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List of works by William J Jusko

2178 Drug development core facilitates institutional collaboration and translational science innovation

scientific article published in June 2018

<b>Physiologically-Based Pharmacokinetics of Lysosomotropic Chloroquine in Rat and Man</b>

scientific article published on 04 December 2020

A microarray analysis of the temporal response of liver to methylprednisolone: a comparative analysis of two dosing regimens

scientific article

A new symbolic representation for the identification of informative genes in replicated microarray experiments

scientific article published on June 2010

ATLAS mPBPK: a MATLAb-based tool for modeling and Simulation of minimal Physiologically Based PharmacoKinetic models

scientific article published on 02 June 2019

Across-Species Scaling of Monoclonal Antibody Pharmacokinetics Using a Minimal PBPK Model

scientific article

Adipose Tissue Deficiency and Chronic Inflammation in Diabetic Goto-Kakizaki Rats ⬇️

scientific article (publication date: 25 February 2011)

Altered methylprednisolone pharmacodynamics in healthy subjects with histamine N-methyltransferase C314T genetic polymorphism

scientific article

Altered pharmacokinetics of combined oral contraceptives in obesity - multistudy assessment

scientific article published on 23 January 2019

Application of scaling factors in simultaneous modeling of microarray data from diverse chips

scientific article

Applications of minimal physiologically-based pharmacokinetic models ⬇️

scientific article published on November 23, 2012

Area/moment and compartmental modeling of pharmacokinetics during pregnancy: applications to maternal/fetal exposures to corticosteroids in sheep and rats

scientific article published in December 2004

Assessing the dynamics of nuclear glucocorticoid-receptor complex: adding flexibility to gene expression modeling

scientific article

Assessment of Pharmacologic Area Under the Curve When Baselines are Variable ⬇️

scientific article published on January 14, 2011

Assessment of Three-Drug Combination Pharmacodynamic Interactions in Pancreatic Cancer Cells

scientific article published on 27 June 2018

Assessment of basic indirect pharmacodynamic response models with physiological limits

scientific article published in April 2006

Assessment of dosing impact on intra-individual variability in estimation of parameters for basic indirect response models

scientific article

Assessment of drug interactions relevant to pharmacodynamic indirect response models

scientific article published on 01 October 2004

Assessment of non-linear combination effect terms for drug-drug interactions

scientific article published on 16 September 2016

Attenuation of colistin bactericidal activity by high inoculum of Pseudomonas aeruginosa characterized by a new mechanism-based population pharmacodynamic model

scientific article

Betamethasone pharmacokinetics after two prodrug formulations in sheep: implications for antenatal corticosteroid use

scientific article

Biodistribution of etanercept to tissues and sites of inflammation in arthritic rats

scientific article published on April 2015

Ceftriaxone disposition in open-heart surgery patients

scientific article

Characterization and Interspecies Scaling of rhTNF-α Pharmacokinetics with Minimal Physiologically Based Pharmacokinetic Models

scientific article published on 14 April 2017

Circadian rhythms in gene expression: Relationship to physiology, disease, drug disposition and drug action

scientific article

Circadian signatures in rat liver: from gene expression to pathways ⬇️

scientific article published on November 1, 2010

Circadian variations in gene expression in rat abdominal adipose tissue and relationship to physiology ⬇️

scientific article published on August 3, 2010

Circadian variations in rat liver gene expression: relationships to drug actions

scientific article published on 18 June 2008

Clarification of contraceptive drug pharmacokinetics in obesity

scientific article

Comparative analysis of acute and chronic corticosteroid pharmacogenomic effects in rat liver: Transcriptional dynamics and regulatory structures ⬇️

scientific article published on October 14, 2010

Comparative pharmacokinetics of coumarin anticoagulants L: Physiologic modeling of S-warfarin in rats and pharmacologic target-mediated warfarin disposition in man.

scientific article published in May 2003

Comparison of dexamethasone pharmacokinetics in female rats after intravenous and intramuscular administration

scientific article

Context specific transcription factor prediction

scientific article

Corticosteroid-regulated genes in rat kidney: mining time series array data

scientific article

D-optimal designs for parameter estimation for indirect pharmacodynamic response models

scientific article published on 11 November 2009

Daily variation of gene expression in diverse rat tissues.

