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List of works by Wolfgang R Sperr

10th anniversary of the Austrian MDS Platform: aims and ongoing projects.

scientific article published on 25 November 2014

A case of smouldering mastocytosis with peripheral blood eosinophilia and lymphadenopathy

scientific article published on 01 June 2002

A novel effective and safe consolidation for patients over 60 years with acute myeloid leukemia: intermediate dose cytarabine (2 x 1 g/m2 on days 1, 3, and 5).

scientific article published on June 2004

A novel pump-driven veno-venous gas exchange system during extracorporeal CO2-removal.

scientific article published on 14 July 2015

A patient with de novo AML M1 and t(16;21) with karyotype evolution.

scientific article

A recombinant hypoallergenic parvalbumin mutant for immunotherapy of IgE-mediated fish allergy.

scientific article published in May 2007

A surge of flu-associated adult respiratory distress syndrome in an Austrian tertiary care hospital during the 2009/2010 Influenza A H1N1v pandemic ⬇️

scientific article published on April 7, 2011

Additional prognostic impact of the percentage of erythroid cells in the bone marrow of patients with myelodysplastic syndromes

scientific article published on 28 December 2018

Advanced systemic mastocytosis: from molecular and genetic progress to clinical practice

scientific article

Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future.

scientific article

Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy

scientific article published on 14 June 2018

Aggressive systemic mastocytosis and related mast cell disorders: current treatment options and proposed response criteria

scientific article

An unusual case of myelodysplastic syndrome with prolonged clonal stability, indolent clinical course over a decade, and spontaneous regression of AML in the terminal phase

scientific article

Assays for measuring in vitro basophil activation induced by recombinant allergens

scientific article published on March 2004

Azacitidine for Front-Line Therapy of Patients with AML: Reproducible Efficacy Established by Direct Comparison of International Phase 3 Trial Data with Registry Data from the Austrian Azacitidine Registry of the AGMT Study Group

scientific article

Azacitidine front-line in 339 patients with myelodysplastic syndromes and acute myeloid leukaemia: comparison of French-American-British and World Health Organization classifications

scientific article published on 16 April 2016

Azacitidine in 302 patients with WHO-defined acute myeloid leukemia: results from the Austrian Azacitidine Registry of the AGMT-Study Group

scientific article

Azacitidine in Acute Myeloid Leukemia with >30% Bone Marrow Blasts and <15 G/L White Blood Cell Count: Results from the Austrian Azacitidine Registry of the AGMT Study Group Versus Randomized Controlled Phase III Clinical Trial Data

Azacitidine in Acute Myeloid Leukemia: Comparison of Patients with AML-MRF Vs AML-NOS Enrolled in the Austrian Azacitidine Registry ⬇️

scholarly article

Azacitidine in CMML: matched-pair analyses of daily-life patients reveal modest effects on clinical course and survival

scientific article published on 18 January 2014

Azacitidine in Patients with Acute Myeloid Leukemia: Impact of Intermediate-Risk Vs High-Risk Cytogenetics on Patient Outcomes ⬇️

scholarly article

A multicenter retrospective evaluation of Chronic Myeloid Leukemia (CML) therapy in Austria assessing the impact of early treatment response on patient outcomes in a real-life setting : R-EFECT study

scientific article published on 12 June 2020

BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin.

scientific article published on 18 July 2002

BCR/ABL+ CML Stem Cells (CD34+/CD38-) Express High Levels of CD33 and Are Responsive to a CD33-Targeting Drug: a New Potential Concept for Eradication of CML Stem Cells. ⬇️

scholarly article

Biology and clinical features of myeloid neoplasms with inv(3)(q21q26) or t(3;3)(q21q26).

scientific article published in November 2007

Bone marrow microvessel density and its prognostic significance in AML

scientific article published on 01 July 2004

Brief report: practicability and safety of amphotericin B deoxycholate as continuous infusion in neutropenic patients with hematological malignancies

scientific article

Bromodomain-Containing Protein 4 (BRD4): A Novel Marker and Drug Target Expressed In Neoplastic Cells In Advanced Mast Cell Neoplasms ⬇️

scholarly article

C5a stimulates production of plasminogen activator inhibitor-1 in human mast cells and basophils.

scientific article published on July 2002

CCL-2 Is a KIT D816V-Dependent Modulator of Bone Marrow Remodeling and Microenvironmental Alterations in Systemic Mastocytosis ⬇️

scholarly article

CCL2 is a KIT D816V-dependent modulator of the bone marrow microenvironment in systemic mastocytosis.

