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List of works by Eugene B Chang

A gene-targeted approach to investigate the intestinal butyrate-producing bacterial community

scientific article

A new role for microbiota? Dulling the thrust of serotonin and 5-HT3 signaling cascade

scientific article

A polyphenol-rich fraction obtained from table grapes decreases adiposity, insulin resistance and markers of inflammation and impacts gut microbiota in high-fat-fed mice

scientific article published on 26 February 2016

AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins

scientific article

Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice

scientific article

Adenomatous Polyps Are Driven by Microbe-Instigated Focal Inflammation and Are Controlled by IL-10–Producing T Cells ⬇️

scientific article published on August 16, 2013

Akt2 phosphorylates ezrin to trigger NHE3 translocation and activation

scientific article

Aldosterone regulation of intestinal Na absorption involves SGK-mediated changes in NHE3 and Na+ pump activity

scientific article published on 18 September 2008

Alpha2-adrenergic receptors attenuate secretagogue-induced endocytosis and promote exocytosis of intestinal NHE2 and NHE3.

scientific article published on 25 June 2009

American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR.

scientific article

Anti-apoptotic effects of L-glutamine-mediated transcriptional modulation of the heat shock protein 72 during heat shock

scientific article published on July 2005

Antibiotics Suppress Activation of Intestinal Mucosal Mast Cells and Reduce Dietary Lipid Absorption in Sprague-Dawley Rats

scientific article

Atypical behavioral and thermoregulatory circadian rhythms in mice lacking a microbiome

scientific article published in 2022

Bacterial community structure and functional contributions to emergence of health or necrotizing enterocolitis in preterm infants

scientific article published on 10 July 2013

Bacterial superantigen-treated intestinal epithelial cells upregulate heat shock proteins 25 and 72 and are resistant to oxidant cytotoxicity

scientific article

Bile Diversion Improves Metabolic Phenotype Dependent on Farnesoid X Receptor (FXR)

scientific article published on 01 April 2019

Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development.

scientific article published on 26 August 2016

Butyrate inhibits pro-proliferative miR-92a by diminishing c-Myc-induced miR-17-92a cluster transcription in human colon cancer cells

scientific article

Challenges in IBD Research: Preclinical Human IBD Mechanisms

scientific article published on 01 May 2019

Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice

scientific article published on 14 October 2016

Chronic acid water feeding protects mice against lethal gut-derived sepsis due to Pseudomonas aeruginosa

scientific article published in March 2006

Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation

scientific article published on 01 November 2018

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

scientific article published on 5 November 2015

Comparative analysis of the in vitro prosecretory effects of balsalazide, sulfasalazine, olsalazine, and mesalamine in rabbit distal ileum

scientific article published in March 2005

Comparison of brush and biopsy sampling methods of the ileal pouch for assessment of mucosa-associated microbiota of human subjects

scientific article published on 14 February 2014

Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and cytoprotection ⬇️

scientific article published on February 3, 2012

Composition of Dietary Fat Source Shapes Gut Microbiota Architecture and Alters Host Inflammatory Mediators in Mouse Adipose Tissue ⬇️

scientific article published on May 2, 2013

Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions

scientific article published on 31 January 2013

Considerations for best practices in studies of fiber or other dietary components and the intestinal microbiome

scientific article published on 21 August 2018

Cyclic AMP-mediated endocytosis of intestinal epithelial NHE3 requires binding to synaptotagmin 1.

scientific article published on 19 November 2009

Cytokine regulation of OCTN2 expression and activity in small and large intestine

scientific article

Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APCmin/+ Mouse Models of Experimental Colon Cancer.

scientific article published on 12 October 2016

Daikenchuto (TU-100) alters murine hepatic and intestinal drug metabolizing enzymes in an in vivo dietary model: effects of gender and withdrawal

scientific article published on October 2017

Daikenchuto (TU-100) shapes gut microbiota architecture and increases the production of ginsenoside metabolite compound K.

scientific article published on 10 February 2016

Determination of American ginseng saponins and their metabolites in human plasma, urine and feces samples by liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

scientific article published on 6 February 2016

Diet, gut microbes, and genetics in immune function: can we leverage our current knowledge to achieve better outcomes in inflammatory bowel diseases?

