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List of works by Martin Hewison

1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3.

scientific article

11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol

scientific article published in November 2002

11beta-hydroxysteroid dehydrogenase type 1 activity predicts the effects of glucocorticoids on bone

scientific article published in August 2003

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response

scientific article

19-Nor-1,25(OH)2D2 (a novel, noncalcemic vitamin D analogue), combined with arsenic trioxide, has potent antitumor activity against myeloid leukemia

scientific article

1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients.

scientific article published in January 2009

1alpha-hydroxylase and innate immune responses to 25-hydroxyvitamin D in colonic cell lines

scientific article

25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 exert distinct effects on human skeletal muscle function and gene expression ⬇️

scientific article

A bioinformatics workflow to decipher transcriptomic data from vitamin D studies

scientific article published on 01 February 2019

A role for vitamin D in placental immunology

scientific article

A switch in dehydrogenase to reductase activity of 11 beta-hydroxysteroid dehydrogenase type 1 upon differentiation of human omental adipose stromal cells

scientific article published in March 2002

Adenosine 5'-triphosphate-dependent vitamin D sterol binding to heat shock protein-70 chaperones

scientific article published on September 2005

Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation

scientific article published on 05 June 2008

Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis

scientific article

An Hsp27-related, dominant-negative-acting intracellular estradiol-binding protein

scientific article published on 29 April 2004

Analysis of multiple vitamin D metabolites by ultra-performance supercritical fluid chromatography-tandem mass spectrometry (UPSFC-MS/MS)

scientific article published on 18 April 2018

Androgen receptor-mediated regulation of the alpha-subunit of the epithelial sodium channel in human kidney

scientific article published on 19 September 2005

Antibacterial responses by peritoneal macrophages are enhanced following vitamin D supplementation

scientific article

Association studies between the HSD11B2 gene (encoding human 11beta-hydroxysteroid dehydrogenase type 2), type 1 diabetes mellitus and diabetic nephropathy

scientific article published in April 2002

Associations Between Change in Total and Free 25-Hydroxyvitamin D With 24,25-Dihydroxyvitamin D and Parathyroid Hormone

scientific article published on 01 September 2018

Autocrine metabolism of vitamin D in normal and malignant breast tissue

scientific article

Back to the future: a new look at 'old' vitamin D

scientific article published on 21 May 2008

Beyond mineral metabolism, is there an interplay between FGF23 and vitamin D in innate immunity?

scientific article

Biological actions of extra-renal 25-hydroxyvitamin D-1alpha-hydroxylase and implications for chemoprevention and treatment

scientific article

Cloning of a functional 25-hydroxyvitamin D-1α-hydroxylase in zebrafish (Danio rerio).

scientific article

Concerted effects of heterogeneous nuclear ribonucleoprotein C1/C2 to control vitamin D-directed gene transcription and RNA splicing in human bone cells.

scientific article published on 26 September 2016

Control of estradiol-directed gene transactivation by an intracellular estrogen-binding protein and an estrogen response element-binding protein

scientific article

Correction: Down-Regulation of Vitamin D Receptor in Mammospheres: Implications for Vitamin D Resistance in Breast Cancer and Potential for Combination Therapy

Cross-Sectional Analysis of Abnormalities of Mineral Homeostasis, Vitamin D and Parathyroid Hormone in a Cohort of Pre-Dialysis Patients

article

DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization.

scientific article

Data comparing the separation and elution of vitamin D metabolites on an ultra performance supercritical fluid chromatography tandem-mass spectrometer (UPSFC-MS/MS) compared to liquid chromatography (LC) and data presenting approaches to UPSFC method

scientific article published on 15 August 2018

Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid joint

scientific article published on 21 October 2017

Dietary vitamin D intake in advanced CKD/ESRD.

scientific article published on July 2010

Dietary vitamin D restriction in pregnant female mice is associated with maternal hypertension and altered placental and fetal development.

