List of works - Ae Nim Pae

(E)-N-[(E)-3-(4-Nitro-phen-yl)allyl-idene]naphthalen-1-amine

scientific article published on 16 March 2013

3D pharmacophore based virtual screening of T-type calcium channel blockers

scientific article published on 30 October 2006

A Potential PET Radiotracer for the 5-HT2C Receptor: Synthesis and in Vivo Evaluation of 4-(3-[18F]fluorophenethoxy)pyrimidine

scientific article published on 14 February 2017

ABL kinase inhibitory and antiproliferative activity of novel picolinamide based benzothiazoles

scientific article

Antioxidant and Anti-Inflammatory Activities of a Natural Compound, Shizukahenriol, through Nrf2 Activation. ⬇️

scientific article published on 2 September 2015

Computational approach to the identification of novel Aurora-A inhibitors

scientific article published on 4 December 2010

Design and synthesis of new 2-anilinoquinolines bearing N-methylpicolinamide moiety as potential antiproliferative agents

scientific article published on 6 August 2016

Design and synthesis of new potent anticancer benzothiazole amides and ureas featuring pyridylamide moiety and possessing dual B-Raf(V600E) and C-Raf kinase inhibitory activities.

scientific article published on 18 February 2016

Design, synthesis, and biological evaluation of 1,3-dioxoisoindoline-5-carboxamide derivatives as T-type calcium channel blockers

scientific article

Design, synthesis, biological evaluation and molecular modelling of 2-(2-aryloxyphenyl)-1,4-dihydroisoquinolin-3(2H)-ones: A novel class of TSPO ligands modulating amyloid-β-induced mPTP opening

scientific article published on 20 April 2017

Design, synthesis, in-vitro antiproliferative activity and kinase profile of new picolinamide based 2-amido and ureido quinoline derivatives

scientific article published on 17 July 2015

Discovery and biological evaluation of tetrahydrothieno[2,3-c]pyridine derivatives as selective metabotropic glutamate receptor 1 antagonists for the potential treatment of neuropathic pain.

scientific article published on 30 April 2015

Discovery and development of heat shock protein 90 inhibitors as anticancer agents: a review of patented potent geldanamycin derivatives

scientific article published on 04 May 2013

Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction.

scientific article published on 29 December 2016

Discovery of 2-aryloxy-4-amino-quinazoline derivatives as novel protease-activated receptor 2 (PAR2) antagonists

scientific article published on 18 November 2015

Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studies.

scientific article

Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease.

scientific article

Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in Aβ-induced mitochondrial dysfunction

scientific article

Discovery of piperidinyl aminopyrimidine derivatives as IKK-2 inhibitors.

scientific article published on 17 March 2011

Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM).

scientific article published on 4 August 2015

Efficient synthesis of mibefradil analogues: an insight into in vitro stability

scientific article

Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca(2+) signaling in Huntington's disease

scientific article

Facile diverted synthesis of pyrrolidinyl triazoles using organotrifluoroborate: discovery of potential mPTP blockers.

scientific article

Functional human 5-HT6 receptor assay for high throughput screening of chemical ligands and binding proteins

scientific article

GRP78-targeted In Silico Virtual Screening of Novel Anticancer Agents.

scientific article published on 2 May 2018

IKKbeta inhibitors identification part I: homology model assisted structure based virtual screening

scientific article

IKKbeta inhibitors identification part II: ligand and structure-based virtual screening

scientific article published on 18 April 2010

IKKβ inhibitor identification: a multi-filter driven novel scaffold ⬇️

scientific article published on October 15, 2010

Identification of novel serotonin 2C receptor ligands by sequential virtual screening

scientific article

Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently.

scientific article published on 26 June 2016

In silico probing and biological evaluation of SETDB1/ESET-targeted novel compounds that reduce tri-methylated histone H3K9 (H3K9me3) level

scientific article

In silico-designed novel non-peptidic ABAD LD hot spot mimetics reverse Aβ-induced mitochondrial impairments in vitro.

scientific article

Indium trichloride mediated intramolecular Prins-type cyclization

scientific article (publication date: 13 June 2002)