scientific article

Development and qualification of a pharmacodynamic model for the pronounced inoculum effect of ceftazidime against Pseudomonas aeruginosa

scientific article published on 13 October 2008

Development and translational application of a minimal physiologically-based pharmacokinetic (mPBPK) model for a monoclonal antibody (mAb) against interleukin 23 (IL-23) in IL-23-induced psoriasis-like (PsL) mice

scientific article

Diabetes disease progression in Goto-Kakizaki rats: effects of salsalate treatment

scientific article published on August 2014

Differential muscle gene expression as a function of disease progression in Goto-Kakizaki diabetic rats ⬇️

scientific article published on February 26, 2011

Disposition of methylprednisolone and its sodium succinate prodrug in vivo and in perfused liver of rats: nonlinear and sequential first-pass elimination

scientific article published on 01 May 1991

Diversity of mechanism-based pharmacodynamic models

scientific article

Dose Equivalency Evaluation of Major Corticosteroids: Pharmacokinetics and Cell Trafficking and Cortisol Dynamics ⬇️

scientific article published on November 1, 2003

Dose- and time-related effect of troleandomycin on methylprednisolone elimination

scientific article published on 01 August 1982

Dose-dependent pharmacokinetics of mezlocillin in rats

scientific article

Down-regulation of heat shock protein 70 improves arsenic trioxide and 17-DMAG effects on constitutive signal transducer and activator of transcription 3 activity

scientific article

Dynamic modeling of methylprednisolone effects on body weight and glucose regulation in rats ⬇️

scientific article published on March 11, 2011

Effect of Disease-Related Changes in Plasma Albumin on the Pharmacokinetics of Naproxen in Male and Female Arthritic Rats

scientific article

Effect of chronic oral contraceptive steroids on theophylline disposition

scientific article published on 01 January 1982

Effects of High Fat Feeding on Adipose Tissue Gene Expression in Diabetic Goto-Kakizaki Rats

scientific article

Effects of High Fat Feeding on Liver Gene Expression in Diabetic Goto-Kakizaki Rats ⬇️

scientific article published on November 28, 2012

Effects of High-Fat Feeding on Skeletal Muscle Gene Expression in Diabetic Goto-Kakizaki Rats

scientific article

Effects of ketoconazole on methylprednisolone pharmacokinetics and cortisol secretion

scientific article published on 01 June 1986

Effects of ritonavir-boosted protease inhibitors on combined oral contraceptive pharmacokinetics and pharmacodynamics in HIV-positive women

scientific article published on 10 June 2019

Endogenous histamine and cortisol levels in subjects with different histamine N-methyltransferase C314T genotypes : a pilot study

scientific article

Erratum to: Translational Biomarkers: from Preclinical to Clinical a Report of 2009 AAPS/ACCP Biomarker Workshop

scholarly article published in The AAPS Journal

Evaluation of Timing and Route of Epinephrine in a Neonatal Model of Asphyxial Arrest.

scientific article published on 18 February 2017

Evidence for a glucocorticoid receptor beta splice variant in the rat and its physiological regulation in liver ⬇️

scientific article published on December 19, 2012

Exposure-Response Analysis of Vamorolone (VBP15) in Boys With Duchenne Muscular Dystrophy

scientific article published on 20 May 2020

Fifth-generation model for corticosteroid pharmacodynamics: application to steady-state receptor down-regulation and enzyme induction patterns during seven-day continuous infusion of methylprednisolone in rats

scientific article

First-dose pharmacokinetics of lithium carbonate in children and adolescents

scientific article

Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism

scientific article published on 14 March 2017

Gender-based effects on methylprednisolone pharmacokinetics and pharmacodynamics

scientific article

Gene arrays and temporal patterns of drug response: corticosteroid effects on rat liver

scientific article

Gene expression analysis of hepatic roles in cause and development of diabetes in Goto-Kakizaki rats

scientific article

Glucocorticoid Effects on Adiponectin Expression ⬇️

scientific article published on January 1, 2012

Glucocorticoid efficacy in asthma: is improved tissue remodeling upstream of anti-inflammation

scientific article published in January 2010

Highly multiplexed and reproducible ion-current-based strategy for large-scale quantitative proteomics and the application to protein expression dynamics induced by methylprednisolone in 60 rats

scientific article

Immunosuppressive interactions among calcium channel antagonists and selected corticosteroids and macrolides using human whole blood lymphocytes

scientific article

Importance of replication in analyzing time-series gene expression data: corticosteroid dynamics and circadian patterns in rat liver

scientific article

In vivo multi-tissue corticosteroid microarray time series available online at Public Expression Profile Resource (PEPR).

