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List of works by Roel G W Verhaak

A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities

scientific article published on 10 June 2020

A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.

scientific article published in September 2007

A modular master regulator landscape controls cancer transcriptional identity

scientific article published on 11 January 2021

A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival

scientific article published on 24 June 2013

A validated integrated clinical and molecular glioblastoma long-term survival-predictive nomogram

scientific article published on 31 October 2020

Abstract 2564: Tracing extrachromosomal DNA inheritance patterns in glioblastoma using CRISPR

scholarly article

Abstract 3106: Identifying drivers in the converging syntenic aneuploidies of spontaneous canine and pediatric high-grade glioma using imaging-based an arrayed CRISPR-Cas9 phenotypic screen

scientific article published in 2022

Abstract 3881:In vivo and in vitro characterization of genomic diversity and clonal evolution in glioblastoma

BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma

scientific article published on 10 October 2019

Biphasic components of sarcomatoid clear cell renal cell carcinomas are molecularly similar to each other, but distinct from, non-sarcomatoid renal carcinomas

scientific article published on 07 July 2015

CMET-09. PAN-CANCER PROFILES OF BRAIN METASTASES: PRIORITIZATION OF THERAPEUTIC TARGETS

COMP-07. COMPARATIVE MOLECULAR LIFE HISTORY OF SPONTANEOUS CANINE AND HUMAN GLIOMA

Central nervous system immune interactome is a function of cancer lineage, tumor microenvironment, and STAT3 expression

scientific article published on 09 May 2022

Characterizing the cancer genome in lung adenocarcinoma

scientific article

Circular ecDNA promotes accessible chromatin and high oncogene expression

scientific article published on 20 November 2019

Comparative Molecular Life History of Spontaneous Canine and Human Gliomas

scientific article published on 01 February 2020

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

scientific article

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

article

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas

scientific article

DDIS-03. EGFR AMPLIFICATION INDUCED INCREASED DNA DAMAGE RESPONSE AND PREDICTED SELECTIVE SENSITIVITY TO TALAZOPARIB (PARP INHIBITOR) IN GLIOBLASTOMA STEM-LIKE CELLS

scientific article published on 5 November 2018

DR-08MSK1/ β-CATENIN SIGNALING MEDIATES RESISTANCE TO PI3K/mTOR INHIBITORS IN GLIOBLASTOMA

scientific article published in November 2014

DRES-04. DEVELOPMENT OF A CRISPR-CAS9 TARGETABLE, HIGH-COMPLEXITY, SINGLE-CELL BARCODING APPROACH FOR ISOLATION OF TREATMENT RESISTANT SUBCLONES FROM HETEROGENOUS MALIGNANT GLIOMAS

scientific article published on 6 November 2017

DRES-05. MOLECULAR EVOLUTION OF DIFFUSE GLIOMAS AND THE GLIOMA LONGITUDINAL ANALYSIS CONSORTIUM

scientific article published on 5 November 2018

DRES-09. THERAPEUTIC TARGETING OF CLK2 AND PI3K/mTOR IN GLIOBLASTOMA STEM CELLS

Differential regulation of Foxo3a target genes in erythropoiesis

scientific article published on May 2007

Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

scientific article published on 23 April 2018

Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.

scientific article

Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

scientific article

Doomed from the TERT? A Two-Stage Model of Tumorigenesis in IDH-Wild-Type Glioblastoma

scientific article published on 01 April 2019

EGFR heterogeneity and implications for therapeutic intervention in glioblastoma

scientific article published on 10 October 2017

EPIG-14EPIGENOMIC (DNA METHYLATION AND EXPRESSION) SIGNATURES DEFINE SUBSETS OF BOTH IDHmut AND IDHwt GLIOMA WITH DISTINCT CLINICAL OUTCOMES.

scientific article

Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells.

scientific article published on 15 October 2006

Ets Factors Regulate Neural Stem Cell Depletion and Gliogenesis in Ras Pathway Glioma.

