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List of works by Christopher Francklyn

11th IUBMB Focused Meeting on the Aminoacyl-tRNA Synthetases: Sailing a New Sea of Complex Functions in Human Biology and Disease.

scientific article

A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases.

scientific article published on 21 September 2017

A substrate-assisted concerted mechanism for aminoacylation by a class II aminoacyl-tRNA synthetase

scientific article

A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases

scientific article published on 26 October 2004

Activation of the hetero-octameric ATP phosphoribosyl transferase through subunit interface rearrangement by a tRNA synthetase paralog

scientific article published on 28 July 2005

Altered nuclear cofactor switching in retinoic‐resistant variants of the PML‐RARα oncoprotein of acute promyelocytic leukemia ⬇️

scientific article published on January 7, 2012

Aminoacyl transfer rate dictates choice of editing pathway in threonyl-tRNA synthetase

scientific article

Aminoacyl-Transfer RNA Synthetases: Connecting Nutrient Status to Angiogenesis Through the Unfolded Protein Response

scientific article

Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor

scientific article

Aminoacyl-tRNA synthetases

scientific article published on January 2017

Aminoacyl-tRNA synthetases: versatile players in the changing theater of translation

scientific article

Aminoacylating Urzymes Challenge the RNA World Hypothesis ⬇️

scientific article published on July 18, 2013

Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo

scientific article (publication date: 23 December 2014)

Asymmetric amino acid activation by class II histidyl-tRNA synthetase from Escherichia coli

scientific article published on June 2009

Bi-allelic mutations in HARS1 severely impair histidyl-tRNA synthetase expression and enzymatic activity causing a novel multi-system ataxic syndrome

scientific article published on 25 April 2020

Biallelic VARS variants cause developmental encephalopathy with microcephaly that is recapitulated in vars knockout zebrafish

scientific article published in Nature Communications

Characterization of aminoacyl-tRNA synthetase stability and substrate interaction by differential scanning fluorimetry.

scientific article

Correction: A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases

scientific article published on 2 January 2018

DNA polymerases and aminoacyl-tRNA synthetases: shared mechanisms for ensuring the fidelity of gene expression

scientific article published on 14 October 2008

Distinct kinetic mechanisms of the two classes of Aminoacyl-tRNA synthetases

scientific article

Evolutionary conservation of a functionally important backbone phosphate group critical for aminoacylation of histidine tRNAs

scientific article

Fidelity Escape by the Unnatural Amino Acid β-Hydroxynorvaline: An Efficient Substrate for Escherichia coli Threonyl-tRNA Synthetase with Toxic Effects on Growth ⬇️

scientific article published on January 24, 2011

G-1:C73 recognition by an arginine cluster in the active site of Escherichia coli histidyl-tRNA synthetase

scientific article published in February 2004

Genetic Mapping and Exome Sequencing Identify Variants Associated with Five Novel Diseases ⬇️

scientific article published on January 17, 2012

Histidyl-tRNA synthetase urzymes: Class I and II aminoacyl tRNA synthetase urzymes have comparable catalytic activities for cognate amino acid activation ⬇️

scientific article

Immunity-Guided Identification of Threonyl-tRNA Synthetase as the Molecular Target of Obafluorin, a β-Lactone Antibiotic

scientific article published on 14 November 2019

Induced fit and kinetic mechanism of adenylation catalyzed by Escherichia coli threonyl-tRNA synthetase

scientific article published in December 2003

Kinetic discrimination of tRNA identity by the conserved motif 2 loop of a class II aminoacyl-tRNA synthetase

scientific article published on February 2007

Knock-Down of Causes Cell Cycle Arrest and Apoptosis of Neuronal Progenitor Cells

Methods for kinetic and thermodynamic analysis of aminoacyl-tRNA synthetases

scientific article published on February 2008

Peripheral neuropathy and cognitive impairment associated with a novel monoallelic HARS variant

scientific article published on 24 May 2019

Progress and challenges in aminoacyl-tRNA synthetase-based therapeutics

scientific article published in 2019

RNA-assisted catalysis in a protein enzyme: The 2'-hydroxyl of tRNA(Thr) A76 promotes aminoacylation by threonyl-tRNA synthetase

scientific article (publication date: 18 November 2008)

Regulation of angiogenesis by aminoacyl-tRNA synthetases

scientific article published on 19 December 2014

Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis

scientific article published on January 2013

Standardizing analysis of circulating microRNA: clinical and biological relevance

scientific article published on May 2014

Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase

scientific article

Substrate interaction defects in histidyl-tRNA synthetase linked to dominant axonal peripheral neuropathy.

scientific article published on 12 December 2017

Substrate recognition by the hetero-octameric ATP phosphoribosyltransferase from Lactococcus lactis

scientific article published on December 2006

Substrate specificity and catalysis by the editing active site of Alanyl-tRNA synthetase from Escherichia coli

scientific article published on 31 January 2011

The Usher Syndrome Type IIIB Histidyl-tRNA Synthetase Mutation Confers Temperature Sensitivity.

scientific article published on 20 June 2017

The quaternary structure of the HisZ-HisG N-1-(5'-phosphoribosyl)-ATP transferase from Lactococcus lactis

scientific article published in October 2002

The α-Amino Group of the Threonine Substrate as The General Base During tRNA Aminoacylation: A New Version of Substrate-Assisted Catalysis Predicted by Hybrid DFT ⬇️

scientific article published on September 26, 2011

Threonyl-tRNA synthetase overexpression correlates with angiogenic markers and progression of human ovarian cancer

scientific article

Transfer RNA and human disease

scientific article

Turning tRNA upside down: When aminoacylation is not a prerequisite to protein synthesis

scholarly article

tRNA as an active chemical scaffold for diverse chemical transformations

scientific article (publication date: 21 January 2010)

tRNA synthetase paralogs: evolutionary links in the transition from tRNA-dependent amino acid biosynthesis to de novo biosynthesis

scientific article published on 11 August 2003

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