scientific article published on 16 November 2016

CD 33 as a target of therapy in acute myeloid leukemia: current status and future perspectives

scientific article

CD34(+)/CD38(-) stem cells in chronic myeloid leukemia express Siglec-3 (CD33) and are responsive to the CD33-targeting drug gemtuzumab/ozogamicin

scientific article published on 11 October 2011

CD44 is a RAS/STAT5-regulated invasion receptor that triggers disease expansion in advanced mastocytosis

scientific article published on 17 July 2018

CDK4/CDK6 inhibition as a novel strategy to suppress the growth and survival of BCR-ABL1T315I+ clones in TKI-resistant CML

scientific article published on 21 November 2019

COVID-19 Vaccination in Mastocytosis: Recommendations of the European Competence Network on Mastocytosis (ECNM) and American Initiative in Mast Cell Diseases (AIM)

scientific article published in 2021

Cell-based and antibody-mediated immunotherapies directed against leukemic stem cells in acute myeloid leukemia: Perspectives and open issues

scientific article published on 13 July 2020

Cerivastatin and atorvastatin inhibit IL-3-dependent differentiation and IgE-mediated histamine release in human basophils and downmodulate expression of the basophil-activation antigen CD203c/E-NPP3.

scientific article published on January 2003

Characterization of mutants of a highly cross-reactive calcium-binding protein from Brassica pollen for allergen-specific immunotherapy

scientific article

Chronic mast cell leukemia: a novel leukemia-variant with distinct morphological and clinical features

scientific article

Chronic myeloid leukemia: pathophysiology, diagnostic parameters, and current treatment concepts

scientific article

Clinical Impact of Skin Lesions in Mastocytosis: A Multicenter Study of the European Competence Network on Mastocytosis

scientific article published in July 2021

Clinical Outcomes of 217 Patients with Acute Erythroleukemia According to Treatment Type and Line: A Retrospective Multinational Study.

scientific article published on 14 April 2017

Clinical features and survival of patients with indolent systemic mastocytosis defined by the updated WHO classification

scientific article published on 28 February 2020

Clofarabine/Cyclophosphamide (ClofCy) for Debulking refractory Acute Leukemias Prior to Allogeneic Hematopoietic Stem Cell Transplantation ⬇️

scholarly article

Clofarabine/cyclophosphamide for debulking before stem cell transplantation

scientific article published on 01 August 2014

Clonal Hematopoiesis with Oncogenic Potential (CHOP): Separation from CHIP and Roads to AML

scientific article published on 12 February 2019

Clonal T cell-mediated cyclic thrombocytopenia

scientific article

Clustering of comorbidities is related to age and sex and impacts clinical outcome in myelodysplastic syndromes.

scientific article published on 11 March 2014

Comparison of BCR-ABL1 quantification in peripheral blood and bone marrow using an International Scale-standardized assay for assessment of deep molecular response in chronic myeloid leukemia

scientific article published on 22 February 2020

Consensus Opinion on Allogeneic Hematopoietic Cell Transplantation in Advanced Systemic Mastocytosis.

scientific article published on 27 April 2016

Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes

scientific article

Conversion of grass pollen allergen-specific human IgE into a protective IgG(1) antibody

scientific article

Core-binding factor acute myeloid leukemia with inv(16): Older age and high white blood cell count are risk factors for treatment failure

scientific article published on 14 September 2020

Core-binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I-CBFit)

Coronavirus Receptor Expression Profiles in Human Mast Cells, Basophils, and Eosinophils

scholarly article published on 17 January 2024

Correlation of RAS-Pathway Mutations and Spontaneous Myeloid Colony Growth with Progression and Transformation in Chronic Myelomonocytic Leukemia-A Retrospective Analysis in 337 Patients

scientific article published on 24 April 2020

Critically ill patients with cancer: chances and limitations of intensive care medicine-a narrative review

scientific article

Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology

scientific article published on 15 October 2015

Cytogenetic and molecular aberrations and worse outcome for male patients in systemic mastocytosis

scientific article published on 01 January 2021

Cytopenia levels for aiding establishment of the diagnosis of myelodysplastic syndromes

scientific article published on 17 August 2016

Cytotoxic effects of packable and nonpackable dental composites

scientific article published on July 2003

Cytotoxicity of resin composites as a function of interface area

scientific article published on 3 August 2007

DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

scientific article

Definitions and standards in the diagnosis and treatment of the myelodysplastic syndromes: Consensus statements and report from a working conference

scientific article published on 25 January 2007

Definitions, criteria and global classification of mast cell disorders with special reference to mast cell activation syndromes: a consensus proposal

scientific article published on 27 October 2011

Delineation of target expression profiles in CD34+/CD38- and CD34+/CD38+ stem and progenitor cells in AML and CML

scientific article published on 01 October 2020

Detection of mi transcription factor (MITF) mRNA in a case of myelodysplastic syndrome and bone marrow mastocytosis

scientific article published on February 13, 1998

Detection of molecular targets on the surface of CD34+/CD38-- stem cells in various myeloid malignancies.

scientific article

Detection of novel CD antigens on the surface of human mast cells and basophils

scientific article

Detection of trisomy 8 in donor-derived Ph- cells in a patient with Ph+ chronic myeloid leukemia successfully treated with Imatinib (STI571) in relapse after allogeneic transplantation

scientific article published in July 2004

Diagnosis and classification of mast cell proliferative disorders: delineation from immunologic diseases and non-mast cell hematopoietic neoplasms.