scientific article published on 2 July 2015

Ets Factors Regulate Neural Stem Cell Depletion and Gliogenesis in Ras Pathway Glioma.

scientific article published in December 2016

Evolving Insights into the Molecular Neuropathology of Diffuse Gliomas in Adults

scientific article published on 01 August 2018

Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers

scientific article published on 17 August 2020

Extrachromosomal oncogene amplification in tumour pathogenesis and evolution

scientific article published on 01 May 2019

GE-14TRANSCRIPTOMICPLASTICITYIS ASSOCIATED WITH THE TUMOR MICROENVIRONMENT IN GLIOBLASTOMA

scientific article published in November 2014

GE-17ALTERATION OF THE p53 PATHWAY AND ANCESTRAL PROGENITORS ARE ASSOCIATED WITH TUMOR RECURRENCE IN GLIOBLASTOMA.

scientific article published in November 2014

GE-37INTEGRATED GENOMIC ANALYSIS OF LOW GRADE GLIOMA AND GLIOBLASTOMA REVEALS MOLECULAR STRATIFICATION BY IDH STATUS ACROSS GRADES AND HISTOLOGIES.

scientific article published in November 2014

GE-41COMPREHENSIVE AND INTEGRATIVE GENOMIC CHARACTERIZATION OF DIFFUSE LOWER GRADE GLIOMAS

scientific article published in November 2014

GENE-23. DISCORDANT INHERITANCE OF CHROMOSOMAL AND EXTRACHROMOSOMAL DNA ELEMENTS CONTRIBUTE TO DYNAMIC DISEASE EVOLUTION IN GLIOBLASTOMA

GENE-29. DEEP PANEL SEQUENCING OF A PROSPECTIVELY COLLECTED GLIOMA COHORT

GENE-40. CHARACTERIZING EPIGENETIC INTRATUMORAL HETEROGENEITY IN GLIOMA USING SINGLE-CELL BISULFITE SEQUENCING ⬇️

scholarly article

GENE-59. CHARACTERIZING EPIGENETIC INTRATUMORAL HETEROGENEITY IN GLIOMA USING SINGLE-CELL REDUCED REPRESENTATION BISULFITE SEQUENCING

GENO-06A PAN-GLIOMA CHARACTERIZATION OF GENOMIC, EPIGENOMIC AND TRANSCRIPTOMIC ACTIVITIES REVEALS NOVEL RELATIONSHIPS BETWEEN HISTOLOGICAL SUBTYPES AND MOLECULAR SIGNATURES.

scientific article

GENO-12CLONAL EVOLUTION AND GENOMIC DIVERSITY IN A PANEL GLIOBLASTOMA TUMORS, NEUROSPHERE CULTURES AND ORTHOTOPIC XENOGRAFTS.

scientific article published on 9 November 2015

GENO-18A 35 GENES SIGNATURE FOR PREDICTING OUTCOME IN GLIOMA PATIENTS WITH 1p/19q CODEL.

scientific article

GENO-36GLIOMA SPHERE-FORMING CELLS REVEAL INTRINSIC GLOBAL HYPERMETHYLATION ASSOCIATED WITH GBM RADIATION RESISTANCE.

scientific article

Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study

scientific article

Genes predictive of outcome and novel molecular classification schemes in adult acute myeloid leukemia

scientific article published on January 2010

Genomic Analysis of Temozolomide-Related Hypermutation in Adult Diffuse Glioma

scholarly article

GlioVis data portal for visualization and analysis of brain tumor expression datasets

scientific article published on 9 November 2016

Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions

scientific article published on 24 April 2020

Glioblastoma-derived epidermal growth factor receptor carboxyl-terminal deletion mutants are transforming and are sensitive to EGFR-directed therapies

scientific article published on 14 October 2011

Glioma: experimental models and reality

scientific article published on 10 January 2017

HeatMapper: powerful combined visualization of gene expression profile correlations, genotypes, phenotypes and sample characteristics

