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List of works by Sinead Toomey

A Stepwise Integrated Approach to Personalized Risk Predictions in Stage III Colorectal Cancer

scientific article

A preclinical evaluation of the MEK inhibitor refametinib in HER2-positive breast cancer cell lines including those with acquired resistance to trastuzumab or lapatinib

scientific article published on 22 July 2017

A preclinical evaluation of the PI3K alpha/delta dominant inhibitor BAY 80-6946 in HER2-positive breast cancer models with acquired resistance to the HER2-targeted therapies trastuzumab and lapatinib.

scientific article published on 21 December 2014

Altered Steroid Milieu in AI-Resistant Breast Cancer Facilitates AR Mediated Gene-Expression Associated with Poor Response to Therapy

scientific article published on 09 July 2019

An insight into the molecular genetics of a uveal melanoma patient cohort

article

BCL-2 system analysis identifies high-risk colorectal cancer patients.

scientific article published on 23 September 2016

BCL2 protein signalling determines acute responses to neoadjuvant chemoradiotherapy in rectal cancer.

scientific article published on 13 November 2014

Development of a personalized therapeutic strategy for ERBB-gene-mutated cancers.

scientific article

Effects of HER family-targeting tyrosine kinase inhibitors on antibody-dependent cell-mediated cytotoxicity in HER2-expressing breast cancer

scientific article published on 29 October 2020

Frequency, impact and a preclinical study of novel gene family mutations in HER2-positive breast cancer

article

Genomic and Transcriptomic Characterisation of Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer

scientific article published on 06 July 2020

Genomic profiling of a dedifferentiated mucosal melanoma following exposure to immunotherapy

scientific article published on 01 April 2020

Germline single nucleotide polymorphisms in ERBB3 and BARD1 genes result in a worse relapse free survival response for HER2-positive breast cancer patients treated with adjuvant based docetaxel, carboplatin and trastuzumab (TCH)

scientific article published in PLoS ONE

HER2-family signalling mechanisms, clinical implications and targeting in breast cancer

scientific article published on 27 December 2014

High-throughput oncogene mutation profiling shows demographic differences in BRAF mutation rates among melanoma patients.

scientific article

Identification and clinical impact of potentially actionable somatic oncogenic mutations in solid tumor samples

scientific article published on 22 February 2020

Immune effects of bevacizumab: killing two birds with one stone

scientific article published on 18 October 2014

Impact of somatic PI3K pathway and ERBB family mutations on pathological complete response (pCR) in HER2-positive breast cancer patients who received neoadjuvant HER2-targeted therapies.

scientific article published on 27 July 2017

Non-invasive genotyping and monitoring of tumor evolution in locally advanced rectal cancer (LARC) patients using circulating tumor DNA (ctDNA)

scientific article published on 25 October 2018

Preclinical drug testing and clinical trial planning of palbociclib (CDK4/6 inhibitor) drug combination with a PI3K or MAPK inhibitor for colorectal cancer (CRC)

scientific article published on 01 February 2019

Preclinical evaluation of a novel triple-acting PIM/PI3K/mTOR inhibitor, IBL-302, in breast cancer

scientific article published on 10 February 2020

Prevalence of tumor BRCA1 and BRCA2 dysfunction in unselected patients with ovarian cancer

scientific article published on 02 September 2020

RE: RNA Disruption Assay as a Biomarker of Pathological Complete Response in Neoadjuvant Trastuzumab-Treated Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer

scientific article published on 4 July 2016

The frequencies and clinical implications of mutations in 33 kinase-related genes in locally advanced rectal cancer: a pilot study.

scientific article

The impact of ERBB-family germline single nucleotide polymorphisms on survival response to adjuvant trastuzumab treatment in HER2-positive breast cancer

scientific article published on 20 October 2016

Use of exhaled breath condensate (EBC) in the diagnosis of SARS-COV-2 (COVID-19)

scientific article published on 23 October 2020

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