scientific article

Diet, microbes, and host genetics: the perfect storm in inflammatory bowel diseases ⬇️

scientific article published on March 12, 2013

Dietary antioxidant micronutrients alter mucosal inflammatory risk in a murine model of genetic and microbial susceptibility.

scientific article published on 10 December 2017

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10−/− mice ⬇️

scientific article published on July 5, 2012

Distinct roles of intracellular heat shock protein 70 in maintaining gastrointestinal homeostasis

scientific article

Divergent responses of viral and bacterial communities in the gut microbiome to dietary disturbances in mice

scientific article published on 16 October 2015

Do heat shock proteins play any role in gut inflammation?

scientific article published on 01 October 2008

Droplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes

scientific article published on 17 June 2020

Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis

scientific article

Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism

scientific article published on 16 April 2015

Enteric flora and lymphocyte-derived cytokines determine expression of heat shock proteins in mouse colonic epithelial cells ⬇️

scientific article published on May 1, 2003

Escherichia coli LPS induces heat shock protein 25 in intestinal epithelial cells through MAP kinase activation

scientific article published on 20 November 2003

Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity

scientific article

Ezrin regulates NHE3 translocation and activation after Na+-glucose cotransport.

scholarly article

Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3.

scientific article published on 04 December 2008

Functional predictions from inference and observation in sequence-based inflammatory bowel disease research

scientific article

Gene-targeted microfluidic cultivation validated by isolation of a gut bacterium listed in Human Microbiome Project's Most Wanted taxa.

scientific article

Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease

scientific article published in January 2016

Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer ⬇️

scientific article published on March 12, 2012

Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells

scientific article

Glutamine increases autophagy under Basal and stressed conditions in intestinal epithelial cells

scientific article published on 03 December 2008

Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism

scientific article published in 2021

Heat induction of heat shock protein 25 requires cellular glutamine in intestinal epithelial cells

scientific article published on 22 March 2006

High-fat diet disrupts REG3γ and gut microbial rhythms promoting metabolic dysfunction

scientific article published in 2022

High-molecular-weight polyethylene glycol prevents lethal sepsis due to intestinal Pseudomonas aeruginosa

scientific article published in February 2004

Human microbiome science: vision for the future, Bethesda, MD, July 24 to 26, 2013

scientific article

Immunologic basis for diarrhea

scientific article published on 01 November 2002

Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer

scientific article

Inflammation-induced, 3'UTR-dependent translational inhibition of Hsp70 mRNA impairs intestinal homeostasis

scientific article published on 19 March 2009

Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility

scientific article

Interactions between Diet, Bile Acid Metabolism, Gut Microbiota, and Inflammatory Bowel Diseases

scientific article published on 27 May 2015

Intersection of the Gut Microbiome and Circadian Rhythms in Metabolism

scientific article published on 31 October 2019

Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling

scientific article published on 01 May 2020

Laser capture microdissection and metagenomic analysis of intact mucosa-associated microbial communities of human colon

scientific article

Lubiprostone Decreases Mouse Colonic Inner Mucus Layer Thickness and Alters Intestinal Microbiota ⬇️

scientific article published on January 18, 2013

Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72.

scientific article published on 4 November 2004

Metabolic acidosis in rats increases intestinal NHE2 and NHE3 expression and function

scientific article published on 01 July 2002

Metagenomic alterations in gut microbiota precede and predict onset of colitis in the IL10 gene-deficient murine model

scientific article published on 21 August 2020

Michael Field, MD (1933-2014).

scientific article published on 25 October 2014

Microbe-Derived Butyrate and Its Receptor, Free Fatty Acid Receptor 3, But Not Free Fatty Acid Receptor 2, Mitigate Neointimal Hyperplasia Susceptibility After Arterial Injury

scientific article published on 25 June 2020

Microbial Colonization of Germ-Free Mice Restores Neointimal Hyperplasia Development After Arterial Injury

scientific article published on 24 February 2020

Microbial metabolites in health and disease: Navigating the unknown in search of function

scientific article

Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.

