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List of works by Daisy W Leung

A Sensitive in Vitro High-Throughput Screen To Identify Pan-filoviral Replication Inhibitors Targeting the VP35-NP Interface.

scientific article

A large kindred with X-linked neutropenia with an I294T mutation of the Wiskott-Aldrich syndrome gene.

scientific article

An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions

scientific article

Aptamers in virology: recent advances and challenges

scientific article

Arp2/3-independent assembly of actin by Vibrio type III effector VopL.

scientific article

Basic residues within the ebolavirus VP35 protein are required for its viral polymerase cofactor function

scientific article published on 4 August 2010

Conservation of Structure and Immune Antagonist Functions of Filoviral VP35 Homologs Present in Microbat Genomes

scientific article published on 01 July 2018

Crystallization and preliminary X-ray analysis of Ebola VP35 interferon inhibitory domain mutant proteins

scientific article

DRBP76 associates with Ebola virus VP35 and suppresses viral polymerase function

scientific article

Development of RNA Aptamers Targeting Ebola Virus VP35

scientific article

Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins

scientific article published on 10 February 2016

Dimerization Controls Marburg Virus VP24-dependent Modulation of Host Antioxidative Stress Responses

scientific article

Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.

scientific article

Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis

scientific article

Ebola virus VP35 interaction with dynein LC8 regulates viral RNA synthesis.

scientific article published on 4 March 2015

Ebolavirus VP35 is a multifunctional virulence factor

scientific article

Expression, purification, crystallization and preliminary X-ray studies of the Ebola VP35 interferon inhibitory domain.

scientific article published on 31 January 2009

Filoviral immune evasion mechanisms

scientific article

Filovirus Strategies to Escape Antiviral Responses

scientific article published on 8 July 2017

Genetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway

scholarly article

In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity

scientific article

Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP.

scientific article

Marburg virus RNA synthesis is inhibited by a synthetic anti-VP35 antibody

scientific article published on 04 June 2019

Molecular Mechanisms of Innate Immune Inhibition by Non-Segmented Negative-Sense RNA Viruses

scientific article

Molecular mechanisms of viral inhibitors of RIG-I-like receptors

scientific article

Mutations Abrogating VP35 Interaction with Double-Stranded RNA Render Ebola Virus Avirulent in Guinea Pigs

scientific article

Mutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome

scientific article

Nipah Virus V Protein Binding Alters MDA5 Helicase Folding Dynamics

scientific article published on 08 December 2021

Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway

scientific article published on 18 December 2017

Parental response to child's isolation during the SARS outbreak

scientific article

Small Molecule Compounds That Inhibit Antioxidant Response Gene Expression in an Inducer-Dependent Manner

scientific article published on 15 January 2020

Sodium-dependent reorganization of the sugar-binding site of SGLT1.

scientific article published on 26 October 2007

Structural and Functional Characterization of Reston Ebola Virus VP35 Interferon Inhibitory Domain

scientific article

Structural basis for Marburg virus VP35-mediated immune evasion mechanisms

scientific article

Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35

scientific article

Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses.

scientific article published on 30 June 2017

Structural insights into RNA recognition and activation of RIG-I-like receptors

scientific article published on 02 May 2012

Structure of the Ebola VP35 interferon inhibitory domain

scientific article

The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway

scientific article

The nucleotide switch in Cdc42 modulates coupling between the GTPase-binding and allosteric equilibria of Wiskott-Aldrich syndrome protein

scientific article

Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion

scientific article

VP24-Karyopherin Alpha Binding Affinities Differ between Ebolavirus Species, Influencing Interferon Inhibition and VP24 Stability.

scientific article published on 14 December 2016

When your cap matters: structural insights into self vs non-self recognition of 5' RNA by immunomodulatory host proteins

scientific article published on 22 February 2016

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