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List of works by Koichi Noguchi

Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury.

scientific article published in August 2006

Activation of extracellular signal-regulated protein kinase in dorsal horn neurons in the rat neuropathic intermittent claudication model

scientific article published in May 2004

Activation of extracellular signal-regulated protein kinases 5 in primary afferent neurons contributes to heat and cold hyperalgesia after inflammation

scientific article published on 15 June 2007

Activation of p38 MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia

scientific article published in January 2005

Activation of p38 MAPK through transient receptor potential A1 in a rat model of gastric distension-induced visceral pain

scientific article published on January 23, 2013

Agonist of proteinase-activated receptor 2 increases painful behavior produced by alpha, beta-methylene adenosine 5'-triphosphate

scientific article published on 01 August 2006

Alteration of the cell adhesion molecule L1 expression in a specific subset of primary afferent neurons contributes to neuropathic pain

scientific article (publication date: February 2007)

An ultrastructural evidence for the expression of transient receptor potential ankyrin 1 (TRPA1) in astrocytes in the rat trigeminal caudal nucleus

scientific article published on July 17, 2012

Analysis of gene expression following spinal cord injury in rat using complementary DNA microarray

scholarly article

Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats

scientific article published on 20 March 2006

Axotomy increases plasma membrane Ca2+ pump isoform4 in primary afferent neurons.

scientific article published in January 2007

COX-1-dependent prostaglandin D2 in microglia contributes to neuropathic pain via DP2 receptor in spinal neurons

scientific article published on 18 March 2013

Ca(2+)/calmodulin-protein kinase IIalpha in the trigeminal subnucleus caudalis contributes to neuropathic pain following inferior alveolar nerve transection

scientific article

Ca2+/calmodulin-dependent protein kinase II in the spinal cord contributes to neuropathic pain in a rat model of mononeuropathy

scientific article published in May 2005

Changes in DRG neurons and spinal excitability in neuropathy

scientific article published on 01 January 2004

Changes in phosphorylation of ERK and Fos expression in dorsal horn neurons following noxious stimulation in a rat model of neuritis of the nerve root

scientific article published in March 2003

Changes in transient receptor potential channels in the rat geniculate ganglion after chorda tympani nerve injury.

scientific article

Comparative study of the distribution of the alpha-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons

scientific article

Contribution of degeneration of motor and sensory fibers to pain behavior and the changes in neurotrophic factors in rat dorsal root ganglion

scientific article

Contribution of injured and uninjured dorsal root ganglion neurons to pain behavior and the changes in gene expression following chronic constriction injury of the sciatic nerve in rats

scientific article published in January 2003

Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons

scientific article published in April 2004

Contribution of the spared primary afferent neurons to the pathomechanisms of neuropathic pain

scientific article

Correlation Between DNA Methylation of TRPA1 and Chronic Pain States in Human Whole Blood Cells

scientific article published on 5 February 2016

Daikenchuto attenuates visceral pain and suppresses eosinophil infiltration in inflammatory bowel disease in murine models

scientific article published on 22 August 2020

Differential activation of MAPK in injured and uninjured DRG neurons following chronic constriction injury of the sciatic nerve in rats

scientific article published on 01 December 2004

Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury.

scientific article published in May 2003

Differential activation of p38 and extracellular signal-regulated kinase in spinal cord in a model of bee venom-induced inflammation and hyperalgesia

scientific article (publication date: 30 April 2008)

Differential expression of capsaicin-, menthol-, and mustard oil-sensitive receptors in naive rat geniculate ganglion neurons.

scientific article

Differential expression of mGluRs in rat spinal dorsal horns and their modulatory effects on nocifensive behaviors

scientific article published on 01 January 2019

Differential expression patterns of mRNAs for P2X receptor subunits in neurochemically characterized dorsal root ganglion neurons in the rat

scientific article published on 01 January 2005

Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors

scientific article published in December 2005

Elevated H2 O2 levels in trinitrobenzene sulfate-induced colitis rats contributes to visceral hyperalgesia through interaction with the transient receptor potential ankyrin 1 cation channel

scientific article published on 17 November 2015

Enhancement of stimulation-induced ERK activation in the spinal dorsal horn and gracile nucleus neurons in rats with peripheral nerve injury

scientific article published in February 2004

Eosinophil-associated micro-inflammation in the gastroduodenal tract contributes to gastric hypersensitivity in a rat model of early life adversity

scientific article published on 11 November 2020

Etodolac activates and desensitizes transient receptor potential ankyrin 1.