scientific article

Differential Responses to Vitamin D2 and Vitamin D3 Are Associated With Variations in Free 25-Hydroxyvitamin D.

scientific article published on 11 July 2016

Differential expression, function and response to inflammatory stimuli of 11beta-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation ⬇️

scientific article published on January 2006

Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells

scientific article published in June 2003

Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain

scientific article

Divergence of macrophage phagocytic and antimicrobial programs in leprosy

scientific article published on October 2009

Down-regulation of vitamin D receptor in mammospheres: implications for vitamin D resistance in breast cancer and potential for combination therapy

scientific article

Dynamic development of glucocorticoid resistance during autoimmune neuroinflammation

scientific article

Effect of vitamin D deficiency in developed countries

scientific article published on 9 March 2017

Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on cytokine production by human decidual cells

scientific article

Effects of Cholecalciferol vs Calcifediol on Total and Free 25-Hydroxyvitamin D and Parathyroid Hormone

scientific article published on 10 February 2017

Effects of High-Dose Vitamin D2 Versus D3 on Total and Free 25-Hydroxyvitamin D and Markers of Calcium Balance

scientific article published on 18 May 2016

Effects of vitamin D supplementation on circulating concentrations of growth factors and immune-mediators in healthy women during pregnancy

scientific article published on 20 April 2020

Estradiol and tamoxifen mediate rescue of the dominant-negative effects of estrogen response element-binding protein in vivo and in vitro

scientific article published on 23 December 2008

Expression of 11beta-hydroxysteroid dehydrogenase type 1 permits regulation of glucocorticoid bioavailability by human dendritic cells

scientific article published on 7 June 2005

Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets.

scientific article published on May 2004

Expression of renal 11beta-hydroxysteroid dehydrogenase type 2 is decreased in patients with impaired renal function

scientific article published in August 2005

Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease

scientific article published on March 2007

Fibroblast growth factor 23 inhibits extrarenal synthesis of 1,25-dihydroxyvitamin D in human monocytes

scientific article

Free 25-Hydroxyvitamin D: Impact of Vitamin D Binding Protein Assays on Racial-Genotypic Associations

scientific article published on 23 March 2016

Functional characterization of heterogeneous nuclear ribonuclear protein C1/C2 in vitamin D resistance: a novel response element-binding protein

scientific article

Gene targeting by the vitamin D response element binding protein reveals a role for vitamin D in osteoblast mTOR signaling

scientific article

Glucocorticoid-induced apoptosis in human decidua: a novel role for 11beta-hydroxysteroid dehydrogenase in late gestation

scientific article published in October 2007

Heterogeneous nuclear ribonucleoprotein (hnRNP) binding to hormone response elements: a cause of vitamin D resistance

scientific article

High throughput LC-MS/MS method for the simultaneous analysis of multiple vitamin D analytes in serum

scientific article published on 2 February 2016

Highlights from the 19th Workshop on Vitamin D in Boston, March 29-31, 2016.

scientific article published in October 2017

Highlights from the 20th Workshop on Vitamin D in Orlando, Mar. 28-31, 2017.

scientific article published on 24 November 2017

Highlights from the 21st Workshop on Vitamin D in Barcelona, May 2018

scientific article published on 26 March 2019

Highlights from the 22nd Workshop on Vitamin D in New York City, May 2019

scientific article published on 25 August 2020

Hormone response element binding proteins: novel regulators of vitamin D and estrogen signaling

scientific article

Hormones and immune function: implications of aging

scientific article published in August 2004

Hypercalcemia associated with mineral oil-induced sclerosing paraffinomas.

scientific article published in March 2013

IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway

scientific article published in November 2008

IL-32 is a molecular marker of a host defense network in human tuberculosis.

scientific article published on August 2014

Identification of VDR-responsive gene signatures in breast cancer cells

scientific article

Immunomodulation by vitamin D: implications for TB.

