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List of works by Gary W Cline

13C NMR isotopomer analysis of anaplerotic pathways in INS-1 cells

scientific article published on 9 August 2004

A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance

scientific article published on 26 August 2020

A Non-invasive Method to Assess Hepatic Acetyl-CoA In Vivo

scientific article published on 18 January 2017

A role for mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) in the regulation of hepatic gluconeogenesis

scientific article published on 04 February 2014

A β-peptide agonist of the GLP-1 receptor, a class B GPCR.

scientific article

Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome

scientific journal article

Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents.

scientific article

Acute inhibition of lipolysis does not affect postprandial suppression of endogenous glucose production

scientific article published on 5 July 2005

Adipocyte-specific overexpression of FOXC2 prevents diet-induced increases in intramuscular fatty acyl CoA and insulin resistance

scientific article published in June 2005

Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action

scientific article published on 28 March 2019

Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes

scientific article published in December 2004

Altered Brain Response to Drinking Glucose and Fructose in Obese Adolescents.

scientific article published on 05 April 2016

Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy

scientific article

Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance

scientific article published on 04 July 2019

Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism

scientific article published on 31 May 2016

Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism

scientific article

Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo

scientific article published on 01 March 2019

Blunted suppression of acyl-ghrelin in response to fructose ingestion in obese adolescents: the role of insulin resistance

scientific article

Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight

scientific article published on 28 January 2008

CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance

scientific article published on 9 January 2013

Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver

scientific article published in September 2005

Clinical and scientific value in the pursuit of quantification of beta cells in the pancreas by PET imaging

scientific article published on 22 August 2018

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

scholarly article

Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates

scientific article published on 01 October 2019

Coordinated defects in hepatic long chain fatty acid metabolism and triglyceride accumulation contribute to insulin resistance in non-human primates

scientific article

Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion

scientific article

Decreased VMAT2 in the pancreas of humans with type 2 diabetes mellitus measured in vivo by PET imaging

scientific article published on 02 May 2018

Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo

scientific article published in April 2004

Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy

scientific article published on 08 December 2013

Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference

scientific article published on 06 October 2020

Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease

scientific article published on 16 March 2020

Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients

scientific article

Effect of aging on muscle mitochondrial substrate utilization in humans

scientific article

Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats

scientific article published in October 2002

Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways

scientific article

Effects of pioglitazone on intramyocellular fat metabolism in patients with type 2 diabetes mellitus

scientific article

Effects of rexinoids on glucose transport and insulin-mediated signaling in skeletal muscles of diabetic (db/db) mice

scientific article published on 2 March 2004

Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice

scientific article published on 01 April 2006

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.

scientific article

Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake

scientific article

Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance.

scientific article

Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis

scientific article published on 04 March 2020

Glycerol-3-phosphate acyltransferase 1 deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity

scientific article

Hepatic Insulin Resistance Is Not Pathway Selective in Humans With Nonalcoholic Fatty Liver Disease

scientific article published on 08 December 2020

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

scientific article published on 5 February 2015

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

scientific article published on 8 February 2004

Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance

scientific article

Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart

scientific article published on 8 February 2005

Hypophosphatemia promotes lower rates of muscle ATP synthesis

scientific article published on 23 June 2016

In vivo imaging of endogenous pancreatic β-cell mass in healthy and type 1 diabetic subjects using 18F-fluoropropyl-dihydrotetrabenazine and PET.

scientific article published on 09 May 2012

In vivo studies on the mechanism of methylene cyclopropyl acetic acid and methylene cyclopropyl glycine-induced hypoglycemia

scientific article published on 26 February 2018

Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle

scientific journal article

Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats

scientific article published on 25 September 2007

Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids.

scientific article

Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle

scientific article published on 22 September 2015

Investigating the roles of mitochondrial and cytosolic malic enzyme in insulin secretion

scientific article

Islet-selectivity of G-protein coupled receptor ligands evaluated for PET imaging of pancreatic β-cell mass ⬇️

scientific article published on July 28, 2011

Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation

scientific article published on 29 December 2017

Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis

scientific article

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

scientific article

Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice

scientific article

Liver fatty acid binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPARalpha in fasting mice

scientific article

Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition

scientific article published on August 2009

Liver‐Specific Pyruvate Dehydrogenase Complex Deficiency Upregulates Lipogenesis in Adipose Tissue and Improves Peripheral Insulin Sensitivity ⬇️

scientific article published on September 12, 2010

Long term evaluation of disease progression through the quantitative magnetic resonance imaging of symptomatic knee osteoarthritis patients: correlation with clinical symptoms and radiographic changes

scientific article

Lysophosphatidic acid activates peroxisome proliferator activated receptor-γ in CHO cells that over-express glycerol 3-phosphate acyltransferase-1

scientific article (publication date: 20 April 2011)

Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation

scientific article published on 22 January 2009

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

scientific article

Mechanism for leptin's acute insulin-independent effect to reverse diabetic ketoacidosis

scientific article published on 23 January 2017

Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes

scientific article

Membrane bound diacylglycerols explain the dissociation of hepatic insulin resistance from steatosis in MTTP-/- mice

scientific article published on 09 September 2020

Metabolic control analysis of hepatic glycogen synthesis in vivo

scientific article published on 18 March 2020

Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.

scientific article

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

scientific article

Mitochondrial GTP regulates glucose-stimulated insulin secretion

scientific journal article

Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.

scientific article published on 17 April 2009

Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance

scientific article

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

scientific article (publication date: 16 May 2003)

Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs

scientific journal article

Mitochondrial phosphate transport during nutrient stimulation of INS-1E insulinoma cells.

scientific article published on 9 August 2013

Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophy

scientific article

N-acylphosphatidylethanolamine, a gut- derived circulating factor induced by fat ingestion, inhibits food intake.

scientific article published in November 2008

Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).

scientific article published on 6 October 2017

Nonacute effects of H-FABP deficiency on skeletal muscle glucose uptake in vitro

scientific article

PEPCK1 Antisense Oligonucleotide Prevents Adiposity and Impairs Hepatic Glycogen Synthesis in High-Fat Male Fed Rats

scientific article published on 01 January 2019

PET Imaging of Pancreatic Dopamine D2 and D3 Receptor Density with 11C-(+)-PHNO in Type 1 Diabetes

scientific article published on 10 October 2019

PKC-theta knockout mice are protected from fat-induced insulin resistance

scientific article

Pancreatic beta cell mass PET imaging and quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in rodent models of diabetes

scientific article published on 08 September 2010

Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

scholarly article

Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion

scientific article

Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry

scientific article published on 15 June 2003

Plasma membrane electron transport in pancreatic β-cells is mediated in part by NQO1 ⬇️

scientific article published on April 19, 2011

Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein

scientific article published on December 2009

Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice

scientific journal article

Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism

scientific article published on 21 March 2016

Publisher Correction: Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).

scientific article published on 31 January 2018

Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb’s cycle flux independent of ATP synthesis ⬇️

scientific article published on October 7, 2011

Re-patterning of skeletal muscle energy metabolism by fat storage-inducing transmembrane protein 2.

scientific article published on 14 October 2011

Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice.

scientific article published on 10 May 2016

Regulation of gluconeogenesis by Krüppel-like factor 15

scientific article published in April 2007

Regulation of hepatic energy metabolism and gluconeogenesis by BAD

scientific article published on February 2014

Regulation of hepatic mitochondrial oxidation by glucose-alanine cycling during starvation in humans

scientific article published on 01 November 2019

Regulation of hypothalamic malonyl-CoA by central glucose and leptin.

scholarly article

Reply to Constantin-Teodosiu et al.: mice with genetic PDH activation are not protected from high-fat diet-induced muscle insulin resistance

scientific article published on 23 January 2015

Resistance to high-fat diet-induced obesity but exacerbated insulin resistance in mice overexpressing preadipocyte factor-1 (Pref-1): a new model of partial lipodystrophy

scientific article published on 03 October 2008

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

scientific article published on 16 February 2006

Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler

scientific article

Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes

scientific article

Risk factors associated with the loss of cartilage volume on weight-bearing areas in knee osteoarthritis patients assessed by quantitative magnetic resonance imaging: a longitudinal study

scientific article

Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion

scientific article

Role of Gut Microbiota and Short Chain Fatty Acids in Modulating Energy Harvest and Fat Partitioning in Youth.

scientific article

Role of caspase-1 in regulation of triglyceride metabolism.

scientific article published on 4 March 2013

Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats

scientific article published on 25 January 2013

Skeletal muscle lipid metabolism with obesity

scientific article published on 27 December 2002

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance

scientific journal article

Synthesis and evaluation of [18F]exendin (9-39) as a potential biomarker to measure pancreatic β-cell mass

scientific article published on 26 October 2011

Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance

scientific article published on 19 February 2013

The "obese insulin-sensitive" adolescent: importance of adiponectin and lipid partitioning

scientific article

The Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic 13C Nuclear Magnetic Resonance Spectroscopy

scientific article

The effects of increased acetate turnover on glucose-induced insulin secretion in lean and obese humans

scientific article published on 01 February 2019

The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes

scientific article

The role of intramyocellular lipids during hypoglycemia in patients with intensively treated type 1 diabetes

scientific article published on 5 July 2005

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

scholarly article

The role of the carbohydrate response element-binding protein in male fructose-fed rats

scientific article

UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals

scientific article published on 30 July 2008

cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) promotes glucagon clearance and hepatic amino acid catabolism to regulate glucose homeostasis.

scientific article published on 17 April 2013

n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner.

scientific article published on 24 January 2007

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