteoarthritis features in older adults: the Health, Aging and Body Composition Study

scientific article

The combination of insulin-like growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human articular chondrocytes

scientific article published in August 2003

The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence

scientific article published on 20 November 2020

The effect of weight loss on the progression of meniscal extrusion and size in knee osteoarthritis: a post-hoc analysis of the Intensive Diet and Exercise for Arthritis (IDEA) trial

scientific article published on 31 January 2020

The effects of aging on the development of osteoarthritis

scientific article published on 23 December 2011

The effects of intensive dietary weight loss and exercise on gait in overweight and obese adults with knee osteoarthritis. The Intensive Diet and Exercise for Arthritis (IDEA) trial

scientific article published on 31 October 2019

The independent and combined effects of intensive weight loss and exercise training on bone mineral density in overweight and obese older adults with osteoarthritis.

scientific article

Therapeutic exercise for rheumatoid arthritis and osteoarthritis

scientific article published on August 1990

Time between anterior cruciate ligament injury and reconstruction and cartilage metabolism six-months following reconstruction.

scientific article published on 7 March 2018

Toward optimal health: the experts discuss osteoarthritis in women [interviewed by Jodi Godfrey Meisler].

scientific article published in November 2002

Transcriptional response of human articular chondrocytes treated with fibronectin fragments: an in vitro model of the osteoarthritis phenotype

scientific article published on 25 November 2020

Uptake of the OMERACT-OARSI Hip and Knee Osteoarthritis Core Outcome Set: Review of Randomized Controlled Trials from 1997 to 2017

scientific article published on 01 March 2019

VITAMIN K ANTAGONISM AND CHONDROCALCINOSIS IN THE OSTEOARTHRITIS INITIATIVE

scientific article published on 8 November 2019

Vitamin K Status and Lower Extremity Function in Older Adults: The Health Aging and Body Composition Study

scientific article

Vitamin K Status and Mobility Limitation and Disability in Older Adults: The Health, Aging, and Body Composition Study

scientific article published on 01 March 2020

Weight-loss and exercise for communities with arthritis in North Carolina (we-can): design and rationale of a pragmatic, assessor-blinded, randomized controlled trial

scientific article

Why is osteoarthritis an age-related disease?

scientific article

Wnt5a induces catabolic signaling and matrix metalloproteinase production in human articular chondrocytes

scientific article

p38gamma mitogen-activated protein kinase suppresses chondrocyte production of MMP-13 in response to catabolic stimulation

scientific article

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