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List of works by Mohammad Seyedsayamdost

A genetics-free method for high-throughput discovery of cryptic microbial metabolites ⬇️

scientific article published on 07 January 2019

Acinetodin and Klebsidin, RNA Polymerase Targeting Lasso Peptides Produced by Human Isolates of Acinetobacter gyllenbergii and Klebsiella pneumoniae.

scientific article published on 20 January 2017

Algal p-coumaric acid induces oxidative stress and siderophore biosynthesis in the bacterial symbiont Phaeobacter inhibens ⬇️

scientific article published on 25 August 2021

Aliphatic Ether Bond Formation Expands the Scope of Radical SAM Enzymes in Natural Product Biosynthesis.

scientific article published on 27 June 2019

Bioactivity-HiTES Unveils Cryptic Antibiotics Encoded in Actinomycete Bacteria ⬇️

scientific article published on 19 March 2019

CanE, an Iron/2-Oxoglutarate-Dependent Lasso Peptide Hydroxylase from Streptomyces canus

scientific article published on 30 March 2020

Catecholate siderophores protect bacteria from pyochelin toxicity

scientific article

Cebulantin, a Cryptic Lanthipeptide Antibiotic Uncovered Using Bioactivity-Coupled HiTES ⬇️

scientific article published on 28 March 2019

Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif

scientific article published on 05 December 2018

Corrigendum: Discovery of a Cryptic Depsipeptide from Streptomyces ghanaensis via MALDI-MS-Guided High-Throughput Elicitor Screening

scientific article published on 01 December 2020

Crochelins: Siderophores with an Unprecedented Iron-Chelating Moiety from the Nitrogen-Fixing Bacterium Azotobacter chroococcum.

scientific article published on 14 November 2017

Cytotoxic alkyl-quinolones mediate surface-induced virulence in Pseudomonas aeruginosa

scientific article published on 14 September 2020

Direct observation of a transient tyrosine radical competent for initiating turnover in a photochemical ribonucleotide reductase

scientific article published on 18 October 2007

Discovery and Biosynthesis of Streptosactin, a Sactipeptide with an Alternative Topology Encoded by Commensal Bacteria in the Human Microbiome

scientific article published on 26 August 2020

Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens ⬇️

scientific article published on 07 June 2017

Discovery of a Cryptic Depsipeptide from Streptomyces ghanaensis via MALDI-MS-Guided High-Throughput Elicitor Screening

scientific article published on 12 August 2020

Discovery of a New Class I Ribonucleotide Reductase with an Essential DOPA Radical and NO Metal as an Initiator of Long-Range Radical Transfer

scientific article published on 26 December 2018

Discovery of scmR as a global regulator of secondary metabolism and virulence in Burkholderia thailandensis E264.

scientific article published on 20 March 2017

Electron transfer reactions of fluorotyrosyl radicals

scientific article published on 01 October 2006

Forward and reverse electron transfer with the Y356DOPA-beta2 heterodimer of E. coli ribonucleotide reductase.

scientific article published on 6 February 2007

Function of the diiron cluster of Escherichia coli class Ia ribonucleotide reductase in proton-coupled electron transfer

scientific article published on 31 May 2013

Generation of the R2 subunit of ribonucleotide reductase by intein chemistry: insertion of 3-nitrotyrosine at residue 356 as a probe of the radical initiation process

scientific article

Hybrid biosynthesis of roseobacticides from algal and bacterial precursor molecules

scientific article

Identification of the Hypertension Drug Guanfacine as an Antivirulence Agent in Pseudomonas aeruginosa

scientific article published on 03 July 2019

In Vitro Reconstitution of OxyA Enzymatic Activity Clarifies Late Steps in Vancomycin Biosynthesis.

scientific article published on 11 July 2017

In Vitro Reconstitution of OxyC Activity Enables Total Chemo-Enzymatic Syntheses of Vancomycin Aglycone Variants.

scientific article

Induction of Diverse Cryptic Fungal Metabolites by Steroids and Channel Blockers

Installation of Multiple Aryl Ether Crosslinks onto Non-Native Substrate Peptides by the Vancomycin OxyB

Interspecies modulation of bacterial development through iron competition and siderophore piracy

scientific article

Investigation of the Genetics and Biochemistry of Roseobacticide Production in the Roseobacter Clade Bacterium Phaeobacter inhibens ⬇️

scientific article published on 22 March 2016

Kinetics of Radical Intermediate Formation and Deoxynucleotide Production in 3-Aminotyrosine-Substituted Escherichia coli Ribonucleotide Reductases

scientific article

Long-range proton-coupled electron transfer in the Escherichia coli class Ia ribonucleotide reductase

scientific article

Lysine-Tryptophan-Crosslinked Peptides Produced by Radical SAM Enzymes in Pathogenic Streptococci.

scientific article published on 13 February 2017

Macrocyclization via an Arginine-Tyrosine Crosslink Broadens the Reaction Scope of Radical S-Adenosylmethionine Enzymes

scientific article published on 14 October 2019

Mapping the Trimethoprim-Induced Secondary Metabolome of Burkholderia thailandensis.

scientific article published in July 2016

Mechanistic Investigations of Lysine-Tryptophan Cross-Link Formation Catalyzed by Streptococcal Radical S-Adenosylmethionine Enzymes.

scientific article published on 10 January 2018

Mixing and matching siderophore clusters: structure and biosynthesis of serratiochelins from Serratia sp. V4. ⬇️

scientific article

Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the γ-glutamyl cycle as a proton sink

scientific article published on 22 January 2016

Modulating OxyB-Catalyzed Cross-Coupling Reactions in Vancomycin Biosynthesis by Incorporation of Diverse d-Tyr Analogues

scientific article published on 19 June 2018

Momomycin, an Antiproliferative Cryptic Metabolite from the Oxytetracycline Producer Streptomyces rimosus

Mono-, di-, tri-, and tetra-substituted fluorotyrosines: new probes for enzymes that use tyrosyl radicals in catalysis

scientific article published in February 2006

Multi-Omic Analyses Provide Links between Low-Dose Antibiotic Treatment and Induction of Secondary Metabolism in Burkholderia thailandensis

scientific article published on 25 February 2020

Natural products and synthetic biology

scientific article published on 07 January 2014

Nonomuraea sp. ATCC 55076 harbours the largest actinomycete chromosome to date and the kistamicin biosynthetic gene cluster ⬇️

scientific article published on 30 January 2017

Old meets new: using interspecies interactions to detect secondary metabolite production in actinomycetes

scientific article published on January 2012

PELDOR spectroscopy with DOPA-beta2 and NH2Y-alpha2s: distance measurements between residues involved in the radical propagation pathway of E. coli ribonucleotide reductase

scientific article published on 30 November 2007

Photoactive peptides for light-initiated tyrosyl radical generation and transport into ribonucleotide reductase.

scientific article published on 14 June 2007

Radical Approach to Enzymatic β-Thioether Bond Formation

scientific article published on 28 December 2018

Re(bpy)(CO)3CN as a probe of conformational flexibility in a photochemical ribonucleotide reductase

scientific article published in June 2009

Recent advances in activating silent biosynthetic gene clusters in bacteria

scientific article published on 05 June 2018

Replacement of Y730 and Y731 in the alpha2 subunit of Escherichia coli ribonucleotide reductase with 3-aminotyrosine using an evolved suppressor tRNA/tRNA-synthetase pair

scientific article

Reporter-Guided Transposon Mutant Selection for Activation of Silent Gene Clusters in Burkholderia thailandensis

scientific article published on 26 January 2020

Roseobacticides: small molecule modulators of an algal-bacterial symbiosis ⬇️

scientific article

Roseochelin B, an Algaecidal Natural Product Synthesized by the Roseobacter Phaeobacter inhibens in Response to Algal Sinapic Acid.

scientific article published on 18 September 2017

Site-specific incorporation of fluorotyrosines into the R2 subunit of E. coli ribonucleotide reductase by expressed protein ligation

scientific article published in January 2007

Site-specific insertion of 3-aminotyrosine into subunit alpha2 of E. coli ribonucleotide reductase: direct evidence for involvement of Y730 and Y731 in radical propagation

scientific article published on 9 November 2007

Site-specific replacement of Y356 with 3,4-dihydroxyphenylalanine in the beta2 subunit of E. coli ribonucleotide reductase

scientific article published in March 2006

Special Issue in Honor of Professor Jon Clardy

scientific article published on 01 March 2020

Structural Elucidation of Cryptic Algaecides in Marine Algal‐Bacterial Symbioses by NMR Spectroscopy and MicroED

Structural examination of the transient 3-aminotyrosyl radical on the PCET pathway of E. coli ribonucleotide reductase by multifrequency EPR spectroscopy

scientific article published in November 2009

Structure and biosynthesis of amychelin, an unusual mixed-ligand siderophore from Amycolatopsis sp. AA4. ⬇️

scientific article

Synergy and Target Promiscuity Drive Structural Divergence in Bacterial Alkylquinolone Biosynthesis.

scientific article published on 28 September 2017

Targeted Discovery of Cryptic Metabolites with Antiproliferative Activity

Thailandenes, Cryptic Polyene Natural Products Isolated from Burkholderia thailandensis Using Phenotype-Guided Transposon Mutagenesis

scientific article published on 02 January 2020

The Chemistry and Biology of Bactobolin: A 10-Year Collaboration with Natural Product Chemist Extraordinaire Jon Clardy

scientific article published on 27 February 2020

The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis

scientific article

The Polyene Natural Product Thailandamide A Inhibits Fatty Acid Biosynthesis in Gram-Positive and Gram-Negative Bacteria

scientific article published on 12 July 2018

Total Synthesis and Stereochemical Assignment of Streptide

scientific article published on 17 October 2019

Toward a global picture of bacterial secondary metabolism

scientific article published on 25 January 2019

Unlocking Cryptic Metabolites with Mass Spectrometry-Guided Transposon Mutant Selection

scientific article

Use of 2,3,5-F(3)Y-β2 and 3-NH(2)Y-α2 to study proton-coupled electron transfer in Escherichia coli ribonucleotide reductase

scientific article

Use of 3-aminotyrosine to examine the pathway dependence of radical propagation in Escherichia coli ribonucleotide reductase

scientific article published on December 2009

pH Rate profiles of FnY356-R2s (n = 2, 3, 4) in Escherichia coli ribonucleotide reductase: evidence that Y356 is a redox-active amino acid along the radical propagation pathway

scientific article published in February 2006

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