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List of works by John E Shively

124I-labeled engineered anti-CEA minibodies and diabodies allow high-contrast, antigen-specific small-animal PET imaging of xenografts in athymic mice

scientific article

161 Evaluating changes in stable chromosomal translocation frequency as a biodosimeter in patients receiving radioimmunotherapy

scholarly article

A Phase I trial of 90Y-anti-carcinoembryonic antigen chimeric T84.66 radioimmunotherapy with 5-fluorouracil in patients with metastatic colorectal cancer

scientific article published on December 2003

A chimeric anti-CEA antibody with heavy interchain disulfide bonds deleted: molecular characterization and biodistributions in normal and tumor bearing mice

scientific article published on 01 January 1999

A facile, water-soluble method for modification of proteins with DOTA. Use of elevated temperature and optimized pH to achieve high specific activity and high chelate stability in radiolabeled immunoconjugates

scientific article published in November 1994

A phase I radioimmunotherapy trial evaluating 90yttrium-labeled anti-carcinoembryonic antigen (CEA) chimeric T84.66 in patients with metastatic CEA-producing malignancies.

scientific article

A phase I trial of (90)Y-DOTA-anti-CEA chimeric T84.66 (cT84.66) radioimmunotherapy in patients with metastatic CEA-producing malignancies

scientific article

A pretherapy biodistribution and dosimetry study of indium-111-radiolabeled trastuzumab in patients with human epidermal growth factor receptor 2-overexpressing breast cancer

scientific article

A series of anti-CEA/anti-DOTA bispecific antibody formats evaluated for pre-targeting: comparison of tumor uptake and blood clearance

scientific article published on 21 November 2012

A transition metal complex (Venus flytrap cluster) for radioimmunodetection and radioimmunotherapy

scientific article published on April 1991

A versatile bifunctional chelate for radiolabeling humanized anti-CEA antibody with In-111 and Cu-64 at either thiol or amino groups: PET imaging of CEA-positive tumors with whole antibodies

scientific article published on 8 November 2007

Accumulation of radiolabeled anti-CEA antibody (mT84.66) in the case of multiple LS174T tumors in a nude mouse model

scientific article published in April 2001

An improved method for conjugating monoclonal antibodies with N-hydroxysulfosuccinimidyl DOTA.

scientific article published in March 2001

Antibody Targeted PET Imaging of 64Cu-DOTA-Anti-CEA PEGylated Lipid Nanodiscs in CEA Positive Tumors

scientific article published on 30 January 2020

Antigenic sites in carcinoembryonic antigen

scientific article published on 01 September 1989

Artifactual CEA elevation due to human anti-mouse antibodies

scientific article published in October 1988

Biodistribution and radioimmunotherapy of human breast cancer xenografts with radiometal-labeled DOTA conjugated anti-HER2/neu antibody 4D5.

scientific article

Biodistribution of 111In- and 90Y-Labeled DOTA and Maleimidocysteineamido-DOTA Conjugated to Chimeric Anticarcinoembryonic Antigen Antibody in Xenograft-Bearing Nude Mice: Comparison of Stable and Chemically Labile Linker Systems ⬇️

scientific article published on January 1, 1998

CEA-related antigens: molecular biology and clinical significance

scientific article

CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes

scientific article published on 23 January 2019

CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis

scientific journal article

Carcinoembryonic antigen expression of resurgent human colon carcinoma after treatment with therapeutic doses of 90Y-alpha-carcinoembryonic antigen monoclonal antibody

scientific article published in July 1991

Characterization of 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[Methoxy(polyethylene glycerol)-2000] and Its Complex with Doxorubicin Using Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics

scientific article

Characterization of engineered anti-p185HER-2 (scFv-CH3)2 antibody fragments (minibodies) for tumor targeting

scientific article published on April 2004

Clinical evaluation of indium-111-labeled chimeric anti-CEA monoclonal antibody ⬇️

scientific article published on December 1, 1997

Cloning of the genes for T84.66, an antibody that has a high specificity and affinity for carcinoembryonic antigen, and expression of chimeric human/mouse T84.66 genes in myeloma and Chinese hamster ovary cells

scientific article published on April 1990

Combined radioimmunotherapy and chemotherapy of breast tumors with Y-90-labeled anti-Her2 and anti-CEA antibodies with taxol