scientific article

Incorporating target-mediated drug disposition in a minimal physiologically-based pharmacokinetic model for monoclonal antibodies

scientific article

Indirect pharmacodynamic models for responses with circadian removal

scientific article published on 29 January 2019

Induction of imatinib metabolism by hypericum perforatum

scientific article

Integrated QSPR--pharmacodynamic model of genomic effects of several corticosteroids

scientific article published in April 2003

Interactions of Everolimus and Sorafenib in Pancreatic Cancer Cells ⬇️

scientific article published on October 9, 2012

Interactions of Everolimus and Sorafenib in Whole Blood Lymphocyte Proliferation ⬇️

scientific article published on November 14, 2012

Interactions of Tofacitinib and Dexamethasone on Lymphocyte Proliferation

scientific article published on 26 May 2020

Interactions of prednisolone and other immunosuppressants used in dual treatment of systemic lupus erythematosus in lymphocyte proliferation assays

scientific article

Interrelationships between Infliximab and Recombinant Tumor Necrosis Factor-α in Plasma Using Minimal Physiologically Based Pharmacokinetic Models

scientific article published on 14 April 2017

Interspecies comparisons of pharmacokinetics and pharmacodynamics of recombinant human erythropoietin

scientific article published on 18 June 2007

Journal editor's final report

scientific article published on 01 December 2019

Ketoconazole effects on methylprednisolone disposition and their joint suppression of endogenous cortisol

scientific article published on 01 October 1987

Kinetics of betamethasone and fetal cardiovascular adverse effects in pregnant sheep after different doses

scientific article

Light-dark oscillations in the lung transcriptome: implications for lung homeostasis, repair, metabolism, disease, and drug action ⬇️

scientific article published on March 24, 2011

Mathematical assessment of properties of precursor-dependent indirect pharmacodynamic response models

scientific article published on 12 October 2006

Mathematical modeling of corticosteroid pharmacogenomics in rat muscle following acute and chronic methylprednisolone dosing

scientific article

Mechanism-based disease progression modeling of type 2 diabetes in Goto-Kakizaki rats ⬇️

scientific article published on 03 December 2010

Mechanism-based mathematical modeling of combined gemcitabine and birinapant in pancreatic cancer cells

scientific article

Mechanism-based modeling of nutritional and leptin influences on growth in normal and type 2 diabetic rats

scientific article published on 29 October 2008

Mechanism-based population modelling for assessment of L-cell function based on total GLP-1 response following an oral glucose tolerance test

scientific article published on 16 September 2011

Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects.

scientific article published on 2 August 2015

Mechanism‐based population modelling of the effects of vildagliptin on GLP‐1, glucose and insulin in patients with type 2 diabetes ⬇️

scientific article published on March 1, 2012

Mechanism‐based population pharmacokinetic modelling in diabetes: vildagliptin as a tight binding inhibitor and substrate of dipeptidyl peptidase IV ⬇️

scientific article published on March 1, 2012

Mechanistic Modeling of the Effects of Glucocorticoids and Circadian Rhythms on Adipokine Expression ⬇️

scientific article published on March 11, 2011

Mechanistic Multi-Tissue Modeling of Glucocorticoid-Induced Leucine Zipper Regulation: Integrating Circadian Gene Expression with Receptor-Mediated Corticosteroid Pharmacodynamics

scientific article published on 20 July 2017

Mechanistic population modeling of diabetes disease progression in Goto‐Kakizaki rat muscle ⬇️

scientific article published on December 5, 2010

Mechanistic population pharmacokinetics of total and unbound paclitaxel for a new nanodroplet formulation versus Taxol in cancer patients

scientific article published on 13 September 2008

Meta-modeling of methylprednisolone effects on glucose regulation in rats

scientific article (publication date: 2013)

Methods of utilizing baseline values for indirect response models

scientific article published on 21 August 2009

Microarray analysis of the temporal response of skeletal muscle to methylprednisolone: comparative analysis of two dosing regimens

scientific article

Minimal physiologically-based pharmacokinetic (mPBPK) model for a monoclonal antibody against interleukin-6 in mice with collagen-induced arthritis.

