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List of works by Sharath S Hegde

A multivalent approach to drug discovery for novel antibiotics

scientific article published in October 2008

A multivalent approach towards linked dual-pharmacology prostaglandin F receptor agonist/carbonic anhydrase-II inhibitors for the treatment of glaucoma

scientific article published on 22 December 2012

Activity of telavancin against heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) in vitro and in an in vivo mouse model of bacteraemia

scientific article published on 5 February 2010

Antimuscarinics for the treatment of overactive bladder: current options and emerging therapies.

scientific article published on January 2004

Application of the classical Einthoven model of bronchoconstriction to the study of inhaled bronchodilators in rodents

scientific article published on 8 June 2010

Comparative efficacy of AHU-377, a potent neprilysin inhibitor, in two rat models of volume-dependent hypertension.

scientific article published in August 2011

Concomitant Angiotensin AT1 Receptor Antagonism and Neprilysin Inhibition Produces Omapatrilat-like Antihypertensive Effects Without Promoting Tracheal Plasma Extravasation in the Rat ⬇️

scientific article published on April 1, 2011

Discovery of (R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate (TD-5959, GSK961081, batefenterol): first-in-class dual p

scientific article published on 9 February 2015

Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI)

scientific article published on 03 December 2018

Efficacy of telavancin (TD-6424), a rapidly bactericidal lipoglycopeptide with multiple mechanisms of action, in a murine model of pneumonia induced by methicillin-resistant Staphylococcus aureus

scientific article

Efficacy of telavancin against glycopeptide-intermediate Staphylococcus aureus in the neutropenic mouse bacteraemia model

scientific article published on 20 January 2009

Efficacy of telavancin in a murine model of bacteraemia induced by methicillin-resistant Staphylococcus aureus

scientific article published on 30 May 2006

Efficacy of telavancin in a murine model of pneumonia induced by methicillin-susceptible Staphylococcus aureus

scientific article published on 9 November 2007

Exploring the positional attachment of glycopeptide/beta-lactam heterodimers

scientific article published in October 2008

In Vitro Isolated Tissue Functional Muscarinic Receptor Assays ⬇️

scientific article published on March 1, 2010

In Vitro Muscarinic Receptor Radioligand‐Binding Assays ⬇️

scientific article published on March 1, 2010

In Vivo Pharmacodynamic Assays for M2 and M3 Muscarinic Receptors ⬇️

scientific article published on March 1, 2010

Pharmacodynamics of TD-1792, a Novel Glycopeptide-Cephalosporin Heterodimer Antibiotic Used against Gram-Positive Bacteria, in a Neutropenic Murine Thigh Model ⬇️

scientific article published on December 12, 2011

Pharmacodynamics of telavancin (TD-6424), a novel bactericidal agent, against gram-positive bacteria

scientific article published on August 2004

Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties

scientific article

Pharmacological analysis of the interaction of antimuscarinic drugs at M(2) and M(3) muscarinic receptors in vivo using the pithed rat assay

scientific article published on 7 December 2007

Pharmacological properties of TD-6301, a novel bladder selective muscarinic receptor antagonist

scientific article published on 10 January 2009

Pharmacological properties of revefenacin (TD-4208), a novel, nebulized long-acting, and lung selective muscarinic antagonist, at human recombinant muscarinic receptors and in rat, guinea pig, and human isolated airway tissues.

scientific article published on 30 April 2018

Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and β(2)-adrenoceptor agonist (MABA)

article

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