List of works - Wendy B Macklin

A new model of cuprizone-mediated demyelination/remyelination.

scientific article published on 30 September 2014

A novel PET marker for in vivo quantification of myelination.

scientific article

Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination.

scientific article published on May 2009

Astrocyte expression of a dominant-negative interferon-gamma receptor.

scientific article published in October 2005

Automatic and adaptive heterogeneous refractive index compensation for light-sheet microscopy

scientific article published on 20 September 2017

Bace1 modulates myelination in the central and peripheral nervous system.

scientific article published on 12 November 2006

Concentration-dependent effects of CSF1R inhibitors on oligodendrocyte progenitor cells ex vivo and in vivo

scientific article published on 25 April 2019

Conditional ablation of raptor or rictor has differential impact on oligodendrocyte differentiation and CNS myelination.

scientific article published on March 2014

Constitutively active Akt induces enhanced myelination in the CNS

scientific article

Delayed inhibition of tonic inhibition enhances functional recovery following experimental ischemic stroke.

scientific article published in January 2017

Distinct modes of migration position oligodendrocyte precursors for localized cell division in the developing spinal cord

scientific article published on November 2009

Distinct patterns of glia repair and remyelination in antibody-mediated demyelination models of multiple sclerosis and neuromyelitis optica

scientific article published on 21 September 2018

Dynamics and mechanisms of CNS myelination.

scientific article

Dynamics of ten-eleven translocation hydroxylase family proteins and 5-hydroxymethylcytosine in oligodendrocyte differentiation.

scientific article

Endogenous Neuronal Replacement in the Juvenile Brain Following Cerebral Ischemia

scientific article published on 9 April 2018

Evolution of a neuroprotective function of central nervous system myelin

scientific article

Expression of a dominant negative IFN-gammareceptor on mouse oligodendrocytes

scientific article

Expression of matrix metalloproteinases and their tissue inhibitor during viral encephalitis.

scientific article

Expression of proteolipid protein gene in spinal cord stem cells and early oligodendrocyte progenitor cells is dispensable for normal cell migration and myelination

scientific article published on January 2014

Glutamate stimulates oligodendrocyte progenitor migration mediated via an alphav integrin/myelin proteolipid protein complex.

scientific article

Golli myelin basic proteins regulate oligodendroglial progenitor cell migration through voltage-gated Ca2+ influx

scientific article

Human antibodies against the myelin oligodendrocyte glycoprotein can cause complement-dependent demyelination

scientific article published on 25 October 2017

Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes

scientific article published on 24 May 2002

In situ fluorescence imaging of myelination

scientific article

Induction of class I antigen processing components in oligodendroglia and microglia during viral encephalomyelitis.

scientific article

Inhibition of interferon-gamma signaling in oligodendroglia delays coronavirus clearance without altering demyelination

scientific article

Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation

scientific article published on 25 July 2014

Juvenile striatal white matter is resistant to ischemia-induced damage

scientific article published on 27 July 2016

Long-lasting masculinizing effects of postnatal androgens on myelin governed by the brain androgen receptor.

scientific article published on 6 November 2017

Longitudinal Near-Infrared Imaging of Myelination ⬇️

scientific article published on February 16, 2011

Loss of Tuberous Sclerosis Complex1 in Adult Oligodendrocyte Progenitor Cells Enhances Axon Remyelination and Increases Myelin Thickness after a Focal Demyelination.

scientific article

Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination.

scientific article published on March 2014

Mechanistic Target of Rapamycin Regulates the Oligodendrocyte Cytoskeleton during Myelination

scientific article published on 05 March 2020

Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone

scientific article published on 13 February 2018

Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients

scientific article

Myelin Proteolipid Protein Complexes with αv Integrin and AMPA Receptors In Vivo and Regulates AMPA-Dependent Oligodendrocyte Progenitor Cell Migration through the Modulation of Cell-Surface GluR2 Expression

scientific article

Myelin antigen load influences antigen presentation and severity of central nervous system autoimmunity

scientific article published on 17 April 2013

Myelin proteolipid protein forms a complex with integrins and may participate in integrin receptor signaling in oligodendrocytes

scientific journal article

Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination

scientific article

Netrin-1 is required for the normal development of spinal cord oligodendrocytes

scientific journal article

Neuronal expression of the proteolipid protein gene in the medulla of the mouse.

scientific article published in October 2009

Olig1 Acetylation and Nuclear Export Mediate Oligodendrocyte Development

scientific article

Olig1 function is required for oligodendrocyte differentiation in the mouse brain

scientific article published on March 2015

Oligodendrocyte Progenitor Cell Proliferation and Fate after White Matter Stroke in Juvenile and Adult Mice

scientific article published on 12 March 2019

Oligodendrogenesis is differentially regulated in gray and white matter of jimpy mice

scientific article published in December 2002

Phosphodiesterase-Ialpha/autotaxin: a counteradhesive protein expressed by oligodendrocytes during onset of myelination

scientific journal article

Progesterone and Nestorone facilitate axon remyelination: a role for progesterone receptors.

scientific article

Proteolipid promoter activity distinguishes two populations of NG2-positive cells throughout neonatal cortical development.

scientific article published in February 2002

Proteolipid protein gene mutation induces altered ventilatory response to hypoxia in the myelin-deficient rat.

scientific article published in March 2003

Selective alteration of the ventilatory response to hypoxia results from mutation in the myelin proteolipid protein gene.

scientific article published in January 2004

Signaling mechanisms regulating myelination in the central nervous system.

scientific article published on 05 April 2013

Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells

scientific article (publication date: April 2003)

Targeted overexpression of a golli-myelin basic protein isoform to oligodendrocytes results in aberrant oligodendrocyte maturation and myelination

scientific article published on 23 September 2009

The mechanistic target of rapamycin pathway downregulates bone morphogenetic protein signaling to promote oligodendrocyte differentiation

scientific article published on 06 January 2020

The neural androgen receptor: a therapeutic target for myelin repair in chronic demyelination

scientific article

The protein tyrosine phosphatase Shp2 regulates oligodendrocyte differentiation and early myelination and contributes to timely remyelination.

scientific article published on 7 December 2017

Variable sensitivity to complement-dependent cytotoxicity in murine models of neuromyelitis optica

scientific article published on December 2016

Visual abnormalities associated with enhanced optic nerve myelination ⬇️

scientific article published on December 21, 2010

mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development

scientific article published on 19 March 2013

List of works by Wendy B Macklin

A new model of cuprizone-mediated demyelination/remyelination.

