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List of works by Hiromitsu Takayama

A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans.

scientific article

A flavonoid 3-O-glucoside:2"-O-glucosyltransferase responsible for terminal modification of pollen-specific flavonols in Arabidopsis thaliana

scientific article

Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa

scientific article published on 15 September 2005

Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa

scientific article (publication date: 12 March 2004)

Artoindonesianin P, a new prenylated flavone with cytotoxic activity from Artocarpus lanceifolius

scientific article

Asymmetric Total Synthesis and Evaluation of Antitumor Activity of Ophiorrhisine A and Its Derivatives

scientific article published on 04 December 2018

Asymmetric Total Synthesis of Biphenylquinolizidine Alkaloids 4″-O-Demethyllythridine and 14-epi-4″-O-Demethyllythridine

scientific article published on 16 September 2019

Asymmetric Total Synthesis of Fawcettimine-Type Lycopodium Alkaloid, Lycopoclavamine-A

scientific article published on 09 April 2019

Asymmetric Total Synthesis of Kopsiyunnanine K, a Monoterpenoid Indole Alkaloid with a Rearranged Skeleton

scientific article published on 29 June 2016

Asymmetric total syntheses of two phlegmarine-type alkaloids, lycoposerramines-V and -W, newly isolated from Lycopodium serratum

scientific article published on 08 September 2007

Biosynthesis of camptothecin. In silico and in vivo tracer study from [1-13C]glucose

scientific article

Boosting Sensitivity in Liquid Chromatography-Fourier Transform Ion Cyclotron Resonance-Tandem Mass Spectrometry for Product Ion Analysis of Monoterpene Indole Alkaloids

scientific article published on 17 December 2015

Characterization of a recently evolved flavonol-phenylacyltransferase gene provides signatures of natural light selection in Brassicaceae

scientific article

Chemistry and pharmacology of analgesic indole alkaloids from the rubiaceous plant, Mitragyna speciosa ⬇️

scientific article

Cytotoxic chalcones and flavanones from the tree bark of Cryptocarya costata

scientific article published in March 2006

Design, Synthesis, and Antitumor Activity of 4-Halocolchicines and Their Pro-drugs Activated by Cathepsin B.

scientific article published on 4 March 2011

Determination of absolute configuration of trimeric indole alkaloid, psychotrimine, by first asymmetric total synthesis

scientific article published on February 2010

Diptoindonesin A, a new C-glucoside of epsilon-viniferin from Shorea seminis (Dipterocarpaceae).

scientific article

Effect of mitragynine, derived from Thai folk medicine, on gastric acid secretion through opioid receptor in anesthetized rats

scientific article published in May 2002

Fawcettimine-related alkaloids from Lycopodium serratum

scientific article published on 16 May 2007

Indole alkaloids of a Thai medicinal herb, Mitragyna speciosa, that has opioid agonistic effect in guinea-pig ileum

scientific article (publication date: March 2005)

Inhibitory effect of mitragynine, an analgesic alkaloid from Thai herbal medicine, on neurogenic contraction of the vas deferens

scientific article published on 16 August 2005

Involvement of mu-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa

scientific article

Iridoids and a norsesquiterpenoid from the leaves of Villaria odorata

scientific article published on September 2014

Isolation of gelsedine-type indole alkaloids from Gelsemium elegans and evaluation of the cytotoxic activity of gelsemium alkaloids for A431 epidermoid carcinoma cells

scientific article published on April 2006

Lycopodium Alkaloids: Isolation and Asymmetric Synthesis ⬇️

scientific article published on January 1, 2012

MGM-9 [(E)-methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate], a derivative of the indole alkaloid mitragynine: a novel dual-acting mu- and kappa-opioid agonist wi

scientific article

Mesaconitine-induced relaxation in rat aorta: role of Na+/Ca2+ exchangers in endothelial cells

scientific article

Metabolomics-oriented isolation and structure elucidation of 37 compounds including two anthocyanins from Arabidopsis thaliana

scientific article published in May 2009

Monoterpenoid Bisindole Alkaloids

scientific article published on 21 October 2015

New otonecine-type pyrrolizidine alkaloid from Petasites japonicus

scientific article published on 19 February 2019

Orally active opioid μ/δ dual agonist MGM-16, a derivative of the indole alkaloid mitragynine, exhibits potent antiallodynic effect on neuropathic pain in mice.

scientific article published on 17 December 2013

Pandanus alkaloids: chemistry and biology

scientific article published on January 2008

Partial agonistic effect of 9-hydroxycorynantheidine on mu-opioid receptor in the guinea-pig ileum

scientific article published on 2 November 2005

Phenolic constituents from the wood of Morus australis with cytotoxic activity.

scientific article

Prenylated flavones from Artocarpus lanceifolius and their cytotoxic properties against P-388 cells

scientific article

Protective effect of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus: putative neurotransmitter receptors involved in their action

scientific article

Rhynchophylline and isorhynchophylline inhibit NMDA receptors expressed in Xenopus oocytes

scientific article

Selenosugars are key and urinary metabolites for selenium excretion within the required to low-toxic range

scientific article

Seven New Lycopodium Alkaloids, Lycoposerramines-C, -D, -E, -P, -Q, -S, and -U, from Lycopodium serratum Thunb.

scientific article published on 30 June 2005

Seven new Lycopodium alkaloids, lycoposerramines-C, -D, -E, -P, -Q, -S, and -U, from Lycopodium serratum Thunb.

scientific article published on 25 March 2003

Structure elucidation and synthesis of lycoposerramine-B, a novel oxime-containing Lycopodium alkaloid from Lycopodium serratum Thunb

scientific article

Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands

scientific article (publication date: 25 April 2002)

Ten New Lycopodium Alkaloids Having the Lycopodane Skeleton Isolated from Lycopodium serratum THUNB ⬇️

scientific article published on October 1, 2003

Ten New Lycopodium Alkaloids Having the Lycopodane Skeleton Isolated from Lycopodium serratum Thunb.

scientific article published on 25 March 2004

Ten new fawcettimine-related alkaloids from three species of Lycopodium

scientific article published on 5 June 2011

The botanical origin of kratom (Mitragyna speciosa; Rubiaceae) available as abused drugs in the Japanese markets

scientific article

Total Syntheses of Pleiocarpamine, Normavacurine, and C-Mavacurine

scientific article published on 18 April 2019

Total Synthesis of (-)-14-Hydroxygelsenicine and Six Biogenetically Related Gelsemium Alkaloids

scientific article published on 12 August 2019

Two oligostilbenes, cis- and trans-diptoindonesin B, from Dryobalanops oblongifolia

scientific article

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