List of works - Gudrun Schleiermacher

ALK germline mutations in patients with neuroblastoma: a rare and weakly penetrant syndrome

scientific article published on 9 November 2011

Accumulation of Segmental Alterations Determines Progression in Neuroblastoma

scientific article published on 01 June 2010

Accurate outcome prediction in neuroblastoma across independent data sets using a multigene signature

scientific article

Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma

scientific article

Breakpoint features of genomic rearrangements in neuroblastoma with unbalanced translocations and chromothripsis

scientific article

Characterization of amplicons in neuroblastoma: High-resolution mapping using DNA microarrays, relationship with outcome, and identification of overexpressed genes

article

Characterization of rearrangements involving the ALK gene reveals a novel truncated form associated with tumor aggressiveness in neuroblastoma

scientific article

Circulating tumor DNA analysis enables molecular characterization of pediatric renal tumors at diagnosis

scientific article published on 26 October 2018

Clinical characteristics and outcome of patients with neuroblastoma presenting genomic amplification of loci other than MYCN.

scientific article

Combined 24-color karyotyping and comparative genomic hybridization analysis indicates predominant rearrangements of early replicating chromosome regions in neuroblastoma

scientific article published on February 2003

Control-FREEC: a tool for assessing copy number and allelic content using next-generation sequencing data

scientific article

Deep Sequencing Reveals Occurrence of Subclonal ALK Mutations in Neuroblastoma at Diagnosis.

scientific article published on 9 June 2015

Emergence of new ALK mutations at relapse of neuroblastoma

scientific article

Feasibility and clinical integration of molecular profiling for target identification in pediatric solid tumors.

scientific article

From class waivers to precision medicine in paediatric oncology.

scientific article published in July 2017

Gene expression profiling of 1p35-36 genes in neuroblastoma

scientific article published on August 2004

Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma.

scientific article published on 20 July 2016

Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma

scientific article

Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries.

scientific article

Learning smoothing models of copy number profiles using breakpoint annotations

scientific article

Meta-mining of copy number profiles of high-risk neuroblastoma tumors

scientific article published on 30 October 2018

Minimally invasive surgery of neuroblastic tumors in children: Indications depend on anatomical location and image-defined risk factors

scientific article published on 04 October 2014

Mosaicism for oncogenic G12D KRAS mutation associated with epidermal nevus, polycystic kidneys and rhabdomyosarcoma.

scientific article published on 30 August 2010

Oncologic Phenotype of Peripheral Neuroblastic Tumors Associated With PHOX2B Non-Polyalanine Repeat Expansion Mutations

scientific article published on 16 September 2015

Opsoclonus-myoclonus in children associated or not with neuroblastoma.

scientific article published on 27 January 2010

Overall genomic pattern is a predictor of outcome in neuroblastoma

scientific article

Parental smoking, maternal alcohol consumption during pregnancy and the risk of neuroblastoma in children. A pooled analysis of the ESCALE and ESTELLE French studies

scientific article published on 21 February 2019

Pediatric Patient With Renal Cell Carcinoma Treated by Successive Antiangiogenics Drugs: A Case Report and Review of the Literature

scientific article published on 23 March 2017

Predicting outcomes for children with neuroblastoma using a multigene-expression signature: a retrospective SIOPEN/COG/GPOH study

scientific article

Preferential occurrence of chromosome breakpoints within early replicating regions in neuroblastoma

scientific article published on 14 December 2005

Prognostic impact of gene expression-based classification for neuroblastoma.

scientific article published on 21 June 2010

QuantumClone: Clonal assessment of functional mutations in cancer based on a genotype-aware method for clonal reconstruction

scientific article published on 12 January 2018

Radiogenomics of neuroblastomas: Relationships between imaging phenotypes, tumor genomic profile and survival.

scientific article published on 25 September 2017

Recent insights into the biology of neuroblastoma

scientific article

Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations

scientific article published on 29 June 2015

Revised risk estimation and treatment stratification of low- and intermediate-risk neuroblastoma patients by integrating clinical and molecular prognostic markers

scientific article published on 17 September 2014

SegAnnDB: interactive Web-based genomic segmentation

scientific article

Segmental Chromosomal Aberrations in Localized Neuroblastoma Can be Detected in Formalin-Fixed Paraffin-Embedded Tissue Samples and Are Associated With Recurrence

scientific article published on 10 February 2016

Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

scientific article published on October 2008

Stepwise occurrence of a complex unbalanced translocation in neuroblastoma leading to insertion of a telomere sequence and late chromosome 17q gain.