scientific article published in July 2004

Diagnosis and treatment of systemic mastocytosis: state of the art.

scientific article

Diagnosis, management and response criteria of iron overload in myelodysplastic syndromes (MDS): updated recommendations of the Austrian MDS platform

scientific article published on 02 January 2018

Diagnosis, progression patterns and prognostication in mastocytosis

scientific article published on June 2012

Diagnostic and Prognostic Significance of Tryptase in Clinical Hematology: A Single Center Experience from 1070 Patients. ⬇️

scholarly article

Diagnostic and prognostic value of new biochemical and immunohistochemical parameters in chronic myeloid leukemia.

scientific article published on April 2008

Diagnostic and subdiagnostic accumulation of mast cells in the bone marrow of patients with anaphylaxis: Monoclonal mast cell activation syndrome.

scientific article published on 20 October 2006

Differing clinical features between Japanese and Caucasian patients with myelodysplastic syndromes: Analysis from the International Working Group for Prognosis of MDS

scientific article published on 06 September 2018

Digital PCR: A Sensitive and Precise Method for KIT D816V Quantification in Mastocytosis

scientific article

Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia

scientific article published on 28 April 2014

Does high-dose cytarabine cause cumulative toxicity in patients undergoing consolidation therapy for acute myeloid leukemia?

scientific article published on 02 May 2013

Dose study of the multikinase inhibitor, LY2457546, in patients with relapsed acute myeloid leukemia to assess safety, pharmacokinetics, and pharmacodynamics

scientific article

Drug-induced mast cell eradication: A novel approach to treat mast cell activation disorders?

scientific article published in 2022

Efficacy and tolerability of non-invasive ventilation delivered via a newly developed helmet in immunosuppressed patients with acute respiratory failure ⬇️

scientific article published on September 15, 2003

Emicizumab for the treatment of acquired hemophilia A

scientific article published on 07 August 2020

Eosinophilia in systemic mastocytosis: clinical and molecular correlates and prognostic significance

scientific article published on 23 April 2007

Establishment and validation of a novel risk model for estimating time to first treatment in 120 patients with chronic myelomonocytic leukaemia

scientific article published on 30 January 2018

European Competence Network on Mastocytosis (ECNM): 10-year jubilee, update, and future perspectives

scientific article

Evaluation of Cell Surface Markers and Targets in Leukemic Stem Cells (LSC) Reveals Distinct Expression Profiles, Unique Drug Effects, and Specific Checkpoint Regulation in AML LSC and CML LSC ⬇️

scholarly article

Evaluation of angiogenesis and vascular endothelial growth factor expression in the bone marrow of patients with aplastic anemia.

scientific article

Evaluation of biologic activity of tryptase secreted from blast cells in acute myeloid leukemia.

scientific article

Evaluation of efficacy of alemtuzumab in 5 patients with aplastic anemia and/or myelodysplastic neoplasm

scientific article published on 14 October 2016

Evaluation of in vitro effects of various targeted drugs on plasma cells and putative neoplastic stem cells in patients with multiple myeloma.

scientific article published on 25 August 2016

Evaluation of in vivo antineoplastic effects of rapamycin in patients with chemotherapy-refractory AML.

scientific article published on 7 October 2009

Evaluation of normal and neoplastic human mast cells for expression of CD172a (SIRPalpha), CD47, and SHP-1.

scientific article

Evaluation of the prognostic significance of eosinophilia and basophilia in a larger cohort of patients with myelodysplastic syndromes

scientific article

Evaluation of treatment responses and colony-forming progenitor cells in 50 patients with aplastic anemia after immunosuppressive therapy or hematopoietic stem cell transplantation: a single-center experience.

scientific article published on 18 January 2014

Expression and prognostic significance of different mRNA 5'-end variants of the oncogene EVI1 in 266 patients with de novo AML: EVI1 and MDS1/EVI1 overexpression both predict short remission duration

scientific article

Expression of CD25 on leukemic stem cells in BCR-ABL1+ CML: Potential diagnostic value and functional implications.

scientific article published on 27 April 2017

Expression of cell surface antigens on mast cells: mast cell phenotyping.

scientific article published in January 2006

Extracorporeal CO2 removal as bridge to lung transplantation in life-threatening hypercapnia.

scientific article published on 5 December 2014

Extracorporeal membrane oxygenation in adult patients with hematologic malignancies and severe acute respiratory failure

scientific article

FLAG-induced remission in a patient with acute mast cell leukemia (MCL) exhibiting t(7;10)(q22;q26) and KIT D816H

scientific article published on 26 November 2013

First experience with a new miniaturized pump-driven venovenous extracorporeal CO2 removal system (iLA Activve): a retrospective data analysis

scientific article

First-in-human response of BCL-2 inhibitor venetoclax in T-cell prolymphocytic leukemia.