scientific article published on 30 August 2013

Evodiamine suppresses capsaicin-induced thermal hyperalgesia through activation and subsequent desensitization of the transient receptor potential V1 channels

scientific article published on 19 July 2015

Expression of ATP receptors in the rat dorsal root ganglion and spinal cord

scientific article published on November 20, 2012

Expression of Activating Transcription Factor 3 and Growth-associated Protein 43 in the Rat Geniculate Ganglion Neurons after Chorda Tympani Injury

journal article; published in Acta Oto-Laryngologica in 2002

Expression of Apc2 during mouse development

scientific article published on 01 January 2002

Expression of Leukotriene Receptors in the Rat Dorsal Root Ganglion and the Effects on Pain Behaviors

scientific article published on September 17, 2010

Expression of mRNA for four subtypes of the proteinase-activated receptor in rat dorsal root ganglia

scientific article published in April 2005

Expression of neurotrophic factors in the dorsal root ganglion in a rat model of lumbar disc herniation

scientific article published in September 2002

Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn

scientific article published in March 2010

Filamin A interacting protein plays a role in proper positioning of callosal projection neurons in the cortex.

scientific article published in December 2015

Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation.

scientific article

Frequency-dependent ERK phosphorylation in spinal neurons by electric stimulation of the sciatic nerve and the role in electrophysiological activity

scientific article (publication date: 16 July 2007)

Heme oxygenase-1 expression after spinal cord injury: the induction in activated neutrophils

scientific article published on 01 April 2002

Increase of close homolog of cell adhesion molecule L1 in primary afferent by nerve injury and the contribution to neuropathic pain

scientific article published on 01 June 2011

Increase of preprotachykinin mRNA in the uninjured mandibular neurons after rat infraorbital nerve transection

scientific article published on 01 July 2003

Increased expression of 3 beta-hydroxysteroid dehydrogenase mRNA in dorsal root ganglion neurons of adult rats following peripheral nerve injury

scientific article published in April 2003

Increased expression of interleukin-18 in the trigeminal spinal subnucleus caudalis after inferior alveolar nerve injury in the rat

scientific article published on September 18, 2012

Induction of neuronal nitric oxide synthase by sympathetic denervation is mediated via alpha 2-adrenoceptors in the jejunal myenteric plexus

scientific article published in March 2003

Induction of the P2X7 receptor in spinal microglia in a neuropathic pain model

scientific article published on September 8, 2011

Inhibition of TRPA1 Channel Activity in Sensory Neurons by the Glial Cell Line-Derived Neurotrophic Factor Family Member, Artemin

scientific article published on May 27, 2011

Intensity-dependent activation of extracellular signal-regulated protein kinase 5 in sensory neurons contributes to pain hypersensitivity

scientific article published on 19 January 2007

Intensity-dependent activation of extracellular signal-regulated protein kinases (ERK) 5 in sensory neurons contributes to pain hypersensitivity

scientific article published on 01 November 2008

Interleukin-18 and its receptor are expressed in gonadotropin-releasing hormone neurons of mouse and rat forebrain

scientific article published on 31 March 2017

Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury.

scientific article

Involvement of glutamate receptors on hyperexcitability of wide dynamic range neurons in the gracile nucleus of the rats with experimental mononeuropathy

scientific article published in January 2002

Leukotriene enhances NMDA-induced inward currents in dorsal horn neurons of the rat spinal cord after peripheral nerve injury

scientific article published on 9 September 2015

Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain

scientific journal article

Leukotrienes in Nociceptive Pathway and Neuropathic/Inflammatory Pain

scientific article published on January 1, 2011

Localization of prostaglandin E2 synthases and E-prostanoid receptors in the spinal cord in a rat model of neuropathic pain

scientific article published on 10 October 2020

Macrophage-Colony Stimulating Factor Derived from Injured Primary Afferent Induces Proliferation of Spinal Microglia and Neuropathic Pain in Rats

scientific article

Microglial TNFα Induces COX2 and PGI2 Synthase Expression in Spinal Endothelial Cells during Neuropathic Pain

scientific article

Modulation of TRP Channels by Resveratrol and other Stilbenoids

scientific article published on February 15, 2013

Multiple P2Y subtypes in spinal microglia are involved in neuropathic pain after peripheral nerve injury

scientific article published on June 26, 2012

Negative Regulation of TRPA1 by AMPK in Primary Sensory Neurons as a Potential Mechanism of Painful Diabetic Neuropathy.

scientific article published on 12 October 2017

Neurons and glial cells differentially express P2Y receptor mRNAs in the rat dorsal root ganglion and spinal cord

scientific article published on 01 October 2006

P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain

scientific article published in March 2008

Pain matrix shift in the rat brain following persistent colonic inflammation revealed by voxel-based statistical analysis

scientific article published on 01 January 2019

Partial Activation and Inhibition of TRPV1 Channels by Evodiamine and Rutaecarpine, Two Major Components of the Fruits of Evodia rutaecarpa

scientific article published on 9 May 2016

Peripherally increased artemin is a key regulator of TRPA1/V1 expression in primary afferent neurons

scientific article

Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain.

