List of works - Glenn S Cowley

( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible ⬇️

scientific article published on 07 February 2013

A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines

scientific article published on 3 October 2017

A comprehensive platform for highly multiplexed mammalian functional genetic screens

scientific article

A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition

scientific article

A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor

scientific article published on 01 June 2020

A null mutation in the rhodopsin gene causes rod photoreceptor dysfunction and autosomal recessive retinitis pigmentosa

scientific article published on 01 June 1992

A point mutation of the rhodopsin gene in one form of retinitis pigmentosa

scientific article

BIOL-04. INTEGRATED COPY-NUMBER AND CANCER DEPENDENCY ANALYSIS REVEALS ALTERED SPLICEOSOME STOICHIOMETRY AS A NOVEL VULNERABILITY IN GENOMICALLY DISRUPTED CANCERS.

scientific article published on 31 May 2017

CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.

scientific article published on 4 December 2017

Cancer vulnerabilities unveiled by genomic loss

scientific article

Cells Lacking the RB1 Tumor Suppressor Gene are Hyperdependent on Aurora B Kinase for Survival

article

Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance Mechanisms to Selective RAF Inhibitors.

scientific article

Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

scientific article

Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.

scientific article

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.

scientific article

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

scientific article published on April 2016

Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.

scientific article

Defining a Cancer Dependency Map.

scientific article

Detection of the XbaI RFLP within the retinoblastoma locus by PCR.

scientific article published on January 1990

Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden

scientific article published on 4 December 2017

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

scientific article

Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells

scientific article

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma

scientific article

Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells.

scientific article

Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

scientific article published on 09 May 2019

Genetic variation in the 3' untranslated region of the neurofibromatosis 1 gene: application to unequal allelic expression

scientific article published on 01 March 1998

Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity

scientific article published on 24 July 2018

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

scientific article published on 3 June 2016

HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase.

scientific article published in July 2017

In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling

scientific article published on 13 June 2013

In vivo discovery of immunotherapy targets in the tumour microenvironment

scientific article

Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation

scientific article

Integrated genetic and pharmacologic interrogation of rare cancers

scientific article

MEDULLOBLASTOMA

MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

scientific article published on 11 February 2016

Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer

scientific article published on 28 May 2013

Mutations within the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa

scientific article

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

scientific article published on 03 June 2019

PDTM-36. FUNCTIONAL GENOMIC ANALYSIS OF -AMPLIFIED MEDULLOBLASTOMA NOMINATES THE TGFB PATHWAY AS A CLINICALLY VIABLE TARGET

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

scientific article published on 10 April 2017

PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.

scientific article

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

scientific article published on 30 September 2014

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

scientific article published on 11 November 2014

Probing the virus host interaction in high containment: an approach using pooled short hairpin RNA

scientific article

Reply to Haffner et al.: DNA hypomethylation renders tumors more immunogenic

scientific article published on 04 September 2018

Rescue of a Drosophila NF1 mutant phenotype by protein kinase A.

scientific article published in May 1997

SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer

scientific article published on December 2013

Small-molecule targeting of brachyury transcription factor addiction in chordoma

scientific article published on 21 January 2019

Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington's disease

scientific article

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

scientific article

Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4

scientific article published on August 2012

The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection

scientific article (publication date: February 2014)

The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity

scientific article

β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis

scientific article

List of works by Glenn S Cowley

( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible ⬇️

A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines

A comprehensive platform for highly multiplexed mammalian functional genetic screens

A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition

A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor

A null mutation in the rhodopsin gene causes rod photoreceptor dysfunction and autosomal recessive retinitis pigmentosa

A point mutation of the rhodopsin gene in one form of retinitis pigmentosa

BIOL-04. INTEGRATED COPY-NUMBER AND CANCER DEPENDENCY ANALYSIS REVEALS ALTERED SPLICEOSOME STOICHIOMETRY AS A NOVEL VULNERABILITY IN GENOMICALLY DISRUPTED CANCERS.

CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.

Cancer vulnerabilities unveiled by genomic loss

Cells Lacking the RB1 Tumor Suppressor Gene are Hyperdependent on Aurora B Kinase for Survival

Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance Mechanisms to Selective RAF Inhibitors.

Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.

Defining a Cancer Dependency Map.

Detection of the XbaI RFLP within the retinoblastoma locus by PCR.

Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma

Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells.

Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

Genetic variation in the 3' untranslated region of the neurofibromatosis 1 gene: application to unequal allelic expression

Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase.

In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling

In vivo discovery of immunotherapy targets in the tumour microenvironment

Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation

Integrated genetic and pharmacologic interrogation of rare cancers

MEDULLOBLASTOMA

MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer

Mutations within the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

PDTM-36. FUNCTIONAL GENOMIC ANALYSIS OF -AMPLIFIED MEDULLOBLASTOMA NOMINATES THE TGFB PATHWAY AS A CLINICALLY VIABLE TARGET

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

Probing the virus host interaction in high containment: an approach using pooled short hairpin RNA

Reply to Haffner et al.: DNA hypomethylation renders tumors more immunogenic

Rescue of a Drosophila NF1 mutant phenotype by protein kinase A.

SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer

Small-molecule targeting of brachyury transcription factor addiction in chordoma

Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington's disease

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4

The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection

The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity

β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis