List of works by John C Bell

A Viro-Immunotherapy Triple Play for the Treatment of Glioblastoma

scientific article published on August 2017

A high-throughput pharmacoviral approach identifies novel oncolytic virus sensitizers

scientific article

A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication

scientific article

A mechanistic proof-of-concept clinical trial with JX-594, a targeted multi-mechanistic oncolytic poxvirus, in patients with metastatic melanoma

scientific article

A phase 1 clinical study of intravenous administration of PV701, an oncolytic virus, using two-step desensitization

scientific article

A selectable and excisable marker system for the rapid creation of recombinant poxviruses

scientific article

Activating transcription factor 4 is translationally regulated by hypoxic stress

scientific article published on September 2004

Adenovirus-Mediated Expression of the p14 Fusion-Associated Small Transmembrane Protein Promotes Cancer Cell Fusion and Apoptosis In Vitro but Does Not Provide Therapeutic Efficacy in a Xenograft Mouse Model of Cancer

scientific article (publication date: 2016)

Amplification of oncolytic vaccinia virus widespread tumor cell killing by sunitinib through multiple mechanisms.

scientific article published on 19 December 2017

An Oncolytic Adenovirus Vector Expressing p14 FAST Protein Induces Widespread Syncytium Formation and Reduces Tumor Growth Rate In Vivo.

scientific article

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

scientific article (publication date: March 2003)

Anti-Fab aptamers for shielding virus from neutralizing antibodies

scientific article

Antiangiogenic arming of an oncolytic vaccinia virus enhances antitumor efficacy in renal cell cancer models

scientific article

Aptamer-based viability impedimetric sensor for viruses

scientific article published on 01 February 2012

Aptamer-facilitated Protection of Oncolytic Virus from Neutralizing Antibodies

scientific article published on 03 June 2014

Bacterial-mediated knockdown of tumor resistance to an oncolytic virus enhances therapy.

scientific article

Bax-dependent mitochondrial membrane permeabilization enhances IRF3-mediated innate immune response during VSV infection

scientific article published on 23 April 2007

Carrier cell-based delivery of an oncolytic virus circumvents antiviral immunity.

scientific article published on January 2007

Cell carriers for oncolytic viruses: current challenges and future directions

scientific article

Cell-based delivery of oncolytic viruses: a new strategic alliance for a biological strike against cancer

scientific article published on 30 January 2007

Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis.

scholarly article

Chromosomal position effects are linked to sir2-mediated variation in transcriptional burst size

scientific article

Complement inhibition prevents oncolytic vaccinia virus neutralization in immune humans and cynomolgus macaques

scientific article published on 25 March 2015

Complex rearrangement of chromosomes 19, 21, and 22 in Ewing sarcoma involving a novel reciprocal inversion-insertion mechanism of EWS-ERG fusion gene formation: a case analysis and literature review

scientific article published on March 2008

Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade.

scientific article published on 10 September 2018

Correction: Surgical Stress Abrogates Pre-Existing Protective T Cell Mediated Anti-Tumor Immunity Leading to Postoperative Cancer Recurrence.

scientific article published on 18 July 2016

Development and applications of oncolytic Maraba virus vaccines

Dimethyl fumarate potentiates oncolytic virotherapy through NF-κB inhibition

scientific article published in January 2018

Diplomatic immunity: turning a foe into an ally.

scientific article published on February 2009

Double trouble for tumours: exploiting the tumour microenvironment to enhance anticancer effect of oncolytic viruses

scientific article published on 24 March 2010

Double-deleted vaccinia virus in virotherapy for refractory and metastatic pediatric solid tumors

scientific article published on 14 June 2013

Down-regulation of type I interferon receptor sensitizes bladder cancer cells to vesicular stomatitis virus-induced cell death

scientific article

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

scientific article published on 8 September 2005

Editorial overview: Oncolytic viruses--replicating virus therapeutics for the treatment of cancer

scientific article

Effects of intravenously administered recombinant vesicular stomatitis virus (VSV(deltaM51)) on multifocal and invasive gliomas.

scientific article published on November 2006

Efficacy and safety/toxicity study of recombinant vaccinia virus JX-594 in two immunocompetent animal models of glioma.

scientific article

Efficacy of systemically administered mutant vesicular stomatitis virus (VSVDelta51) combined with radiation for nasopharyngeal carcinoma

scientific article

Efficacy of systemically administered oncolytic vaccinia virotherapy for malignant gliomas is enhanced by combination therapy with rapamycin or cyclophosphamide

scientific article published on 7 April 2009

Electrochemical differentiation of epitope-specific aptamers.

scientific article

Electrochemical sensing of aptamer-facilitated virus immunoshielding.

scientific article

Enhanced susceptibility of cancer cells to oncolytic rhabdo-virotherapy by expression of Nodamura virus protein B2 as a suppressor of RNA interference.

