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List of works by Wadih Arap

A Hybrid Vector for Ligand-Directed Tumor Targeting and Molecular Imaging

scientific article published on 01 April 2006

A complex of α6 integrin and E-cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6

scientific article

A heterotypic bystander effect for tumor cell killing after adeno-associated virus/phage-mediated, vascular-targeted suicide gene transfer

scientific article

A ligand motif enables differential vascular targeting of endothelial junctions between brain and retina

scientific article published on 22 January 2019

A ligand peptide motif selected from a cancer patient is a receptor-interacting site within human interleukin-11.

scientific article

A multifunctional streptococcal collagen-mimetic protein coating prevents bacterial adhesion and promotes osteoid formation on titanium

scientific article published on 13 April 2014

A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys

scientific article

A physical sciences network characterization of non-tumorigenic and metastatic cells

scientific article published on January 2013

A population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networks

scientific article published on 25 October 2007

A preclinical model for predicting drug response in soft-tissue sarcoma with targeted AAVP molecular imaging

scholarly article

A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications

scientific article

A subset of host B lymphocytes controls melanoma metastasis through a melanoma cell adhesion molecule/MUC18-dependent interaction: evidence from mice and humans

scientific article

A total transcriptome profiling method for plasma-derived extracellular vesicles: applications for liquid biopsies.

scientific article

AAVP displaying octreotide for ligand-directed therapeutic transgene delivery in neuroendocrine tumors of the pancreas

scientific article published on 16 February 2016

Abstract 5620: Novel phage display-derived neuroblastoma-targeting peptides potentiate the effect of drug nanocarriers in preclinical settings

Abstract LB-006: Receptor tyrosine kinase EphA5 is a functional molecular target in human lung cancer

Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V

scientific article (publication date: May 2003)

Aminopeptidase A is a functional target in angiogenic blood vessels

scientific article

Aminopeptidase N inhibitors and SARS ⬇️

scientific article published on May 3, 2003

Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis

scientific article

An AAVP-based solid-phase transducing matrix for transgene delivery: potential for translational applications.

scientific article published on 26 May 2017

An Artificially Designed Pore-forming Protein with Anti-tumor Effects ⬇️

scientific article published on May 14, 2003

An HSP90-mimic peptide revealed by fingerprinting the pool of antibodies from ovarian cancer patients

scientific article published in November 2004

An anti-angiogenic state in mice and humans with retinal photoreceptor cell degeneration

scientific article

An anti-ubiquitin antibody response in transitional cell carcinoma of the urinary bladder

scientific article

An antimicrobial peptidomimetic induces Mucorales cell death through mitochondria-mediated apoptosis

scientific article (publication date: 2013)

An antivascular vaccine to boost self-immunity and strike the tumor

scientific article published on 11 April 2017

An integrated approach for the rational design of nanovectors for biomedical imaging and therapy

scientific article

An unrecognized extracellular function for an intracellular adapter protein released from the cytoplasm into the tumor microenvironment.

scientific article

Angiogenesis with pericyte abnormalities in a transgenic model of prostate carcinoma

scientific article published on November 2005

Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions

Anti-cancer activity of targeted pro-apoptotic peptides

scientific article published on September 1999

Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice ⬇️

scientific article published on April 2, 2012

Antiangiogenic therapy decreases integrin expression in normalized tumor blood vessels

scientific article published in March 2006

Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor

scientific article

B-cell receptor epitope recognition correlates with the clinical course of chronic lymphocytic leukemia

scientific article

BCAM and LAMA5 Mediate the Recognition between Tumor Cells and the Endothelium in the Metastatic Spreading of KRAS Mutant Colorectal Cancer

scientific article published on 3 May 2016

BMTP-11 is active in preclinical models of human osteosarcoma and a candidate targeted drug for clinical translation

scientific article published on 11 July 2017

Bacteriophage Associated Silicon Particles: Design and Characterization of a Novel Theranostic Vector with Improved Payload Carrying Potential

scientific article published on October 2013

Beyond receptor expression levels: the relevance of target accessibility in ligand-directed pharmacodelivery systems

scientific article

Biobehavioral effects of Tai Chi Qigong in men with prostate cancer: Study design of a three-arm randomized clinical trial

scientific article published on 21 August 2019

Biopanning and rapid analysis of selective interactive ligands

scientific article

Bone marrow-derived CD13(+) cells sustain tumor progression: A potential non-malignant target for anticancer therapy