KKHA-761, a potent D3 receptor antagonist with high 5-HT1A receptor affinity, exhibits antipsychotic properties in animal models of schizophrenia

scientific article published on 10 October 2005

Lead discovery and optimization of T-type calcium channel blockers

scientific article

Novel 5-substituted-2-anilinoquinolines with 3-(morpholino or 4-methylpiperazin-1-yl)propoxy moiety as broad spectrum antiproliferative agents: Synthesis, cell based assays and kinase screening.

scientific article published on 17 May 2016

Novel 6-N-arylcarboxamidopyrazolo[4,3-d]pyrimidin-7-one derivatives as potential anti-cancer agents

scientific article

Novel Scaffold Identification of mGlu1 Receptor Negative Allosteric Modulators Using a Hierarchical Virtual Screening Approach.

scientific article published on 7 September 2015

Novel T-type calcium channel blockers: dioxoquinazoline carboxamide derivatives

scientific article

Novel quinazolinone derivatives as 5-HT7 receptor ligands

scientific article

Pharmacophore-based virtual screening, biological evaluation and binding mode analysis of a novel protease-activated receptor 2 antagonist

scientific article

Psoralidin, a coumestan analogue, as a novel potent estrogen receptor signaling molecule isolated from Psoralea corylifolia

scientific article published on 20 January 2014

Receptor-ligand interaction-based virtual screening for novel Eg5/kinesin spindle protein inhibitors

scientific article published on March 2012

Screening, Synthesis, and In Vitro Evaluation of Vinyl Sulfones as Inhibitors of Complement-Dependent Cytotoxicity in Neuromyelitis Optica

scientific article published on 25 January 2016

Structure based design of heat shock protein 90 inhibitors acting as anticancer agents

scientific article

Synthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers

scientific article published on 28 March 2010

Synthesis and biological evaluation of 2,4-diaminoquinazoline derivatives as novel heat shock protein 90 inhibitors

scientific article published on 2 February 2011

Synthesis and biological evaluation of novel T-type Ca2+ channel blockers

scientific article

Synthesis and biological evaluation of novel T-type calcium channel blockers

scientific article published on 12 October 2006

Synthesis and biological evaluation of pyrrolidine-based T-type calcium channel inhibitors for the treatment of neuropathic pain

scientific article published on 01 December 2018

Targeting EGFR/HER2 tyrosine kinases with a new potent series of 6-substituted 4-anilinoquinazoline hybrids: Design, synthesis, kinase assay, cell-based assay, and molecular docking

scientific article published on 9 October 2015

Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).

scientific article published on 6 September 2016

Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).

scientific article published on 8 September 2016

Tubulin inhibitor identification by bioactive conformation alignment pharmacophore-guided virtual screening.

scientific article published on 6 April 2015

α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors

scientific article

List of works by Ae Nim Pae

(E)-N-[(E)-3-(4-Nitro-phen-yl)allyl-idene]naphthalen-1-amine

3D pharmacophore based virtual screening of T-type calcium channel blockers

A Potential PET Radiotracer for the 5-HT2C Receptor: Synthesis and in Vivo Evaluation of 4-(3-[18F]fluorophenethoxy)pyrimidine

ABL kinase inhibitory and antiproliferative activity of novel picolinamide based benzothiazoles

Antioxidant and Anti-Inflammatory Activities of a Natural Compound, Shizukahenriol, through Nrf2 Activation. ⬇️

Computational approach to the identification of novel Aurora-A inhibitors

Design and synthesis of new 2-anilinoquinolines bearing N-methylpicolinamide moiety as potential antiproliferative agents

Design and synthesis of new potent anticancer benzothiazole amides and ureas featuring pyridylamide moiety and possessing dual B-Raf(V600E) and C-Raf kinase inhibitory activities.