scientific article published on 27 September 2017

Frequency, onset and clinical impact of somatic DNMT3A mutations in therapy-related and secondary acute myeloid leukemia

scientific article published on 11 October 2011

Further Evaluation of Pro-Atherogenic and Anti-Angiogenic Effects of Nilotinib in Mice and in Patients with Ph-Chromosome+ CML ⬇️

scholarly article

Gain of structure and IgE epitopes by eukaryotic expression of the major Timothy grass pollen allergen, Phl p 1.

scientific article

Generation of an allergy vaccine by disruption of the three-dimensional structure of the cross-reactive calcium-binding allergen, Phl p 7.

scientific article published on May 2004

Genetic engineering of the major timothy grass pollen allergen, Phl p 6, to reduce allergenic activity and preserve immunogenicity

scientific article published in August 2007

Genome wide molecular analysis of minimally differentiated acute myeloid leukemia

scientific article published on 22 September 2009

Global Classification of Mast Cell Activation Disorders: An ICD-10-CM–Adjusted Proposal of the ECNM-AIM Consortium

scientific article published in 2022

Guidelines and diagnostic algorithm for patients with suspected systemic mastocytosis: a proposal of the Austrian competence network (AUCNM)

scientific article published on 5 May 2013

Haematopoietic stem cell transplantation for treatment of primary CNS lymphoma: single-centre experience and literature review.

scientific article published on 23 March 2015

Hematopoietic stem-cell transplantation for advanced systemic mastocytosis

scientific article

Heme Oxygenase-1 (HO-1)/Heat Shock Protein 32 (Hsp32) as a Novel Survival Factor and Target in AML. ⬇️

scholarly article

Hereditary alpha tryptasemia is a valid genetic biomarker for severe mediator-related symptoms in mastocytosis

scientific article published on 10 August 2020

High Spontaneous In Vitro Myeloid Colony Formation in Chronic Myelomonocytic Leukemia is Associated with Mutations in Rasopathy Genes, Myeloproliferation and Inferior Prognosis ⬇️

scholarly article

High dose intermittent ARA-C (HiDAC) for consolidation of patients with de novo AML: a single center experience.

scientific article published on 25 January 2005

High frequency of concomitant mastocytosis in patients with acute myeloid leukemia exhibiting the transforming KIT mutation D816V.

scientific article published on 24 April 2010

Highly refractory acute myeloid leukemia.

scientific article published in August 2004

Hom s 4, an IgE-reactive autoantigen belonging to a new subfamily of calcium-binding proteins, can induce Th cell type 1-mediated autoreactivity

scientific article published on July 2005

How I treat patients with advanced systemic mastocytosis.

scientific article

Hydroxyurea Induces Growth Inhibition in BCR-ABL1 T315I+ Clones and Synergizes with Ponatinib in Killing TKI-Resistant CML Cells ⬇️

scholarly article

Identification of CAR As a Novel Mediator of Erythroid Differentiation and Migration That Is Specifically Downregulated in Erythropoietic Progenitor Cells in Patients with MDS ⬇️

scholarly article

Identification of CD25 as STAT5-Dependent Growth Regulator of Leukemic Stem Cells in Ph+ CML.

scientific article published on 25 November 2015

Identification of CD44 As a RAS-MEK-Regulated Invasion Receptor That Is Overexpressed in Neoplastic Mast Cells and Triggers Disease Expansion in Advanced Systemic Mastocytosis ⬇️

scholarly article

Identification of a Neoplastic Stem Cell in Human Mast Cell Leukemia ⬇️

scholarly article

Identification of a leukemia-initiating stem cell in human mast cell leukemia

scientific article published on 05 April 2019

Identification of campath-1 (CD52) as novel drug target in neoplastic stem cells in 5q-patients with MDS and AML.

scientific article published on 5 May 2014

Identification of heat shock protein 32 (Hsp32) as a novel target in acute lymphoblastic leukemia

scientific article published on March 2014

Identification of heme oxygenase-1 as a novel BCR/ABL-dependent survival factor in chronic myeloid leukemia

scientific article published on May 2004

Identification of mTOR as a novel bifunctional target in chronic myeloid leukemia: dissection of growth-inhibitory and VEGF-suppressive effects of rapamycin in leukemic cells.

scientific article published on 22 March 2005

Identification of the Epigenetic Reader BRD4 As a Novel Potential Target in Ph+ CML ⬇️

scholarly article

Idiopathic bone marrow dysplasia of unknown significance (IDUS): definition, pathogenesis, follow up, and prognosis ⬇️

scientific article published on March 16, 2010

Idiopathic cytopenia of undetermined significance (ICUS) and idiopathic dysplasia of uncertain significance (IDUS), and their distinction from low risk MDS ⬇️

scientific article published on September 13, 2011

Idiopathic cytopenia of undetermined significance (ICUS) versus low risk MDS: the diagnostic interface.