scientific article

Microbiome characterization by high-throughput transfer RNA sequencing and modification analysis

scientific article published in Nature Communications

Microbiota composition modulates inflammation and neointimal hyperplasia after arterial angioplasty

scientific article published on 05 February 2020

Microbiota control acute arterial inflammation and neointimal hyperplasia development after arterial injury

scientific article published in PLoS ONE

Minimizing confounders and increasing data quality in murine models for studies of the gut microbiome

scientific article published on 12 July 2018

Multiphasic analysis of the temporal development of the distal gut microbiota in patients following ileal pouch anal anastomosis

scientific article published on 04 March 2013

Mutual reinforcement of pathophysiological host-microbe interactions in intestinal stasis models.

scientific article published on March 2017

Navigating the Human Gut Microbiome: Pathway to Success from Lessons Learned

scientific article published on 07 September 2020

Navigating the Microbial Basis of Inflammatory Bowel Diseases: Seeing the Light at the End of the Tunnel

scientific article

Nutrition, microbiomes, and intestinal inflammation

scientific article

Oral PEG 15-20 protects the intestine against radiation: role of lipid rafts

scientific article

Oxalobacter formigenes-Derived Bioactive Factors Stimulate Oxalate Transport by Intestinal Epithelial Cells

scientific article published on 13 October 2016

Patient-Specific Bacteroides Genome Variants in Pouchitis

scientific article

Peptide fragments of AMP-18, a novel secreted gastric antrum mucosal protein, are mitogenic and motogenic

scientific article

Peripartum Antibiotics Promote Gut Dysbiosis, Loss of Immune Tolerance, and Inflammatory Bowel Disease in Genetically Prone Offspring.

scientific article published in July 2017

Plasma microbiome-modulated indole- and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes

scientific article published on 13 December 2017

Polyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response ⬇️

scientific article published on April 21, 2011

Preserved Na(+)/H(+) exchanger isoform 3 expression and localization, but decreased NHE3 function indicate regulatory sodium transport defect in ulcerative colitis

scientific article published in July 2010

Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition

scientific article published in November 2004

Proceedings of the 2013 A.S.P.E.N. Research workshop: the interface between nutrition and the gut microbiome: implications and applications for human health [corrected].

scientific article

Protective role of HSP72 against Clostridium difficile toxin A-induced intestinal epithelial cell dysfunction

scientific article published on 18 December 2002

Pseudomonas aeruginosa expresses a lethal virulence determinant, the PA-I lectin/adhesin, in the intestinal tract of a stressed host: the role of epithelia cell contact and molecules of the Quorum Sensing Signaling System

scientific article published in November 2003

Pseudomonas aeruginosa wound infection involves activation of its iron acquisition system in response to fascial contact

scientific article published on April 2015

Recognition of host immune activation by Pseudomonas aeruginosa

scientific article

Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa.

scientific article published on 10 August 2006

Region-specific adaptation of apical Na/H exchangers after extensive proximal small bowel resection

scientific article published in October 2002

Regional Diversity of the Gastrointestinal Microbiome

scientific article published on 01 September 2019

Regional differences in colonic mucosa-associated microbiota determine the physiological expression of host heat shock proteins ⬇️

scientific article published on September 23, 2010

Regional mucosa-associated microbiota determine physiological expression of TLR2 and TLR4 in murine colon

scientific article

Role and regulation of intestinal epithelial heat shock proteins in health and disease

scientific article

Role of intestinal Hsp70 in barrier maintenance: contribution of milk to the induction of Hsp70.2.

scientific article published in December 2017

Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption

scientific article published on 20 October 2005

Short-chain fatty acids impact on intestinal adaptation, inflammation, carcinoma, and failure

scientific article

Significant difference in active metabolite levels of ginseng in humans consuming Asian or Western diet: The link with enteric microbiota

scientific article

Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids

scientific article published on 01 April 2018

Small intestinal microbiota: the neglected stepchild needed for fat digestion and absorption

scientific article published on 23 August 2018

Soluble bioactive microbial mediators regulate proteasomal degradation and autophagy to protect against inflammation-induced stress

scientific article published on 11 August 2016

Standard Colonic Lavage Alters the Natural State of Mucosal-Associated Microbiota in the Human Colon ⬇️

scientific article published on February 28, 2012

Stress granule formation mediates the inhibition of colonic Hsp70 translation by interferon-gamma and tumor necrosis factor-alpha

scientific article

Studying the Enteric Microbiome in Inflammatory Bowel Diseases: Getting through the Growing Pains and Moving Forward

scientific article published on 05 July 2011

Surgical injury and metabolic stress enhance the virulence of the human opportunistic pathogen Pseudomonas aeruginosa

scientific article published on January 2005

Synaptotagmin I binds intestinal epithelial NHE3 and mediates cAMP- and Ca2+-induced endocytosis by recruitment of AP2 and clathrin

scientific article published on 15 February 2007

Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer's transgenic mice

scientific article published on 18 May 2020

T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase.