scientific article

Model-based development of a PPARgamma agonist, rivoglitazone, to aid dose selection and optimize clinical trial designs

scientific article published on 20 October 2008

Modeling Combined Anti-Inflammatory Effects of Dexamethasone and Tofacitinib in Arthritic Rats

scientific article published on 24 July 2019

Modeling Combined Immunosuppressive and Anti-inflammatory Effects of Dexamethasone and Naproxen in Rats Predicts the Steroid-Sparing Potential of Naproxen

scientific article published on 17 April 2017

Modeling Corticosteroid Pharmacogenomics and Proteomics in Rat Liver

scientific article published on 07 August 2018

Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part I: Determination and Prediction of Dexamethasone and Methylprednisolone Tissue Binding in the Rat

scientific article published on 13 June 2019

Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part II: Sex Differences in Methylprednisolone Pharmacokinetics and Corticosterone Suppression

scientific article published on 13 June 2019

Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part III: Estrous Cycle and Estrogen Receptor-Dependent Antagonism of Glucocorticoid-Induced Leucine Zipper (GILZ) Enhancement by Corticosteroids ⬇️

scientific article published on 13 June 2019

Modeling Diabetes Disease Progression and Salsalate Intervention in Goto-Kakizaki Rats ⬇️

scientific article published on September 8, 2011

Modeling Disease Progression and Rosiglitazone Intervention in Type 2 Diabetic Goto-Kakizaki Rats ⬇️

scientific article published on February 29, 2012

Modeling Pathway Dynamics of the Skeletal Muscle Response to Intravenous Methylprednisolone (MPL) Administration in Rats: Dosing and Tissue Effects

scientific article published on 14 July 2020

Modeling Sex Differences in Anti-inflammatory Effects of Dexamethasone in Arthritic Rats

scientific article published on 06 September 2018

Modeling Sex Differences in Pharmacokinetics, Pharmacodynamics, and Disease Progression Effects of Naproxen in Rats with Collagen-Induced Arthritis

scientific article

Modeling circadian rhythms of glucocorticoid receptor and glutamine synthetase expression in rat skeletal muscle

scientific journal article

Modeling circadian variability of core-clock and clock-controlled genes in four tissues of the rat.

scientific article published on 12 June 2018

Modeling corticosteroid effects in a rat model of rheumatoid arthritis I: mechanistic disease progression model for the time course of collagen-induced arthritis in Lewis rats

scientific article published on 30 April 2008

Modeling corticosteroid effects in a rat model of rheumatoid arthritis II: mechanistic pharmacodynamic model for dexamethasone effects in Lewis rats with collagen-induced arthritis

scientific article published on 30 April 2008

Modeling effects of dexamethasone on disease progression of bone mineral density in collagen-induced arthritic rats

scientific article published on 3 August 2015

Modeling glucocorticoid-mediated fetal lung maturation: I. Temporal patterns of corticosteroids in rat pregnancy

scientific article published on 21 December 2005

Modeling glucocorticoid-mediated fetal lung maturation: II. Temporal patterns of gene expression in fetal rat lung

scientific journal article

Modeling of corticosteroid effects on hepatic low-density lipoprotein receptors and plasma lipid dynamics in rats

scientific article

Modeling of corticosteroid pharmacogenomics in rat liver using gene microarrays

scientific article

Modeling pharmacokinetics/pharmacodynamics of abatacept and disease progression in collagen-induced arthritic rats: a population approach

scientific article published on December 2013

Modeling receptor/gene-mediated effects of corticosteroids on hepatic tyrosine aminotransferase dynamics in rats: dual regulation by endogenous and exogenous corticosteroids

scientific article

Modeling the metabolic effects of terbutaline in beta2-adrenergic receptor diplotypes.

scientific article

Moving from basic toward systems pharmacodynamic models

scientific article published on 16 May 2013

Multi-Scale Network Model Supported by Proteomics for Analysis of Combined Gemcitabine and Birinapant Effects in Pancreatic Cancer Cells

article

Multiple-dose pharmacokinetics of imipramine and its major active and conjugated metabolites in depressed patients

scientific article published on 01 February 1988

Multiple-pool cell lifespan model of hematologic effects of anticancer agents

scientific article

Multiple-pool cell lifespan models for neutropenia to assess the population pharmacodynamics of unbound paclitaxel from two formulations in cancer patients

scientific article

Oral contraceptive effects on methylprednisolone pharmacokinetics and pharmacodynamics

scientific article published on 01 March 1996

Pathway-Based Analysis of the Liver Response to Intravenous Methylprednisolone Administration in Rats: Acute Versus Chronic Dosing