scientific article

Image-based ex-vivo drug screening for patients with aggressive haematological malignancies: interim results from a single-arm, open-label, pilot study

scientific article published on 15 November 2017

Imatinib Inhibits SCF-Induced Development Of Human Mast Cells In Vitro and Induces Profound and Selective Mast Cell Deficiency In Patients With Ph+ CML ⬇️

scholarly article

Immunohistochemical detection of VEGF in the bone marrow of patients with acute myeloid leukemia. Correlation between VEGF expression and the FAB category.

scientific article published in May 2003

Immunohistochemical detection of VEGF in the bone marrow of patients with chronic myeloid leukemia and correlation with the phase of disease.

scientific article published in April 2004

Immunohistochemical detection of vascular endothelial growth factor (VEGF) in the bone marrow in patients with myelodysplastic syndromes: correlation between VEGF expression and the FAB category

scientific article published in March 2006

Immunological characterization and antibacterial function of persisting granulocytes in leukemic patients receiving pulse cytosine arabinoside-consolidation chemotherapy on days 1, 3, and 5.

scientific article published in February 2006

Immunotherapy-Based Targeting and Elimination of Leukemic Stem Cells in AML and CML ⬇️

scientific article published on 29 August 2019

Impact of age and comorbidity in myelodysplastic syndromes

scientific article published on October 2008

Improved outcome in patients with chronic myelogenous leukemia after allogeneic hematopoietic stem cell transplantation over the past 25 years: a single-center experience.

scientific article published in July 2010

In vitro and in vivo growth-inhibitory effects of cladribine on neoplastic mast cells exhibiting the imatinib-resistant KIT mutation D816V.

scientific article published on 27 May 2010

Incidence of intensive care unit admission, outcome and post intensive care survival in patients with diffuse large B-cell lymphoma

scientific article

Increased angiogenesis in the bone marrow of patients with systemic mastocytosis.

scientific article published on May 2002

Individualized management and therapy of myelodysplastic syndromes

scientific article

Indolent systemic mastocytosis associated with atypical small lymphocytic lymphoma: a rare form of concomitant lymphoproliferative disease.

scientific article published on 2 May 2008

Indolent systemic mastocytosis with elevated serum tryptase, absence of skin lesions, and recurrent severe anaphylactoid episodes.

scientific article published on 17 February 2005

Induction of apoptosis in the human mast cell leukemia cell line HMC-1 by various antineoplastic drugs.

scientific article published on March 2003

Influence of dental amalgam and heavy metal cations on in vitro interleukin-1beta production by human peripheral blood mononuclear cells

scientific article published on 01 July 2000

Intensive consolidation with G-CSF support: Tolerability, safety, reduced hospitalization, and efficacy in acute myeloid leukemia patients ≥60 years.

scientific article published on 11 July 2017

International Working Group-Myeloproliferative Neoplasms Research and Treatment (IWG-MRT) & European Competence Network on Mastocytosis (ECNM) consensus response criteria in advanced systemic mastocytosis.

scientific article published on 16 January 2013

International prognostic scoring system for mastocytosis (IPSM): a retrospective cohort study

scientific article published on 31 October 2019

KIT D816 mutated/CBF-negative acute myeloid leukemia: a poor-risk subtype associated with systemic mastocytosis

scientific article published on 11 January 2019

Karyotype plus NPM1 mutation status defines a group of elderly patients with AML (≥60 years) who benefit from intensive post-induction consolidation therapy

scientific article published on 19 September 2016

Limited value of FLT3 mRNA expression in the bone marrow for prognosis and monitoring of patients with acute myeloid leukemia.

scientific article published in May 2005

Liposome-Encapsulated Doxorubicin Is Highly Active in Patients with B- as Well as T/NK-Cell Lymphomas and Cardiac Comorbidity or Older Age ⬇️

scholarly article

Long-lasting complete response to imatinib in a patient with systemic mastocytosis exhibiting wild type KIT.

scientific article

Long-term follow-up after allogeneic stem cell transplantation in patients with myelodysplastic syndromes or secondary acute myeloid leukemia: a single center experience

scientific article

Long-term treatment with imatinib results in profound mast cell deficiency in Ph+ chronic myeloid leukemia

scientific article published on February 2015

Ludwig Boltzmann Cluster Oncology (LBC ONC): first 10 years and future perspectives

scientific article published on 13 July 2018

MARS: Mutation-Adjusted Risk Score for Advanced Systemic Mastocytosis

scientific article published on 11 September 2019

Maintenance therapy with histamine plus IL-2 induces a striking expansion of two CD56bright NK cell subpopulations in patients with acute myeloid leukemia and supports their activation

scientific article published on 21 June 2016

Major response of PNH to an AML chemotherapy protocol

scientific article published on 22 March 2018

Massive release of the histamine-degrading enzyme diamine oxidase during severe anaphylaxis in mastocytosis patients

