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List of works by Julien Sage

A Call to Action: Dismantling Racial Injustices in Preclinical Research and Clinical Care of Black Patients Living with Small Cell Lung Cancer

scientific article published on 14 December 2020

A Novel, Fully Human Anti-fucosyl-GM1 Antibody Demonstrates Potent and Antitumor Activity in Preclinical Models of Small Cell Lung Cancer

scientific article published on 18 July 2018

A PHASE IIA STUDY REPOSITIONING DESIPRAMINE IN SMALL CELL LUNG CANCER AND OTHER HIGH-GRADE NEUROENDOCRINE TUMORS

scientific article published on 20 April 2020

A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs

scientific article published on 16 May 2022

A crucial requirement for Hedgehog signaling in small cell lung cancer

scientific article

A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.

scientific article published on 26 September 2013

A dual role for A-type lamins in DNA double-strand break repair

scientific article (publication date: August 2011)

Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation.

scientific article published on 10 December 2016

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

scientific journal article

An in vivo transfection system for inducible gene expression and gene silencing in murine hepatocytes

scientific article published on 23 December 2016

An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation

scientific article

An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer.

scientific article published on 21 February 2017

Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication

scientific article published in 2022

Are there multiple cells of origin of Merkel cell carcinoma?

scientific article published on 11 January 2018

Author Correction: Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data

scientific article published on 01 July 2019

Axon-like protrusions promote small cell lung cancer migration and metastasis

scientific article published on 13 December 2019

Beyond the Cell Cycle: Enhancing the Immune Surveillance of Tumors Via CDK4/6 Inhibition

scientific article published on 22 June 2018

C/EBPbeta cooperates with RB:E2F to implement Ras(V12)-induced cellular senescence.

scientific article

CD47 is not Over-Expressed in Fibrolamellar Hepatocellular Carcinoma

scientific article published on August 2017

CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer

scientific article published on 13 June 2016

CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib.

scientific article published on 10 May 2017

Cancer origins-genetics rules the day

scientific article published in Science

Cancer: The origin of human retinoblastoma.

scientific article published on 24 September 2014

Cell type-specific effects of Rb deletion in the murine retina.

scientific article published on July 2004

Cellular mechanisms of tumour suppression by the retinoblastoma gene.

scientific article published on September 2008

Characterization of the cell of origin for small cell lung cancer

scientific article published on 15 August 2011

Chemosensitive Relapse in Small Cell Lung Cancer Proceeds through an EZH2-SLFN11 Axis.

scientific article published on February 2017

Coexpression of Normally Incompatible Developmental Pathways in Retinoblastoma Genesis ⬇️

scientific article (publication date: 16 August 2011)

Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma

scientific article published on 21 September 2015

Complex transcriptional regulatory networks around the retinoblastoma tumor suppressor gene.

scientific article published on 19 May 2010

Comprehensive genomic profiles of small cell lung cancer

scientific article published on 13 July 2015

Control of Proliferation and Cancer Growth by the Hippo Signaling Pathway

scientific article published on 02 October 2015

Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer

scientific article published on 17 March 2016

Correction: Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation

scientific article published on July 2017

Crosstalk between stem cell and cell cycle machineries

scientific article

Cyclin C makes an entry into the cell cycle

scientific article published on May 2004

Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein's C-Terminal Helix

scientific article published on 11 April 2019

Defining a new vision for the retinoblastoma gene: report from the 3rd International Rb Meeting

scientific article published on 21 November 2013

Discovery and preclinical validation of drug indications using compendia of public gene expression data

scientific article

Discrete signaling pathways participate in RB-dependent responses to chemotherapeutic agents

scientific article published in May 2004

Dual tumor suppressive and oncogenic roles for Notch signaling in small cell lung cancer

scientific article published on 31 January 2018

E2F4 regulates transcriptional activation in mouse embryonic stem cells independently of the RB family

scientific article published on 03 July 2019

Essential role for the planarian intestinal GATA transcription factor in stem cells and regeneration

scientific article published on 16 August 2016

From fly wings to targeted cancer therapies: a centennial for notch signaling

scientific article

Functional interactions between retinoblastoma and c-MYC in a mouse model of hepatocellular carcinoma.

scientific article

G1 arrest and differentiation can occur independently of Rb family function ⬇️

scientific article published on November 8, 2010

G1 cyclins protect pluripotency.

scientific article published in March 2017

GFP reporter mice for the retinoblastoma-related cell cycle regulator p107.

scientific article published on 12 August 2008

Genomic analysis of fibrolamellar hepatocellular carcinoma

scientific article

Genomics: The path to retinoblastoma

scientific article published on 18 January 2012

Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family

scientific article published on October 2008

Hope in sight for retinoblastoma

scientific article published in January 2007

Human hepatic organoids for the analysis of human genetic diseases

scientific article published on 7 September 2017

IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors.

