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List of works by Daniel Lajeunesse

Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts

scientific article published on January 2006

Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts.

scientific article

Alteration of Wnt5a expression and of the non-canonical Wnt/PCP and Wnt/PKC-Ca2+ pathways in human osteoarthritis osteoblasts

scientific article

Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production

scientific article published on May 2009

Beneficial effect of resveratrol on phenotypic features and activity of osteoarthritic osteoblasts.

scientific article

Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study

scientific article

Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: influence of osteotropic factors

scientific article published on 26 April 2008

Human adult chondrocytes express hepatocyte growth factor (HGF) isoforms but not HgF: potential implication of osteoblasts on the presence of HGF in cartilage

scientific article

IGF/IGFBP axis in cartilage and bone in osteoarthritis pathogenesis ⬇️

scientific article published on March 1, 1998

Influence of Aluminum on the Regulation of PTH- and 1,25(OH)2D3-Dependent Pathways in the Rat Osteosarcoma Cell Line ROS 17/2.8 ⬇️

scientific article published on June 1, 1998

Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/β-catenin activity

scientific article

Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis

scientific article published on 17 September 2009

Modulation of insulin-like growth factor 1 levels in human osteoarthritic subchondral bone osteoblasts

scientific article

New thoughts on the pathophysiology of osteoarthritis: one more step toward new therapeutic targets

scientific article

Osteoarthritis: a metabolic disease induced by local abnormal leptin activity?

scientific article published in April 2005

Osteoblast-like cells from human subchondral osteoarthritic bone demonstrate an altered phenotype in vitro: Possible role in subchondral bone sclerosis ⬇️

scientific article published on May 1, 1998

PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage

scientific article published on 8 January 2015

Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts

scientific article

R-spondins are newly recognized players in osteoarthritis that regulate Wnt signaling in osteoblasts

scientific article published in December 2011

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis ⬇️

scientific article published on November 30, 2010

Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium

scientific article published on 13 October 2012

Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition

scientific article

Targeting subchondral bone for treating osteoarthritis: what is the evidence?

scientific article published on February 2010

The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K.

scientific article published in March 2004

The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.

scientific article

The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein

scientific article published on January 2006

Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model

scientific article published on 21 June 2011

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