List of works - Marcin Golczak

A genetic dissection of intestinal fat-soluble vitamin and carotenoid absorption

scientific journal article

A mitochondrial enzyme degrades carotenoids and protects against oxidative stress

scientific article

A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration.

scientific article

A putative consensus sequence for the nucleotide-binding site of annexin A6.

scientific article published in August 2003

Aberrant metabolites in mouse models of congenital blinding diseases: formation and storage of retinyl esters.

scientific article

Abnormal Cannabidiol Modulates Vitamin A Metabolism by Acting as a Competitive Inhibitor of CRBP1

scientific article published on 18 February 2019

Activation of retinoic acid receptors by dihydroretinoids

scientific article published on 21 September 2009

An acyl-covalent enzyme intermediate of lecithin:retinol acyltransferase

scientific article

Analysis of Carotenoid Isomerase Activity in a Prototypical Carotenoid Cleavage Enzyme, Apocarotenoid Oxygenase (ACO)

scientific article

Annexin-A6 presents two modes of association with phospholipid membranes. A combined QCM-D, AFM and cryo-TEM study

scientific article

Asymmetry of the rhodopsin dimer in complex with transducin ⬇️

scientific article published on January 9, 2013

Beta,beta-carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta,beta-carotene oxygenase 1-dependent manner

scientific article

Catalytic mechanism of a retinoid isomerase essential for vertebrate vision

scientific article

Cellular retinaldehyde binding protein-different binding modes and micro-solvation patterns for high-affinity 9-cis- and 11-cis-retinal substrates

scientific article published on 10 September 2013

Characterization of the Role of β-Carotene 9,10-Dioxygenase in Macular Pigment Metabolism

scientific article

Chemistry of the retinoid (visual) cycle

scientific article

Crystal structure of a photoactivated deprotonated intermediate of rhodopsin

scientific article

Crystal structure of native RPE65, the retinoid isomerase of the visual cycle

scientific article

DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice.

scientific article

Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents

scientific article published on January 2007

Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice

scientific article

Endogenous fluorophores enable two-photon imaging of the primate eye.

scientific article

Enzyme That Makes You Cry-Crystal Structure of Lachrymatory Factor Synthase from Allium cepa.

scientific article published on 14 July 2017

Evidence for RPE65-independent vision in the cone-dominated zebrafish retina

scientific article published on 14 September 2007

Expansion of first-in-class drug candidates that sequester toxic all-trans-retinal and prevent light-induced retinal degeneration

scientific article

GTP-induced membrane binding and ion channel activity of annexin VI: is annexin VI a GTP biosensor?

scientific article published on May 2002

Heterologous expression of the adenosine A1 receptor in transgenic mouse retina

scientific article

Human Cellular Retinaldehyde-Binding Protein Has Secondary Thermal 9- cis -Retinal Isomerase Activity

scientific article

Human cone photoreceptor dependence on RPE65 isomerase

scientific article

Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase

scientific article

Impact of LCA-Associated E14L LRAT Mutation on Protein Stability and Retinoid Homeostasis.

scientific article published on 31 July 2017

Impact of retinal disease-associated RPE65 mutations on retinoid isomerization

scientific article published on 23 August 2008

Importance of Membrane Structural Integrity for RPE65 Retinoid Isomerization Activity

scientific article

Inner retinal photoreception independent of the visual retinoid cycle.

scientific article

Involvement of all-trans-retinal in acute light-induced retinopathy of mice

scientific article published on 20 March 2009

Isolation and functional characterization of a stable complex between photoactivated rhodopsin and the G protein, transducin

scientific article published on 30 September 2008

Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase

scientific article published on 24 July 2016

Key enzymes of the retinoid (visual) cycle in vertebrate retina

scientific article

LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3

scientific article

Lecithin:Retinol Acyltransferase Is Critical for Cellular Uptake of Vitamin A from Serum Retinol-binding Protein ⬇️

scientific article published on May 27, 2012

Lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle

scientific article published on 10 October 2005

Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina

scientific article published on 24 June 2009

Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate

scientific article published on April 2009

Mechanism of All-trans-retinal Toxicity with Implications for Stargardt Disease and Age-related Macular Degeneration ⬇️

scientific article published on December 19, 2011

Melanopsin is highly resistant to light and chemical bleaching in vivo.