scientific article published on September 2005

Comparison of CD38 targeted alpha- vs beta-radionuclide therapy of disseminated multiple myeloma in an animal model

scientific article published on 30 October 2020

Copper-64-labeled daratumumab as a PET/CT imaging tracer for multiple myeloma

scientific article published on 4 January 2018

Covalent disulfide-linked anti-CEA diabody allows site-specific conjugation and radiolabeling for tumor targeting applications

scientific article

Development and evaluation of 18F-TTCO-Cys40-Exendin-4: a PET probe for imaging transplanted islets

scientific article published on 7 January 2013

Diagnostic PET Imaging of Mammary Microcalcifications Using 64Cu-DOTA-Alendronate in a Rat Model of Breast Cancer

scientific article

Differential regulation of carcinoembryonic antigen and biliary glycoprotein by gamma-interferon.

scientific article published on April 1993

Dose escalation trial of indium-111-labeled anti-carcinoembryonic antigen chimeric monoclonal antibody (chimeric T84.66) in presurgical colorectal cancer patients.

scientific article

Effect of specific antibody pretreatment on liver uptake of 111In-labeled anticarcinoembryonic antigen monoclonal antibody in nude mice bearing human colon cancer xenografts

scientific article

Effective Targeting of TAG72 Peritoneal Ovarian Tumors via Regional Delivery of CAR-Engineered T Cells

scientific article published on 19 November 2018

Effects of recombinant human gamma-interferon on carcinoembryonic antigen expression of human colon cancer cells

scientific article published on February 1, 1992

Essential role of biliary glycoprotein (CD66a) in morphogenesis of the human mammary epithelial cell line MCF10F.

scientific article

Estimation of monoclonal antibody-associated 90Y activity needed to achieve certain tumor radiation doses in colorectal cancer patients.

scientific article published in February 1990

Evaluating changes in stable chromosomal translocation frequency in patients receiving radioimmunotherapy.

scientific article

Evaluation of [Ga]DO3A-VS-Cys-Exendin-4 as a PET Probe for Imaging Human Transplanted Islets in the Liver

Expression of biliary glycoprotein (CD66a) in normal and malignant breast epithelial cells.

scientific article

Facile Preparation of a Thiol-Reactive (18)F-Labeling Agent and Synthesis of (18)F-DEG-VS-NT for PET Imaging of a Neurotensin Receptor-Positive Tumor

scientific article published on 22 May 2014

Functional imaging of human epidermal growth factor receptor 2-positive metastatic breast cancer using (64)Cu-DOTA-trastuzumab PET.

scientific article

Generation of dual specific bivalent BiTEs (dbBIspecific T-cell engaging antibodies) for cellular immunotherapy

scientific article published on 05 September 2019

High-resolution microPET imaging of carcinoembryonic antigen-positive xenografts by using a copper-64-labeled engineered antibody fragment

scientific article published on July 2000

High-specific-activity 111In-labeled anticarcinoembryonic antigen monoclonal antibody: biodistribution and imaging in nude mice bearing human colon cancer xenografts

High-specific-activity 111In-labeled anticarcinoembryonic antigen monoclonal antibody: improved method for the synthesis of diethylenetriaminepentaacetic acid conjugates

Humanization of the anti-CEA T84.66 antibody based on crystal structure data

scientific article

Identification and characterization of new antigenic fragments related to carcinoembryonic antigen in adult feces ⬇️

scientific article published on 01 August 1992

Identifying CD38+ cells in patients with multiple myeloma: first-in-human imaging using copper-64-labeled daratumumab

scientific article published on 01 October 2020

Imaging of colon carcinoma with 111-indium-labeled anti-CEA monoclonal antibodies (Indacea) prior to surgery

scientific article published in October 1987

Imaging of human colorectal adenocarcinoma with indium-labeled anticarcinoembryonic antigen monoclonal antibody

scientific article published in November 1986

ImmunoPET, [64Cu]Cu-DOTA-Anti-CD33 PET-CT, Imaging of an AML Xenograft Model

scientific article published on 23 September 2019

Impact of radiolabeled antibody imaging on management of colon cancer

scientific article

Improved biodistribution and radioimmunoimaging with poly(ethylene glycol)-DOTA-conjugated anti-CEA diabody

scientific article published on January 2006

Improved targeting of an anti-TAG-72 antibody drug conjugate for the treatment of ovarian cancer

