List of works - Asim K Debnath

A cell-penetrating helical peptide as a potential HIV-1 inhibitor

scientific article

A predicted receptor-binding and critical neutralizing domain in S protein of the novel human coronavirus HCoV-EMC.

scientific article

ADS-J1 inhibits human immunodeficiency virus type 1 entry by interacting with the gp41 pocket region and blocking fusion-active gp41 core formation

scientific article published on 28 September 2009

Active amino acids of the Kell blood group protein and model of the ectodomain based on the structure of neutral endopeptidase 24.11.

scientific article

Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1

scientific article

Anti-HIV-1 activity of cellulose acetate phthalate: synergy with soluble CD4 and induction of "dead-end" gp41 six-helix bundles

scientific article

Antiviral Activity of Dual-acting Hydrocarbon-stapled Peptides against HIV-1 Predominantly Circulating in China

scientific article

Antiviral activity of α-helical stapled peptides designed from the HIV-1 capsid dimerization domain ⬇️

scientific article

Approaches for identification of HIV-1 entry inhibitors targeting gp41 pocket

scientific article published on 11 January 2013

Binding mode characterization of NBD series CD4-mimetic HIV-1 entry inhibitors by X-ray structure and resistance study

scientific article

Comparative Pharmacokinetics of a Dual Inhibitor of HIV-1, NBD-14189, in Rats and Dogs with a Proof-of-Concept Evaluation of Antiviral Potency in SCID-hu Mouse Model

scientific article published in 2022

Conserved salt bridge between the N- and C-terminal heptad repeat regions of the human immunodeficiency virus type 1 gp41 core structure is critical for virus entry and inhibition

scientific article published on 3 September 2008

Correction to Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120.

scientific article published on 18 May 2017

Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site

scientific article

Design of antiviral stapled peptides containing a biphenyl cross-linker

scientific article published on 22 February 2014

Design, synthesis and evaluation of small molecule CD4-mimics as entry inhibitors possessing broad spectrum anti-HIV-1 activity.

scientific article published on 24 September 2016

Design, synthesis, and antiviral activity of entry inhibitors that target the CD4-binding site of HIV-1.

scientific article

Design, synthesis, and biological activity of novel 5-((arylfuran/1H-pyrrol-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-ones as HIV-1 fusion inhibitors targeting gp41.

scientific article published on 29 December 2010

Design, synthesis, and structure-activity relationship of a novel series of 2-aryl 5-(4-oxo-3-phenethyl-2-thioxothiazolidinylidenemethyl)furans as HIV-1 entry inhibitors

scientific article

Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41

scientific article published on September 2015

Dual-acting stapled peptides target both HIV-1 entry and assembly

scientific article

Identification of Combinations of Protein Kinase C Activators and Histone Deacetylase Inhibitors That Potently Reactivate Latent HIV

scientific article published on 03 June 2020

Identification of a receptor-binding domain in the S protein of the novel human coronavirus Middle East respiratory syndrome coronavirus as an essential target for vaccine development

scientific article

Molecular basis of two novel and related high-prevalence antigens in the Kell blood group system, KUCI and KANT, and their serologic and spatial association with K11 and KETI

scientific article published on 08 April 2013

N-substituted pyrrole derivatives as novel human immunodeficiency virus type 1 entry inhibitors that interfere with the gp41 six-helix bundle formation and block virus fusion

scientific article

Novel anti-HIV peptides containing multiple copies of artificially designed heptad repeat motifs

scientific article published on 3 August 2008

Novel structures of self-associating stapled peptides

scientific article published on 14 December 2011

Peptide and non-peptide HIV fusion inhibitors

scientific article

Preclinical Optimization of gp120 Entry Antagonists as anti-HIV-1 Agents with Improved Cytotoxicity and ADME Properties through Rational Design, Synthesis, and Antiviral Evaluation

scientific article published on 17 February 2020

Progress in identifying peptides and small-molecule inhibitors targeted to gp41 of HIV-1.

scientific article

Prospects and strategies for the discovery and development of small-molecule inhibitors of six-helix bundle formation in class 1 viral fusion proteins

scientific article

Punica granatum (Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide

scientific article

Punica granatum (pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide.

scientific article

Putative conformations of the receptor-binding domain in S protein of hCoV-EMC in complex with its receptor dipeptidyl peptidase-4.

scientific article

Rational design of HIV-1 entry inhibitors

scientific article published on January 2013

Solution Structure of a Hydrocarbon Stapled Peptide Inhibitor in Complex with Monomeric C-terminal Domain of HIV-1 Capsid

scientific article

Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV-1 Activity

scientific article

Structure-based identification and neutralization mechanism of tyrosine sulfate mimetics that inhibit HIV-1 entry

scientific article

Synthesis of 2-Oxo-1, 2-Dihydroquinoline Chemotype with Multiple Attachment Points as Novel Screening Compounds for Drug Discovery

scientific article published on 26 October 2016

Synthesis, Antiviral Activity, and Structure-Activity Relationship of 1,3-Benzodioxolyl Pyrrole-Based Entry Inhibitors Targeting the Phe43 Cavity in HIV-1 gp120

article

Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120.

scientific article published on 7 March 2017

Synthesis, antiviral activity and resistance of a novel small molecule HIV-1 entry inhibitor

scientific article published on 10 November 2015

The conserved residue Arg46 in the N-terminal heptad repeat domain of HIV-1 gp41 is critical for viral fusion and entry

scientific article

Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41

scientific article (publication date: 25 May 2005)

Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

scientific article

Viral inhibition studies on sulfated lignin, a chemically modified biopolymer and a potential mimic of heparan sulfate.

scientific article published on 17 April 2007

Virtual screening based identification of novel small-molecule inhibitors targeted to the HIV-1 capsid

scientific article

XTT formazan widely used to detect cell viability inhibits HIV type 1 infection in vitro by targeting gp41.

scientific article published on September 2002

List of works by Asim K Debnath

A cell-penetrating helical peptide as a potential HIV-1 inhibitor

A predicted receptor-binding and critical neutralizing domain in S protein of the novel human coronavirus HCoV-EMC.

