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List of works by Jan-Willem C Alffenaar

Adequate design of pharmacokinetic-pharmacodynamic studies will help optimize tuberculosis treatment for the future.

scientific article published on April 2015

Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis

scientific article

Bioavailability of voriconazole in hospitalised patients.

scientific article published on 23 November 2016

Clarithromycin significantly increases linezolid serum concentrations

scientific article published on 13 September 2010

Clinical relevance of the pharmacokinetic interactions of azole antifungal drugs with other coadministered agents

scientific article published on May 2009

Clinical validation of the analysis of fluconazole in oral fluid in hospitalized children

scientific article

Commemorating World TB Day 2020: “IT’S TIME” — It’s time to End the Global TB Epidemic

scientific article published on 04 March 2020

Comparison of the pharmacokinetics of two dosage regimens of linezolid in multidrug-resistant and extensively drug-resistant tuberculosis patients

scientific article published on August 2010

Current status and opportunities for therapeutic drug monitoring in the treatment of tuberculosis

scientific article published on 7 March 2016

Determination of bedaquiline in human serum using liquid chromatography-tandem mass spectrometry

scientific article

Diabetes mellitus comorbidity in patients enrolled in tuberculosis drug efficacy trials around the world: A systematic review

scientific article published on 17 May 2019

Discrepancies Between Bayesian Vancomycin Models Can Affect Clinical Decisions in the Critically Ill

scientific article published in 2022

Dosing ethambutol in obese patients.

scientific article published on September 2010

Dried blood spot analysis suitable for therapeutic drug monitoring of voriconazole, fluconazole, and posaconazole.

scientific article published on 29 July 2013

Drug monitoring and individual dose optimization of antimicrobial drugs: oxazolidinones

scientific article published on 16 March 2016

Effectiveness and safety of bedaquiline-containing regimens in the treatment of MDR- and XDR-TB: a multicentre study.

scientific article

Epidemic and pandemic viral infections: impact on tuberculosis and the lung. A consensus by the World Association for Infectious Diseases and Immunological Disorders (WAidid), Global Tuberculosis Network (GTN) and members# of ESCMID Study Group for

scientific article published on 25 June 2020

Evaluation of co-trimoxazole in the treatment of multidrug-resistant tuberculosis

scientific article

Evaluation of macrolides for possible use against multidrug-resistant Mycobacterium tuberculosis

scientific article published on 28 May 2015

Exploring failure of antimicrobial prophylaxis and pre-emptive therapy for transplant recipients: a systematic review

scientific article published on 07 January 2020

Food intake and darunavir plasma concentrations in people living with HIV in an outpatient setting.

scientific article published on 7 July 2017

Ganciclovir Therapeutic Drug Monitoring: A Case Series

scientific article published on 01 April 2019

Impact of food on the pharmacokinetics of first-line anti-TB drugs in treatment-naive TB patients: a randomized cross-over trial.

scientific article published on 11 December 2015

Individualizing management of extensively drug-resistant tuberculosis: diagnostics, treatment, and biomarkers

scientific article

Inflammation is associated with voriconazole trough concentrations.

scientific article

Insufficient fluconazole exposure in pediatric cancer patients and the need for therapeutic drug monitoring in critically ill children

scientific article

Limited sampling strategies for therapeutic drug monitoring of linezolid in patients with multidrug-resistant tuberculosis

scientific article

Limited-sampling strategies for anidulafungin in critically ill patients

scientific article

Low Caspofungin Exposure in Patients in Intensive Care Units.