scientific article published on 20 March 2008

Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization.

scientific article published in September 2002

Phosphorylation of ezrin/radixin/moesin (ERM) protein in spinal microglia following peripheral nerve injury and lysophosphatidic acid administration

scientific article published on October 12, 2012

Plasma membrane calcium ATPase expression in the rat spinal cord

scientific article published in November 2004

Plastic changes in nociceptive transmission of the rat spinal cord with advancing age.

scientific article published in February 2002

Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity.

scientific article

Potentiation of the P2X3 ATP receptor by PAR-2 in rat dorsal root ganglia neurons, through protein kinase-dependent mechanisms, contributes to inflammatory pain

scientific article published on 23 May 2012

Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain.

scientific article

Re-evaluation of the phenotypic changes in L4 dorsal root ganglion neurons after L5 spinal nerve ligation

scientific article published on 03 November 2011

Recombinant interleukin-4 alleviates mechanical allodynia via injury-induced interleukin-4 receptor alpha in spinal microglia in a rat model of neuropathic pain.

scientific article

RhoA/ROCK pathway mediates p38 MAPK activation and morphological changes downstream of P2Y12/13 receptors in spinal microglia in neuropathic pain.

scientific article published on 14 August 2014

Role of Rho-associated coiled-coil containing protein kinase in the spinal cord injury induced neuropathic pain

scientific article published on 24 August 2020

Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation.

scientific article published in November 2004

Roles of extracellular signal-regulated protein kinases 5 in spinal microglia and primary sensory neurons for neuropathic pain

scientific article published on 17 May 2007

Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain

scientific article (publication date: July 2007)

Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain.

scientific article published in October 2007

Spinal 5-HT3 receptors mediate descending facilitation and contribute to behavioral hypersensitivity via a reciprocal neuron-glial signaling cascade

scientific article published on 9 June 2014

Spinal glial cell line-derived neurotrophic factor infusion reverses reduction of Kv4.1-mediated A-type potassium currents of injured myelinated primary afferent neurons in a neuropathic pain model

Suppression of the p75 neurotrophin receptor in uninjured sensory neurons reduces neuropathic pain after nerve injury.

scientific article

Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor

scientific article published on 22 May 2017

TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury

scientific article

TRPA1-expressing lamina propria mesenchymal cells regulate colonic motility

scientific article published on 02 May 2019

Taste disturbance after stapes surgery--clinical and experimental study.

scientific article published on June 2009

The effects of dexmedetomidine and halothane on Fos expression in the spinal dorsal horn using a rat postoperative pain model

scientific article published on May 29, 2003

The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed knee joint

scientific article published on 17 April 2006

The ubiquitin E3 ligase Nedd4-2 relieves mechanical allodynia through ubiquitination of TRPA1 channel in db/db mice

scientific article published on 25 November 2020

Tissue plasminogen activator in primary afferents induces dorsal horn excitability and pain response after peripheral nerve injury

scientific article published on 01 January 2004

Tissue type plasminogen activator induced in rat dorsal horn astrocytes contributes to mechanical hypersensitivity following dorsal root injury

scientific article published on 01 April 2007

Toll-like receptor 3 contributes to spinal glial activation and tactile allodynia after nerve injury

scientific journal article

Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury

scientific article published on 01 May 2008

Transient receptor potential channel A1 involved in calcitonin gene-related peptide release in neurons

scientific article

Two types of GABAergic miniature inhibitory postsynaptic currents in mouse substantia gelatinosa neurons

scientific article published on 28 September 2006

Up-Regulation of Platelet-Activating Factor Synthases and its Receptor in Spinal Cord Contribute to Development of Neuropathic Pain following Peripheral Nerve Injury

scientific article published on February 2, 2012

Upregulated glial cell line-derived neurotrophic factor through cyclooxygenase-2 activation in the muscle is required for mechanical hyperalgesia after exercise in rats

scientific article published on 15 April 2013

Upregulation of calcium channel alpha-2-delta 1 subunit in dorsal horn contributes to spinal cord injury-induced tactile allodynia

scientific article published on 16 January 2018

VR1, but not P2X(3), increases in the spared L4 DRG in rats with L5 spinal nerve ligation

scientific article published on 01 September 2002

Xilei san ameliorates experimental colitis in rats by selectively degrading proinflammatory mediators and promoting mucosal repair.

scientific article