List of works - David Fulton

A new role for Nogo as a regulator of vascular remodeling

scientific article

Activation of the JAK/STAT pathway in vascular smooth muscle by serotonin

scientific article published on 15 December 2004

Adenosine kinase is critical for neointima formation after vascular injury by inducing aberrant DNA hypermethylation

scientific article published on 17 February 2020

Agonist-stimulated endothelial nitric oxide synthase activation and vascular relaxation. Role of eNOS phosphorylation at Tyr83.

scientific article

Angiotensin II-induced insulin resistance and protein tyrosine phosphatases

scientific article published on 22 July 2004

Angiotensin II-induced signaling pathways in diabetes

scientific article published on May 2005

Arginase in the vascular endothelium: friend or foe?

scientific article published on 17 November 2014

Asymmetric dimethylarginine induces endothelial nitric-oxide synthase mitochondrial redistribution through the nitration-mediated activation of Akt1

scientific article published on 19 December 2012

Beta-actin association with endothelial nitric-oxide synthase modulates nitric oxide and superoxide generation from the enzyme

scientific article

Calcineurin-mediated dephosphorylation of eNOS at serine 116 affects eNOS enzymatic activity indirectly by facilitating c-Src binding and tyrosine 83 phosphorylation

scientific article published on 30 May 2013

Caveolin-1 stabilizes ATP7A, Cu transporter for Extracellular SOD, in Vascular Tissue to Maintain Endothelial Function

scientific article published on 16 September 2020

Chaperone-dependent E3 ligase CHIP ubiquitinates and mediates proteasomal degradation of soluble guanylyl cyclase

scientific article

Circadian clock control of Nox4 and reactive oxygen species in the vasculature.

scientific article

Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase

scientific article published on 18 February 2003

Coordinated regulation of endothelial nitric oxide synthase activity by phosphorylation and subcellular localization

scientific article published on 05 April 2006

Copper Transporter ATP7A (Copper-Transporting P-Type ATPase/Menkes ATPase) Limits Vascular Inflammation and Aortic Aneurysm Development: Role of MicroRNA-125b

scientific article published on 26 September 2019

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release

scientific journal article

Dominant-negative Hsp90 reduces VEGF-stimulated nitric oxide release and migration in endothelial cells

scientific article published in November 2007

Dual role of hydrogen peroxide as an oxidant in pneumococcal pneumonia

scientific article published on 13 April 2020

Effect of simvastatin on high glucose- and angiotensin II-induced activation of the JAK/STAT pathway in mesangial cells

scientific article published on 31 January 2006

Endothelial NO synthase phosphorylated at SER635 produces NO without requiring intracellular calcium increase

scientific article published on October 2003

Endothelin-1 activation of JAK2 in vascular smooth muscle cells involves NAD(P)H oxidase-derived reactive oxygen species

scientific article published in November 2005

Epithelial Sodium Channel-α Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction

scientific article

Estrogen-induced contraction of coronary arteries is mediated by superoxide generated in vascular smooth muscle

scientific article

Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion

scientific article

Functional relevance of Golgi- and plasma membrane-localized endothelial NO synthase in reconstituted endothelial cells

scientific article published on 2 March 2006

Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche

scientific article published on 01 August 2020

Heat Shock Protein 70 Prevents Hyperoxia-Induced Disruption of Lung Endothelial Barrier via Caspase-Dependent and AIF-Dependent Pathways

scientific article published on 11 June 2015

Heat shock protein 90 inhibitors prevent LPS-induced endothelial barrier dysfunction by disrupting RhoA signaling

scientific article published on January 2014

Histone deacetylases in vascular permeability and remodeling associated with acute lung injury

scientific article published on 10 July 2018

Hsp90 inhibition suppresses NF-κB transcriptional activation via Sirt-2 in human lung microvascular endothelial cells

scientific article published on April 2016

Hyperglycemia and reactive oxygen species mediate apoptosis in aortic endothelial cells through Janus kinase 2.

scientific article published on 27 October 2005

Insulin resistance does not diminish eNOS expression, phosphorylation, or binding to HSP-90.

scientific article

Intracellular location regulates calcium-calmodulin-dependent activation of organelle-restricted eNOS.

scientific article published on 25 May 2005

LPS induces pp60c-src-mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung

scientific article

Lipopolysaccharide-induced lung injury involves the nitration-mediated activation of RhoA.

scientific article published on 7 January 2014

Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme.

scientific article

Mechanisms of Diabetes-Induced Endothelial Cell Senescence: Role of Arginase 1.

scientific article published on 17 April 2018

Mechanisms of nitric oxide synthase uncoupling in endotoxin-induced acute lung injury: role of asymmetric dimethylarginine

scientific article

Modification of Cardiac Progenitor Cell-Derived Exosomes by miR-322 Provides Protection against Myocardial Infarction through Nox2-Dependent Angiogenesis

scientific article published on 10 January 2019

Molecular characterization of myosin phosphatase in endothelium.