scientific article published on 05 May 2020

In vivo imaging of transplanted islets with 64Cu-DO3A-VS-Cys40-Exendin-4 by targeting GLP-1 receptor

scientific article published on 14 July 2011

Indole-Based and Cyclopentenylindole-Based Analogues Containing Fluorine Group as Potential 18F-Labeled Positron Emission Tomography (PET) G-Protein Coupled Receptor 44 (GPR44) Tracers

scientific article published in 2023

Initial clinical experience evaluating Yttrium-90-chimeric T84.66 anticarcinoembryonic antigen antibody and autologous hematopoietic stem cell support in patients with carcinoembryonic antigen-producing metastatic breast cancer.

scientific article

Initial experience evaluating 90yttrium-radiolabeled anti-carcinoembryonic antigen chimeric T84.66 in a phase I radioimmunotherapy trial

scientific article

Interferon regulatory factor 1 and a variant of heterogeneous nuclear ribonucleoprotein L coordinately silence the gene for adhesion protein CEACAM1

scientific article published on 02 May 2018

Kinetic and affinity constants of epitope specific anti-carcinoembryonic antigen (CEA) monoclonal antibodies for CEA and engineered CEA domain constructs ⬇️

scientific article published on June 1, 1998

Localization of intraperitoneal xenografts of human colon cancer by radiolabeled anti-CEA antibodies

scientific article published in June 1990

Maleimidocysteineamido-DOTA Derivatives: New Reagents for Radiometal Chelate Conjugation to Antibody Sulfhydryl Groups Undergo pH-Dependent Cleavage Reactions ⬇️

scientific article published on January 1, 1998

Mammalian expression and hollow fiber bioreactor production of recombinant anti-CEA diabody and minibody for clinical applications

scientific article published in July 2001

Metabolism and renal clearance of 111In-labeled DOTA-conjugated antibody fragments

scientific article published in March 2001

Minibody: A novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-CH3) which exhibits rapid, high-level targeting of xenografts

scientific article

Monoclonal antibodies for carcinoembryonic antigen and related antigens as a model system: a systematic approach for the determination of epitope specificities of monoclonal antibodies

scientific article published on 01 May 1983

Monoclonal antibodies for carcinoembryonic antigen and related antigens as a model system: determination of affinities and specificities of monoclonal antibodies by using biotin-labeled antibodies and avidin as precipitating agent in a solution phas

scientific article published on 01 May 1983

Monodispersed DOTA-PEG-conjugated anti-TAG-72 diabody has low kidney uptake and high tumor-to-blood ratios resulting in improved 64Cu PET.

scientific article published on 16 June 2010

Mutation analysis of the short cytoplasmic domain of the cell-cell adhesion molecule CEACAM1 identifies residues that orchestrate actin binding and lumen formation

scientific journal article

Numerical selection of optimal tumor imaging agents with application to engineered antibodies

scientific article published in February 2001

Optimizing radiolabeled engineered anti-p185HER2 antibody fragments for in vivo imaging

scientific article

PET imaging of 64Cu-DOTA-scFv-anti-PSMA lipid nanoparticles (LNPs): Enhanced tumor targeting over anti-PSMA scFv or untargeted LNPs

scientific article published on 17 January 2017

PET of Adoptively Transferred Chimeric Antigen Receptor T Cells with 89Zr-Oxine

scientific article published on 04 May 2018

Pharmacokinetics of an anti-carcinoembryonic antigen monoclonal antibody conjugated to a bifunctional transition metal carborane complex (venus flytrap cluster) in tumor-bearing mice.

scientific article published in August 1993

Phase I Study of Yttrium-90 Radiolabeled M5A Anti-Carcinoembryonic Antigen Humanized Antibody in Patients with Advanced Carcinoembryonic Antigen Producing Malignancies

scientific article published on 07 January 2020

Phase I/II Trial of Anticarcinoembryonic Antigen Radioimmunotherapy, Gemcitabine, and Hepatic Arterial Infusion of Fluorodeoxyuridine Postresection of Liver Metastasis for Colorectal Carcinoma.