scientific article

Enhanced vesicular stomatitis virus (VSVΔ51) targeting of head and neck cancer in combination with radiation therapy or ZD6126 vascular disrupting agent

scientific article published on 15 June 2012

Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors

scientific article

Enhancing Expression of Functional Human Sodium Iodide Symporter and Somatostatin Receptor in Recombinant Oncolytic Vaccinia Virus for In Vivo Imaging of Tumors

scientific article published on 15 September 2016

Evidence for differential viral oncolytic efficacy in an in vitro model of epithelial ovarian cancer metastasis

scientific article published on 23 September 2015

Ex vivo infection of live tissue with oncolytic viruses

scientific article published on 25 June 2011

Exploiting tumor epigenetics to improve oncolytic virotherapy

scientific article published in 2013

First-in-class small molecule potentiators of cancer virotherapy

scientific article published on 26 May 2016

First-in-man study of western reserve strain oncolytic vaccinia virus: safety, systemic spread, and antitumor activity

scientific article published on 8 October 2014

From scourge to cure: tumour-selective viral pathogenesis as a new strategy against cancer

scientific article

Getting oncolytic virus therapies off the ground

scientific article published in July 2003

Going viral with cancer immunotherapy

scientific article

HDAC inhibition suppresses primary immune responses, enhances secondary immune responses, and abrogates autoimmunity during tumor immunotherapy

scientific article published on 8 January 2013

Harnessing oncolytic virus-mediated antitumor immunity in an infected cell vaccine.

scientific article

Identification of genetically modified Maraba virus as an oncolytic rhabdovirus.

scientific article

Innate immunity, tumor microenvironment and oncolytic virus therapy: friends or foes?

scientific article published on February 2008

Intelligent design: combination therapy with oncolytic viruses

scientific article

Intercellular trafficking of VP22, a herpes simplex virus type 1 tegument protein.

scientific article

Interfering with tumor pathways that augment viral oncolysis

scientific article

Interferon-β sensitivity of tumor cells correlates with poor response to VA7 virotherapy in mouse glioma models

scientific article

Internal ribosome entry site-mediated translation of Apaf-1, but not XIAP, is regulated during UV-induced cell death.

scientific article published on 4 April 2006

Internal translation initiation mediated by the angiogenic factor Tie2.

scientific article

Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans

scientific article

Intravenously administered alphavirus vector VA7 eradicates orthotopic human glioma xenografts in nude mice

scientific article

Leukemia cell-rhabdovirus vaccine: personalized immunotherapy for acute lymphoblastic leukemia.

scientific article published on 28 May 2013

Lighting a Fire in the Tumor Microenvironment Using Oncolytic Immunotherapy.

scientific article

Loss of the Ste20-like kinase induces a basal/stem-like phenotype in HER2-positive breast cancers

scientific article published on 11 May 2020

Maraba MG1 virus enhances natural killer cell function via conventional dendritic cells to reduce postoperative metastatic disease

scientific article

Matrix protein mediated shutdown of host cell metabolism limits vesicular stomatitis virus-induced interferon-alpha responses to plasmacytoid dendritic cells

scientific article published on 9 November 2007

Matrix protein of Vesicular stomatitis virus harbours a cryptic mitochondrial-targeting motif

scientific article published on November 2006

MicroRNAs fine-tune oncolytic viruses

scientific article published on 01 December 2008

Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing

scientific article

Model-based rational design of an oncolytic virus with improved therapeutic potential.

scientific article published in January 2013

Moving oncolytic viruses into the clinic: clinical-grade production, purification, and characterization of diverse oncolytic viruses

scientific article

Multi-modal Potentiation of Oncolytic Virotherapy by Vanadium Compounds

scientific article published on 24 October 2017

Myxoma virus is a novel oncolytic virus with significant antitumor activity against experimental human gliomas

scientific article

Myxoma virus virotherapy for glioma in immunocompetent animal models: optimizing administration routes and synergy with rapamycin

scientific article

N-Myc expression enhances the oncolytic effects of vesicular stomatitis virus in human neuroblastoma cells

scientific article published on 16 March 2016

NK-Cell Recruitment Is Necessary for Eradication of Peritoneal Carcinomatosis with an IL12-Expressing Maraba Virus Cellular Vaccine

scientific article published on 3 February 2017

Navigating the clinical development landscape for oncolytic viruses and other cancer therapeutics: no shortcuts on the road to approval

scientific article published on April 2010

Neoadjuvant oncolytic virotherapy before surgery sensitizes triple-negative breast cancer to immune checkpoint therapy.

scientific article published in January 2018

Novel oncolytic viruses: riding high on the next wave?

scientific article published on 12 March 2010

ORFV: a novel oncolytic and immune stimulating parapoxvirus therapeutic.