scientific article published on 16 January 2014

Bottom-up assembly of hydrogels from bacteriophage and Au nanoparticles: the effect of cis- and trans-acting factors

scientific article

Brain endothelial cell-targeted gene therapy of neurovascular disorders

scientific article published on 10 May 2016

CD13-positive bone marrow-derived myeloid cells promote angiogenesis, tumor growth, and metastasis

scientific article published on 02 December 2013

CD13/APN is activated by angiogenic signals and is essential for capillary tube formation

scientific article published on February 2001

CTHRSSVVC Peptide as a Possible Early Molecular Imaging Target for Atherosclerosis.

scientific article published on 24 August 2016

Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model ⬇️

scientific article published on January 16, 1998

Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands

scientific article published on 01 September 2004

Cell surface-associated Tat modulates HIV-1 infection and spreading through a specific interaction with gp120 viral envelope protein

scientific article

Ceramide launches an acute anti-adhesion pro-migration cell signaling program in response to chemotherapy

scientific article published on 20 April 2020

Ceramide-mediated apoptosis following ionizing radiation in human prostate cancer cells: PKCalpha joins the fray

scientific article

Chapter 4. Screening phage-display Peptide libraries for vascular targeted peptides

scientific article

Chemotherapy targeted to tumor vasculature.

scientific article published in November 1998

Combinatorial ligand-directed lung targeting

scientific article

Combinatorial screenings in patients: the interleukin-11 receptor alpha as a candidate target in the progression of human prostate cancer

scientific article (publication date: 15 January 2004)

Combinatorial targeting and discovery of ligand-receptors in organelles of mammalian cells

scientific article

Combinatorial targeting and nanotechnology applications

scientific article

Combinatorial targeting of the macropinocytotic pathway in leukemia and lymphoma cells

scientific article

Combinatorial vascular targeting in translational medicine ⬇️

scientific article published on March 24, 2010

Combined targeting of perivascular and endothelial tumor cells enhances anti-tumor efficacy of liposomal chemotherapy in neuroblastoma

scientific article published on 24 March 2010

Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment

scientific article published on 17 January 2012

Coronary microvascular pericytes are the cellular target of sunitinib malate-induced cardiotoxicity

scientific article published on May 2013

Correction: Poly (A)+Transcriptome Assessment of ERBB2-Induced Alterations in Breast Cell Lines

scientific article published in PLoS ONE

Cracking the code for compartment-specific dual functionality proteins in cancer: the case for CRKL

scientific article published on 09 January 2010

Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA.

scientific article

Design and construction of targeted AAVP vectors for mammalian cell transduction

scientific article published on 01 January 2007

Design and validation of a bifunctional ligand display system for receptor targeting

scientific article published on August 2004

Design, development, and validation of a high-throughput drug-screening assay for targeting of human leukemia

scientific article

Development of a ligand-directed approach to study the pathogenesis of invasive aspergillosis

scientific article

Differential binding of drugs containing the NGR motif to CD13 isoforms in tumor vessels, epithelia, and myeloid cells

scientific article published on 01 February 2002

Discovery and horizontal follow-up of an autoantibody signature in human prostate cancer

scientific article

Discovery of DNA Repair Inhibitors by Combinatorial Library Profiling ⬇️

scientific article published on February 22, 2011

Discovery of a functional protein complex of netrin-4, laminin gamma1 chain, and integrin alpha6beta1 in mouse neural stem cells

scholarly article

Display technologies: application for the discovery of drug and gene delivery agents

scientific article

Does the RAAS play a role in loss of taste and smell during COVID-19 infections?

scientific article published on 15 December 2020

Does the renin-angiotensin system participate in regulation of human vasculogenesis and angiogenesis?

