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List of works by Timothy M Doyle

A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways.

scientific article published on 19 September 2014

Activation of Sphingosine-1-Phosphate Receptor 1 in the Spinal Cord Produces Mechanohypersensitivity Through the Activation of Inflammasome and IL-1β Pathway

scientific article published on 23 February 2019

Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents

scientific article published on 13 April 2020

Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase

scientific article published on 25 July 2013

Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels via astrocyte-dependent mechanisms

scientific article

Controlling murine and rat chronic pain through A3 adenosine receptor activation

scientific article published on 17 February 2012

Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids

scientific article

Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain.

scientific article published on 27 April 2018

Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states

scientific article

Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain

scientific article

GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents

scientific article published on 13 April 2020

GPR183-oxysterol axis in spinal cord contributes to neuropathic pain

scientific article published on 10 September 2020

Hypoxic suppression of E. coli-induced NF-kappa B and AP-1 transactivation by oxyradical signaling

scientific article published in April 2004

Immunoprotective properties of primary Sertoli cells in mice: potential functional pathways that confer immune privilege

scientific article published on 10 January 2012

Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway

scientific article

Multiplex serology for impact evaluation of bed net distribution on burden of lymphatic filariasis and four species of human malaria in northern Mozambique

scientific article published on 14 February 2018

NMDA-receptor activation and nitroxidative regulation of the glutamatergic pathway during nociceptive processing

scientific article published on 18 February 2010

Retooling manganese(III) porphyrin-based peroxynitrite decomposition catalysts for selectivity and oral activity: a potential new strategy for treating chronic pain

scientific article published on 22 November 2011

Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats ⬇️

scientific article published on January 15, 2011

Sexually dimorphic therapeutic response in bortezomib-induced neuropathic pain reveals altered pain physiology in female rodents

scientific article published on 01 January 2020

Sphingosine-1-phosphate acting via the S1P₁ receptor is a downstream signaling pathway in ceramide-induced hyperalgesia

scientific article

Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain

scientific article published on 08 May 2019

Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents

scientific article published on 22 October 2020

Spinal NADPH oxidase is a source of superoxide in the development of morphine-induced hyperalgesia and antinociceptive tolerance

scientific article

Spinal ceramide and neuronal apoptosis in morphine antinociceptive tolerance

scientific article published on 23 July 2009

Spinal mitochondrial-derived peroxynitrite enhances neuroimmune activation during morphine hyperalgesia and antinociceptive tolerance

scientific article published on 27 February 2013

Spinal neuroimmune activation is independent of T-cell infiltration and attenuated by A3 adenosine receptor agonists in a model of oxaliplatin-induced peripheral neuropathy

scientific article

Supraspinal Peroxynitrite Modulates Pain Signaling by Suppressing the Endogenous Opioid Pathway ⬇️

scientific article published on August 8, 2012

Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation

scientific article published on 31 May 2017

Targeting the overproduction of peroxynitrite for the prevention and reversal of paclitaxel-induced neuropathic pain

scientific article published on May 2012

The cystine/glutamate antiporter system xc- drives breast tumor cell glutamate release and cancer-induced bone pain

scientific article published on 02 August 2016

The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.

scientific article

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