scientific article published in September 2017

Phosphorylation of human CEACAM1-LF by PKA and GSK3β promotes its interaction with β-catenin ⬇️

scientific article published on 14 October 2021

Pilot trial evaluating an 123I-labeled 80-kilodalton engineered anticarcinoembryonic antigen antibody fragment (cT84.66 minibody) in patients with colorectal cancer

scientific article published in August 2004

Potent immunomodulatory effects of an anti-CEA-IL-2 immunocytokine on tumor therapy and effects of stereotactic radiation

scientific article published on 14 February 2020

Preclinical PET Imaging of NTSR-1-Positive Tumors with 64Cu- and 68Ga-DOTA-Neurotensin Analogs and Therapy with an 225Ac-DOTA-Neurotensin Analog

scientific article published on 19 August 2020

Preoperative imaging of colorectal carcinoma with 111In-labeled anticarcinoembryonic antigen monoclonal antibody

scientific article published on 01 December 1986

Presurgical imaging with indium-labeled anti-carcinoembryonic antigen for colon cancer staging

scientific article published on February 1990

Prognostic relevance of carcinoembryonic antigen and estrogen receptor status in breast cancer patients

scientific article published on September 1994

Prototype Small-Animal PET-CT Imaging System for Image-guided Radiation Therapy

scientific article published on 30 September 2019

Radioiodinated versus radiometal-labeled anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments: optimal pharmacokinetics for therapy

scientific article published on January 2007

Reduction of kidney uptake in radiometal labeled peptide linkers conjugated to recombinant antibody fragments. Site-specific conjugation of DOTA-peptides to a Cys-diabody

scientific article published in September 2002

Site-specific conjugation of monodispersed DOTA-PEGn to a thiolated diabody reveals the effect of increasing peg size on kidney clearance and tumor uptake with improved 64-copper PET imaging

scientific article

Structural characterization of a dimeric complex between the short cytoplasmic domain of CEACAM1 and the pseudo tetramer of S100A10-Annexin A2 using NMR and molecular dynamics

scientific article published on 21 August 2020

Synthesis and characterization of oligomeric nido-carboranyl phosphate diester conjugates to antibody and antibody fragments for potential use in boron neutron capture therapy of solid tumors

scientific article

Synthesis and evaluation of 18F-PTTCO-Cys40-Exendin-4 for PET imaging of ectopic insulinomas in rodents

scientific article published on 05 March 2020

Synthesis, positron emission tomography imaging, and therapy of diabody targeted drug lipid nanoparticles in a prostate cancer murine model

scientific article

TAG-72 targeted α-radionuclide therapy of ovarian cancer using actinium-225 labeled DOTAylated-huCC49 antibody

scientific article published on 03 July 2020

Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments.

scientific article

Targeting and therapy of carcinoembryonic antigen-expressing tumors in transgenic mice with an antibody-interleukin 2 fusion protein

scientific article published on 01 August 2000

Targeting, imaging, and therapy using a humanized antiprostate stem cell antigen (PSCA) antibody

scientific article published on May 2007

Testis imaging with 111In-labeled anticarcinoembryonic antigen monoclonal antibody: identification of carcinoembryonic antigen in normal germ cells

scientific article published on 01 December 1986

The crystal structure of an anti-CEA scFv diabody assembled from T84.66 scFvs in V(L)-to-V(H) orientation: implications for diabody flexibility

scientific article (publication date: 14 February 2003)

The effect of tumor CEA content and tumor size on tissue uptake of indium 111-labeled anti-CEA monoclonal antibody

scientific article published in February 1986

The effects of hyperthermia on tumor carcinoembryonic antigen expression

scientific article published in October 1989

The effects of tumor mass, tumor age, and external beam radiation on tumor-specific antibody uptake

scientific article published in March 1989

Tumor Uptake of 64Cu-DOTA-Trastuzumab in Patients with Metastatic Breast Cancer.

scientific article published on 21 June 2017

Tumor localization of anti-CEA single-chain Fvs: improved targeting by non-covalent dimers ⬇️

scientific article published on February 1, 1996

Tumor targeting of radiometal labeled anti-CEA recombinant T84.66 diabody and t84.66 minibody: comparison to radioiodinated fragments

scientific article published on March 2001

Tumor uptake as a function of tumor mass: a mathematic model

scientific article published in January 1988

Vinyl sulfone bifunctional derivatives of DOTA allow sulfhydryl- or amino-directed coupling to antibodies. Conjugates retain immunoreactivity and have similar biodistributions

scientific article published in January 2002

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