List of works - Ailong Ke

A conformational switch controls hepatitis delta virus ribozyme catalysis

scientific article

A fast and efficient procedure to produce scFvs specific for large macromolecular complexes

scientific article

A three-helix junction is the interface between two functional domains of prohead RNA in 29 DNA packaging.

scientific article

ATP/ADP modulates gp16-pRNA conformational change in the Phi29 DNA packaging motor

scientific article published on 01 October 2019

Acting in tandem.

scientific article published on 23 April 2018

Architecture of the yeast Rrp44 exosome complex suggests routes of RNA recruitment for 3' end processing

scientific article

Assembly and Translocation of a CRISPR-Cas Primed Acquisition Complex

scientific article published on 18 October 2018

Building the Class 2 CRISPR-Cas Arsenal.

scientific article published in February 2017

Cas5d Protein Processes Pre-crRNA and Assembles into a Cascade-like Interference Complex in Subtype I-C/Dvulg CRISPR-Cas System

scientific article

Characterizing Metal-Dependent Nucleases of CRISPR-Cas Prokaryotic Adaptive Immunity Systems.

scientific article published in January 2015

Common themes and differences in SAM recognition among SAM riboswitches

scientific article

Craspase is a CRISPR RNA-guided, RNA-activated protease

scientific article published on 16 September 2022

Crystal structure of clustered regularly interspaced short palindromic repeats (CRISPR)-associated Csn2 protein revealed Ca2+-dependent double-stranded DNA binding activity.

scientific article

Crystal structure of the S. solfataricus archaeal exosome reveals conformational flexibility in the RNA-binding ring

scientific article

Crystal structures of the SAM-III/S(MK) riboswitch reveal the SAM-dependent translation inhibition mechanism

scientific article

Crystallization of RNA and RNA-protein complexes

scientific article published in November 2004

Double-stranded endonuclease activity in Bacillus halodurans clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas2 protein

scientific article

Elastic coupling between RNA degradation and unwinding by an exoribonuclease

scientific article published on June 2012

Engineering antibody fitness and function using membrane-anchored display of correctly folded proteins.

scientific article

Envelope stress is a trigger of CRISPR RNA-mediated DNA silencing in Escherichia coli

scientific article

Functional characterization and crystal structure of thermostable amylase from Thermotoga petrophila, reveals high thermostability and an unusual form of dimerization.

scientific article published on 22 June 2017

Guanidine-sensing riboswitches: How do they work and what do they regulate?

scientific article

How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration.

scientific article published on 4 September 2017

Identification of a conserved branched RNA structure that functions as a factor-independent terminator

scientific article published on 18 February 2014

Insights into binding cooperativity of MATa1/MATalpha2 from the crystal structure of a MATa1 homeodomain-maltose binding protein chimera

scientific article

Introducing a Spectrum of Long-Range Genomic Deletions in Human Embryonic Stem Cells Using Type I CRISPR-Cas

scientific article published on 08 April 2019

Local-to-global signal transduction at the core of a Mn2+ sensing riboswitch

scientific article published on 20 September 2019

Making water-soluble integral membrane proteins in vivo using an amphipathic protein fusion strategy

scientific article

Massively Parallel Biophysical Analysis of CRISPR-Cas Complexes on Next Generation Sequencing Chips

scientific article published in June 2017

Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas

scientific article published on 29 September 2021

Mn(2+)-sensing mechanisms of yybP-ykoY orphan riboswitches

scientific article

Nucleic acid binding surface and dimer interface revealed by CRISPR-associated CasB protein structures

scientific article

One more piece down to solve the III-A CRISPR puzzle

scientific article

One platform, five brands: how nature cuts the cost on riboswitches

scientific article published on 28 March 2013

PIWI Takes a Giant Step

scientific article published in October 2016

RNA-mediated interaction between the peptide-binding and GTPase domains of the signal recognition particle.

scientific article published on 20 November 2005

Real-time observation of CRISPR spacer acquisition by Cas1-Cas2 integrase

scientific article published on 04 May 2020

Reconstitution and biochemical characterization of ribonucleoprotein complexes in Type I-E CRISPR-Cas systems

scientific article published on 17 December 2018

SAM Recognition and Conformational Switching Mechanism in the Bacillus subtilis yitJ S Box/SAM-I Riboswitch ⬇️

scientific article published on October 15, 2010

Sequence, structure, and stacking: specifics of tRNA anchoring to the T box riboswitch

scientific article

Sortase-mediated fluorescent labeling of CRISPR complexes

scientific article published on 17 December 2018

Structural Determinants for Geometry and Information Decoding of tRNA by T Box Leader RNA

scientific article

Structural and thermodynamic characterization of the DNA binding properties of a triple alanine mutant of MATalpha2

scientific article

Structural basis for RNA-guided DNA cleavage by IscB-ωRNA and mechanistic comparison with Cas9

scientific article published on 24 June 2022

Structural basis for guanidine sensing by the ykkC family of riboswitches.