scientific article

Drug design strategies for the treatment of prostate cancer

scientific article

Emerging Pharmacologic Targets in Cerebral Cavernous Malformation and Potential Strategies to Alter the Natural History of a Difficult Disease: A Review

scientific article published on 01 April 2019

Engineered embryonic endothelial progenitor cells as therapeutic Trojan horses

scientific article published in May 2004

Enhanced relative biological effectiveness of proton radiotherapy in tumor cells with internalized gold nanoparticles

scientific article published on 10 May 2011

Eph receptors as cancer targets for antibody-based therapy

scientific article published on 12 June 2020

Ethics guidelines for research with the recently dead

scientific article

Extracellular and intracellular mechanisms that mediate the metastatic activity of exogenous osteopontin

scientific article published on April 2009

Fingerprinting the circulating repertoire of antibodies from cancer patients

scientific article

From combinatorial peptide selection to drug prototype (I): targeting the vascular endothelial growth factor receptor pathway

scientific article

From combinatorial peptide selection to drug prototype (II): targeting the epidermal growth factor receptor pathway

scientific article

GRP78 signaling hub a receptor for targeted tumor therapy

scientific article published on January 2010

Genetic basis for in vivo daptomycin resistance in enterococci

scientific article

Going viral? Linking the etiology of human prostate cancer to the PCA3 long noncoding RNA and oncogenic viruses.

scientific article

Hybridoma-free generation of monoclonal antibodies

scholarly article

IFATS collection: Combinatorial peptides identify alpha5beta1 integrin as a receptor for the matricellular protein SPARC on adipose stromal cells

scientific article

Identification of novel immunoregulatory molecules in human thymic regulatory CD4+CD25+ T cells by phage display

scientific article

Identification of receptor ligands with phage display peptide libraries

scientific article

Impaired angiogenesis in aminopeptidase N-null mice

scholarly article

In Vivo Detection of Gold−Imidazole Self-Assembly Complexes: NIR-SERS Signal Reporters

scientific article published in 2006

In vivo phage display and vascular heterogeneity: implications for targeted medicine

scientific article

Inhibition of established micrometastases by targeted drug delivery via cell surface-associated GRP78.

scientific article

Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1.

scientific article

Innate Immunity Plays a Key Role in Controlling Viral Load in COVID-19: Mechanistic Insights from a Whole-Body Infection Dynamics Model

Innate immunity plays a key role in controlling viral load in COVID-19: mechanistic insights from a whole-body infection dynamics model

scientific article published on 05 November 2020

Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release

scientific article published on 2 February 2016

Integrin-binding peptides derived from phage display libraries.

scientific article

Interaction between Tumor Cell Surface Receptor RAGE and Proteinase 3 Mediates Prostate Cancer Metastasis to Bone

scientific article published on 20 April 2017

Interleukin-11 Receptor Is a Candidate Target for Ligand-Directed Therapy in Lung Cancer: Analysis of Clinical Samples and BMTP-11 Preclinical Activity

scientific article published on 15 June 2016

Intracellular targeting of annexin A2 inhibits tumor cell adhesion, migration, and in vivo grafting

scientific article published on 26 June 2017

Intravascular delivery of particulate systems: does geometry really matter?

scientific article

Is annexin 7 a tumor suppressor gene in prostate cancer?

scientific article published on 01 January 2001

Launching a novel preclinical infrastructure: comparative oncology trials consortium directed therapeutic targeting of TNFalpha to cancer vasculature

scientific article

Leveraging molecular heterogeneity of the vascular endothelium for targeted drug delivery and imaging

scientific article published on April 2010

Ligand-directed cancer gene therapy to angiogenic vasculature

scientific article published on January 2009

Ligand-directed profiling of organelles with internalizing phage libraries

scientific article published on 2 February 2015

Ligand-directed profiling: applications to target drug discovery in cancer

scientific article

Ligand-directed surface profiling of human cancer cells with combinatorial peptide libraries

scientific article published in January 2006

Ligand-directed targeting of lymphatic vessels uncovers mechanistic insights in melanoma metastasis

scientific article

Ligand-targeted theranostic nanomedicines against cancer

scientific article published on 6 January 2016

Linear mRNA amplification approach for RNAseq from limited amount of RNA.

scientific article published on 28 March 2015

Loss of P16INK4 expression is frequent in high grade gliomas.

scientific article published in May 1995

MLH1-rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques

scientific article published on 28 February 2018

Mapping tumor vascular diversity by screening phage display libraries

scientific article

Mathematical prediction of clinical outcomes in advanced cancer patients treated with checkpoint inhibitor immunotherapy

scientific article published on 29 April 2020

Mechanism of action and initial evaluation of a membrane active all-D-enantiomer antimicrobial peptidomimetic

scientific article published on 23 January 2013

Meeting report: innovations in prostate cancer research

scientific article published on 01 February 2008

MicroRNAs and ultraconserved genes as diagnostic markers and therapeutic targets in cancer and cardiovascular diseases

scientific article published on 05 May 2010

Model of unidirectional transluminal gene transfer

scientific article published on 01 February 2004

Molecular PET imaging of HSV1-tk reporter gene expression using [18F]FEAU.

