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List of works by Alfred H Schinkel

A Critical Analysis of the Interplay between Cytochrome P450 3A and P-Glycoprotein: Recent Insights from Knockout and Transgenic Mice ⬇️

scientific article published on April 13, 2011

ABCC2, ABCC3, and ABCB1, but not CYP3A, Protect against Trabectedin-Mediated Hepatotoxicity

scientific article

Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity

scientific article published on 17 November 2009

Apical ABC transporters and cancer chemotherapeutic drug disposition.

scientific article

Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment

scientific article published on 10 March 2009

Brain accumulation of the EML4-ALK inhibitor ceritinib is restricted by P-glycoprotein (P-GP/ABCB1) and breast cancer resistance protein (BCRP/ABCG2).

scientific article published on 8 September 2015

Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1) restrict oral availability and brain accumulation of the PARP inhibitor rucaparib (AG-014699).

scientific article

Breast cancer resistance protein (Bcrp1/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin B1, IQ and Trp-P-1 but also mediates their secretion into breast milk

scientific article published on 6 July 2005

Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation

scientific article published on 26 January 2010

Combined quantification of paclitaxel, docetaxel and ritonavir in human feces and urine using LC-MS/MS.

scientific article

Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver

scientific article

Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2.

scientific article

Contribution of the ABC transporters Bcrp1 and Mdr1a/1b to the side population phenotype in mammary gland and bone marrow of mice

scientific article published on 7 July 2005

Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations

scientific article

Differential Impact of P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) on Axitinib Brain Accumulation and Oral Plasma Pharmacokinetics ⬇️

scientific article published on January 31, 2011

Double-Transduced MDCKII Cells To Study Human P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Interplay in Drug Transport across the Blood−Brain Barrier ⬇️

scientific article published on March 4, 2011

Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes

scientific article

Extrahepatic metabolism of ibrutinib

scientific article published on 04 July 2020

Functions of OATP1A and 1B transporters in vivo: insights from mouse models ⬇️

scientific article published on November 28, 2011

Genetically modified mouse models for oral drug absorption and disposition

scientific article published on 08 September 2013

Hepatic clearance of reactive glucuronide metabolites of diclofenac in the mouse is dependent on multiple ATP-binding cassette efflux transporters

scientific article published on 19 January 2010

Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b.

scientific article published on 7 May 2015

How important is intestinal cytochrome P450 3A metabolism?

scientific article published on 28 March 2009

Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam

scientific article published on 14 September 2009

Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver

scientific journal article

Investigation of efflux transport of dehydroepiandrosterone sulfate and mitoxantrone at the mouse blood-brain barrier: a minor role of breast cancer resistance protein

scientific article

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism

scientific article

Liquid chromatography-tandem mass spectrometric assay for pravastatin and two isomeric metabolites in mouse plasma and tissue homogenates ⬇️

scientific article published on August 21, 2010

Liquid chromatography-tandem mass spectrometric assay for the light sensitive tyrosine kinase inhibitor axitinib in human plasma

scientific article published on 30 October 2009

Liquid chromatography-tandem mass spectrometric assay for the multikinase inhibitor regorafenib in plasma

scientific article

Liquid chromatography-tandem mass spectrometric assay for the tyrosine kinase inhibitor afatinib in mouse plasma using salting-out liquid-liquid extraction

scientific article published on 21 January 2016

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview.

scientific article

Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4.

scientific article published on 21 April 2005

Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes

scientific article published on 21 December 2007

Multidrug resistance and pharmacological protection mediated by the breast cancer resistance protein (BCRP/ABCG2).

scientific article

Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk

scientific article published on 4 December 2006

OATP1A/1B, CYP3A, ABCB1, and ABCG2 limit oral availability of NTRK inhibitor larotrectinib, while ABCB1 and ABCG2 also restrict its brain accumulation

scientific article published on 22 February 2020

Ochratoxin A transport by the human breast cancer resistance protein (BCRP), multidrug resistance protein 2 (MRP2), and organic anion-transporting polypeptides 1A2, 1B1 and 2B1.

scientific article published on 19 May 2017

Oral availability and brain penetration of the B-RAFV600E inhibitor vemurafenib can be enhanced by the P-GLYCOprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar

scientific article

Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors

scientific article

Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions

scientific article

P glycoprotein in human immunodeficiency virus type 1 infection and therapy

scientific article published on April 2004

P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict brain accumulation of the active sunitinib metabolite N-desethyl sunitinib

scientific article published on 11 January 2012

P-glycoprotein (MDR1/ABCB1) controls brain accumulation and intestinal disposition of the novel TGF-β signaling pathway inhibitor galunisertib

scientific article published on 15 July 2019

P-glycoprotein (MDR1/ABCB1) restricts brain accumulation and Cytochrome P450-3A (CYP3A) limits oral availability of the novel ALK/ROS1 inhibitor lorlatinib.

scientific article

P-glycoprotein Limits Ribociclib Brain Exposure and CYP3A4 Restricts Its Oral Bioavailability

scientific article published on 05 August 2019

P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin

scientific article published on 14 January 2008

P-glycoprotein, CYP3A, and plasma carboxylesterase determine brain and blood disposition of the mTOR Inhibitor everolimus (Afinitor) in mice.

scientific article published on 11 April 2014

PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide

scientific article

Pharmacokinetic assessment of multiple ATP-binding cassette transporters: the power of combination knockout mice

scientific article published on June 2009

Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3).

scientific article published on 23 October 2003

Physiological and pharmacological roles of ABCG2 (BCRP): recent findings in Abcg2 knockout mice

scientific article

Polymorphisms affecting function of the human organic cation transporter hOCT1 (SLC22A1)

scientific article (publication date: November 2002)

Polymorphisms affecting function of the human organic cation transporter hOCT1 (SLC22A1): what are the consequences?

scientific article (publication date: November 2002)

Recent advances in molecular pharmacology of the histamine systems: organic cation transporters as a histamine transporter and histamine metabolism

scientific journal article

Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse

scientific article

Role of breast cancer resistance protein (Bcrp1/Abcg2) in the extrusion of glucuronide and sulfate conjugates from enterocytes to intestinal lumen

scientific journal article

Sex-dependent expression and activity of the ATP-binding cassette transporter breast cancer resistance protein (BCRP/ABCG2) in liver

scientific article

Targeted disruption of organic cation transporter 3 (Oct3) ameliorates ischemic brain damage through modulating histamine and regulatory T cells.

scientific article

The breast cancer resistance protein (BCRP/ABCG2) affects pharmacokinetics, hepatobiliary excretion, and milk secretion of the antibiotic nitrofurantoin.

scientific article published on 11 February 2005

The breast cancer resistance protein (Bcrp1/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

scientific article published on October 2003

The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk.

scientific article

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.

scientific article

The function of breast cancer resistance protein in epithelial barriers, stem cells and milk secretion of drugs and xenotoxins

scientific article

Transport of biogenic amine neurotransmitters at the mouse blood-retina and blood-brain barriers by uptake1 and uptake2

scientific article

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