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List of works by Paolo Madeddu

Angiotensin AT(1) receptor signalling modulates reparative angiogenesis induced by limb ischaemia

scientific article

Benfotiamine improves functional recovery of the infarcted heart via activation of pro-survival G6PD/Akt signaling pathway and modulation of neurohormonal response

scientific article published on 8 June 2010

Cardiac Nerve Growth Factor Overexpression Induces Bone Marrow-derived Progenitor Cells Mobilization and Homing to the Infarcted Heart

scientific article

Cardiac hypertrophy and microvascular deficit in kinin B2 receptor knockout mice

scientific article published on 24 March 2003

Changing the logic of therapeutic angiogenesis for ischemic disease

scientific article

Combined Intramyocardial Delivery of Human Pericytes and Cardiac Stem Cells Additively Improves the Healing of Mouse Infarcted Hearts Through Stimulation of Vascular and Muscular Repair

scientific article published on 23 March 2015

Concise Review: The Regenerative Journey of Pericytes Toward Clinical Translation

scientific article published on 31 May 2018

Concise review: diabetes, the bone marrow niche, and impaired vascular regeneration.

scientific article

Data supporting the activation of autophagy genes in the diabetic heart

scientific article

Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia

scientific article

Diabetes Impairs Bone Marrow Microenvironment Affecting Progenitor Cell Number, Mobilization and Engraftment in Humans. ⬇️

scholarly article

Diabetes and vessel wall remodelling: from mechanistic insights to regenerative therapies.

scientific article

Diabetes mellitus induces bone marrow microangiopathy

scientific article

Diagnostic tools for the study of vascular cognitive dysfunction in hypertension and antihypertensive drug research.

scientific article

Expansion and characterization of neonatal cardiac pericytes provides a novel cellular option for tissue engineering in congenital heart disease.

scientific article

Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage

scientific article

Genetically engineered stem cell therapy for tissue regeneration

scientific article published on May 2004

Human CD133+ progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling

scientific article

Human adult vena saphena contains perivascular progenitor cells endowed with clonogenic and proangiogenic potential

scientific article

Human fetal aorta contains vascular progenitor cells capable of inducing vasculogenesis, angiogenesis, and myogenesis in vitro and in a murine model of peripheral ischemia

scientific article published in June 2007

Inhibition of delta-like-4-mediated signaling impairs reparative angiogenesis after ischemia

scientific article

Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling

scientific journal article

Local inhibition of microRNA-24 improves reparative angiogenesis and left ventricle remodeling and function in mice with myocardial infarction

scientific article published on 18 June 2013

MicroRNA-15a and microRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia

scientific article published on 11 December 2012

Migration towards SDF-1 selects angiogenin-expressing bone marrow monocytes endowed with cardiac reparative activity in patients with previous myocardial infarction

scientific article published on 11 April 2015

NEUROTROPHIN-3 (NT-3) PROMOTES REPARATIVE NEOVASCULARIZATION AND BLOOD FLOW RECOVERY IN A MOUSE MODEL OF LIMB ISCHEMIA

Nerve growth factor promotes angiogenesis and arteriogenesis in ischemic hindlimbs

scientific article published in October 2002

Nerve growth factor promotes cardiac repair following myocardial infarction

scientific article

Neurotrophin p75 receptor (p75NTR) promotes endothelial cell apoptosis and inhibits angiogenesis: implications for diabetes-induced impaired neovascularization in ischemic limb muscles

scientific article published on 19 June 2008

Neurotrophin-3 is a novel angiogenic factor capable of therapeutic neovascularization in a mouse model of limb ischemia.

scientific article

Nitric oxide-releasing aspirin derivative, NCX 4016, promotes reparative angiogenesis and prevents apoptosis and oxidative stress in a mouse model of peripheral ischemia

scientific article (publication date: November 2004)

Notch signalling in ischaemia-induced angiogenesis.

scientific article

Paracrine control of vascularization and neurogenesis by neurotrophins

scientific article

Perivascular delivery of encapsulated mesenchymal stem cells improves postischemic angiogenesis via paracrine activation of VEGF-A.

scientific article

Phosphoinositide 3-kinase gamma gene knockout impairs postischemic neovascularization and endothelial progenitor cell functions

scientific article published on 25 October 2007

Protease-activated receptor-2 stimulates angiogenesis and accelerates hemodynamic recovery in a mouse model of hindlimb ischemia

scientific article

Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1

scientific article

Regional and global protective effects of tissue kallikrein gene delivery to the peri-infarct myocardium

scientific article

Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential

scientific article

S100A1: A novel and essential molecular component for postischemic angiogenesis

scientific article

Sensory neuropathy hampers nociception-mediated bone marrow stem cell release in mice and patients with diabetes.

scientific article published on 10 September 2015

Soluble ST2 is regulated by p75 neurotrophin receptor and predicts mortality in diabetic patients with critical limb ischemia

scientific article published on 11 October 2012

Switching on reparative angiogenesis: essential role of the vascular erythropoietin receptor

scientific article

Therapeutic angiogenesis: translating experimental concepts to medically relevant goals

scientific article published on 23 August 2006

Tissue kallikrein is essential for invasive capacity of circulating proangiogenic cells.

scientific article published on 16 December 2010

Type-2 diabetic Lepr(db/db) mice show a defective microvascular phenotype under basal conditions and an impaired response to angiogenesis gene therapy in the setting of limb ischemia

scientific article

Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway

scientific article

miR-15a/-16 Inhibit Angiogenesis by Targeting the Tie2 Coding Sequence: Therapeutic Potential of a miR-15a/16 Decoy System in Limb Ischemia.

scientific article published on 17 May 2019

microRNA-21/PDCD4 Proapoptotic Signaling From Circulating CD34+ Cells to Vascular Endothelial Cells: A Potential Contributor to Adverse Cardiovascular Outcomes in Patients With Critical Limb Ischemia

scientific article published on 01 May 2020

p75(NTR)-dependent activation of NF-κB regulates microRNA-503 transcription and pericyte-endothelial crosstalk in diabetes after limb ischaemia

scientific journal article

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