scientific article

Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer

scientific article

Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer

scientific article published on 01 November 2016

IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy

scholarly article

IMMU-36. IMMUNE RESPONSES IN CANINE GLIOMAS ARE ENRICHED AT THE INFILTRATING EDGE OF ASTROCYTOMAS

scientific article published on 5 November 2018

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

scientific article

Immune checkpoint blockade as a potential therapeutic target: surveying CNS malignancies

scientific article published on July 2016

Inferring tumour purity and stromal and immune cell admixture from expression data

scientific article

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

scientific article

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma

scientific article published on August 2017

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma

scientific article

Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer

scientific article published on 02 June 2013

Intragenic breakpoint: a marker of genome instability in glioblastoma

scientific article published on 21 October 2013

Lineage-coupled clonal capture identifies clonal evolution mechanisms and vulnerabilities of BRAFV600E inhibition resistance in melanoma

scientific article published in 2022

Longitudinal genomic characterization of brain tumors for identification of therapeutic vulnerabilities

scientific article published on 28 May 2016

Longitudinal molecular trajectories of diffuse glioma in adults

scientific article published on 20 November 2019

MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas

scientific article published on 04 August 2020

MSK1-Mediated β-Catenin Phosphorylation Confers Resistance to PI3K/mTOR Inhibitors in Glioblastoma

scientific article published on 22 April 2016

MTR-19A MACROPHAGE-/MICROGLIAL-RICH TUMOR MICROENVIRONMENT MIMICS PRONEURAL TO MESENCHYMAL TRANSITION IN GLIOBLASTOMA.

scientific article

Mir-21-Sox2 Axis Delineates Glioblastoma Subtypes with Prognostic Impact

scientific article

Molecular Evolution of IDH Wild-Type Glioblastomas Treated With Standard of Care Affects Survival and Design of Precision Medicine Trials: A Report From the EORTC 1542 Study

scientific article published on 19 November 2019

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

scientific article published on January 2016

Molecular and clonal evolution in recurrent metastatic gliosarcoma

scientific article published on 03 February 2020

Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain

scientific article published on May 2015

Mosaic analysis with double markers reveals tumor cell of origin in glioma

scientific article

Moving the needle: Optimizing classification for glioma

scientific article

Multigene signature for predicting prognosis of patients with 1p19q co-deletion diffuse glioma.

scientific article published on 8 March 2017

Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance

scientific article

Navigating the Cancer Transcriptome by Decoding Divergent Oncogenic States

scientific article published on 01 August 2017

Novel kinase fusion transcripts found in endometrial cancer

scientific article

Novel therapeutic strategy for cervical cancer harboring FGFR3-TACC3 fusions

scientific article

Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma.

scientific article published in July 2018

Osteopontin mediates glioblastoma-associated macrophage infiltration and is a therapeutic target

scientific article published on 19 November 2018

PAF promotes stemness and radioresistance of glioma stem cells.

scientific article published on 9 October 2017

PATH-45. INTEGRATION OF MULTI-REGION (EPI)GENOMICS WITH MULTIMODALITY ADVANCED IMAGING HIGHLIGHTS GLIOMA INTRATUMORAL HETEROGENEITY

PRADA: pipeline for RNA sequencing data analysis

scientific article

PathSeq: software to identify or discover microbes by deep sequencing of human tissue

scientific article

Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy

scientific article published on 27 September 2018

Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions

scientific article published on 18 May 2009

Predicting time to ovarian carcinoma recurrence using protein markers.

scientific article published on 15 August 2013

Predicting time to ovarian carcinoma recurrence using protein markers.

scientific article

Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling

scientific article published on 06 October 2008

Proceedings of the Comprehensive Oncology Network Evaluating Rare CNS Tumors (NCI-CONNECT) Oligodendroglioma Workshop

scientific article published on 06 December 2019

Prognostically relevant gene signatures of high-grade serous ovarian carcinoma

scientific article

Prognostically useful gene-expression profiles in acute myeloid leukemia

scientific article published in April 2004

RBTT-07. NUTMEG: A RANDOMISED PHASE II STUDY OF NIVOLUMAB AND TEMOZOLOMIDE (TMZ) VS TMZ ALONE IN ELDERLY PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA (GBM): TRIAL IN PROGRESS