A novel PET marker for in vivo quantification of myelination.

Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination.

Astrocyte expression of a dominant-negative interferon-gamma receptor.

Automatic and adaptive heterogeneous refractive index compensation for light-sheet microscopy

Bace1 modulates myelination in the central and peripheral nervous system.

Concentration-dependent effects of CSF1R inhibitors on oligodendrocyte progenitor cells ex vivo and in vivo

Conditional ablation of raptor or rictor has differential impact on oligodendrocyte differentiation and CNS myelination.

Constitutively active Akt induces enhanced myelination in the CNS

Delayed inhibition of tonic inhibition enhances functional recovery following experimental ischemic stroke.

Distinct modes of migration position oligodendrocyte precursors for localized cell division in the developing spinal cord

Distinct patterns of glia repair and remyelination in antibody-mediated demyelination models of multiple sclerosis and neuromyelitis optica

Dynamics and mechanisms of CNS myelination.

Dynamics of ten-eleven translocation hydroxylase family proteins and 5-hydroxymethylcytosine in oligodendrocyte differentiation.

Endogenous Neuronal Replacement in the Juvenile Brain Following Cerebral Ischemia

Evolution of a neuroprotective function of central nervous system myelin

Expression of a dominant negative IFN-gammareceptor on mouse oligodendrocytes

Expression of matrix metalloproteinases and their tissue inhibitor during viral encephalitis.

Expression of proteolipid protein gene in spinal cord stem cells and early oligodendrocyte progenitor cells is dispensable for normal cell migration and myelination

Glutamate stimulates oligodendrocyte progenitor migration mediated via an alphav integrin/myelin proteolipid protein complex.

Golli myelin basic proteins regulate oligodendroglial progenitor cell migration through voltage-gated Ca2+ influx

Human antibodies against the myelin oligodendrocyte glycoprotein can cause complement-dependent demyelination

Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes

In situ fluorescence imaging of myelination

Induction of class I antigen processing components in oligodendroglia and microglia during viral encephalomyelitis.

Inhibition of interferon-gamma signaling in oligodendroglia delays coronavirus clearance without altering demyelination

Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation

Juvenile striatal white matter is resistant to ischemia-induced damage

Long-lasting masculinizing effects of postnatal androgens on myelin governed by the brain androgen receptor.

Longitudinal Near-Infrared Imaging of Myelination ⬇️

Loss of Tuberous Sclerosis Complex1 in Adult Oligodendrocyte Progenitor Cells Enhances Axon Remyelination and Increases Myelin Thickness after a Focal Demyelination.

Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination.

Mechanistic Target of Rapamycin Regulates the Oligodendrocyte Cytoskeleton during Myelination

Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone

Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients

Myelin Proteolipid Protein Complexes with αv Integrin and AMPA Receptors In Vivo and Regulates AMPA-Dependent Oligodendrocyte Progenitor Cell Migration through the Modulation of Cell-Surface GluR2 Expression

Myelin antigen load influences antigen presentation and severity of central nervous system autoimmunity

Myelin proteolipid protein forms a complex with integrins and may participate in integrin receptor signaling in oligodendrocytes

Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination

Netrin-1 is required for the normal development of spinal cord oligodendrocytes

Neuronal expression of the proteolipid protein gene in the medulla of the mouse.

Olig1 Acetylation and Nuclear Export Mediate Oligodendrocyte Development

Olig1 function is required for oligodendrocyte differentiation in the mouse brain

Oligodendrocyte Progenitor Cell Proliferation and Fate after White Matter Stroke in Juvenile and Adult Mice

Oligodendrogenesis is differentially regulated in gray and white matter of jimpy mice

Phosphodiesterase-Ialpha/autotaxin: a counteradhesive protein expressed by oligodendrocytes during onset of myelination

Progesterone and Nestorone facilitate axon remyelination: a role for progesterone receptors.

Proteolipid promoter activity distinguishes two populations of NG2-positive cells throughout neonatal cortical development.

Proteolipid protein gene mutation induces altered ventilatory response to hypoxia in the myelin-deficient rat.

Selective alteration of the ventilatory response to hypoxia results from mutation in the myelin proteolipid protein gene.

Signaling mechanisms regulating myelination in the central nervous system.

Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells

Targeted overexpression of a golli-myelin basic protein isoform to oligodendrocytes results in aberrant oligodendrocyte maturation and myelination

The mechanistic target of rapamycin pathway downregulates bone morphogenetic protein signaling to promote oligodendrocyte differentiation

The neural androgen receptor: a therapeutic target for myelin repair in chronic demyelination

The protein tyrosine phosphatase Shp2 regulates oligodendrocyte differentiation and early myelination and contributes to timely remyelination.

Variable sensitivity to complement-dependent cytotoxicity in murine models of neuromyelitis optica

Visual abnormalities associated with enhanced optic nerve myelination ⬇️

mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development