scientific article

Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli

scientific article

Structural basis for tRNA decoding and aminoacylation sensing by T-box riboregulators

scientific article published on 18 November 2019

Structural roles of monovalent cations in the HDV ribozyme

scientific article

Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System

scientific article published in June 2017

Structure and assembly of the essential RNA ring component of a viral DNA packaging motor

scientific article

Structure basis for RNA-guided DNA degradation by Cascade and Cas3

scientific article

Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation

scientific article

Structures of Large RNAs and RNA-Protein Complexes: Toward Structure Determination of Riboswitches

scientific article

T box RNA decodes both the information content and geometry of tRNA to affect gene expression

scientific article

The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor

scientific article

Variable sequences outside the SAM-binding core critically influence the conformational dynamics of the SAM-III/SMK box riboswitch

scientific article published on 27 April 2011

Visualization of distinct substrate-recruitment pathways in the yeast exosome by EM.

scientific article published on 15 December 2013

List of works by Ailong Ke

A conformational switch controls hepatitis delta virus ribozyme catalysis

A fast and efficient procedure to produce scFvs specific for large macromolecular complexes

A three-helix junction is the interface between two functional domains of prohead RNA in 29 DNA packaging.

ATP/ADP modulates gp16-pRNA conformational change in the Phi29 DNA packaging motor

Acting in tandem.

Architecture of the yeast Rrp44 exosome complex suggests routes of RNA recruitment for 3' end processing

Assembly and Translocation of a CRISPR-Cas Primed Acquisition Complex

Building the Class 2 CRISPR-Cas Arsenal.

Cas5d Protein Processes Pre-crRNA and Assembles into a Cascade-like Interference Complex in Subtype I-C/Dvulg CRISPR-Cas System

Characterizing Metal-Dependent Nucleases of CRISPR-Cas Prokaryotic Adaptive Immunity Systems.

Common themes and differences in SAM recognition among SAM riboswitches

Craspase is a CRISPR RNA-guided, RNA-activated protease

Crystal structure of clustered regularly interspaced short palindromic repeats (CRISPR)-associated Csn2 protein revealed Ca2+-dependent double-stranded DNA binding activity.

Crystal structure of the S. solfataricus archaeal exosome reveals conformational flexibility in the RNA-binding ring

Crystal structures of the SAM-III/S(MK) riboswitch reveal the SAM-dependent translation inhibition mechanism

Crystallization of RNA and RNA-protein complexes

Double-stranded endonuclease activity in Bacillus halodurans clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas2 protein

Elastic coupling between RNA degradation and unwinding by an exoribonuclease

Engineering antibody fitness and function using membrane-anchored display of correctly folded proteins.

Envelope stress is a trigger of CRISPR RNA-mediated DNA silencing in Escherichia coli

Functional characterization and crystal structure of thermostable amylase from Thermotoga petrophila, reveals high thermostability and an unusual form of dimerization.

Guanidine-sensing riboswitches: How do they work and what do they regulate?

How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration.

Identification of a conserved branched RNA structure that functions as a factor-independent terminator

Insights into binding cooperativity of MATa1/MATalpha2 from the crystal structure of a MATa1 homeodomain-maltose binding protein chimera

Introducing a Spectrum of Long-Range Genomic Deletions in Human Embryonic Stem Cells Using Type I CRISPR-Cas

Local-to-global signal transduction at the core of a Mn2+ sensing riboswitch

Making water-soluble integral membrane proteins in vivo using an amphipathic protein fusion strategy

Massively Parallel Biophysical Analysis of CRISPR-Cas Complexes on Next Generation Sequencing Chips

Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas

Mn(2+)-sensing mechanisms of yybP-ykoY orphan riboswitches

Nucleic acid binding surface and dimer interface revealed by CRISPR-associated CasB protein structures

One more piece down to solve the III-A CRISPR puzzle

One platform, five brands: how nature cuts the cost on riboswitches

PIWI Takes a Giant Step

RNA-mediated interaction between the peptide-binding and GTPase domains of the signal recognition particle.

Real-time observation of CRISPR spacer acquisition by Cas1-Cas2 integrase

Reconstitution and biochemical characterization of ribonucleoprotein complexes in Type I-E CRISPR-Cas systems

SAM Recognition and Conformational Switching Mechanism in the Bacillus subtilis yitJ S Box/SAM-I Riboswitch ⬇️

Sequence, structure, and stacking: specifics of tRNA anchoring to the T box riboswitch

Sortase-mediated fluorescent labeling of CRISPR complexes

Structural Determinants for Geometry and Information Decoding of tRNA by T Box Leader RNA

Structural and thermodynamic characterization of the DNA binding properties of a triple alanine mutant of MATalpha2

Structural basis for RNA-guided DNA cleavage by IscB-ωRNA and mechanistic comparison with Cas9

Structural basis for guanidine sensing by the ykkC family of riboswitches.

Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli

Structural basis for tRNA decoding and aminoacylation sensing by T-box riboregulators

Structural roles of monovalent cations in the HDV ribozyme

Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System

Structure and assembly of the essential RNA ring component of a viral DNA packaging motor

Structure basis for RNA-guided DNA degradation by Cascade and Cas3

Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation

Structures of Large RNAs and RNA-Protein Complexes: Toward Structure Determination of Riboswitches

T box RNA decodes both the information content and geometry of tRNA to affect gene expression

The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor

Variable sequences outside the SAM-binding core critically influence the conformational dynamics of the SAM-III/SMK box riboswitch

Visualization of distinct substrate-recruitment pathways in the yeast exosome by EM.