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List of works by Dirk Schnappinger

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Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment

scientific journal article
The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

scientific article (publication date: December 2009)
Reprogramming of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase

scientific article
Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system

scientific article
Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor

scientific article
Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection

scientific article
Mycobacterial survival strategies in the phagosome: defence against host stresses

scientific article
A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis

scientific article
In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice

scientific journal article
Ancestral antibiotic resistance in Mycobacterium tuberculosis

scientific journal article
Tetracyclines: antibiotic action, uptake, and resistance mechanisms

scientific article published on June 1996
Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis

scientific article
MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis

scientific article
Depletion of antibiotic targets has widely varying effects on growth

scientific article
Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier

scientific article published on 10 May 2011
Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment

scientific article
Silencing Mycobacterium smegmatis by using tetracycline repressors

scientific article published on 4 May 2007
Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli

scientific journal article
Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection

scientific article (publication date: February 2014)
A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence

scientific article
Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression

scientific article
Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes

scientific article published on January 2011
Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform

scientific article published on 6 February 2017
Conformational changes of the Tet repressor induced by tetracycline trapping

scientific article
Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes

scientific article
Nitrate respiration protects hypoxic Mycobacterium tuberculosis against acid- and reactive nitrogen species stresses

scientific journal article
Improved tetracycline repressors for gene silencing in mycobacteria

scientific article published on 27 January 2009
Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaks

scientific article
Protein inactivation in mycobacteria by controlled proteolysis and its application to deplete the beta subunit of RNA polymerase.

scientific article
Energy transfer between fluorescent proteins using a co-expression system in Mycobacterium smegmatis

scientific article published in October 2001
Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis

scientific article (publication date: May 2014)
Simultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivo

scientific article
Glycolytic and Non-glycolytic Functions of Mycobacterium tuberculosis Fructose-1,6-bisphosphate Aldolase, an Essential Enzyme Produced by Replicating and Non-replicating Bacilli

scientific article
Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells

scientific article published on 22 January 2015
Bisubstrate Adenylation Inhibitors of Biotin Protein Ligase from Mycobacterium tuberculosis

scientific article
Post-translational regulation via Clp protease is critical for survival of Mycobacterium tuberculosis.

scientific article
Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3

scientific article published on 13 June 2016
Expression profiling of host pathogen interactions: how Mycobacterium tuberculosis and the macrophage adapt to one another

scientific article
Single-chain Tet transregulators

scientific article
Mycobacterial genes essential for the pathogen's survival in the host

scientific article published on March 1, 2015
Fast large-scale purification of tetracycline repressor variants from overproducing Escherichia coli strains

scientific article
Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection

scientific article published on 22 April 2014
Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis

scientific article
Detection and treatment of subclinical tuberculosis

article
Mycobacterium tuberculosis virulence: lipids inside and out

scientific article published on 01 March 2007
Determinants of protein-protein recognition by four helix bundles: changing the dimerization specificity of Tet repressor

scientific article published on January 15, 1998
Mechanism-based Inactivation by Aromatization of the Transaminase BioA Involved in Biotin Biosynthesis in Mycobaterium tuberculosis

scientific article
Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis

scientific article published on 6 March 2017
Controlling gene expression in mycobacteria

scientific article published on August 2006
Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense

scientific article

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