scientific article published on January 2007

Molecular addresses in blood vessels as targets for therapy.

scientific article

Molecular heterogeneity of the vascular endothelium revealed by in vivo phage display

scientific article

Molecular targets on blood vessels for cancer therapies in clinical trials

scientific article published on October 2007

Monoclonal IgG in MGUS and multiple myeloma targets infectious pathogens

scientific article published on 5 October 2017

Networks of gold nanoparticles and bacteriophage as biological sensors and cell-targeting agents

scholarly article

Next-generation of targeted AAVP vectors for systemic transgene delivery against cancer

scientific article published on 02 August 2019

Next-generation phage display: integrating and comparing available molecular tools to enable cost-effective high-throughput analysis

scientific article

Nna1 gene deficiency triggers Purkinje neuron death by tubulin hyperglutamylation and ER dysfunction

scientific article published on 02 October 2020

Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signaling

scientific article published on October 2010

Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of SPARC

scientific journal article

Novel phage display-derived neuroblastoma-targeting peptides potentiate the effect of drug nanocarriers in preclinical settings.

scientific article

On the synergistic effects of ligand-mediated and phage-intrinsic properties during in vivo selection

scientific article

PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3.

scientific article published on 15 June 2015

Peptidase substrates via global peptide profiling

scientific article

Peptides targeting caspase inhibitors

scientific article

Phage display technology for stem cell delivery and systemic therapy ⬇️

scientific article published on September 30, 2010

Phase II presurgical feasibility study of bevacizumab in untreated patients with metastatic renal cell carcinoma

scientific article

Phenotypic diversity of the lung vasculature in experimental models of metastases

scientific article published in December 2005

Platinum-based chemotherapy for variant castrate-resistant prostate cancer

scientific article published on 06 May 2013

Poly (A)+ transcriptome assessment of ERBB2-induced alterations in breast cell lines

scientific article

Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes

scientific article published on 01 January 2020

Predicting breast cancer response to neoadjuvant chemotherapy based on tumor vascular features in needle biopsies.

scientific article

Probing the structural and molecular diversity of tumor vasculature

scientific article

Processing of the matricellular protein hevin in mouse brain is dependent on ADAMTS4

scientific article

Prohibitin/annexin 2 interaction regulates fatty acid transport in adipose tissue

scientific article published on July 2016

Prostate Cancer Progression and the Epigenome

scientific article published on 01 December 2020

Protocol for design, construction, and selection of genome phage (gPhage) display libraries

scientific article published on 08 November 2021

Pulmonary Targeting of Adeno-associated Viral Vectors by Next-generation Sequencing-guided Screening of Random Capsid Displayed Peptide Libraries

scientific article

Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors

scientific article

Reactive antibodies against bacillus Calmette-Guerin heat-shock protein-65 potentially predict the outcome of immunotherapy for high-grade transitional cell carcinoma of the bladder

scientific article

Receptor tyrosine kinase EphA5 is a functional molecular target in human lung cancer

scientific article

Replacement of the p16/CDKN2 gene suppresses human glioma cell growth

scientific article published on 01 March 1995

Reversal of obesity by targeted ablation of adipose tissue

scientific article

Revisiting ethical guidelines for research with terminal wean and brain-dead participants.

scientific article published in January 2003

Role of leukemia cell invadosome in extramedullary infiltration

scientific article published on 27 July 2009

Role of the gp85/trans-sialidases in Trypanosoma cruzi tissue tropism: preferential binding of a conserved peptide motif to the vasculature in vivo

scientific article

SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activity

scientific article published on 22 August 2005

Selection and identification of ligand peptides targeting a model of castrate-resistant osteogenic prostate cancer and their receptors

scientific article

Selection of phage-displayed accessible recombinant targeted antibodies (SPARTA): methodology and applications.

scientific article published on 3 May 2018

Self-targeting of TNF-releasing cancer cells in preclinical models of primary and metastatic tumors

scientific article published on 8 February 2016

Semiparametric Bayesian inference for phage display data

scientific article

Speaker Abstracts

State of the art. Cellular and molecular mechanisms of alveolar destruction in emphysema: an evolutionary perspective

scientific article published on August 2006

Steps toward mapping the human vasculature by phage display.