Perspectives on the history and scientific contributions of Gerhard Levy

scientific article published on 24 September 2015

Perspectives on variability in pharmacokinetics of an oral contraceptive product

scientific article

Pharmacodynamic Modeling of Cell Cycle Effects for Gemcitabine and Trabectedin Combinations in Pancreatic Cancer Cells

scientific article

Pharmacodynamic interaction of recombinant human interleukin-10 and prednisolone using in vitro whole blood lymphocyte proliferation

scientific article published in May 2002

Pharmacodynamic interactions between recombinant mouse interleukin-10 and prednisolone using a mouse endotoxemia model

scientific article

Pharmacodynamic model for chemotherapy-induced anemia in rats

scientific article

Pharmacodynamic model for joint exogenous and endogenous corticosteroid suppression of lymphocyte trafficking

scientific article published on 01 December 1994

Pharmacodynamic modeling of acute and chronic effects of methylprednisolone on hepatic urea cycle genes in rats.

scientific article published on 14 February 2008

Pharmacodynamic modeling of cell cycle and apoptotic effects of gemcitabine on pancreatic adenocarcinoma cells

scientific article published on 09 July 2013

Pharmacodynamic modeling of combined chemotherapeutic effects predicts synergistic activity of gemcitabine and trabectedin in pancreatic cancer cells

scientific article

Pharmacodynamic modeling of cortisol suppression from fluocortolone

scientific article published on 01 January 1993

Pharmacodynamic modeling of thrombopoietin, platelet, and megakaryocyte dynamics in patients with acute myeloid leukemia undergoing dose intensive chemotherapy

scientific article

Pharmacodynamic models for agents that alter production of natural cells with various distributions of lifespans

scientific article published on 25 March 2006

Pharmacodynamic/pharmacogenomic modeling of insulin resistance genes in rat muscle after methylprednisolone treatment: exploring regulatory signaling cascades

scientific article published on 23 April 2008

Pharmacodynamics and pharmacogenomics of diverse receptor-mediated effects of methylprednisolone in rats using microarray analysis

scientific article published in April 2002

Pharmacodynamics and pharmacogenomics of methylprednisolone during 7-day infusions in rats

scientific article published in January 2002

Pharmacodynamics of glucose regulation by methylprednisolone. I. Adrenalectomized rats

scientific article published on January 2009

Pharmacodynamics of glucose regulation by methylprednisolone. II. normal rats

scientific article published on January 2009

Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy.

scientific article

Pharmacogenomic responses of rat liver to methylprednisolone: an approach to mining a rich microarray time series

scientific article published on 18 August 2005

Pharmacokinetic Interactions between Sirolimus and Microemulsion Cyclosporine When Orally Administered Jointly and 4 Hours Apart in Healthy Volunteers ⬇️

scientific article published on October 1, 2003

Pharmacokinetic and Pharmacodynamic Modeling of Exendin-4 in Type 2 Diabetic Goto-Kakizaki Rats ⬇️

scientific article published on December 14, 2010

Pharmacokinetic and pharmacodynamic interactions between diltiazem and methylprednisolone in healthy volunteers

scientific article published in October 2002

Pharmacokinetic and pharmacodynamic modeling of a copper-selective chelator (TETA) in healthy adults

scientific article published in August 2009

Pharmacokinetic and pharmacodynamic modeling of humanized anti-factor IX antibody (SB 249417) in humans

scientific article published in April 2002

Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after intravenous and subcutaneous administration in rats

scientific article published on 14 September 2006

Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after intravenous and subcutaneous dose administration in cynomolgus monkeys

scientific article published on 03 April 2003

Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after multiple subcutaneous doses in healthy subjects

scientific article published in November 2005

Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after single and multiple doses in healthy volunteers

scientific article published in September 2004

Pharmacokinetic-pharmacodynamic disease progression model for effect of etanercept in Lewis rats with collagen-induced arthritis