scientific article

Impact of vitamin D on immune function: lessons learned from genome-wide analysis

scientific article published on 21 April 2014

Increased expression of 25-hydroxyvitamin D-1alpha-hydroxylase in dysgerminomas: a novel form of humoral hypercalcemia of malignancy

scientific article

Increased expression of mineralocorticoid effector mechanisms in kidney biopsies of patients with heavy proteinuria

scientific article

Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells ⬇️

scientific article published on July 2012

Intrinsic activation of the vitamin D antimicrobial pathway by M. leprae infection is inhibited by type I IFN

article

Late-onset apparent mineralocorticoid excess caused by novel compound heterozygous mutations in the HSD11B2 gene

scientific article

List of Contributors

Mechanisms of decreased Vitamin D 1alpha-hydroxylase activity in prostate cancer cells

scientific article published on June 2004

Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency

scientific article

Non-linear associations of 25-hydroxyvitamin D concentrations with risk of cardiovascular disease and all-cause mortality: Results from The Health Improvement Network (THIN) database

scientific article published on 18 September 2019

Osteoblastic 11beta-hydroxysteroid dehydrogenase type 1 activity increases with age and glucocorticoid exposure

scientific article

Pathway analysis of transcriptomic data shows immunometabolic effects of vitamin D.

scientific article published on 12 December 2017

Prereceptor regulation of glucocorticoid action by 11β‐hydroxysteroid dehydrogenase: a novel determinant of cell proliferation ⬇️

scientific article published on January 1, 2002

Prevalence and treatment of hypovitaminosis D in the haemodialysis population of Coventry

scientific article published on 11 February 2016

Reduction of the vitamin D hormonal system in kidney disease is associated with increased renal inflammation

scientific article published on 10 September 2008

Regulation of the extrarenal CYP27B1-hydroxylase

scientific article

Relationship between vitamin D status and the vaginal microbiome during pregnancy

scientific article published on 11 March 2019

Renal PPARγ mRNA expression increases with impairment of renal function in patients with chronic kidney disease

scientific article published on October 2010

Renal TLR4 mRNA expression correlates with inflammatory marker MCP-1 and profibrotic molecule TGF-β₁ in patients with chronic kidney disease

scientific article published on 15 June 2011

Response element binding proteins and intracellular vitamin D binding proteins: novel regulators of vitamin D trafficking, action and metabolism

scientific article published in May 2004

Role of Assay Type in Determining Free 25-Hydroxyvitamin D Levels in Diverse Populations

scientific article published on 23 March 2016

Role of vitamin D in cytotoxic T lymphocyte immunity to pathogens and cancer

scientific article

Serum and synovial fluid vitamin D metabolites and rheumatoid arthritis

scholarly article by Danyang Li et al published March 2019 in The Journal of Steroid Biochemistry and Molecular Biology

Serum- and glucocorticoid-regulated kinase isoform-1 and epithelial sodium channel subunits in human ocular ciliary epithelium

scientific article published on April 2003

Substrate and enzyme trafficking as a means of regulating 1,25-dihydroxyvitamin D synthesis and action: the human innate immune response

scientific article published on December 2007

Suppression of iron-regulatory hepcidin by vitamin D

scientific article

Synthesis of 1,25-dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesion

scientific journal article

T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism

scientific article

The Role of Vitamin D in Inflammatory Bowel Disease: Mechanism to Management

scientific article published on 07 May 2019

The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs.

scientific article published in January 2003

The heterodimeric structure of heterogeneous nuclear ribonucleoprotein C1/C2 dictates 1,25-dihydroxyvitamin D-directed transcriptional events in osteoblasts

scientific article

The ontogeny of 25-hydroxyvitamin D(3) 1alpha-hydroxylase expression in human placenta and decidua

scientific article published on July 2002

Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response

scientific article

Trends in the incidence of testing for vitamin D deficiency in primary care in the UK: a retrospective analysis of The Health Improvement Network (THIN), 2005-2015

scientific article published on 04 June 2019

Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses

scientific article

Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity

scientific article

Update in vitamin D

scientific article

Vitamin D Binding Protein and the Biological Activity of Vitamin D

scientific article published on 24 October 2019

Vitamin D Deficiency in Mice Impairs Colonic Antibacterial Activity and Predisposes to Colitis

