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List of works by H Uri Saragovi

A Pro-Nerve Growth Factor (proNGF) and NGF Binding Protein, α2-Macroglobulin, Differentially Regulates p75 and TrkA Receptors and Is Relevant to Neurodegeneration Ex Vivo and In Vivo

scientific article published on 27 July 2015

A combinatorial method for solution-phase synthesis of labeled bivalent beta-turn mimics.

scientific article

A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin.

scientific article

A monovalent agonist of TrkA tyrosine kinase receptors can be converted into a bivalent antagonist

scientific article

A neurotrophic rationale for the therapy of neurodegenerative disorders

scientific article published on October 2009

A peptidomimetic of NT-3 acts as a TrkC antagonist

scientific article

Aiming for the Sweet Spot: Glyco-Immune Checkpoints and γδ T Cells in Targeted Immunotherapy ⬇️

journal article from 'Frontiers in Immunology' published in 2020

Alpha2-macroglobulin is a mediator of retinal ganglion cell death in glaucoma

scientific article published on 13 August 2008

An agonistic TrkB mAb causes sustained TrkB activation, delays RGC death, and protects the retinal structure in optic nerve axotomy and in glaucoma

scientific article published on 31 March 2010

An agonistic mAb directed to the TrkC receptor juxtamembrane region defines a trophic hot spot and interactions with p75 coreceptors

scientific article

Angiotensin II type I and prostaglandin F2α receptors cooperatively modulate signaling in vascular smooth muscle cells

scientific article published on 15 December 2014

Antagonism of proNGF or its receptor p75NTR reverses remodelling and improves bladder function in a mouse model of diabetic voiding dysfunction

scientific article published on 22 July 2020

Bivalent diketopiperazine-based tropomysin receptor kinase C (TrkC) antagonists

scientific article

Bivalent peptidomimetic ligands of TrkC are biased agonists and selectively induce neuritogenesis or potentiate neurotrophin-3 trophic signals

scientific article

Chronic and Acute Models of Retinal Neurodegeneration TrkA Activity Are Neuroprotective whereas p75NTR Activity Is Neurotoxic through a Paracrine Mechanism ⬇️

scientific article published on October 13, 2010

Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors

scientific article

Differential roles of Trk and p75 neurotrophin receptors in tumorigenesis and chemoresistance ex vivo and in vivo

scientific article

Functional consequences of the in-frame insertion of a transposon into the mutated gamma amino butyric acid transporter of Saccharomyces cerevisiae.

scientific article published on November 2002

HER2-mediated internalization of a targeted prodrug cytotoxic conjugate is dependent on the valency of the targeting ligand

scientific article published on June 2005

In glaucoma the upregulated truncated TrkC.T1 receptor isoform in glia causes increased TNF-alpha production, leading to retinal ganglion cell death

scientific article

Inhibition of p75(NTR) in glia potentiates TrkA-mediated survival of injured retinal ganglion cells

scientific journal article

Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology

scientific article published on 7 August 2015

Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA.

scientific article

Longitudinal study of retinal degeneration in a rat using spectral domain optical coherence tomography

scientific article published on October 2010

Modulation of p75(NTR) prevents diabetes- and proNGF-induced retinal inflammation and blood-retina barrier breakdown in mice and rats.

scientific article published on 7 August 2013

Nerve growth factor stimulation of ERK1/2 phosphorylation requires both p75NTR and α9β1 integrin and confers myoprotection towards ischemia in C2C12 skeletal muscle cell model ⬇️

scientific article published on August 30, 2012

Neuronal injury external to the retina rapidly activates retinal glia, followed by elevation of markers for cell cycle re-entry and death in retinal ganglion cells

scientific article

Neurotrophin receptor agonists and antagonists as therapeutic agents: An evolving paradigm.

scientific article

New templates for syntheses of ring-fused, C(10) beta-turn peptidomimetics leading to the first reported small-molecule mimic of neurotrophin-3.

scientific article

Novel approaches for targeted cancer therapy

scientific article published on June 2004

Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation

scientific article published on 24 June 2019

Preparation and characterization of new anti-PSMA monoclonal antibodies with potential clinical use.

scientific article published on December 2007

Pro370Leu MYOC gene mutation in a large Chinese family with juvenile-onset open angle glaucoma: correlation between genotype and phenotype.

scientific article published on 22 August 2008

Progression of age-associated cognitive impairment correlates with quantitative and qualitative loss of TrkA receptor protein in nucleus basalis and cortex

scientific article published on 7 October 2005

Raft-dependent endocytosis of autocrine motility factor/phosphoglucose isomerase: a potential drug delivery route for tumor cells

scientific article

Rapid High-Yield Production of Functional SARS-CoV-2 Receptor Binding Domain by Viral and Non-Viral Transient Expression for Pre-Clinical Evaluation

scientific article published on 04 November 2020

Reduction of cortical TrkA but not p75(NTR) protein in early-stage Alzheimer's disease.

scientific article published on October 2004

Selective small molecule peptidomimetic ligands of TrkC and TrkA receptors afford discrete or complete neurotrophic activities

scientific article

Signaling pathways mediating a selective induction of nitric oxide synthase II by tumor necrosis factor alpha in nerve growth factor-responsive cells

scientific article

Small molecule peptidomimetic ligands of neurotrophin receptors, identifying binding sites, activation sites and regulatory sites

scientific article

Small-molecule ligands of GD2 ganglioside, designed from NMR studies, exhibit induced-fit binding and bioactivity

scientific article published in February 2010

Syntheses and activities of new C10 beta-turn peptidomimetics

scientific article published on February 2004

The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS.

scientific article

The adhesion and differentiation-inhibitory activities of the immunoglobulin superfamily member, carcinoembryonic antigen, can be independently blocked

scientific article (publication date: 25 April 2003)

The influence of tumor-host interactions in the stromal cell-derived factor-1/CXCR4 ligand/receptor axis in determining metastatic risk in breast cancer

scientific article published on 04 June 2009

The route of administration influences the therapeutic index of an anti-proNGF neutralizing mAb for experimental treatment of Diabetic Retinopathy.

scientific article published on 21 June 2018

TrkA receptor "hot spots" for binding of NT-3 as a heterologous ligand

scientific article published on 17 April 2007

p75-nerve growth factor as an antiapoptotic complex: independence versus cooperativity in protection from enediyne chemotherapeutic agents.

scientific article published in April 2002

p75NTR antagonists attenuate photoreceptor cell loss in murine models of retinitis pigmentosa

scientific article

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