scientific article

Oncolysis of prostate cancers induced by vesicular stomatitis virus in PTEN knockout mice

scientific article published on 9 February 2010

Oncolytic Vesicular Stomatitis Viruses Are Potent Agents for Intravesical Treatment of High-Risk Bladder Cancer

scientific article published on 01 June 2008

Oncolytic Viruses: Exploiting Cancer's Deal with the Devil

scientific article published on 21 November 2015

Oncolytic Viruses: The Best is Yet to Come

scientific article published on 6 February 2017

Oncolytic Viruses: Therapeutics With an Identity Crisis

scientific article

Oncolytic and immunotherapeutic vaccinia induces antibody-mediated complement-dependent cancer cell lysis in humans

scientific article published on May 2013

Oncolytic efficacy of recombinant vesicular stomatitis virus and myxoma virus in experimental models of rhabdoid tumors

scientific article

Oncolytic measles virus encoding interleukin-12 mediates potent antitumor effects through T cell activation

scientific article published on 31 January 2017

Oncolytic targeting of renal cell carcinoma via encephalomyocarditis virus

scientific article

Oncolytic vaccinia virotherapy for endometrial cancer

scientific article published on 14 January 2014

Oncolytic vaccinia virus disrupts tumor-associated vasculature in humans.

scientific article published on 07 February 2013

Oncolytic virotherapy

scientific article published on 10 July 2012

Oncolytic viruses as engineering platforms for combination immunotherapy.

scientific article published on 25 April 2018

Oncolytic viruses sensitize human tumor cells for NY-ESO-1 tumor antigen recognition by CD4+ effector T cells.

scientific article published on 26 December 2017

Oncolytic viruses-immunotherapeutics on the rise

scientific article

Oncolytic viruses: an approved product on the horizon?

scientific article published on February 2010

Oncolytic viruses: immune or cytolytic therapy?

scientific article published on July 2014

Oncolytic viruses: smart therapeutics for smart cancers.

scientific article published in January 2012

Oncolytic viruses: what's next?

scientific article published on March 2007

Panorama from the oncolytic virotherapy summit

scientific article published on October 2013

Perioperative influenza vaccination reduces postoperative metastatic disease by reversing surgery-induced dysfunction in natural killer cells

scientific article

Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress

scientific article

Pexa-Vec double agent engineered vaccinia: oncolytic and active immunotherapeutic

scientific article published on 16 April 2015

Phase 1 study of intratumoral Pexa-Vec (JX-594), an oncolytic and immunotherapeutic vaccinia virus, in pediatric cancer patients

scientific article

Potent oncolytic activity of raccoonpox virus in the absence of natural pathogenicity

scientific article

Pre-surgical neoadjuvant oncolytic virotherapy confers protection against rechallenge in a murine model of breast cancer

scientific article published in Scientific Reports

Preventing postoperative metastatic disease by inhibiting surgery-induced dysfunction in natural killer cells

scientific article published on 22 October 2012

Propagation, purification, and in vivo testing of oncolytic vesicular stomatitis virus strains

scientific article published in January 2012

Publisher Correction: Oncolytic viruses as engineering platforms for combination immunotherapy

scientific article published on 01 August 2018

Radioiodide imaging and radiovirotherapy of multiple myeloma using VSV(Delta51)-NIS, an attenuated vesicular stomatitis virus encoding the sodium iodide symporter gene

scientific article

Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer

scientific article

Rapid Generation of Multiple Loci-Engineered Marker-free Poxvirus and Characterization of a Clinical-Grade Oncolytic Vaccinia Virus

scientific article published on 30 September 2017

Rational strain selection and engineering creates a broad-spectrum, systemically effective oncolytic poxvirus, JX-963

scientific article

Re-engineering vesicular stomatitis virus to abrogate neurotoxicity, circumvent humoral immunity, and enhance oncolytic potency

scientific article published on 8 May 2014

Recent advances in the development of oncolytic viruses as cancer therapeutics. Foreword

scientific article published in April 2010

Recent progress in the battle between oncolytic viruses and tumours

scientific article

Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity.

scientific article

Regulation of Macropinocytosis by Diacylglycerol Kinase ζ

scientific article

Relationship between within-host fitness and virulence in the vesicular stomatitis virus: correlation with partial decoupling

scientific article

Replicating oncolytic virus therapeutics - Third International Meeting.

scientific article

Resistance to two heterologous neurotropic oncolytic viruses, Semliki Forest virus and vaccinia virus, in experimental glioma.

scientific article

Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR

scientific journal article

Sensitivity of cervical carcinoma cells to vesicular stomatitis virus-induced oncolysis: potential role of human papilloma virus infection.