scientific article published on 01 January 2019

Mast cell proliferative disorders: current view on variants recognized by the World Health Organization

scientific article published on October 2003

Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts

scientific article published on 29 August 2020

Mastocytosis: pathology, genetics, and current options for therapy

scientific article

Meeting report: Vienna 2008 Workshop of the German-Austrian Working Group for Studying Prognostic Factors in Myelodysplastic Syndromes

scientific article published on 16 January 2009

Microarray-based Detection of Allergen-Reactive IgE in Patients with Mastocytosis

scientific article published on 26 April 2020

Molecular Quantification of Tissue Mast Cell Burden in Systemic Mastocytosis: A New Approach for Diagnostics and Prognostication ⬇️

scholarly article

Molecular characterization of polygalacturonases as grass pollen-specific marker allergens: expulsion from pollen via submicronic respirable particles

scientific article published in May 2004

Molecular characterization of recombinant T1, a non-allergenic periwinkle (Catharanthus roseus) protein, with sequence similarity to the Bet v 1 plant allergen family

scientific article

Molecular disease eradication is a prerequisite for long-term remission in patients with t(8;21) positive acute myeloid leukemia: a single center study.

scientific article

Molecular quantification of tissue disease burden is a new biomarker and independent predictor of survival in mastocytosis

scientific article published on 31 January 2020

Multidisciplinary Challenges in Mastocytosis and How to Address with Personalized Medicine Approaches

scientific article published on 18 June 2019

Myelodysplastic syndromes, aging, and age: correlations, common mechanisms, and clinical implications.

scientific article published on October 2007

Myeloid leukemias express a broad spectrum of VEGF receptors including neuropilin-1 (NRP-1) and NRP-2.

scientific article

Myelomastocytic leukemia: evidence for the origin of mast cells from the leukemic clone and eradication by allogeneic stem cell transplantation

scientific article

Myelomastocytic leukemia: myeloid neoplasm characterized by partial differentiation of mast cell-lineage cells

scientific article

Neoplastic stem cells: a novel therapeutic target in clinical oncology

scientific article published on November 2006

New developments in the field of mastocytosis and mast cell activation syndromes: a summary of the Annual Meeting of the European Competence Network on Mastocytosis (ECNM) 2019

scientific article published on 26 December 2019

Next Generation Sequencing Identifies DNA Methylation Patterns Indicative of Disease Progression in Ph+ CML ⬇️

scholarly article

Nilotinib Exerts Direct Effects on Vascular Endothelial Cells and May Act As a Co-Trigger of Atherosclerosis in Patients with Ph+ CML ⬇️

scholarly article

Nilotinib Exerts Direct Pro-Atherogenic and Anti-Angiogenic Effects On Vascular Endothelial Cells: A Potential Explanation For Drug-Induced Vasculopathy In CML ⬇️

scholarly article

Nonpegylated liposomal doxorubicin is highly active in patients with B and T/NK cell lymphomas with cardiac comorbidity or higher age.

scientific article

Normal and pathological erythropoiesis in adults: from gene regulation to targeted treatment concepts

article

Normal bone marrow function over 6 years in a patient with dysplastic hematopoiesis and a complex karyotype.

scientific article published in June 2004

One-year evaluation of two hybrid composites placed in a randomized-controlled clinical trial

scientific article

Pathogenesis, classification, and treatment of myelodysplastic syndromes (MDS).

scientific article

Personalized Management Strategies in Mast Cell Disorders: ECNM-AIM User’s Guide for Daily Clinical Practice

scientific article published in 2022

Phenotypic heterogeneity, novel diagnostic markers, and target expression profiles in normal and neoplastic human mast cells

scientific article published on 12 August 2010

Phenotyping Of Leukemic Stem Cells In Ph+ ALL and Ph- ALL Reveals Unique Profiles Of Markers and Targets In Distinct Disease Variants ⬇️

scholarly article

Phenotyping and Target Expression Profiling of CD34+/CD38- and CD34+/CD38+ Stem- and Progenitor cells in Acute Lymphoblastic Leukemia.

scientific article published on 15 May 2018

Prevalence and Impact of Vitamin D Deficiency in Critically Ill Cancer Patients Admitted to the Intensive Care Unit

scientific article published on 23 December 2020

Prevalence of Comorbidities in Periodontitis Patients Compared to the General Austrian Population

scientific article published on 28 August 2017

Proceedings from the Inaugural American Initiative in Mast Cell Diseases (AIM) Investigator Conference

scientific article published in 2021

Prognosis of acute myeloid leukemia transformed from myelodysplastic syndromes: a multicenter retrospective study

scientific article published on 16 March 2013

Prognostic Factors Predicting Survival in De Novo AML Patients Requiring Intensive Care. ⬇️

scholarly article

Prognostic Factors and Survival Prediction in 1,088 Patients with Mastocytosis Collected in the Registry of the European Competence Network on Mastocytosis (ECNM Registry) ⬇️

scholarly article

Prognostic factors for intensive care unit admission, intensive care outcome, and post-intensive care survival in patients with de novo acute myeloid leukemia: a single center experience ⬇️

scientific article published on November 11, 2010

Prognostic factors, long-term survival, and outcome of cancer patients receiving chemotherapy in the intensive care unit.

