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List of works by Reuben S Harris

1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal Structure

scientific article

A Conserved Mechanism of APOBEC3 Relocalization by Herpesviral Ribonucleotide Reductase Large Subunits

scientific article published on 13 November 2019

A Naturally Occurring Domestic Cat APOBEC3 Variant Confers Resistance to Feline Immunodeficiency Virus Infection.

scientific article published on 21 October 2015

A fluorescent reporter for quantification and enrichment of DNA editing by APOBEC-Cas9 or cleavage by Cas9 in living cells.

scientific article

A panel of eGFP reporters for single base editing by APOBEC-Cas9 editosome complexes

scientific article published in Scientific Reports

A rabbit monoclonal antibody against the antiviral and cancer genomic DNA mutating enzyme APOBEC3B

A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans

scientific article published on 10 September 2020

A single amino acid in human APOBEC3F alters susceptibility to HIV-1 Vif

scientific article

AID can restrict L1 retrotransposition suggesting a dual role in innate and adaptive immunity

scientific article published on 02 February 2009

AID is essential for immunoglobulin V gene conversion in a cultured B cell line

scientific article published on March 2002

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

scientific article (publication date: 4 July 2002)

APOBEC Enzymes as Targets for Virus and Cancer Therapy.

scientific article published on 14 November 2017

APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity

scientific article published on 19 June 2015

APOBEC3 Mediates Resistance to Oncolytic Viral Therapy ⬇️

APOBEC3 inhibits DEAD-END function to regulate microRNA activity ⬇️

scientific article published on July 26, 2013

APOBEC3 multimerization correlates with HIV-1 packaging and restriction activity in living cells.

scientific article published on 17 December 2013

APOBEC3 proteins mediate the clearance of foreign DNA from human cells

scientific article

APOBEC3B Nuclear Localization Requires two Distinct N-Terminal Domain Surfaces.

scientific article

APOBEC3B and AID have similar nuclear import mechanisms

scientific article

APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism

scientific article (publication date: 23 June 2006)

APOBEC3B is an enzymatic source of mutation in breast cancer.

scientific article published on 06 February 2013

APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.

scientific article published on 23 October 2013

APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy

scientific article published on 07 February 2020

APOBEC3B: pathological consequences of an innate immune DNA mutator

scientific article published on March 2015

APOBEC3F determinants of HIV-1 Vif sensitivity

scientific article

APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo

scientific article

APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma

scientific article

APOBEC3G Interacts with ssDNA by Two Modes: AFM Studies

scientific article

APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis

scientific article

APOBEC3G enhances lymphoma cell radioresistance by promoting cytidine deaminase-dependent DNA repair ⬇️

scientific article published on May 29, 2012

APOBEC3G hypermutates genomic DNA and inhibits Ty1 retrotransposition in yeast

scientific article

APOBEC3H Subcellular Localization Determinants Define Zipcode for Targeting HIV-1 for Restriction

scholarly article by Daniel J Salamango published in December 2018

APOBECs and virus restriction

scientific article published on 26 March 2015

Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B

scholarly article published 7 January 2019

An extended structure of the APOBEC3G catalytic domain suggests a unique holoenzyme model

scientific article

Atomic force microscopy studies of APOBEC3G oligomerization and dynamics

scientific article

Atomic force microscopy studies provide direct evidence for dimerization of the HIV restriction factor APOBEC3G

scientific article

CEM-T4 cells do not lack an APOBEC3G cofactor

scientific article

Cancer mutation signatures, DNA damage mechanisms, and potential clinical implications

scientific article published on 27 September 2013

Catalytic activity of APOBEC3F is required for efficient restriction of Vif-deficient human immunodeficiency virus

scientific article published on 20 December 2013

Cellular requirements for bovine immunodeficiency virus Vif-mediated inactivation of bovine APOBEC3 proteins

scientific article

Characterization of BK Polyomaviruses from Kidney Transplant Recipients Suggests a Role for APOBEC3 in Driving In-Host Virus Evolution.

scientific article

Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B

scientific article published on 28 September 2020

Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo

scientific article published in March 2004

Competition of Escherichia coli DNA polymerases I, II and III with DNA Pol IV in stressed cells

scientific article

Computational Model and Dynamics of Monomeric Full-Length APOBEC3G.

scientific article published on 20 October 2017

Correction: HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective pressure and promotes virus adaptation

scientific article published on 7 September 2017

Corrigendum: APOBEC3B is an enzymatic source of mutation in breast cancer

scientific article published on 23 October 2013

Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition

scientific article published on 27 April 2022

Crystal Structure of the DNA Cytosine Deaminase APOBEC3F: The Catalytically Active and HIV-1 Vif-Binding Domain

scientific article

Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain

scientific article

Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces

scientific article

D316 is critical for the enzymatic activity and HIV-1 restriction potential of human and rhesus APOBEC3B.

scientific article published on 29 March 2013

DNA Deamination Mediates Innate Immunity to Retroviral Infection

DNA deamination mediates innate immunity to retroviral infection

scientific article (publication date: 13 June 2003)

DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses

scientific article (publication date: July 2003)

DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer

scientific article

DNA-dependent protein kinase inhibits AID-induced antibody gene conversion

scientific article

Dancin' deaminase

scientific article published on 01 May 2006

Defining HIV-1 Vif residues that interact with CBFβ by site-directed mutagenesis

scientific article

Degradation of the cancer genomic DNA deaminase APOBEC3B by SIV Vif

scientific article

Differential evolution of antiretroviral restriction factors in pteropid bats as revealed by APOBEC3 gene complexity

scientific article published on 29 March 2018

Directed DNA deamination by AID/APOBEC3 in immunity

Dispersed sites of HIV Vif-dependent polyubiquitination in the DNA deaminase APOBEC3F.

scientific article published on 11 January 2013

Elevated APOBEC3B correlates with poor outcomes for estrogen-receptor-positive breast cancers

scientific article

Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells

scientific article

Endogenous APOBEC3A DNA cytosine deaminase is cytoplasmic and nongenotoxic.

scientific article published on 02 May 2013

Endogenous APOBEC3B overexpression characterizes HPV-positive and HPV-negative oral epithelial dysplasias and head and neck cancers

scientific article published on 06 July 2020

Endogenous Origins of HIV-1 G-to-A Hypermutation and Restriction in the Nonpermissive T Cell Line CEM2n ⬇️

scientific article published on July 12, 2012

Engineered proteins detect spontaneous DNA breakage in human and bacterial cells

scientific article

Enhancing immunity to HIV through APOBEC.

scientific article

Epstein-Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity

scientific article published on 12 November 2018

Evidence for APOBEC3B mutagenesis in multiple human cancers

scientific article

Evolution of HIV-1 isolates that use a novel Vif-independent mechanism to resist restriction by human APOBEC3G.

scientific article published on 22 May 2008

Evolutionarily conserved and non-conserved retrovirus restriction activities of artiodactyl APOBEC3F proteins

scientific article published on 11 October 2006

Evolutionary Paradigms from Ancient and Ongoing Conflicts between the Lentiviral Vif Protein and Mammalian APOBEC3 Enzymes.

scientific article

Extensive mutagenesis experiments corroborate a structural model for the DNA deaminase domain of APOBEC3G.

scientific article published on 7 September 2007

Extensive somatic L1 retrotransposition in colorectal tumors

scientific article

First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G

scientific article

Functional Upregulation of the DNA Cytosine Deaminase APOBEC3B by Polyomaviruses.

scientific article published on 04 May 2016

Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated using Patient HIV-1 Isolates and Computational Modeling

scientific article published on 26 August 2020

Gain-of-function assay for SARS-CoV-2 M pro inhibition in living cells

scientific article published on 09 November 2020

Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease

scientific article published in Nature Communications

Guidelines for naming nonprimate APOBEC3 genes and proteins

scientific article

HIV type 1 viral infectivity factor and the RUNX transcription factors interact with core binding factor β on genetically distinct surfaces.

scientific article published on 13 August 2012

HIV-1 adaptation studies reveal a novel Env-mediated homeostasis mechanism for evading lethal hypermutation by APOBEC3G.

scientific article published on 20 April 2018

HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective pressure and promotes virus adaptation

scientific article

HIV-1 restriction by endogenous APOBEC3G in the myeloid cell line THP-1

scientific article published on 30 May 2019

Human APOBEC3 proteins, retrovirus restriction, and HIV drug resistance.

scientific article

Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1

scientific article

Human immunodeficiency virus type 1 Vif induces cell cycle delay via recruitment of the same E3 ubiquitin ligase complex that targets APOBEC3 proteins for degradation.

scientific article

Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration

scientific article

Human papillomavirus E6 triggers upregulation of the antiviral and cancer genomic DNA deaminase APOBEC3B

scientific article

Immunity through DNA deamination

scientific article (publication date: June 2003)

Impact of H216 on the DNA Binding and Catalytic Activities of the HIV Restriction Factor APOBEC3G ⬇️

scientific article published on April 17, 2013

Induction of APOBEC3-mediated genomic damage in urothelium implicates BK polyomavirus (BKPyV) as a hit-and-run driver for bladder cancer

scientific article published on 22 February 2022

Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G

scientific article

Interaction of APOBEC3A with DNA assessed by atomic force microscopy

scientific article (publication date: 2014)

Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics

scientific article

Lentiviral Vif degrades the APOBEC3Z3/APOBEC3H protein of its mammalian host and is capable of cross-species activity

scientific article

Leveraging APOBEC3 proteins to alter the HIV mutation rate and combat AIDS.

