List of works - Alan T Nurden

A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.

scientific article

A gain-of-function variant in DIAPH1 causes dominant macrothrombocytopenia and hearing loss.

scientific article

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders

scientific article published on 15 April 2016

A novel missense mutation shows that GPIbbeta has a dual role in controlling the processing and stability of the platelet GPIb-IX adhesion receptor

scientific article published on April 2003

Absence of GPIbalpha is responsible for aberrant membrane development during megakaryocyte maturation: ultrastructural study using a transgenic model

scientific article

Activation of alphaIIbbeta3 is a sufficient but also an imperative prerequisite for activation of alpha2beta1 on platelets

scientific article published on 19 September 2006

Are bone defects in rare patients with Glanzmann's thrombasthenia associated withITGB3orITGA2Bmutations? ⬇️

scientific article published on May 11, 2011

Autologous fibrin matrices: A potential source of biological mediators that modulate tendon cell activities

scientific article published on 01 May 2006

Clinical utility gene card for: Glanzmann thrombasthenia

scientific article

Congenital disorders associated with platelet dysfunctions

scientific article

Congenital platelet disorders and understanding of platelet function

scientific article

Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture

scientific article

Delayed immunologic thrombocytopenia induced by abciximab

scientific article

Development of a high-throughput ELISA assay for platelet function testing using platelet-rich plasma or whole blood.

scientific article published on 27 May 2010

Founder effect and estimation of the age of the French Gypsy mutation associated with Glanzmann thrombasthenia in Manouche families

scientific article

GPIIb/IIIa antagonists and other anti-integrins

scientific article published on May 2003

Genetic testing in the diagnostic evaluation of inherited platelet disorders

scientific article published on March 2009

Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors

scientific article

Glanzmann thrombasthenia

scientific article

Glanzmann thrombasthenia-like syndromes associated with Macrothrombocytopenias and mutations in the genes encoding the αIIbβ3 integrin

scientific article

Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models ⬇️

scientific article published on September 13, 2011

Glanzmann thrombasthenia: state of the art and future directions

scientific article

Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice.

scientific article

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding

scientific article

Human phenotype ontology annotation and cluster analysis to unravel genetic defects in 707 cases with unexplained bleeding and platelet disorders

scientific article published on 9 April 2015

ITGA2B and ITGB3 gene mutations associated with Glanzmann thrombasthenia

scientific article published on 10 November 2017

Identification of human scFvs targeting atherosclerotic lesions: selection by single round in vivo phage display

scientific article

Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system

scientific article

Impaired megakaryocytopoiesis in type 2B von Willebrand disease with severe thrombocytopenia

scientific article

In silico analysis of structural modifications in and around the integrin αIIb genu caused by ITGA2B variants in human platelets with emphasis on Glanzmann thrombasthenia

scientific article

Increasing the platelet count in chronic ITP.

scientific article

Inherited disorders of platelets: an update

scientific article

Inherited platelet disorders

scientific article published on 01 July 2012

Intracellular interaction of von Willebrand factor and factor VIII depends on cellular context: lessons from platelet-expressed factor VIII.

scientific article published on 24 February 2005

Management of pregnancy for a patient with the new syndromic macrothrombocytopenia, DIAPH1-related disease

scientific article published on 09 July 2018

Marked bleeding diathesis in patients with platelet dysfunction due to a novel mutation in RASGRP2, encoding CalDAG-GEFI (p.Gly305Asp).

scientific article published on 20 July 2017

Molecular dynamics analysis of a novel β3 Pro189Ser mutation in a patient with glanzmann thrombasthenia differentially affecting αIIbβ3 and αvβ3 expression

scientific article

New insights into and novel applications for platelet-rich fibrin therapies

scientific article

New-generation drugs that stimulate platelet production in chronic immune thrombocytopenic purpura

scientific article

Personal reflections on the early contributions of Gus Born to platelet research

scientific article published on 05 September 2018

Phosphatidylserine exposure and other apoptotic-like events in Bernard-Soulier syndrome platelets

scientific article published on August 2010

Phosphatidylserine exposure, microparticle formation and mitochondrial depolarisation in Glanzmann thrombasthenia platelets

scientific article published on 30 January 2014

Platelet membrane glycoproteins: a historical review

scientific article published on 26 June 2014

Platelet-associated CD154 in immune thrombocytopenic purpura

scientific article

Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A.

scientific article published on January 2013

Platelets and wound healing

scientific article published on May 2008

Platelets, inflammation and tissue regeneration

scientific article (publication date: May 2011)

Procoagulant platelets form an α-granule protein-covered "cap" on their surface that promotes their attachment to aggregates

scientific article published on 30 August 2013

Reciprocal actions of platelet-secreted TGF-beta1 on the production of VEGF and HGF by human tendon cells.

scientific article published in March 2007

Should any genetic defect affecting α-granules in platelets be classified as gray platelet syndrome?

scientific article published on 11 March 2016

Should studies on Glanzmann thrombasthenia not be telling us more about cardiovascular disease and other major illnesses?

scientific article published on 4 April 2017

The Nbeal2(-/-) mouse as a model for the gray platelet syndrome

scientific article

The gray platelet syndrome: clinical spectrum of the disease

scientific article

Tissue inhibitors of matrix metalloproteinases in platelets and megakaryocytes: a novel organization for these secreted proteins.

scientific article published on 3 May 2009

Two types of procoagulant platelets are formed upon physiological activation and are controlled by integrin α(IIb)β(3).

scientific article

Understanding the genetic basis of Glanzmann thrombasthenia: implications for treatment

scientific article published on October 2012

List of works by Alan T Nurden

A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.