scientific article

Structural basis for the interaction of a vascular endothelial growth factor mimic peptide motif and its corresponding receptors

scientific article published in October 2005

Superfibronectin, a multimeric form of fibronectin, increases HIV infection of primary CD4+ T lymphocytes.

scientific article

Synchronous down-modulation of miR-17 family members is an early causative event in the retinal angiogenic switch

scientific article

Synchronous selection of homing peptides for multiple tissues by in vivo phage display

scientific article

Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma

scientific article

TLR9/MyD88/TRIF signaling activates host immune inhibitory CD200 in Leishmania infection.

scientific article published on 16 May 2019

Targeted AAVP-based therapy in a mouse model of human glioblastoma: a comparison of cytotoxic versus suicide gene delivery strategies

scientific article published on 27 May 2019

Targeted drug delivery and penetration into solid tumors

scientific article published on February 2011

Targeted induction of lung endothelial cell apoptosis causes emphysema-like changes in the mouse

scientific article

Targeted molecular-genetic imaging and ligand-directed therapy in aggressive variant prostate cancer

scientific article published on 24 October 2016

Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens

scientific article

Targeting Synthetic Lethality in DNA Damage Repair Pathways as an Anti-Cancer Strategy ⬇️

scientific article published on October 1, 2010

Targeting cancer-specific synthetic lethality in double-strand DNA break repair

scientific article published on 15 June 2009

Targeting mammalian organelles with internalizing phage (iPhage) libraries

scientific article published on 12 September 2013

Targeting neuropilin-1 in human leukemia and lymphoma

scientific article

Targeting pancreatic islets with phage display assisted by laser pressure catapult microdissection

scientific article

Targeting the extracellular signature of metastatic colorectal cancers

scientific article published on 01 March 2009

Targeting the interleukin-11 receptor α in metastatic prostate cancer: A first-in-man study

scientific article published on April 2015

Targeting the prostate for destruction through a vascular address

scientific article

Targeting urothelium: ex vivo assay standardization and selection of internalizing ligands

scientific article

Techniques to decipher molecular diversity by phage display

scientific article

Teratogenicity induced by targeting a placental immunoglobulin transporter

scientific article

The Neuronal Pentraxin-2 Pathway Is an Unrecognized Target in Human Neuroblastoma, Which Also Offers Prognostic Value in Patients.

scientific article published on 20 August 2015

The interleukin-11 receptor alpha as a candidate ligand-directed target in osteosarcoma: consistent data from cell lines, orthotopic models, and human tumor samples

scientific article

The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury

scientific article published on 19 November 2020

The neovasculature homing motif NGR: more than meets the eye.

scientific article published on 23 June 2008

The original Pathologische Anatomie Leiden-Endothelium monoclonal antibody recognizes a vascular endothelial growth factor binding site within neuropilin-1.

scientific article

The peptidomimetic Vasotide targets two retinal VEGF receptors and reduces pathological angiogenesis in murine and nonhuman primate models of retinal disease

scientific article published on October 2015

Therapeutic targeting of membrane-associated GRP78 in leukemia and lymphoma: preclinical efficacy in vitro and formal toxicity study of BMTP-78 in rodents and primates.

scientific article published on 5 December 2017

Three-dimensional tissue culture based on magnetic cell levitation.

scientific article

Tissue plasminogen activator regulates Purkinje neuron development and survival

scientific article published on 14 May 2013

Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes

scientific article published on 24 October 2016

Treatment of hypoxia-induced retinopathy with targeted proapoptotic peptidomimetic in a mouse model of disease

scientific article

Trends in United States Prostate Cancer Incidence Rates by Age and Stage, 1995-2012.

scientific article published on 8 December 2015

Tumor targeting with a selective gelatinase inhibitor

scientific article

Tumor vasculature-targeted delivery of tumor necrosis factor-alpha

scientific article

Tumor-targeted gene delivery using molecularly engineered hybrid polymers functionalized with a tumor-homing peptide

scientific article published on 12 January 2008

Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients

scientific article

Vascular targeting: recent advances and therapeutic perspectives

scientific article published in April 2006

Vessel maneuvers: zinc fingers promote angiogenesis

scientific article published on 01 December 2002

White adipose tissue cells are recruited by experimental tumors and promote cancer progression in mouse models

scientific article published on 2 June 2009

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