Reconstructing the molecular life history of gliomas

scientific article published on 3 April 2018

Regulation of mRNA expression in breast cancer - a cis-tematic trans-action ⬇️

scientific article published on October 29, 2012

SNPExpress: integrated visualization of genome-wide genotypes, copy numbers and gene expression levels

scientific article

Seek and destroy: relating cancer drivers to therapies

scientific article published in March 2015

Significance of murine retroviral mutagenesis for identification of disease genes in human acute myeloid leukemia

scientific article published on 01 January 2006

Silent mutations make some noise

scientific article published on 01 March 2014

Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response

scientific article published on 30 September 2021

Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure

scientific article published on 05 October 2020

Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium

scientific article published on 17 February 2022

Src Inhibition with saracatinib reverses fulvestrant resistance in ER-positive ovarian cancer models in vitro and in vivo

scientific article published on 15 August 2012

Studying a complex tumor: potential and pitfalls

scientific article published in January 2012

Suppression of lung adenocarcinoma progression by Nkx2-1

scientific article

Systematic analysis of telomere length and somatic alterations in 31 cancer types.

scientific article published on 30 January 2017

THE P53 PATHWAY AND ANCESTRAL PROGENITORS ARE ASSOCIATED WITH TUMOR RECURRENCE IN GLIOBLASTOMA.

scientific article published in July 2014

TMIC-22. DECIPHERING GLIOMA INTRINSIC TRANSCRIPTIONAL SUBTYPES IDENTIFIES TUMOR EVOLUTION ASSOCIATES WITH CHANGES IN IMMUNE-MICROENVIRONMENT

scientific article published on 6 November 2017

TMOD-04. A COMPREHENSIVE GENOMIC LANDSCAPE OF GLIOMA SPHEROID CULTURES RECAPITULATES THE HETEROGENEITY OF GLIOBLASTOMA AND IDENTIFIES DNA METHYLATION PREDICTORS OF RADIOTHERAPY RESPONSE

TMOD-18. THE PATIENT DERIVED XENOGRAFT NATIONAL RESOURCE: A COMPREHENSIVE COLLECTION OF HIGH-GRADE GLIOMA MODELS FOR PRE-CLINICAL AND TRANSLATIONAL STUDIES

TMOD-36. GENE EXPRESSION ANALYSIS OF SHORT AND LONG SURVIVAL GROUPS OF GLIOBLASTOMA PATIENT-DERIVED ORTHOTOPIC XENOGRAFTS

article

Targeting tyrosine receptor kinase B in gliomas.

scientific article

The Somatic Genomic Landscape of Glioblastoma

article

The Tandem Duplicator Phenotype Is a Prevalent Genome-Wide Cancer Configuration Driven by Distinct Gene Mutations

scientific article published on 12 July 2018

The cellular origin for malignant glioma and prospects for clinical advancements ⬇️

scientific article published on May 1, 2012

The effect of oligonucleotide microarray data pre-processing on the analysis of patient-cohort studies

scientific article

The evolutionary pattern of mutations in glioblastoma reveals therapy-mediated selection.

scientific article published on 15 December 2017

The polo-like kinase 1 inhibitor volasertib synergistically increases radiation efficacy in glioma stem cells

scientific article published on 8 January 2018

The somatic genomic landscape of glioblastoma

scientific article

Toward understanding and exploiting tumor heterogeneity

scientific article

Transcriptional mimicry by tumor-associated stroma

scientific article published on April 2015

Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma

scientific article published on 26 August 2020

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

scientific article

Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process

scientific article

Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.

scientific article published in July 2017

Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.

scientific article

TumorFusions: an integrative resource for cancer-associated transcript fusions.

scientific article published in November 2017

Unifying Gene Expression Measures from Multiple Platforms Using Factor Analysis ⬇️

scientific article published on March 11, 2011

Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy

scientific article published on 13 January 2021

Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution

scientific article

ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state

scientific journal article

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