A gain-of-function variant in DIAPH1 causes dominant macrothrombocytopenia and hearing loss.

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders

A novel missense mutation shows that GPIbbeta has a dual role in controlling the processing and stability of the platelet GPIb-IX adhesion receptor

Absence of GPIbalpha is responsible for aberrant membrane development during megakaryocyte maturation: ultrastructural study using a transgenic model

Activation of alphaIIbbeta3 is a sufficient but also an imperative prerequisite for activation of alpha2beta1 on platelets

Are bone defects in rare patients with Glanzmann's thrombasthenia associated withITGB3orITGA2Bmutations? ⬇️

Autologous fibrin matrices: A potential source of biological mediators that modulate tendon cell activities

Clinical utility gene card for: Glanzmann thrombasthenia

Congenital disorders associated with platelet dysfunctions

Congenital platelet disorders and understanding of platelet function

Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture

Delayed immunologic thrombocytopenia induced by abciximab

Development of a high-throughput ELISA assay for platelet function testing using platelet-rich plasma or whole blood.

Founder effect and estimation of the age of the French Gypsy mutation associated with Glanzmann thrombasthenia in Manouche families

GPIIb/IIIa antagonists and other anti-integrins

Genetic testing in the diagnostic evaluation of inherited platelet disorders

Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors

Glanzmann thrombasthenia

Glanzmann thrombasthenia-like syndromes associated with Macrothrombocytopenias and mutations in the genes encoding the αIIbβ3 integrin

Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models ⬇️

Glanzmann thrombasthenia: state of the art and future directions

Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice.

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding

Human phenotype ontology annotation and cluster analysis to unravel genetic defects in 707 cases with unexplained bleeding and platelet disorders

ITGA2B and ITGB3 gene mutations associated with Glanzmann thrombasthenia

Identification of human scFvs targeting atherosclerotic lesions: selection by single round in vivo phage display

Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system

Impaired megakaryocytopoiesis in type 2B von Willebrand disease with severe thrombocytopenia

In silico analysis of structural modifications in and around the integrin αIIb genu caused by ITGA2B variants in human platelets with emphasis on Glanzmann thrombasthenia

Increasing the platelet count in chronic ITP.

Inherited disorders of platelets: an update

Inherited platelet disorders

Intracellular interaction of von Willebrand factor and factor VIII depends on cellular context: lessons from platelet-expressed factor VIII.

Management of pregnancy for a patient with the new syndromic macrothrombocytopenia, DIAPH1-related disease

Marked bleeding diathesis in patients with platelet dysfunction due to a novel mutation in RASGRP2, encoding CalDAG-GEFI (p.Gly305Asp).

Molecular dynamics analysis of a novel β3 Pro189Ser mutation in a patient with glanzmann thrombasthenia differentially affecting αIIbβ3 and αvβ3 expression

New insights into and novel applications for platelet-rich fibrin therapies

New-generation drugs that stimulate platelet production in chronic immune thrombocytopenic purpura

Personal reflections on the early contributions of Gus Born to platelet research

Phosphatidylserine exposure and other apoptotic-like events in Bernard-Soulier syndrome platelets

Phosphatidylserine exposure, microparticle formation and mitochondrial depolarisation in Glanzmann thrombasthenia platelets

Platelet membrane glycoproteins: a historical review

Platelet-associated CD154 in immune thrombocytopenic purpura

Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A.

Platelets and wound healing

Platelets, inflammation and tissue regeneration

Procoagulant platelets form an α-granule protein-covered "cap" on their surface that promotes their attachment to aggregates

Reciprocal actions of platelet-secreted TGF-beta1 on the production of VEGF and HGF by human tendon cells.

Should any genetic defect affecting α-granules in platelets be classified as gray platelet syndrome?

Should studies on Glanzmann thrombasthenia not be telling us more about cardiovascular disease and other major illnesses?

The Nbeal2(-/-) mouse as a model for the gray platelet syndrome

The gray platelet syndrome: clinical spectrum of the disease

Tissue inhibitors of matrix metalloproteinases in platelets and megakaryocytes: a novel organization for these secreted proteins.

Two types of procoagulant platelets are formed upon physiological activation and are controlled by integrin α(IIb)β(3).

Understanding the genetic basis of Glanzmann thrombasthenia: implications for treatment