scientific article

TGR5 signaling mitigates parenteral nutrition-associated liver disease

scientific article published on 06 January 2020

TU-100 (Daikenchuto) and ginger ameliorate anti-CD3 antibody induced T cell-mediated murine enteritis: microbe-independent effects involving Akt and NF-κB suppression

scientific article

Table grape consumption reduces adiposity and markers of hepatic lipogenesis and alters gut microbiota in butter fat-fed mice.

scientific article published on 2 September 2015

The Colitis-Associated Transcriptional Profile of Commensal Bacteroides thetaiotaomicron Enhances Adaptive Immune Responses to a Bacterial Antigen ⬇️

scientific article published on August 3, 2012

The Gut Microbiota: The Gateway to Improved Metabolism.

scientific article

The Hospital Microbiome Project: Meeting report for the 2nd Hospital Microbiome Project, Chicago, USA, January 15(th), 2013.

scientific article

The Human Microbiome and Obesity: Moving beyond Associations

scientific article published in November 2017

The gut microbiota and inflammatory bowel diseases

scientific article

The intestinal microbiota in the pathogenesis of inflammatory bowel diseases: new insights into complex disease

scientific article published on 18 September 2018

The microbe-derived short chain fatty acid butyrate targets miRNA-dependent p21 gene expression in human colon cancer

scientific article

The microbial basis of inflammatory bowel diseases

scientific article

The re-emerging role of the intestinal microflora in critical illness and inflammation: why the gut hypothesis of sepsis syndrome will not go away

scientific article published on 26 December 2007

The role of diet in triggering human inflammatory disorders in the modern age.

scientific article published on 20 July 2013

This month in gastroenterology

scientific article published on 01 October 2005

Time-, Sex-, and Dose-Dependent Alterations of the Gut Microbiota by Consumption of Dietary Daikenchuto (TU-100).

scientific article published on 22 February 2018

Towards anatomic scale agent-based modeling with a massively parallel spatially explicit general-purpose model of enteric tissue (SEGMEnT_HPC).

scientific article

Transcriptional modulation of intestinal innate defense/inflammation genes by preterm infant microbiota in a humanized gnotobiotic mouse model

scientific article published on 30 April 2015

Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation

scientific article

Transplanting a Microbial Organ: the Good, the Bad, and the Unknown

scientific article published on 03 May 2016

Tu1248 MUCOSAL FIBROBLASTS SUPPORT EPITHELIAL-FIBROBLAST NICHE REORGANIZATION AND RECRUITMENT OF MYELOID CELLS IN CROHN'S DISEASE AT SINGLE CELL LEVEL

scientific article published in 2023

Tumor necrosis factor-alpha and interferon-gamma increase PepT1 expression and activity in the human colon carcinoma cell line Caco-2/bbe and in mouse intestine

scientific article published on 19 November 2005

Ultra-Performance Liquid Chromatography and Time-of-Flight Mass Spectrometry Analysis of Ginsenoside Metabolites in Human Plasma ⬇️

scientific article published on January 1, 2011

Using corticosteroids to reshape the gut microbiome: implications for inflammatory bowel diseases

scientific article

Vancomycin treatment and butyrate supplementation modulate gut microbe composition and severity of neointimal hyperplasia after arterial injury

scientific article published on December 2015

Western Diet Promotes Intestinal Colonization by Collagenolytic Microbes and Promotes Tumor Formation After Colorectal Surgery

scientific article published on 23 October 2019

Western diets, gut dysbiosis, and metabolic diseases: Are they linked?

scientific article published on 6 January 2017

fMLP induces Hsp27 expression, attenuates NF-kappaB activation, and confers intestinal epithelial cell protection

scientific article published on 21 December 2006

miR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and protooncogenes

scientific article published on 06 May 2011

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