Vitamin D Modulation of Mitochondrial Oxidative Metabolism and mTOR Enforces Stress Adaptations and Anticancer Responses

scientific article published on 01 December 2021

Vitamin D Promotes Trophoblast Cell Induced Separation of Vascular Smooth Muscle Cells in Vascular Remodeling <i>via</i> Induction of G-CSF

scientific article published on 22 December 2020

Vitamin D Supplementation in Pregnancy and Lactation and Infant Growth

Vitamin D activation of functionally distinct regulatory miRNAs in primary human osteoblasts

scientific article

Vitamin D and DBP: the free hormone hypothesis revisited. ⬇️

scientific article published on 04 October 2013

Vitamin D and SARS-CoV-2 virus/COVID-19 disease

scientific article published on 13 May 2020

Vitamin D and alternative splicing of RNA

scientific article

Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylase

scientific article published on February 2004

Vitamin D and early rheumatoid arthritis

scientific article published on 27 July 2020

Vitamin D and immune regulation: antibacterial, antiviral, anti-inflammatory

scientific article published on 22 August 2020

Vitamin D and innate immunity

scientific article published on May 2008

Vitamin D and placental-decidual function

scientific article published in July 2004

Vitamin D and the intracrinology of innate immunity

scientific article

Vitamin D and the regulation of placental inflammation.

scientific article published on 11 April 2011

Vitamin D binding protein and monocyte response to 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D: analysis by mathematical modeling

scientific article

Vitamin D bioavailability and catabolism in pediatric chronic kidney disease ⬇️

scientific article published on June 2, 2013

Vitamin D deficiency in mice impairs colonic antibacterial activity and predisposes to colitis

scientific article

Vitamin D deficiency modulates Graves' hyperthyroidism induced in BALB/c mice by thyrotropin receptor immunization

scientific article published on 16 October 2008

Vitamin D in defense of the human immune response

scientific article published on 26 July 2007

Vitamin D in rheumatoid arthritis-towards clinical application

scientific article

Vitamin D insufficiency and skeletal development in utero

scientific article published on January 2010

Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages

scientific article published on October 2011

Vitamin D metabolism and innate immunity

scientific article

Vitamin D supplementation and antibacterial immune responses in adolescents and young adults with HIV/AIDS.

scientific article

Vitamin D, Autoimmune Disease and Rheumatoid Arthritis

scientific article published on 08 July 2019

Vitamin D, the placenta and early pregnancy: effects on trophoblast function

scientific article published on 6 November 2017

Vitamin D-binding protein directs monocyte responses to 25-hydroxy- and 1,25-dihydroxyvitamin D

scientific article (publication date: July 2010)

Vitamin D-deficiency and sex-specific dysregulation of placental inflammation

scientific article

Vitamin D-mediated hypercalcemia and Cushing syndrome as manifestations of malignant pleural mesothelioma

scientific article published on 01 November 2008

Vitamin D-mediated hypercalcemia in lymphoma: evidence for hormone production by tumor-adjacent macrophages

scientific article published on 01 March 2003

Vitamin D-mediated hypercalcemia in slack skin disease: evidence for involvement of extrarenal 25-hydroxyvitamin D 1alpha-hydroxylase

scientific article published on September 2006

Vitamin D: a new player in the world of mTOR signaling

scientific article published on 15 June 2011

Vitamin D: beyond bone ⬇️

scientific article published on May 17, 2013

Vitamin d-directed rheostatic regulation of monocyte antibacterial responses

scientific article published on April 2009

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