scientific article published in March 2011

Pharmacokinetic/Pharmacodynamic Modeling of GLP-1 in Healthy Rats ⬇️

scientific article published on December 17, 2011

Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone Effects on iNOS mRNA Expression and Nitric Oxide During LPS-Induced Inflammation in Rats ⬇️

scientific article published on March 16, 2012

Pharmacokinetic/pharmacodynamic model for prednisolone inhibition of whole blood lymphocyte proliferation

scientific article published on May 2002

Pharmacokinetic/pharmacodynamic modeling of corticosterone suppression and lymphocytopenia by methylprednisolone in rats

scientific article published on July 2008

Pharmacokinetic/pharmacodynamic modeling of glucose clamp effects of inhaled and subcutaneous insulin in healthy volunteers and diabetic patients.

scientific article published on 30 September 2010

Pharmacokinetic/pharmacodynamic modelling in diabetes mellitus.

scientific article published on January 2008

Pharmacokinetics and Pharmacodynamics of Intramuscular and Oral Betamethasone and Dexamethasone in Reproductive Age Women in India

scientific article published on 13 December 2019

Pharmacokinetics and antibody responses to the CD3 antibody otelixizumab used in the treatment of type 1 diabetes.

scientific article published on 10 February 2010

Pharmacokinetics and bioequivalence of a liquid formulation of hydroxyurea in children with sickle cell anemia

scientific article published on 22 July 2015

Pharmacokinetics and cell trafficking dynamics of 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride (FTY720) in cynomolgus monkeys after single oral and intravenous doses

scientific article published in May 2002

Pharmacokinetics and pharmacodynamic modeling of direct suppression effects of methylprednisolone on serum cortisol and blood histamine in human subjects

scientific article

Pharmacokinetics and pharmacodynamics of PEGylated IFN-beta 1a following subcutaneous administration in monkeys

scientific article

Pharmacokinetics and pharmacodynamics of a chimeric/humanized anti-CD3 monoclonal antibody, otelixizumab (TRX4), in subjects with psoriasis and with type 1 diabetes mellitus

scientific article published on 23 November 2009

Pharmacokinetics and pharmacodynamics of liposomal chemophototherapy with short drug-light intervals

scientific article published on 23 January 2019

Pharmacokinetics and pharmacodynamics of methylprednisolone when administered at 8 am versus 4 pm.

scientific article

Pharmacokinetics of Hormonal Contraception in Individuals with Obesity: a Review

scientific article published on 04 May 2020

Pharmacokinetics of Inter-Alpha Inhibitor Proteins and Effects on Hemostasis after Hypoxic-Ischemic Brain Injury in Neonatal Rats

scientific article published on 21 April 2020

Pharmacokinetics of dexamethasone in a rat model of rheumatoid arthritis

scientific article published on September 2008

Pharmacokinetics of methylprednisolone after intravenous and intramuscular administration in rats.

scientific article

Pharmacokinetics of methylprednisolone hemisuccinate and methylprednisolone in chronic liver disease

scientific article published on 01 September 1993

Pharmacokinetics of salsalate and salicylic acid in normal and diabetic rats ⬇️

scientific article published on July 26, 2012

Pharmacokinetics of single and multiple doses of ethinyl estradiol and levonorgestrel in relation to smoking

scientific article published on 01 January 1988

Pharmacokinetics of the 1.5 mg levonorgestrel emergency contraceptive in women with normal, obese and extremely obese body mass index

scientific article published on 28 January 2019

Pharmacokinetics, pharmacodynamics and toxicities of methotrexate in healthy and collagen‐induced arthritic rats ⬇️

scientific article published on April 7, 2013

Phase IIa trial in Duchenne muscular dystrophy shows vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug

scientific article published on 13 September 2018

Physiologically based pharmacokinetic modeling of FTY720 (2-amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in rats after oral and intravenous doses.