scientific article

Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina

scientific journal article

MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice

scientific article

Molecular Basis for Vitamin A Uptake and Storage in Vertebrates

scientific article

Molecular biology and analytical chemistry methods used to probe the retinoid cycle

scientific article

Molecular pharmacodynamics of emixustat in protection against retinal degeneration

scientific article

Multifunctional PEG retinylamine conjugate provides prolonged protection against retinal degeneration in mice

scientific article

Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye.

scientific article

Phospholipids are needed for the proper formation, stability, and function of the photoactivated rhodopsin-transducin complex

scientific article published on June 2009

Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle

scientific article

Primary amines protect against retinal degeneration in mouse models of retinopathies ⬇️

scientific article published on December 25, 2011

Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations

scientific article

Prolonged prevention of retinal degeneration with retinylamine loaded nanoparticles

scientific article

Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration

scientific article published on 17 July 2018

RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome

scientific article published on March 2008

Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented Epithelium

scientific article published on 14 November 2016

Regulation of DJ-1 by Glutaredoxin 1 in Vivo: Implications for Parkinson's Disease

scientific article

Retinopathy in mice induced by disrupted all-trans-retinal clearance

scientific article

Retinylamine Benefits Early Diabetic Retinopathy in Mice

scientific article

Rhodopsin–transducin heteropentamer: Three-dimensional structure and biochemical characterization ⬇️

scientific article published on September 6, 2011

Role of Bulk Water in Hydrolysis of the Rhodopsin Chromophore ⬇️

scientific article published on May 27, 2011

Stabilizing Function for Myristoyl Group Revealed by the Crystal Structure of a Neuronal Calcium Sensor, Guanylate Cyclase-Activating Protein 1

scientific article

Structural Basis for the Acyltransferase Activity of Lecithin:Retinol Acyltransferase-like Proteins

scientific article

Structure of human annexin a6 at the air-water interface and in a membrane-bound state.

scientific article

Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration

scientific article published on 15 November 2013

Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection

scientific article

The Biochemical Basis of Vitamin A3 Production in Arthropod Vision

scientific article published on 26 January 2016

The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision

scientific article

Topology and membrane association of lecithin: retinol acyltransferase.

scientific article

Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas

scientific article

Two carotenoid oxygenases contribute to mammalian provitamin A metabolism

scientific article published on 08 October 2013

Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice

scientific article published on 24 March 2014

Utilization of Dioxygen by Carotenoid Cleavage Oxygenases

scientific article

List of works by Marcin Golczak

A genetic dissection of intestinal fat-soluble vitamin and carotenoid absorption

A mitochondrial enzyme degrades carotenoids and protects against oxidative stress

A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration.

A putative consensus sequence for the nucleotide-binding site of annexin A6.

Aberrant metabolites in mouse models of congenital blinding diseases: formation and storage of retinyl esters.

Abnormal Cannabidiol Modulates Vitamin A Metabolism by Acting as a Competitive Inhibitor of CRBP1

Activation of retinoic acid receptors by dihydroretinoids

An acyl-covalent enzyme intermediate of lecithin:retinol acyltransferase

Analysis of Carotenoid Isomerase Activity in a Prototypical Carotenoid Cleavage Enzyme, Apocarotenoid Oxygenase (ACO)

Annexin-A6 presents two modes of association with phospholipid membranes. A combined QCM-D, AFM and cryo-TEM study

Asymmetry of the rhodopsin dimer in complex with transducin ⬇️

Beta,beta-carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta,beta-carotene oxygenase 1-dependent manner

Catalytic mechanism of a retinoid isomerase essential for vertebrate vision

Cellular retinaldehyde binding protein-different binding modes and micro-solvation patterns for high-affinity 9-cis- and 11-cis-retinal substrates

Characterization of the Role of β-Carotene 9,10-Dioxygenase in Macular Pigment Metabolism

Chemistry of the retinoid (visual) cycle

Crystal structure of a photoactivated deprotonated intermediate of rhodopsin

Crystal structure of native RPE65, the retinoid isomerase of the visual cycle

DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice.

Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents

Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice

Endogenous fluorophores enable two-photon imaging of the primate eye.

Enzyme That Makes You Cry-Crystal Structure of Lachrymatory Factor Synthase from Allium cepa.

Evidence for RPE65-independent vision in the cone-dominated zebrafish retina

Expansion of first-in-class drug candidates that sequester toxic all-trans-retinal and prevent light-induced retinal degeneration

GTP-induced membrane binding and ion channel activity of annexin VI: is annexin VI a GTP biosensor?

Heterologous expression of the adenosine A1 receptor in transgenic mouse retina

Human Cellular Retinaldehyde-Binding Protein Has Secondary Thermal 9- cis -Retinal Isomerase Activity

Human cone photoreceptor dependence on RPE65 isomerase

Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase

Impact of LCA-Associated E14L LRAT Mutation on Protein Stability and Retinoid Homeostasis.

Impact of retinal disease-associated RPE65 mutations on retinoid isomerization

Importance of Membrane Structural Integrity for RPE65 Retinoid Isomerization Activity

Inner retinal photoreception independent of the visual retinoid cycle.

Involvement of all-trans-retinal in acute light-induced retinopathy of mice

Isolation and functional characterization of a stable complex between photoactivated rhodopsin and the G protein, transducin

Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase

Key enzymes of the retinoid (visual) cycle in vertebrate retina

LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3

Lecithin:Retinol Acyltransferase Is Critical for Cellular Uptake of Vitamin A from Serum Retinol-binding Protein ⬇️

Lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle

Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina

Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate

Mechanism of All-trans-retinal Toxicity with Implications for Stargardt Disease and Age-related Macular Degeneration ⬇️

Melanopsin is highly resistant to light and chemical bleaching in vivo.

Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina

MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice

Molecular Basis for Vitamin A Uptake and Storage in Vertebrates

Molecular biology and analytical chemistry methods used to probe the retinoid cycle

Molecular pharmacodynamics of emixustat in protection against retinal degeneration

Multifunctional PEG retinylamine conjugate provides prolonged protection against retinal degeneration in mice

Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye.

Phospholipids are needed for the proper formation, stability, and function of the photoactivated rhodopsin-transducin complex

Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle

Primary amines protect against retinal degeneration in mouse models of retinopathies ⬇️

Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations

Prolonged prevention of retinal degeneration with retinylamine loaded nanoparticles

Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration

RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome

Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented Epithelium

Regulation of DJ-1 by Glutaredoxin 1 in Vivo: Implications for Parkinson's Disease

Retinopathy in mice induced by disrupted all-trans-retinal clearance

Retinylamine Benefits Early Diabetic Retinopathy in Mice

Rhodopsin–transducin heteropentamer: Three-dimensional structure and biochemical characterization ⬇️

Role of Bulk Water in Hydrolysis of the Rhodopsin Chromophore ⬇️

Stabilizing Function for Myristoyl Group Revealed by the Crystal Structure of a Neuronal Calcium Sensor, Guanylate Cyclase-Activating Protein 1

Structural Basis for the Acyltransferase Activity of Lecithin:Retinol Acyltransferase-like Proteins

Structure of human annexin a6 at the air-water interface and in a membrane-bound state.

Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration

Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection

The Biochemical Basis of Vitamin A3 Production in Arthropod Vision

The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision

Topology and membrane association of lecithin: retinol acyltransferase.

Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas

Two carotenoid oxygenases contribute to mammalian provitamin A metabolism

Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice

Utilization of Dioxygen by Carotenoid Cleavage Oxygenases