scientific article published on 6 July 2014

Prognostic impact of eosinophils in mastocytosis: analysis of 2350 patients collected in the ECNM Registry

scientific article published on 18 November 2019

Proliferation Kinetics of Subclones Carrying Point Mutations In the BCR-ABL TKD During TKI Treatment In CML Patients: Quantitative Monitoring by LD-PCR ⬇️

scholarly article

Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome

scientific article published on 05 February 2019

Proposed European Competence Network on Mastocytosis—American Initiative in Mast Cell Diseases (ECNM-AIM) Response Criteria in Advanced Systemic Mastocytosis

scientific article published in 2022

Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal

scientific article published on 26 November 2017

Proposed minimal diagnostic criteria for myelodysplastic syndromes (MDS) and potential pre-MDS conditions

scientific article published on 5 July 2017

Proposed score for survival of patients with myelodysplastic syndromes

scientific article published on 18 September 2013

Purification, structural and immunological characterization of a timothy grass (Phleum pratense) pollen allergen, Phl p 4, with cross-reactive potential.

scientific article published in September 2002

Quantitation of minimal residual disease in acute myeloid leukemia by tryptase monitoring identifies a group of patients with a high risk of relapse

scientific article published in September 2005

Quantitative, phenotypic, and functional evaluation of basophils in myelodysplastic syndromes ⬇️

scientific article published on October 1, 2001

Recombinant allergens promote expression of CD203c on basophils in sensitized individuals

scientific article

Recombinant carp parvalbumin, the major cross-reactive fish allergen: a tool for diagnosis and therapy of fish allergy.

scientific article

Redistribution, homing and organ-invasion of neoplastic stem cells in myeloid neoplasms

scientific article published on 10 August 2019

Refined Treatment Response Criteria for Indolent Systemic Mastocytosis Proposed by the ECNM-AIM Consortium

scientific article published in 2022

Refinements in response criteria in systemic mastocytosis: reply to a proposal

scientific article published on 26 April 2010

Response to therapy with interferon alpha-2b and prednisolone in aggressive systemic mastocytosis: report of five cases and review of the literature.

scientific article published on March 2004

Revealing Six Phases of CML Stem Cell Development to Explain Clinical Phenomena Seen in TKI-Treated Patients. ⬇️

scholarly article

Revised international prognostic scoring system for myelodysplastic syndromes

scientific article

Risk and Management of Patients with Mastocytosis and MCAS in the SARS-CoV-2 (COVID-19) Pandemic: Expert Opinions

scientific article published on 16 June 2020

Risk factors and mechanisms contributing to TKI-induced vascular events in patients with CML.

scientific article published on 12 May 2017

Scoring the risk of having systemic mastocytosis in adult patients with mastocytosis in the skin

scientific article published on 17 December 2020

Screening for NUP98 rearrangements in hematopoietic malignancies by fluorescence in situ hybridization.

scientific article

Selecting the Right Criteria and Proper Classification to Diagnose Mast Cell Activation Syndromes: A Critical Review

scientific article published in 2021

Serum Tryptase Is a Strong Predictive Biomarker That Improves Prognostication in Ph+ Chronic Myeloid Leukemia. ⬇️

scholarly article

Serum tryptase levels in patients with mastocytosis: correlation with mast cell burden and implication for defining the category of disease.

scientific article

Serum-tryptase at diagnosis: a novel biomarker improving prognostication in Ph(+) CML.

scientific article published on 15 December 2014

Severe life-threatening or disabling anaphylaxis in patients with systemic mastocytosis: a single-center experience.

scientific article published on 25 November 2011

Signal transduction-associated and cell activation-linked antigens expressed in human mast cells

scientific article (publication date: May 2002)

Small-Molecule Inhibition of BRD4 Is a Novel Promising Approach to Therapeutically Target Leukemia Stem Cells in AML, ⬇️

scholarly article

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia AML.

scientific article published on December 2012

Smouldering mastocytosis: a novel subtype of systemic mastocytosis with slow progression

scientific article

Specific Activation of Human Mast Cells by the Ligand for c-Kit: Comparison between Lung, Uterus and Heart Mast Cells ⬇️

scientific article published on January 1, 1993

Spectrum of associated clonal hematologic non-mast cell lineage disorders occurring in patients with systemic mastocytosis.

scientific article

Splenic mastocytosis: report of two cases and detection of the transforming somatic C-KIT mutation D816V.

scientific article

Stable non-transforming minimal residual disease in Philadelphia chromosome positive acute lymphoblastic leukemia after autologous transplantation: origin from neoplastic yet ‘pre-leukemic’ stem cells? ⬇️

scientific article published on April 4, 2011

Standards and Impact of Hematopathology in Myelodysplastic Syndromes (MDS) ⬇️

scientific article published on November 1, 2010

Standards of Genetic Testing in the Diagnosis and Prognostication of Systemic Mastocytosis in 2022: Recommendations of the EU-US Cooperative Group

scientific article published in 2022

Standards of Pathology in the Diagnosis of Systemic Mastocytosis: Recommendations of the EU-US Cooperative Group

scientific article published in 2022

Stem cell factor-induced bone marrow mast cell hyperplasia mimicking systemic mastocytosis (SM): histopathologic and morphologic evaluation with special reference to recently established SM-criteria

scientific article

Successful allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia during respiratory failure and invasive mechanical ventilation.

scientific article

Symptomatic venous thromboembolism in acute leukemia. Incidence, risk factors, and impact on prognosis.

scientific article published in January 2005

Systemic mastocytosis (SM) associated with chronic eosinophilic leukemia (SM-CEL): detection of FIP1L1/PDGFRalpha, classification by WHO criteria, and response to therapy with imatinib.

scientific article published on 6 January 2006

TKI rotation-induced persistent deep molecular response in multi-resistant blast crisis of Ph+ CML

scientific article

The Austrian biodatabase for chronic myelomonocytic leukemia (ABCMML) : A representative and useful real-life data source for further biomedical research

scientific article published on 18 July 2019

The CDK4/6 Inhibitor Palbociclib Exerts Growth-Inhibitory Effects on Neoplastic Mast Cells and Synergizes with Midostaurin in Producing Growth Arrest ⬇️

scholarly article

The Data Registry of the European Competence Network on Mastocytosis (ECNM): Set Up, Projects, and Perspectives

scientific article published on 08 November 2018

The European Competence Network on Mastocytosis (ECNM).

scientific article

The KIT and PDGFRA switch-control inhibitor DCC-2618 blocks growth and survival of multiple neoplastic cell types in advanced mastocytosis.

scientific article published on 8 February 2018

The Oncogenic Transcription Factor STAT5 Triggers Aberrant Expression Of CD25 (IL-2RA) In Neoplastic Stem Cells In Ph+ CML ⬇️

scholarly article

The classification of systemic mastocytosis should include mast cell leukemia (MCL) and systemic mastocytosis with a clonal hematologic non-mast cell lineage disease (SM-AHNMD)

scientific article published on August 2010

The human cardiac mast cell: localization, isolation, phenotype, and functional characterization ⬇️

scientific article published on December 1, 1994

The pan-BCL-2-blocker obatoclax (GX15-070) and the PI3-kinase/mTOR-inhibitor BEZ235 produce cooperative growth-inhibitory effects in ALL cells.

scientific article published on 28 June 2017

The pan-Bcl-2 blocker obatoclax promotes the expression of Puma, Noxa, and Bim mRNA and induces apoptosis in neoplastic mast cells

scientific article published on 19 September 2013

The role of epigenetics in the regulation of apoptosis in myelodysplastic syndromes and acute myeloid leukemia.

scientific article published on 12 October 2013

The serum tryptase test: an emerging robust biomarker in clinical hematology.

scientific article

Time-dependent changes in mortality and transformation risk in MDS.

scientific article published on 22 June 2016

Treatment Of Infection-Associated Purpura Fulminans With Protein C Zymogen Is Associated With a High Survival Rate ⬇️

scholarly article

Treatment concepts for elderly patients with acute myeloid leukemia.

scientific article

Treatment of Patients with Aggressive Systemic Mastocytosis, Mast Cell Leukemia and Mast Cell Sarcoma: A Single Center Experience ⬇️

scholarly article

Tryptase a novel biochemical marker of acute myeloid leukemia

scientific article

Umbilical Cord Blood Transplantation Is a Feasible Rescue Therapeutic Option for Patients Suffering from Graft Failure after Previous Hematopoietic Stem Cell Transplantation

scientific article published on 13 February 2016

Unique effects of KIT D816V in BaF3 cells: induction of cluster formation, histamine synthesis, and early mast cell differentiation antigens.

scientific article

Updated Diagnostic Criteria and Classification of Mast Cell Disorders: A Consensus Proposal

scientific article published in 2021

Validation of cytogenetic risk groups according to International Prognostic Scoring Systems by peripheral blood CD34+FISH: results from a German diagnostic study in comparison with an international control group

scientific article published on 24 October 2014

Variable prognostic value of FLT3 internal tandem duplications in patients with de novo AML and a normal karyotype, t(15;17), t(8;21) or inv(16).

scientific article published in January 2002

cDNA cloning of a major allergen from timothy grass (Phleum pratense) pollen; characterization of the recombinant Phl pV allergen ⬇️

scientific article published on November 1, 1993

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