scientific article

Physiologically based pharmacokinetic models for everolimus and sorafenib in mice

scientific article published on 3 March 2013

Physiologically-Based Pharmacokinetic Modeling Involving Nonlinear Plasma and Tissue Binding: Application to Prednisolone and Prednisone in Rats

scientific article published on 03 September 2020

Physiologically-Based Pharmacokinetics of Dexamethasone in Rats

scientific article published on 29 June 2020

Physiologically-based pharmacokinetic and pharmacodynamic models for gemcitabine and birinapant in pancreatic cancer xenografts

scientific article published on 01 August 2018

Population Pharmacokinetics of Vamorolone (VBP15) in Healthy Men and Boys With Duchenne Muscular Dystrophy

scientific article published on 11 February 2019

Population cell life span models for effects of drugs following indirect mechanisms of action

scientific article published in December 2005

Population pharmacodynamic modeling of intramuscular and oral dexamethasone and betamethasone effects on six biomarkers with circadian complexities in Indian women

scientific article published on 05 May 2021

Population pharmacokinetic modeling of intramuscular and oral dexamethasone and betamethasone in Indian women

scientific article published on 03 January 2021

Population pharmacokinetic/pharmacodynamic modeling of systemic corticosteroid inhibition of whole blood lymphocytes: modeling interoccasion pharmacodynamic variability

scientific article published on 24 March 2007

Population pharmacokinetics and pharmacodynamics of peptidic erythropoiesis receptor agonist (ERA) in healthy volunteers

scientific article published on 19 November 2007

Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy

scientific article

Population pharmacokinetics of prednisolone in children with acute lymphoblastic leukemia

scientific article published on 16 April 2003

Population pharmacokinetic–pharmacodynamic–disease progression model for effects of anakinra in Lewis rats with collagen-induced arthritis ⬇️

scientific article published on October 16, 2011

Prednisolone disposition in steroid-dependent asthmatics

scientific article published on 01 November 1980

Prednisone metabolism in recipients of kidney or liver transplants and in lung recipients receiving ketoconazole

scientific article published in March 2003

Preface to the special issue to honor Gerhard Levy and 50 years of PK/PD

scientific article published on 01 October 2015

Proteomic Analysis of Combined Gemcitabine and Birinapant in Pancreatic Cancer Cells

scientific article published on 19 February 2018

Quantification of dexamethasone and corticosterone in rat biofluids and fetal tissue using highly sensitive analytical methods: assay validation and application to a pharmacokinetic study

scientific article

Quantitative dynamic models of arthritis progression in the rat

scientific article published on 30 August 2008

Quantitative structure-pharmacokinetic/pharmacodynamic relationships of corticosteroids in man.

scientific article published in November 2002

Quantitative tissue-specific dynamics of in vivo GILZ mRNA expression and regulation by endogenous and exogenous glucocorticoids

scientific article

Receptor-mediated pharmacodynamics of prednisolone in the rat

scientific article published on 01 October 1986

Receptor-mediated pharmacokinetic/pharmacodynamic model of interferon-beta 1a in humans

scientific article published in October 2002

Receptor-mediated pharmacokinetics and pharmacodynamics of interferon-beta1a in monkeys

scientific article published on 26 March 2003

Receptor/gene-mediated pharmacodynamic effects of methylprednisolone on phosphoenolpyruvate carboxykinase regulation in rat liver

scientific article

Receptor/gene/protein-mediated signaling connects methylprednisolone exposure to metabolic and immune-related pharmacodynamic actions in liver

scientific article published on 27 April 2018

Reduced methylprednisolone clearance causing prolonged pharmacodynamics in a healthy subject was not associated with CYP3A5*3 allele or a change in diet composition

scientific article

Relationship of serum thiocyanate concentrations to smoking characteristics

scientific article published on 01 January 1984

Relationships between circadian rhythms and modulation of gene expression by glucocorticoids in skeletal muscle

scientific article published on 30 July 2008

Relative immunosuppressive potency of therapeutic corticosteroids measured by whole blood lymphocyte proliferation

scientific article

Report of the 2011-2012 AACP Special Advisory Committee on Research and Graduate Education ⬇️

scientific article published on October 12, 2012

Role of Interstitial Fluid Turnover on Target Suppression by Therapeutic Biologics Using a Minimal Physiologically Based Pharmacokinetic Model

scientific article published on 12 July 2018

Scaling pharmacodynamics from in vitro and preclinical animal studies to humans

scientific article published on January 2009

Second-generation minimal physiologically-based pharmacokinetic model for monoclonal antibodies

scientific article published on 31 August 2013

Seeking Nonspecific Binding: Assessing the Reliability of Tissue Dilutions for Calculating Fraction Unbound ⬇️

scientific article published on 05 August 2020

Semi-mechanistic pharmacokinetic/pharmacodynamic modelling of the antimalarial effect of artemisinin