scientific article

Sequential therapy with JX-594, a targeted oncolytic poxvirus, followed by sorafenib in hepatocellular carcinoma: preclinical and clinical demonstration of combination efficacy

scientific article

Single-particle characterization of oncolytic vaccinia virus by flow virometry.

scientific article published on 7 September 2016

Smac mimetics and innate immune stimuli synergize to promote tumor death

scientific article published on 26 January 2014

Spatial and temporal epithelial ovarian cancer cell heterogeneity impacts Maraba virus oncolytic potential

scientific article published on 30 August 2017

Surgical Stress Abrogates Pre-Existing Protective T Cell Mediated Anti-Tumor Immunity Leading to Postoperative Cancer Recurrence

scientific article (publication date: 2016)

Surgical stress promotes the development of cancer metastases by a coagulation-dependent mechanism involving natural killer cells in a murine model

scientific article published on 01 July 2013

Synergistic interaction between oncolytic viruses augments tumor killing

scientific article

Taming measles virus to create an effective cancer therapeutic

scientific article published on 14 May 2014

Targeted and armed oncolytic poxviruses for cancer: the lead example of JX-594.

scientific article

Targeted inflammation during oncolytic virus therapy severely compromises tumor blood flow

scientific article

Targeting and killing of metastatic cells in the transgenic adenocarcinoma of mouse prostate model with vesicular stomatitis virus

scientific article published on 22 January 2013

Targeting human medulloblastoma: oncolytic virotherapy with myxoma virus is enhanced by rapamycin.

scientific article

Targeting of interferon-beta to produce a specific, multi-mechanistic oncolytic vaccinia virus

scientific article (publication date: December 2007)

Targeting the apoptotic pathway with BCL-2 inhibitors sensitizes primary chronic lymphocytic leukemia cells to vesicular stomatitis virus-induced oncolysis

scientific article published on 25 June 2008

Targeting tumor vasculature with an oncolytic virus

scientific article

The emerging therapeutic potential of the oncolytic immunotherapeutic Pexa-Vec (JX-594)

scientific article

The importance of imaging strategies for pre-clinical and clinical in vivo distribution of oncolytic viruses.

scientific article published in January 2017

The oncolytic poxvirus JX-594 selectively replicates in and destroys cancer cells driven by genetic pathways commonly activated in cancers

scientific article published on 20 December 2011

The p14 FAST protein of reptilian reovirus increases vesicular stomatitis virus neuropathogenesis.

scientific article published on 29 October 2008

The targeted oncolytic poxvirus JX-594 demonstrates antitumoral, antivascular, and anti-HBV activities in patients with hepatocellular carcinoma

scientific article

The virus that came in from the cold

scientific article published in June 2012

Thunder and lightning: immunotherapy and oncolytic viruses collide

scientific article

Transforming the prostatic tumor microenvironment with oncolytic virotherapy

scholarly article by Matthew J Atherton et al published 2018 in OncoImmunology

Translation of targeted oncolytic virotherapeutics from the lab into the clinic, and back again: a high-value iterative loop.

scientific article

Translational control of the innate immune response through IRF-7

scientific article published in Nature

Treating brain tumor-initiating cells using a combination of myxoma virus and rapamycin

scientific article published on 12 April 2013

Tudor Domain Containing Protein 3 Promotes Tumorigenesis and Invasive Capacity of Breast Cancer Cells

scientific article

Tumor vascularization is critical for oncolytic vaccinia virus treatment of peritoneal carcinomatosis.

scientific article published on 29 August 2013

United virus: the oncolytic tag-team against cancer!

scientific article published on 12 March 2010

Use of Precision-Cut Lung Slices as an Tool for Evaluating Viruses and Viral Vectors for Gene and Oncolytic Therapy

article

Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial

scientific article published on 19 May 2008

Using targeted virotherapy to treat a resistant Ewing sarcoma model: from the bedside to the bench and back

scientific article published on 12 January 2014

VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection.

scientific article published on 22 July 2015

VSV Oncolysis in Combination With the BCL-2 Inhibitor Obatoclax Overcomes Apoptosis Resistance in Chronic Lymphocytic Leukemia ⬇️

scientific article published on September 14, 2010

VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents

scientific article

Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production

scientific article

Vesicular stomatitis virus oncolysis of T lymphocytes requires cell cycle entry and translation initiation

scientific article published on 16 April 2008

Vesicular stomatitis virus: a potential therapeutic virus for the treatment of hematologic malignancy

scientific article published on September 2004

Vesicular stomatitis virus: re-inventing the bullet

scientific article published on May 2004

Viral quantitative capillary electrophoresis for counting and quality control of RNA viruses

scientific article published on 19 October 2012

Viral quantitative capillary electrophoresis for counting intact viruses.

scientific article

Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy

scientific article published on 07 April 2022

Viruses for tumor therapy

scientific article

Paulina is supported by:

About Paulina

Help