scientific article published on 21 April 2013

Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer

scientific article published on 29 June 2016

Immune receptor inhibition through enforced phosphatase recruitment

scientific article published on 21 October 2020

In vivo disruption of an Rb-E2F-Ezh2 signaling loop causes bladder cancer.

scientific article published on 24 September 2014

Inactivating All Three Rb Family Pocket Proteins Is Insufficient to Initiate Cervical Cancer ⬇️

scientific article published on August 31, 2012

Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression

scientific article published on 13 May 2013

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

scientific article

Intertumoral Heterogeneity in SCLC Is Influenced by the Cell Type of Origin

scientific article published on 18 September 2018

Is the Canonical RAF/MEK/ERK Signaling Pathway a Therapeutic Target in SCLC?

scientific article

Keeping an eye on retinoblastoma control of human embryonic stem cells

scientific article published on December 2009

Loss of Pten Disrupts the Thymic Epithelium and Alters Thymic Function

scientific article

Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma

scientific article published on 20 April 2010

Lung cancer signatures in plasma based on proteome profiling of mouse tumor models

scientific article

Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease

scientific article published on 12 June 2017

Making young tumors old: a new weapon against cancer?

scientific article

Manipulating the tumour-suppressor protein Rb in lung cancer reveals possible drug targets

scientific article published on 01 May 2019

Mechanisms of small cell lung cancer metastasis

scientific article published on 09 December 2020

Methylation of the retinoblastoma tumor suppressor by SMYD2

scientific article

MicroRNA programs in normal and aberrant stem and progenitor cells.

scientific article

Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data

scientific article published on 01 May 2019

Neat1 is a p53-inducible lincRNA essential for transformation suppression

scientific article published on 11 July 2017

New Approaches to SCLC Therapy: From the Laboratory to the Clinic

scientific article published on 01 February 2020

Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility

scientific article

Non-canonical functions of the RB protein in cancer.

scientific article published on 24 April 2018

Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.

scientific article

Novel functions for the transcription factor E2F4 in development and disease

scientific article published on 18 October 2016

Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase.

scientific article published in June 2016

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway.

scientific article

Organ size control is dominant over Rb family inactivation to restrict proliferation in vivo

scientific article published on 10 July 2014

PDGF signalling controls age-dependent proliferation in pancreatic β-cells

scientific article

Pancreatic cancer takes its Toll.

scientific article published on November 2015

Perp is a mediator of p53-dependent apoptosis in diverse cell types

scientific journal article

RB deletion disrupts coordination between DNA replication licensing and mitotic entry in vivo ⬇️

scientific article published on February 2, 2011

RB goes mitochondrial

scientific article published on May 2013

RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult

scientific article published on 02 January 2004

RB's original CIN?

scientific article published on 15 June 2010

RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression

scientific article published on 29 July 2019

Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivo

scientific article

Regulation of RB transcription in vivo by RB family members

scientific article

Relationship between anti-depressant use and lung cancer survival

scientific article published on 29 January 2017

Road map for fibrolamellar carcinoma: progress and goals of a diversified approach

scientific article published on 31 January 2019

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

scientific article

Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?

scientific article published on 29 January 2016

Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation.

scientific article

Structure and function of the thymic microenvironment.

scientific article published on June 2011

Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers

scientific article published on 31 October 2019

Taking SCLC on a Bad LSD(1) Trip One NOTCH Further

article published in 2019

Tandem E2F binding sites in the promoter of the p107 cell cycle regulator control p107 expression and its cellular functions

scientific article

Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function

scientific article

Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer

scientific article published on 18 February 2019

Tet enzymes are essential for early embryogenesis and completion of embryonic genome activation

scientific article published on 06 December 2021

The MEK5-ERK5 Kinase Axis Controls Lipid Metabolism in Small-Cell Lung Cancer

scientific article published on 22 January 2020

The RB family is required for the self-renewal and survival of human embryonic stem cells ⬇️

scientific article published on January 1, 2012

The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung

scientific article published in April 2015

The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium

scientific article published on 28 October 2005

The retinoblastoma tumor suppressor and stem cell biology

scientific article

The role of the retinoblastoma/E2F1 tumor suppressor pathway in the lesion recognition step of nucleotide excision repair

scientific article published on 18 April 2009

Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle

scientific article

Tumor heterogeneity in small cell lung cancer defined and investigated in pre-clinical mouse models

scientific article

miR than meets the eye.

scientific article

p107 in the public eye: an Rb understudy and more

scientific article

pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.

scientific article published on January 2007

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