scientific article

Lineage-Specific Viral Hijacking of Non-canonical E3 Ubiquitin Ligase Cofactors in the Evolution of Vif Anti-APOBEC3 Activity

scientific article

Long-Term Restriction by APOBEC3F Selects Human Immunodeficiency Virus Type 1 Variants with Restored Vif Function ⬇️

scientific article published on August 4, 2010

MDM2 can interact with the C-terminus of AID but it is inessential for antibody diversification in DT40 B cells

scientific article published on 24 August 2005

MagnEdit-interacting factors that recruit DNA-editing enzymes to single base targets

scientific article published on 24 February 2020

Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma

scientific article published on 03 January 2017

Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3A

scientific article

Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancer

scientific article

Mutation Processes in 293-Based Clones Overexpressing the DNA Cytosine Deaminase APOBEC3B.

scientific article

Mutation Signatures Including APOBEC in Cancer Cell Lines

scientific article published on 01 January 2018

Nanoscale Characterization of Interaction of APOBEC3G with RNA.

scientific article published on 28 December 2016

Nanoscale Structure and Dynamics of ABOBEC3G Complexes with Single-Stranded DNA ⬇️

scientific article published on July 31, 2012

Natural APOBEC3C variants can elicit differential HIV-1 restriction activity

article

Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity

scientific article

Opossum APOBEC1 is a DNA mutator with retrovirus and retroelement restriction activity

scientific article

Optimal translation initiation enables Vif-deficient human immunodeficiency virus type 1 to escape restriction by APOBEC3G.

scientific article published on 18 March 2009

Oxidative Reactivities of 2-Furylquinolines: Ubiquitous Scaffolds in Common High-Throughput Screening Libraries.

scientific article published on 11 September 2015

Phosphorylation Directly Regulates the Intrinsic DNA Cytidine Deaminase Activity of Activation-induced Deaminase and APOBEC3G Protein ⬇️

scientific article published on June 9, 2011

Pillars article: AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature. 2002. 418: 99-103.

scientific article published in March 2015

Polyomavirus T Antigen Induces Expression Using an LXCXE-Dependent and TP53-Independent Mechanism

article published in 2019

Presentation of peptides by cultured monocytes or activated T cells allows specific priming of human cytotoxic T lymphocytes in vitro

Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction

scientific article

RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators

scientific article

Retroviral restriction by APOBEC proteins

scientific article

Role for Msh5 in the regulation of Ig class switch recombination

scientific article

SIVmac239 Vif and Human APOBEC3B Interactions Resemble Those Between HIV-1 Vif and Human APOBEC3G.

scientific article published on 4 April 2018

Single-Molecule Force Spectroscopy Studies of APOBEC3A-Single-Stranded DNA Complexes

scientific article published on 16 May 2016

Small-molecule APOBEC3G DNA cytosine deaminase inhibitors based on a 4-amino-1,2,4-triazole-3-thiol scaffold.

scientific article

Structural basis of host protein hijacking in human T-cell leukemia virus integration

scientific article published on 19 June 2020

Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G

scientific article

Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G

scientific article published on 18 May 2015

Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination.

scientific article published on 6 February 2013

The APOBEC3 Family of Retroelement Restriction Factors ⬇️

scientific article published on January 1, 2013

The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer.

scientific article published on 07 October 2016

The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis.

scientific article published on 21 September 2016

The DNA deaminase APOBEC3B interacts with the cell-cycle protein CDK4 and disrupts CDK4-mediated nuclear import of Cyclin D1

scientific article published on 19 June 2019

The DNA deaminase activity of human APOBEC3G is required for Ty1, MusD, and human immunodeficiency virus type 1 restriction

scientific article

The PKC/NF-κB signaling pathway induces APOBEC3B expression in multiple human cancers

scientific article

The Restriction Factors of Human Immunodeficiency Virus ⬇️

scientific article published on October 5, 2012

The SAMHD1 dNTP Triphosphohydrolase Is Controlled by a Redox Switch.

scientific article

The Vif Protein of HIV Triggers Degradation of the Human Antiretroviral DNA Deaminase APOBEC3G ⬇️

scientific article published on November 11, 2003

The artiodactyl APOBEC3 innate immune repertoire shows evidence for a multi-functional domain organization that existed in the ancestor of placental mammals

scientific article

The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase

scientific article published on 14 October 2019

The interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombination

scientific article (publication date: 20 July 2010)

The local dinucleotide preference of APOBEC3G can be altered from 5'-CC to 5'-TC by a single amino acid substitution.

scientific article published on 11 August 2013

The multidimensional nature of antiviral innate immunity

scientific article published on April 2015

The restriction of zoonotic PERV transmission by human APOBEC3G.

scientific article

The retroviral hypermutation specificity of APOBEC3F and APOBEC3G is governed by the C-terminal DNA cytosine deaminase domain

scientific article

Transcriptional regulation of APOBEC3 antiviral immunity through the CBF-β/RUNX axis

scientific article

Two regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localization

scientific article

Unique DNA repair gene variations and potential associations with the primary antibody deficiency syndromes IgAD and CVID

scientific article

Vif determines the requirement for CBF-β in APOBEC3 degradation

scientific article

Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection ⬇️

scientific article published on December 21, 2011

Vif proteins of human and simian immunodeficiency viruses require cellular CBFβ to degrade APOBEC3 restriction factors

scientific article published on 28 December 2011

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