scientific article published on April 2012

Mutation of protein kinase C phosphorylation site S1076 on alpha-subunits affects BK(Ca) channel activity in HEK-293 cells

scientific article published on 10 July 2009

NOX2-Induced Activation of Arginase and Diabetes-Induced Retinal Endothelial Cell Senescence

scientific article

Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking

scholarly article

Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration

scientific article published on January 2005

Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration.

scientific article

Peroxynitrite increases VEGF expression in vascular endothelial cells via STAT3.

scientific article published in November 2005

Phosphorylation of eNOS initiates excessive NO production in early phases of portal hypertension

scientific article

Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production

scientific article published on 2 September 2003

Pin1 Prolyl Isomerase Regulates Endothelial Nitric Oxide Synthase ⬇️

scientific article published on November 4, 2010

Platelet-Endothelial Cell Adhesion Molecule-1 Regulates Endothelial NO Synthase Activity and Localization Through Signal Transducers and Activators of Transcription 3–Dependent NOSTRIN Expression ⬇️

scientific article published on December 23, 2010

Post-translational regulation of endothelial nitric oxide synthase in vascular endothelium

scientific article published in 2013

Protein kinase G phosphorylates soluble guanylyl cyclase on serine 64 and inhibits its activity.

scientific article published on 17 July 2008

Reactive Oxygen Species-Dependent Calpain Activation Contributes to Airway and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease

scientific article published on 24 June 2019

Reactive Oxygen and Nitrogen Species in the Development of Pulmonary Hypertension

scientific article

Regulation of Ang2 release by PTEN/PI3-kinase/Akt in lung microvascular endothelial cells

scientific article

Regulation of Ang2 release by PTEN/PI3-kinase/Akt in lung microvascular endothelial cells

Regulation of soluble guanylyl cyclase by phosphorylation

Role of eNOS phosphorylation at Ser-116 in regulation of eNOS activity in endothelial cells.

scientific article

Role of growth hormone-releasing hormone in dyslipidemia associated with experimental type 1 diabetes

scientific article published on February 2016

SUMO1 regulates endothelial function by modulating the overall signals in favor of angiogenesis and homeostatic responses

scientific article published on 24 May 2013

Src kinase activates endothelial nitric-oxide synthase by phosphorylating Tyr-83.

scientific article published on 25 August 2005

Subcellular targeting and trafficking of nitric oxide synthases

scientific article

TNFα reduces eNOS activity in endothelial cells through serine 116 phosphorylation and Pin1 binding: Confirmation of a direct, inhibitory interaction of Pin1 with eNOS.

scientific article

Targeting of endothelial nitric-oxide synthase to the cytoplasmic face of the Golgi complex or plasma membrane regulates Akt- versus calcium-dependent mechanisms for nitric oxide release

scientific article

The lectin-like domain of TNF protects from listeriolysin-induced hyperpermeability in human pulmonary microvascular endothelial cells - a crucial role for protein kinase C-alpha inhibition

scientific article published on 13 January 2010

The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation

scientific article

The subcellular compartmentalization of arginine metabolizing enzymes and their role in endothelial dysfunction

scientific article published on 9 July 2013

Vanadate is a potent activator of endothelial nitric-oxide synthase: evidence for the role of the serine/threonine kinase Akt and the 90-kDa heat shock protein.

scientific article published on February 2004

eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity

scientific article published on 3 June 2011

eNOS-β-Actin Interaction Contributes to Increased Peroxynitrite Formation during Hyperoxia in Pulmonary Artery Endothelial Cells and Mouse Lungs ⬇️

scientific article published on September 7, 2010

List of works by David Fulton

A new role for Nogo as a regulator of vascular remodeling

Activation of the JAK/STAT pathway in vascular smooth muscle by serotonin

Adenosine kinase is critical for neointima formation after vascular injury by inducing aberrant DNA hypermethylation

Agonist-stimulated endothelial nitric oxide synthase activation and vascular relaxation. Role of eNOS phosphorylation at Tyr83.

Angiotensin II-induced insulin resistance and protein tyrosine phosphatases

Angiotensin II-induced signaling pathways in diabetes

Arginase in the vascular endothelium: friend or foe?

Asymmetric dimethylarginine induces endothelial nitric-oxide synthase mitochondrial redistribution through the nitration-mediated activation of Akt1

Beta-actin association with endothelial nitric-oxide synthase modulates nitric oxide and superoxide generation from the enzyme

Calcineurin-mediated dephosphorylation of eNOS at serine 116 affects eNOS enzymatic activity indirectly by facilitating c-Src binding and tyrosine 83 phosphorylation

Caveolin-1 stabilizes ATP7A, Cu transporter for Extracellular SOD, in Vascular Tissue to Maintain Endothelial Function

Chaperone-dependent E3 ligase CHIP ubiquitinates and mediates proteasomal degradation of soluble guanylyl cyclase

Circadian clock control of Nox4 and reactive oxygen species in the vasculature.

Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase

Coordinated regulation of endothelial nitric oxide synthase activity by phosphorylation and subcellular localization

Copper Transporter ATP7A (Copper-Transporting P-Type ATPase/Menkes ATPase) Limits Vascular Inflammation and Aortic Aneurysm Development: Role of MicroRNA-125b

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release

Dominant-negative Hsp90 reduces VEGF-stimulated nitric oxide release and migration in endothelial cells

Dual role of hydrogen peroxide as an oxidant in pneumococcal pneumonia

Effect of simvastatin on high glucose- and angiotensin II-induced activation of the JAK/STAT pathway in mesangial cells

Endothelial NO synthase phosphorylated at SER635 produces NO without requiring intracellular calcium increase

Endothelin-1 activation of JAK2 in vascular smooth muscle cells involves NAD(P)H oxidase-derived reactive oxygen species

Epithelial Sodium Channel-α Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction

Estrogen-induced contraction of coronary arteries is mediated by superoxide generated in vascular smooth muscle

Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion

Functional relevance of Golgi- and plasma membrane-localized endothelial NO synthase in reconstituted endothelial cells

Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche

Heat Shock Protein 70 Prevents Hyperoxia-Induced Disruption of Lung Endothelial Barrier via Caspase-Dependent and AIF-Dependent Pathways

Heat shock protein 90 inhibitors prevent LPS-induced endothelial barrier dysfunction by disrupting RhoA signaling

Histone deacetylases in vascular permeability and remodeling associated with acute lung injury

Hsp90 inhibition suppresses NF-κB transcriptional activation via Sirt-2 in human lung microvascular endothelial cells

Hyperglycemia and reactive oxygen species mediate apoptosis in aortic endothelial cells through Janus kinase 2.

Insulin resistance does not diminish eNOS expression, phosphorylation, or binding to HSP-90.

Intracellular location regulates calcium-calmodulin-dependent activation of organelle-restricted eNOS.

LPS induces pp60c-src-mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung

Lipopolysaccharide-induced lung injury involves the nitration-mediated activation of RhoA.

Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme.

Mechanisms of Diabetes-Induced Endothelial Cell Senescence: Role of Arginase 1.

Mechanisms of nitric oxide synthase uncoupling in endotoxin-induced acute lung injury: role of asymmetric dimethylarginine

Modification of Cardiac Progenitor Cell-Derived Exosomes by miR-322 Provides Protection against Myocardial Infarction through Nox2-Dependent Angiogenesis

Molecular characterization of myosin phosphatase in endothelium.

Mutation of protein kinase C phosphorylation site S1076 on alpha-subunits affects BK(Ca) channel activity in HEK-293 cells

NOX2-Induced Activation of Arginase and Diabetes-Induced Retinal Endothelial Cell Senescence

Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking

Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration

Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration.

Peroxynitrite increases VEGF expression in vascular endothelial cells via STAT3.

Phosphorylation of eNOS initiates excessive NO production in early phases of portal hypertension

Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production

Pin1 Prolyl Isomerase Regulates Endothelial Nitric Oxide Synthase ⬇️

Platelet-Endothelial Cell Adhesion Molecule-1 Regulates Endothelial NO Synthase Activity and Localization Through Signal Transducers and Activators of Transcription 3–Dependent NOSTRIN Expression ⬇️

Post-translational regulation of endothelial nitric oxide synthase in vascular endothelium

Protein kinase G phosphorylates soluble guanylyl cyclase on serine 64 and inhibits its activity.

Reactive Oxygen Species-Dependent Calpain Activation Contributes to Airway and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease

Reactive Oxygen and Nitrogen Species in the Development of Pulmonary Hypertension

Regulation of Ang2 release by PTEN/PI3-kinase/Akt in lung microvascular endothelial cells

Regulation of Ang2 release by PTEN/PI3-kinase/Akt in lung microvascular endothelial cells

Regulation of soluble guanylyl cyclase by phosphorylation

Regulation of soluble guanylyl cyclase by phosphorylation

Role of eNOS phosphorylation at Ser-116 in regulation of eNOS activity in endothelial cells.

Role of growth hormone-releasing hormone in dyslipidemia associated with experimental type 1 diabetes

SUMO1 regulates endothelial function by modulating the overall signals in favor of angiogenesis and homeostatic responses

Src kinase activates endothelial nitric-oxide synthase by phosphorylating Tyr-83.

Subcellular targeting and trafficking of nitric oxide synthases

TNFα reduces eNOS activity in endothelial cells through serine 116 phosphorylation and Pin1 binding: Confirmation of a direct, inhibitory interaction of Pin1 with eNOS.

Targeting of endothelial nitric-oxide synthase to the cytoplasmic face of the Golgi complex or plasma membrane regulates Akt- versus calcium-dependent mechanisms for nitric oxide release

The lectin-like domain of TNF protects from listeriolysin-induced hyperpermeability in human pulmonary microvascular endothelial cells - a crucial role for protein kinase C-alpha inhibition

The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation

The subcellular compartmentalization of arginine metabolizing enzymes and their role in endothelial dysfunction

Vanadate is a potent activator of endothelial nitric-oxide synthase: evidence for the role of the serine/threonine kinase Akt and the 90-kDa heat shock protein.

eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity

eNOS-β-Actin Interaction Contributes to Increased Peroxynitrite Formation during Hyperoxia in Pulmonary Artery Endothelial Cells and Mouse Lungs ⬇️