scientific article published in December 2005

Simultaneous analysis of methylprednisolone hemisuccinate, cortisol and methylprednisolone by normal-phase high-performance liquid chromatography in human plasma

scientific article published on 01 November 1988

Stability of dexamethasone sodium phosphate in rat plasma

scientific article

Stabilization and HPLC analysis of betamethasone sodium phosphate in plasma

scientific article published in March 2004

Steroid dose sparing: pharmacodynamic responses to single versus divided doses of methylprednisolone in man

scientific article published on 01 June 1990

Steroid-specific and anticonvulsant interaction aspects of troleandomycin-steroid therapy

scientific article published on 01 May 1982

Study Reanalysis Using a Mechanism-Based Pharmacokinetic/Pharmacodynamic Model of Pramlintide in Subjects with Type 1 Diabetes ⬇️

scientific article published on October 2, 2012

Survey of monoclonal antibody disposition in man utilizing a minimal physiologically-based pharmacokinetic model

scientific article

Synergism between arsenic trioxide and heat shock protein 90 inhibitors on signal transducer and activator of transcription protein 3 activity--pharmacodynamic drug-drug interaction modeling

scientific article published on April 2007

Synergistic interactions between sorafenib and everolimus in pancreatic cancer xenografts in mice

scientific article published on 03 March 2013

Tandem analysis of transcriptome and proteome changes after a single dose of corticosteroid: a systems approach to liver function in pharmacogenomics.

scientific article published on 22 January 2015

Target mediated drug disposition with drug-drug interaction, Part II: competitive and uncompetitive cases

scientific article published on 10 January 2017

Target-mediated drug disposition with drug-drug interaction, Part I: single drug case in alternative formulations

scientific article published on 10 January 2017

Target-mediated pharmacokinetic and pharmacodynamic model of exendin-4 in rats, monkeys, and humans

scientific article published on 15 February 2012

Target-mediated pharmacokinetic and pharmacodynamic model of recombinant human erythropoietin (rHuEPO).

scientific article published on 18 October 2007

Temporal profiling of the transcriptional basis for the development of corticosteroid-induced insulin resistance in rat muscle

scientific article published on January 2005

The PEPR GeneChip data warehouse, and implementation of a dynamic time series query tool (SGQT) with graphical interface

scientific article

The Pharmacokinetics and Pharmacodynamics of Methylprednisolone in Chronic Renal Failure

scientific article published on 01 June 1994

The effect of troleandomycin on methylprednisolone elimination

scientific article published on 01 December 1980

The genomic response of skeletal muscle to methylprednisolone using microarrays: tailoring data mining to the structure of the pharmacogenomic time series

scientific article

The influence of St. John's wort on the pharmacokinetics and protein binding of imatinib mesylate

scientific article published in November 2004

The metyrapone test in affective disorders and schizophrenia ⬇️

scientific article published on June 1, 1984

The metyrapone test in affective disorders and schizophrenia II ⬇️

scientific article published on December 1, 1984

The metyrapone test in affective disorders and schizophrenia II. Changes upon treatment

scientific article published on 01 December 1984

The metyrapone test in schizophrenic patients and healthy subjects

scientific article

Tissue-specific gene expression and regulation in liver and muscle following chronic corticosteroid administration

scientific article published on 10 March 2014

Towards better combination regimens of cytarabine and FLT3 inhibitors in acute myeloid leukemia

scientific article published on 03 August 2020

Transitioning from Basic toward Systems Pharmacodynamic Models: Lessons from Corticosteroids

scientific article published on 01 April 2020

Translational Biomarkers: from Preclinical to Clinical a Report of 2009 AAPS/ACCP Biomarker Workshop ⬇️

scientific article published on March 30, 2011

Two-compartment basophil cell trafficking model for methylprednisolone pharmacodynamics

scientific article published in October 1991

Understanding Physiology in the Continuum: Integration of Information from Multiple -Omics Levels

scientific article published on 27 February 2017

Use of Pharmacokinetic Data Below Lower Limit of Quantitation Values ⬇️

scientific article published on June 23, 2012

Utility of cleavable isotope-coded affinity-tagged reagents for quantification of low-copy proteins induced by methylprednisolone using liquid chromatography/tandem mass spectrometry

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Variability in Zucker diabetic fatty rats: differences in disease progression in hyperglycemic and normoglycemic animals

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