scientific article

Low but sufficient anidulafungin exposure in critically ill patients

scientific article published on 28 October 2013

Membrane Filtration Is Suitable for Reliable Elimination of Mycobacterium tuberculosis from Saliva for Therapeutic Drug Monitoring

scientific article published on 9 August 2017

Patients and Medical Staff Attitudes Toward the Future Inclusion of eHealth in Tuberculosis Management: Perspectives From Six Countries Evaluated using a Qualitative Framework

scientific article published on 02 November 2020

Pharmacodynamics of Voriconazole in Children: Further Steps along the Path to True Individualized Therapy

scientific article published on February 2016

Pharmacokinetic Modeling and Optimal Sampling Strategies for Therapeutic Drug Monitoring of Rifampin in Patients with Tuberculosis

scientific article published on 8 June 2015

Pharmacokinetic Modeling, Simulation, and Development of a Limited Sampling Strategy of Cycloserine in Patients with Multidrug-/Extensively Drug-Resistant Tuberculosis

scientific article published on 25 January 2020

Pharmacokinetic drug interactions of antimicrobial drugs: a systematic review on oxazolidinones, rifamycines, macrolides, fluoroquinolones, and Beta-lactams

scientific article

Pharmacokinetic/pharmacodynamic-based optimization of levofloxacin administration in the treatment of MDR-TB.

scientific article published on 26 May 2016

Pharmacokinetics of Levofloxacin in Multidrug- and Extensively Drug-Resistant Tuberculosis Patients

scientific article published on 15 May 2017

Phenytoin-induced reduction of voriconazole serum concentration is not compensated by doubling the dosage

scientific article published on September 2009

Population Pharmacokinetic Model and Optimal Sampling Strategies for Micafungin in Critically Ill Patients Diagnosed with Invasive Candidiasis

scientific article published in 2022

Posaconazole therapeutic drug monitoring in clinical practice and longitudinal analysis of the effect of routine laboratory measurements on posaconazole concentrations

scientific article published on 18 June 2019

Potential antimicrobial agents for the treatment of multidrug-resistant tuberculosis

scientific article

Precision Therapy for Invasive Fungal Diseases

scientific article published in 2021

Predictors of Prolonged TB Treatment in a Dutch Outpatient Setting

scientific article

Prospective evaluation of improving fluoroquinolone exposure using centralised therapeutic drug monitoring (TDM) in patients with tuberculosis (PERFECT): a study protocol of a prospective multicentre cohort study

scientific article published on 16 June 2020

Quantification of co-trimoxazole in serum and plasma using MS/MS.

scientific article

Risk factors contributing to a low darunavir plasma concentration.

scientific article published on 27 October 2017

Role of therapeutic drug monitoring in pulmonary infections: use and potential for expanded use of dried blood spot samples.

scientific article

Simple strategy to assess linezolid exposure in patients with multi-drug-resistant and extensively-drug-resistant tuberculosis

scientific article

Statin Adjunctive Therapy for Tuberculosis Treatment

scientific article published on 21 October 2016

Sterilizing Effect of Ertapenem-Clavulanate in a Hollow-Fiber Model of Tuberculosis and Implications on Clinical Dosing

scientific article published on 10 July 2017

Surveillance of adverse events in the treatment of drug-resistant tuberculosis: first global report

scientific article published on 10 October 2019

Susceptibility Testing of Antibiotics That Degrade Faster than the Doubling Time of Slow-Growing Mycobacteria: Ertapenem Sterilizing Effect versus Mycobacterium tuberculosis

scientific article published on 29 February 2016

The association between the NAT2 genetic polymorphisms and risk of DILI during anti-TB treatment: a systematic review and meta-analysis.

scientific article published on 3 October 2018

The effect of inflammation on voriconazole trough concentrations in children

scientific article published on 9 November 2016

Therapeutic Drug Monitoring of Posaconazole: an Update

scientific article

Therapeutic drug monitoring: how to improve drug dosage and patient safety in tuberculosis treatment

scientific article published on March 2015

Tolerability and Pharmacokinetic Evaluation of Inhaled Dry Powder Tobramycin Free Base in Non-Cystic Fibrosis Bronchiectasis Patients

scientific article (CC-BY 4.0)

Voriconazole Therapeutic Drug Monitoring Practices in Intensive Care

scientific article published on 3 February 2016

Voriconazole metabolism is influenced by severe inflammation: a prospective study

scientific article published on 6 September 2016

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