ADS-J1 inhibits human immunodeficiency virus type 1 entry by interacting with the gp41 pocket region and blocking fusion-active gp41 core formation

Active amino acids of the Kell blood group protein and model of the ectodomain based on the structure of neutral endopeptidase 24.11.

Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1

Anti-HIV-1 activity of cellulose acetate phthalate: synergy with soluble CD4 and induction of "dead-end" gp41 six-helix bundles

Antiviral Activity of Dual-acting Hydrocarbon-stapled Peptides against HIV-1 Predominantly Circulating in China

Antiviral activity of α-helical stapled peptides designed from the HIV-1 capsid dimerization domain ⬇️

Approaches for identification of HIV-1 entry inhibitors targeting gp41 pocket

Binding mode characterization of NBD series CD4-mimetic HIV-1 entry inhibitors by X-ray structure and resistance study

Comparative Pharmacokinetics of a Dual Inhibitor of HIV-1, NBD-14189, in Rats and Dogs with a Proof-of-Concept Evaluation of Antiviral Potency in SCID-hu Mouse Model

Conserved salt bridge between the N- and C-terminal heptad repeat regions of the human immunodeficiency virus type 1 gp41 core structure is critical for virus entry and inhibition

Correction to Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120.

Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site

Design of antiviral stapled peptides containing a biphenyl cross-linker

Design, synthesis and evaluation of small molecule CD4-mimics as entry inhibitors possessing broad spectrum anti-HIV-1 activity.

Design, synthesis, and antiviral activity of entry inhibitors that target the CD4-binding site of HIV-1.

Design, synthesis, and biological activity of novel 5-((arylfuran/1H-pyrrol-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-ones as HIV-1 fusion inhibitors targeting gp41.

Design, synthesis, and structure-activity relationship of a novel series of 2-aryl 5-(4-oxo-3-phenethyl-2-thioxothiazolidinylidenemethyl)furans as HIV-1 entry inhibitors

Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41

Dual-acting stapled peptides target both HIV-1 entry and assembly

Identification of Combinations of Protein Kinase C Activators and Histone Deacetylase Inhibitors That Potently Reactivate Latent HIV

Identification of a receptor-binding domain in the S protein of the novel human coronavirus Middle East respiratory syndrome coronavirus as an essential target for vaccine development

Molecular basis of two novel and related high-prevalence antigens in the Kell blood group system, KUCI and KANT, and their serologic and spatial association with K11 and KETI

N-substituted pyrrole derivatives as novel human immunodeficiency virus type 1 entry inhibitors that interfere with the gp41 six-helix bundle formation and block virus fusion

Novel anti-HIV peptides containing multiple copies of artificially designed heptad repeat motifs

Novel structures of self-associating stapled peptides

Peptide and non-peptide HIV fusion inhibitors

Preclinical Optimization of gp120 Entry Antagonists as anti-HIV-1 Agents with Improved Cytotoxicity and ADME Properties through Rational Design, Synthesis, and Antiviral Evaluation

Progress in identifying peptides and small-molecule inhibitors targeted to gp41 of HIV-1.

Prospects and strategies for the discovery and development of small-molecule inhibitors of six-helix bundle formation in class 1 viral fusion proteins

Punica granatum (Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide

Punica granatum (pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide.

Putative conformations of the receptor-binding domain in S protein of hCoV-EMC in complex with its receptor dipeptidyl peptidase-4.

Rational design of HIV-1 entry inhibitors

Solution Structure of a Hydrocarbon Stapled Peptide Inhibitor in Complex with Monomeric C-terminal Domain of HIV-1 Capsid

Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV-1 Activity

Structure-based identification and neutralization mechanism of tyrosine sulfate mimetics that inhibit HIV-1 entry

Synthesis of 2-Oxo-1, 2-Dihydroquinoline Chemotype with Multiple Attachment Points as Novel Screening Compounds for Drug Discovery

Synthesis, Antiviral Activity, and Structure-Activity Relationship of 1,3-Benzodioxolyl Pyrrole-Based Entry Inhibitors Targeting the Phe43 Cavity in HIV-1 gp120

Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120.

Synthesis, antiviral activity and resistance of a novel small molecule HIV-1 entry inhibitor

The conserved residue Arg46 in the N-terminal heptad repeat domain of HIV-1 gp41 is critical for viral fusion and entry

Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41

Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

Viral inhibition studies on sulfated lignin, a chemically modified biopolymer and a potential mimic of heparan sulfate.

Virtual screening based identification of novel small-molecule inhibitors targeted to the HIV-1 capsid

XTT formazan widely used to detect cell viability inhibits HIV type 1 infection in vitro by targeting gp41.