scientific article published on May 2005

Study of chromatin remodeling genes implicates SMARCA4 as a putative player in oncogenesis in neuroblastoma

scientific article published on 31 May 2019

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets

scientific article published in Nature Communications

Variety and complexity of chromosome 17 translocations in neuroblastoma

scientific article published on February 2004

Whole exome sequencing of cell-free DNA reveals temporo-spatial heterogeneity and identifies treatment-resistant clones in neuroblastoma

scientific article published on 30 November 2017

[Genetic alterations in neuroblastoma and their usefulness for clinical management]

scientific article published on 01 May 2011

List of works by Gudrun Schleiermacher

ALK germline mutations in patients with neuroblastoma: a rare and weakly penetrant syndrome

Accumulation of Segmental Alterations Determines Progression in Neuroblastoma

Accurate outcome prediction in neuroblastoma across independent data sets using a multigene signature

Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma

Breakpoint features of genomic rearrangements in neuroblastoma with unbalanced translocations and chromothripsis

Characterization of amplicons in neuroblastoma: High-resolution mapping using DNA microarrays, relationship with outcome, and identification of overexpressed genes

Characterization of rearrangements involving the ALK gene reveals a novel truncated form associated with tumor aggressiveness in neuroblastoma

Circulating tumor DNA analysis enables molecular characterization of pediatric renal tumors at diagnosis

Clinical characteristics and outcome of patients with neuroblastoma presenting genomic amplification of loci other than MYCN.

Combined 24-color karyotyping and comparative genomic hybridization analysis indicates predominant rearrangements of early replicating chromosome regions in neuroblastoma

Control-FREEC: a tool for assessing copy number and allelic content using next-generation sequencing data

Deep Sequencing Reveals Occurrence of Subclonal ALK Mutations in Neuroblastoma at Diagnosis.

Emergence of new ALK mutations at relapse of neuroblastoma

Feasibility and clinical integration of molecular profiling for target identification in pediatric solid tumors.

From class waivers to precision medicine in paediatric oncology.

Gene expression profiling of 1p35-36 genes in neuroblastoma

Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma.

Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma

Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries.

Learning smoothing models of copy number profiles using breakpoint annotations

Meta-mining of copy number profiles of high-risk neuroblastoma tumors

Minimally invasive surgery of neuroblastic tumors in children: Indications depend on anatomical location and image-defined risk factors

Mosaicism for oncogenic G12D KRAS mutation associated with epidermal nevus, polycystic kidneys and rhabdomyosarcoma.

Oncologic Phenotype of Peripheral Neuroblastic Tumors Associated With PHOX2B Non-Polyalanine Repeat Expansion Mutations

Opsoclonus-myoclonus in children associated or not with neuroblastoma.

Overall genomic pattern is a predictor of outcome in neuroblastoma

Parental smoking, maternal alcohol consumption during pregnancy and the risk of neuroblastoma in children. A pooled analysis of the ESCALE and ESTELLE French studies

Pediatric Patient With Renal Cell Carcinoma Treated by Successive Antiangiogenics Drugs: A Case Report and Review of the Literature

Predicting outcomes for children with neuroblastoma using a multigene-expression signature: a retrospective SIOPEN/COG/GPOH study

Preferential occurrence of chromosome breakpoints within early replicating regions in neuroblastoma

Prognostic impact of gene expression-based classification for neuroblastoma.

QuantumClone: Clonal assessment of functional mutations in cancer based on a genotype-aware method for clonal reconstruction

Radiogenomics of neuroblastomas: Relationships between imaging phenotypes, tumor genomic profile and survival.

Recent insights into the biology of neuroblastoma

Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations

Revised risk estimation and treatment stratification of low- and intermediate-risk neuroblastoma patients by integrating clinical and molecular prognostic markers

SegAnnDB: interactive Web-based genomic segmentation

Segmental Chromosomal Aberrations in Localized Neuroblastoma Can be Detected in Formalin-Fixed Paraffin-Embedded Tissue Samples and Are Associated With Recurrence

Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

Stepwise occurrence of a complex unbalanced translocation in neuroblastoma leading to insertion of a telomere sequence and late chromosome 17q gain.

Study of chromatin remodeling genes implicates SMARCA4 as a putative player in oncogenesis in neuroblastoma

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets

Variety and complexity of chromosome 17 translocations in neuroblastoma

Whole exome sequencing of cell-free DNA reveals temporo-spatial heterogeneity and identifies treatment-resistant clones in neuroblastoma

[Genetic alterations in neuroblastoma and their usefulness for clinical management]