Design, synthesis, and biological evaluation of 1,3-dioxoisoindoline-5-carboxamide derivatives as T-type calcium channel blockers

Design, synthesis, biological evaluation and molecular modelling of 2-(2-aryloxyphenyl)-1,4-dihydroisoquinolin-3(2H)-ones: A novel class of TSPO ligands modulating amyloid-β-induced mPTP opening

Design, synthesis, in-vitro antiproliferative activity and kinase profile of new picolinamide based 2-amido and ureido quinoline derivatives

Discovery and biological evaluation of tetrahydrothieno[2,3-c]pyridine derivatives as selective metabotropic glutamate receptor 1 antagonists for the potential treatment of neuropathic pain.

Discovery and development of heat shock protein 90 inhibitors as anticancer agents: a review of patented potent geldanamycin derivatives

Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction.

Discovery of 2-aryloxy-4-amino-quinazoline derivatives as novel protease-activated receptor 2 (PAR2) antagonists

Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studies.

Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease.

Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in Aβ-induced mitochondrial dysfunction

Discovery of piperidinyl aminopyrimidine derivatives as IKK-2 inhibitors.

Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM).

Efficient synthesis of mibefradil analogues: an insight into in vitro stability

Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca(2+) signaling in Huntington's disease

Facile diverted synthesis of pyrrolidinyl triazoles using organotrifluoroborate: discovery of potential mPTP blockers.

Functional human 5-HT6 receptor assay for high throughput screening of chemical ligands and binding proteins

GRP78-targeted In Silico Virtual Screening of Novel Anticancer Agents.

IKKbeta inhibitors identification part I: homology model assisted structure based virtual screening

IKKbeta inhibitors identification part II: ligand and structure-based virtual screening

IKKβ inhibitor identification: a multi-filter driven novel scaffold ⬇️

Identification of novel serotonin 2C receptor ligands by sequential virtual screening

Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently.

In silico probing and biological evaluation of SETDB1/ESET-targeted novel compounds that reduce tri-methylated histone H3K9 (H3K9me3) level

In silico-designed novel non-peptidic ABAD LD hot spot mimetics reverse Aβ-induced mitochondrial impairments in vitro.

Indium trichloride mediated intramolecular Prins-type cyclization

KKHA-761, a potent D3 receptor antagonist with high 5-HT1A receptor affinity, exhibits antipsychotic properties in animal models of schizophrenia

Lead discovery and optimization of T-type calcium channel blockers

Novel 5-substituted-2-anilinoquinolines with 3-(morpholino or 4-methylpiperazin-1-yl)propoxy moiety as broad spectrum antiproliferative agents: Synthesis, cell based assays and kinase screening.

Novel 6-N-arylcarboxamidopyrazolo[4,3-d]pyrimidin-7-one derivatives as potential anti-cancer agents

Novel Scaffold Identification of mGlu1 Receptor Negative Allosteric Modulators Using a Hierarchical Virtual Screening Approach.

Novel T-type calcium channel blockers: dioxoquinazoline carboxamide derivatives

Novel quinazolinone derivatives as 5-HT7 receptor ligands

Pharmacophore-based virtual screening, biological evaluation and binding mode analysis of a novel protease-activated receptor 2 antagonist

Psoralidin, a coumestan analogue, as a novel potent estrogen receptor signaling molecule isolated from Psoralea corylifolia

Receptor-ligand interaction-based virtual screening for novel Eg5/kinesin spindle protein inhibitors

Screening, Synthesis, and In Vitro Evaluation of Vinyl Sulfones as Inhibitors of Complement-Dependent Cytotoxicity in Neuromyelitis Optica

Structure based design of heat shock protein 90 inhibitors acting as anticancer agents

Synthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers

Synthesis and biological evaluation of 2,4-diaminoquinazoline derivatives as novel heat shock protein 90 inhibitors

Synthesis and biological evaluation of novel T-type Ca2+ channel blockers

Synthesis and biological evaluation of novel T-type calcium channel blockers

Synthesis and biological evaluation of pyrrolidine-based T-type calcium channel inhibitors for the treatment of neuropathic pain

Targeting EGFR/HER2 tyrosine kinases with a new potent series of 6-substituted 4-anilinoquinazoline hybrids: Design, synthesis, kinase assay, cell-based assay, and molecular docking

Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).

Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).

Tubulin inhibitor identification by bioactive conformation alignment pharmacophore-guided virtual screening.

α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors